{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:00:57Z","timestamp":1793145657297,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"38","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.vaccine.2019.09.065","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T07:43:00Z","timestamp":1570174980000},"page":"6065-6073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Changes in serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates from adult patients in Asia: Emergence of drug-resistant non-vaccine serotypes"],"prefix":"10.1016","volume":"38","author":[{"given":"So Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo Ryeon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5540-2600","authenticated-orcid":false,"given":"Jae-Hoon","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Yang","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visanu","family":"Thamlikitkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-4522","authenticated-orcid":false,"given":"Celia","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norazah","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revathy","family":"Arushothy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Huei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol-In","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Soo","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Ran","family":"Peck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.vaccine.2019.09.065_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11908-018-0607-z","article-title":"Prevention of invasive pneumococcal disease: Problems emerged after some years of the 13-valent pneumococcal conjugate vaccine use","volume":"20","author":"Principi","year":"2018","journal-title":"Curr Infect Dis Rep"},{"issue":"2","key":"10.1016\/j.vaccine.2019.09.065_b0010","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/21645515.2015.1075678","article-title":"Theory and strategy for pneumococcal vaccines in the elderly","volume":"12","author":"Namkoong","year":"2016","journal-title":"Hum Vaccin Immunother"},{"issue":"12","key":"10.1016\/j.vaccine.2019.09.065_b0015","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.rmed.2011.07.008","article-title":"Pneumococcal vaccination in adults: does it really work?","volume":"105","author":"Pitsiou","year":"2011","journal-title":"Respir Med"},{"issue":"43","key":"10.1016\/j.vaccine.2019.09.065_b0020","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1016\/j.vaccine.2017.09.005","article-title":"The impact of 10-valent and 13-valent pneumococcal conjugate vaccines on hospitalization for pneumonia in children: a systematic review and meta-analysis","volume":"35","author":"Alicino","year":"2017","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2019.09.065_b0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/14760584.2018.1411196","article-title":"Pneumococcal conjugate vaccine use for the prevention of pneumococcal disease in adults <50 years of age","volume":"17","author":"Isturiz","year":"2018","journal-title":"Expert Rev Vaccines"},{"issue":"40","key":"10.1016\/j.vaccine.2019.09.065_b0030","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1016\/j.vaccine.2016.08.030","article-title":"Emergence of antibiotic-resistant non-vaccine serotype pneumococci in nasopharyngeal carriage in children after the use of extended-valency pneumococcal conjugate vaccines in Korea","volume":"34","author":"Choe","year":"2016","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2019.09.065_b0035","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jiac.2016.12.016","article-title":"Serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae strains isolated in Japan after introduction of the routine immunization program","volume":"23","author":"Miyazaki","year":"2017","journal-title":"J Infect Chemother"},{"issue":"2","key":"10.1016\/j.vaccine.2019.09.065_b0040","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/1403494817720105","article-title":"Epidemiological characteristics associated with uptake of pneumococcal vaccine among older adults living in the community in Singapore: results from the national health surveillance survey 2013","volume":"46","author":"Ang","year":"2018","journal-title":"Scand J Public Health"},{"issue":"7","key":"10.1016\/j.vaccine.2019.09.065_b0045","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.4161\/hv.28675","article-title":"Changing trends in serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae causing invasive diseases in Central Thailand, 2009\u20132012","volume":"10","author":"Phongsamart","year":"2014","journal-title":"Hum Vaccin Immunother"},{"issue":"6","key":"10.1016\/j.vaccine.2019.09.065_b0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097912","article-title":"Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia","volume":"9","author":"Jefferies","year":"2014","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.vaccine.2019.09.065_b0055","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1080\/21645515.2018.1435224","article-title":"Serotype distribution of Streptococcus pneumoniae and potential impact of pneumococcal conjugate vaccines in China: a systematic review and meta-analysis","volume":"14","author":"Chen","year":"2018","journal-title":"Hum Vaccin Immunother"},{"issue":"5","key":"10.1016\/j.vaccine.2019.09.065_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177342","article-title":"Cost-effectiveness of pneumococcal vaccination strategies for the elderly in Korea","volume":"12","author":"Heo","year":"2017","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.vaccine.2019.09.065_b0065","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000009773","article-title":"Vaccination coverage and associated factors for receipt of the 23-valent pneumococcal polysaccharide vaccine in Taiwan: s nation-wide community-based study","volume":"97","author":"Chen","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"10.1016\/j.vaccine.2019.09.065_b0070","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1473-3099(14)71081-3","article-title":"Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance","volume":"15","author":"Moore","year":"2015","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"10.1016\/j.vaccine.2019.09.065_b0075","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1473-3099(15)70044-7","article-title":"Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: an observational cohort study","volume":"15","author":"Waight","year":"2015","journal-title":"Lancet Infect Dis"},{"issue":"10","key":"10.1016\/j.vaccine.2019.09.065_b0080","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.2217\/fmb.15.81","article-title":"Direct and indirect effects of the 13-valent pneumococcal conjugate vaccine administered to infants and young children","volume":"10","author":"Esposito","year":"2015","journal-title":"Future Microbiol"},{"issue":"5","key":"10.1016\/j.vaccine.2019.09.065_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177113","article-title":"Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: