{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T09:11:58Z","timestamp":1781946718663,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012895","name":"Zoetis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.vaccine.2020.01.013","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T08:58:10Z","timestamp":1579510690000},"page":"1975-1981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Porcine circovirus type 2a or 2b based experimental vaccines provide protection against PCV2d\/porcine parvovirus 2 co-challenge"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9642-0904","authenticated-orcid":false,"given":"Tanja","family":"Opriessnig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbu K.","family":"Karuppannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick G.","family":"Halbur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay G.","family":"Calvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Nitzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon R.","family":"Matzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Jin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2020.01.013_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/104063870001200102","article-title":"Porcine circoviruses: a review","volume":"12","author":"Allan","year":"2000","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.vaccine.2020.01.013_b0010","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1099\/vir.0.000100","article-title":"Global molecular genetic analysis of porcine circovirus type 2 (PCV2) sequences confirms the presence of four main PCV2 genotypes and reveals a rapid increase of PCV2d","volume":"96","author":"Xiao","year":"2015","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.vetmic.2016.10.002","article-title":"Ten years of PCV2 vaccines and vaccination: Is eradication a possibility?","volume":"206","author":"Afghah","year":"2017","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0020","first-page":"259","article-title":"The emergence of a new strain of porcine circovirus-2 in Ontario and Quebec swine and its association with severe porcine circovirus associated disease-2004-2006","volume":"72","author":"Carman","year":"2008","journal-title":"Can J Vet Res"},{"key":"10.1016\/j.vaccine.2020.01.013_b0025","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1099\/vir.0.2008\/001081-0","article-title":"Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection","volume":"89","author":"Opriessnig","year":"2008","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0030","first-page":"811","article-title":"The emergence of porcine circovirus 2b genotype (PCV-2b) in swine in Canada","volume":"48","author":"Gagnon","year":"2007","journal-title":"Can Vet J"},{"key":"10.1016\/j.vaccine.2020.01.013_b0035","doi-asserted-by":"crossref","DOI":"10.3390\/v9050099","article-title":"Porcine circovirus type 2 (PCV2) vaccines in the context of current molecular epidemiology","volume":"9","author":"Karuppannan","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.vaccine.2020.01.013_b0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.virusres.2011.09.014","article-title":"Concurrent infections are important for expression of porcine circovirus associated disease","volume":"164","author":"Opriessnig","year":"2012","journal-title":"Virus Res"},{"issue":"6","key":"10.1016\/j.vaccine.2020.01.013_b0045","doi-asserted-by":"crossref","first-page":"244","DOI":"10.7883\/yoken.JJID.2001.244","article-title":"Identification of new parvovirus DNA sequence in swine sera from Myanmar","volume":"54","author":"Hijikata","year":"2001","journal-title":"Jpn J Infect Dis"},{"issue":"3\u20134","key":"10.1016\/j.vaccine.2020.01.013_b0050","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.vetmic.2012.07.038","article-title":"Characterization of porcine parvovirus type 2 (PPV2) which is highly prevalent in the USA","volume":"161","author":"Xiao","year":"2013","journal-title":"Vet Microbiol"},{"issue":"6","key":"10.1016\/j.vaccine.2020.01.013_b0055","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1111\/tbed.12593","article-title":"Circulation of porcine parvovirus types 1 through 6 in serum samples obtained from six commercial Polish pig farms","volume":"64","author":"Cui","year":"2017","journal-title":"Transbound Emerg Dis"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2020.01.013_b0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.vetmic.2014.06.024","article-title":"Identification of recently described porcine parvoviruses in archived North American samples from 1996 and association with porcine circovirus associated disease","volume":"173","author":"Opriessnig","year":"2014","journal-title":"Vet Microbiol"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2020.01.013_b0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.vetmic.2012.12.019","article-title":"Emergence of a novel mutant PCV2b variant associated with clinical PCVAD in two vaccinated pig farms in the U.S. concurrently infected with PPV2","volume":"163","author":"Opriessnig","year":"2013","journal-title":"Vet Microbiol."},{"issue":"20","key":"10.1016\/j.vaccine.2020.01.013_b0070","doi-asserted-by":"crossref","first-page":"11232","DOI":"10.1128\/JVI.77.20.11232-11243.2003","article-title":"Immunogenicity and pathogenicity of chimeric infectious DNA clones of pathogenic porcine circovirus type 2 (PCV2) and nonpathogenic PCV1 in weanling pigs","volume":"77","author":"Fenaux","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0075","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1099\/vir.0.066423-0","article-title":"Mutant USA strain of porcine circovirus type 2 (mPCV2) exhibits similar virulence to the classical PCV2a and PCV2b strains in caesarean-derived, colostrum-deprived pigs","volume":"95","author":"Opriessnig","year":"2014","journal-title":"J Gen Virol"},{"issue":"5","key":"10.1016\/j.vaccine.2020.01.013_b0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.mex.2018.03.010","article-title":"Refinement of a colostrum-deprived pig model for infectious disease research","volume":"10","author":"Opriessnig","year":"2018","journal-title":"MethodsX"},{"key":"10.1016\/j.vaccine.2020.01.013_b0085","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1354\/vp.40-5-521","article-title":"Effect of vaccination with selective bacterins on conventional pigs infected with type 2 porcine circovirus","volume":"40","author":"Opriessnig","year":"2003","journal-title":"Vet Pathol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0090","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.vaccine.2013.11.010","article-title":"A commercial vaccine based on PCV2a and an experimental vaccine based on a variant mPCV2b are both effective in protecting pigs against challenge with a 2013 U.S. variant mPCV2b strain","volume":"32","author":"Opriessnig","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.01.013_b0095","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.rvsc.2013.06.004","article-title":"Association of concurrent porcine circovirus (PCV) 2a and 2b infection with