a systematic review and meta-analysis","volume":"12","author":"Balsells","year":"2017","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.vaccine.2019.09.065_b0090","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1128\/AAC.05658-11","article-title":"Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study","volume":"56","author":"Kim","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.vaccine.2019.09.065_b0095","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.meegid.2015.12.018","article-title":"Prevalence of antimicrobial resistant Streptococcus pneumoniae serotype 11A isolates in Korea, during 2004\u20132013, due to the increase of multidrug-resistant clone, CC166","volume":"38","author":"Baek","year":"2016","journal-title":"Infect Genet Evol"},{"issue":"6","key":"10.1016\/j.vaccine.2019.09.065_b0100","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/cid\/cix446","volume":"65","author":"Schroeder","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2019.09.065_b0105","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing: Twenty-Seventh Informational Supplement M100. CLSI 2017; Wayne(PA)."},{"key":"10.1016\/j.vaccine.2019.09.065_b0110","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST). EUCAST Clinical Breakpoints. Version 6.0; [accessed October 2018]. http:\/\/www.eucast.org\/ast_of_bacteria\/previous_versions_of_ documents\/"},{"issue":"4","key":"10.1016\/j.vaccine.2019.09.065_b0115","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1086\/422156","article-title":"Evolution of erythromycin-resistant Streptococcus pneumoniae from Asian countries that contains erm(B) and mef(A) genes","volume":"190","author":"Ko","year":"2004","journal-title":"J Infect Dis"},{"issue":"7","key":"10.1016\/j.vaccine.2019.09.065_b0120","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1086\/528996","article-title":"Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005","volume":"197","author":"Moore","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2019.09.065_b0125","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing: Eighteenth Information Supplement M100-S18. CLSI 2008; Wayne(PA)."},{"issue":"1","key":"10.1016\/j.vaccine.2019.09.065_b0130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.diagmicrobio.2014.05.020","article-title":"Serotype distribution and antimicrobial susceptibility of USA Streptococcus pneumoniae isolates collected prior to and post introduction of 13-valent pneumococcal conjugate vaccine","volume":"80","author":"Mendes","year":"2014","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"11","key":"10.1016\/j.vaccine.2019.09.065_b0135","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1017\/S0950268817001194","article-title":"The epidemiology of invasive pneumococcal disease in older adults in the post-PCV era. Has there been a herd effect?","volume":"145","author":"Corcoran","year":"2017","journal-title":"Epidemiol Infect"},{"issue":"9","key":"10.1016\/j.vaccine.2019.09.065_b0140","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3346\/jkms.2013.28.9.1283","article-title":"Comparative estimation of coverage between national immunization program vaccines and non-NIP vaccines in Korea","volume":"28","author":"Choe","year":"2013","journal-title":"J Korean Med Sci"},{"issue":"7","key":"10.1016\/j.vaccine.2019.09.065_b0145","doi-asserted-by":"crossref","first-page":"e365","DOI":"10.1016\/S2214-109X(14)70241-4","article-title":"Herd protection induced by pneumococcal conjugate vaccine","volume":"2","author":"Klugman","year":"2014","journal-title":"Lancet Glob Health"},{"issue":"5","key":"10.1016\/j.vaccine.2019.09.065_b0150","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/INF.0000000000000279","article-title":"Direct and indirect effects of PCV13 on nasopharyngeal carriage of PCV13 unique pneumococcal serotypes in Massachusetts' children","volume":"33","author":"Loughlin","year":"2014","journal-title":"Pediatr Infect Dis J"},{"issue":"5","key":"10.1016\/j.vaccine.2019.09.065_b0155","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.vaccine.2017.12.063","article-title":"Phenotypic and molecular characterization of Streptococcus pneumoniae in pre-conjugate vaccine era: a Chinese hospital-based retrospective study","volume":"36","author":"Li","year":"2018","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2019.09.065_b0160","first-page":"163","article-title":"Recombination rates of Streptococcus pneumoniae isolates with both erm(B) and mef(A) genes","volume":"309","author":"Lee","year":"2010","journal-title":"FEMS Microbiol Lett"},{"issue":"1","key":"10.1016\/j.vaccine.2019.09.065_b0165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.vaccine.2015.11.015","volume":"34","author":"Nakano","year":"2016","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2019.09.065_b0170","doi-asserted-by":"crossref","first-page":"60.e9","DOI":"10.1016\/j.cmi.2015.08.027","article-title":"Strain features and distributions in pneumococci from children with invasive disease before and after 13-valent conjugate vaccine implementation in the USA","volume":"22","author":"Metcalf","year":"2016","journal-title":"Clin Microbiol Infect"},{"issue":"50","key":"10.1016\/j.vaccine.2019.09.065_b0175","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2016.21.50.30423","article-title":"Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014","volume":"21","author":"Sheppard","year":"2016","journal-title":"Euro Surveill"},{"issue":"9560","key":"10.1016\/j.vaccine.2019.09.065_b0180","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0140-6736(07)60235-9","article-title":"Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study","volume":"369","author":"Malhotra-Kumar","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.vaccine.2019.09.065_b0185","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJMoa0800836","article-title":"Effect of pneumococcal conjugate vaccine on pneumococcal meningitis","volume":"360","author":"Hsu","year":"2009","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.vaccine.2019.09.065_b0190","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1128\/AAC.03344-14","article-title":"Changes in pneumococcal serotypes and antimicrobial resistance after introduction of the 13-valent conjugate vaccine in the United States","volume":"58","author":"Richter","year":"2014","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X19312939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X19312939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:45:57Z","timestamp":1759401957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X19312939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":38,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0264410X19312939"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.09.065","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates from adult patients in Asia: Emergence of drug-resistant non-vaccine serotypes","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.09.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}