PCV associated disease in vaccinated pigs","volume":"95","author":"Gerber","year":"2013","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.vaccine.2020.01.013_b0100","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/030098589503200606","article-title":"Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus","volume":"32","author":"Halbur","year":"1995","journal-title":"Vet Pathol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1354\/vp.43-3-281","article-title":"Evidence of breed-dependent differences in susceptibility to porcine circovirus type-2-associated disease and lesions","volume":"43","author":"Opriessnig","year":"2006","journal-title":"Vet Pathol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0110","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1354\/vp.41-6-624","article-title":"Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2","volume":"41","author":"Opriessnig","year":"2004","journal-title":"Vet Pathol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0115","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/104063879901100607","article-title":"Development of a polyclonal-antibody-based immunohistochemical method for the detection of type 2 porcine circovirus in formalin-fixed, paraffin-embedded tissue","volume":"11","author":"Sorden","year":"1999","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.vaccine.2020.01.013_b0120","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.vetmic.2009.09.056","article-title":"Comparison of the effectiveness of passive (dam) versus active (piglet) immunization against porcine circovirus type 2 (PCV2) and impact of passively derived PCV2 vaccine-induced immunity on vaccination","volume":"142","author":"Opriessnig","year":"2010","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0125","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1128\/CVI.00416-07","article-title":"Influence of maternal antibodies on efficacy of porcine circovirus type 2 (PCV2) vaccination to protect pigs from experimental infection with PCV2","volume":"15","author":"Opriessnig","year":"2008","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0130","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.vaccine.2007.12.019","article-title":"Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins","volume":"26","author":"Fort","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.01.013_b0135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.vetmic.2019.03.002","article-title":"Evaluation of a porcine circovirus type 2a (PCV2a) vaccine efficacy against experimental PCV2a, PCV2b, and PCV2d challenge","volume":"231","author":"Park","year":"2019","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.vetmic.2008.03.002","article-title":"Effect of porcine circovirus type 2 (PCV2) vaccination on porcine reproductive and respiratory syndrome virus (PRRSV) and PCV2 coinfection","volume":"131","author":"Opriessnig","year":"2008","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0145","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1016\/j.vaccine.2016.06.005","article-title":"A commercial PCV2a-based vaccine significantly reduces PCV2b transmission in experimental conditions","volume":"34","author":"Rose","year":"2016","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.vaccine.2020.01.013_b0150","article-title":"Efficacy of a commercial PCV2a vaccine with a two-dose regimen against PCV2d","author":"Kolyvushko","year":"2019","journal-title":"Vet Sci"},{"key":"10.1016\/j.vaccine.2020.01.013_b0155","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.vaccine.2016.11.085","article-title":"A commercial porcine circovirus (PCV) type 2a-based vaccine reduces PCV2d viremia and shedding and prevents PCV2d transmission to naive pigs under experimental conditions","volume":"35","author":"Opriessnig","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.01.013_b0160","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1016\/j.vaccine.2015.05.056","article-title":"A commercial PCV2a-based vaccine is effective in protection from experimental challenge of PCV2 mutant with two amino acids elongation in capsid protein","volume":"33","author":"Guo","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.01.013_b0165","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1016\/j.vaccine.2014.06.004","article-title":"Commercial PCV2a-based vaccines are effective in protecting naturally PCV2b-infected finisher pigs against experimental challenge with a 2012 mutant PCV2","volume":"32","author":"Opriessnig","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.01.013_b0170","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.vaccine.2010.10.050","volume":"29","author":"Beach","year":"2010","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2020.01.013_b0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fmicb.2018.00455","article-title":"Evaluation of the efficacy and cross-protective immunity of live-attenuated chimeric PCV1-2b vaccine against PCV2b and PCV2d subtype challenge in pigs","volume":"15","author":"Huan","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0180","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00705-016-3099-x","article-title":"Inactivated chimeric porcine circovirus (PCV) 1\u20132 vaccines based on genotypes 2b and 2d exhibit similar immunological effectiveness in protecting pigs against challenge with PCV2b strain 0233","volume":"162","author":"Li","year":"2017","journal-title":"Arch Virol"},{"key":"10.1016\/j.vaccine.2020.01.013_b0185","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.virol.2016.08.011","article-title":"A chimeric virus created by DNA shuffling of the capsid genes of different subtypes of porcine circovirus type 2 (PCV2) in the backbone of the non-pathogenic PCV1 induces protective immunity against the predominant PCV2b and the emerging PCV2d in pigs","volume":"498","author":"Matzinger","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2020.01.013_b0190","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.vaccine.2012.11.030","article-title":"A PCV2 vaccine based on genotype 2b is more effective than a 2a-based vaccine to protect against PCV2b or combined PCV2a\/2b viremia in pigs with concurrent PCV2, PRRSV and PPV infection","volume":"31","author":"Opriessnig","year":"2013","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2020.01.013_b0195","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/0300985812450726","article-title":"Current state of knowledge on porcine circovirus type 2-associated lesions","volume":"50","author":"Opriessnig","year":"2013","journal-title":"Vet Pathol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X20300177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X20300177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:38:36Z","timestamp":1759401516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X20300177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0264410X20300177"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2020.01.013","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porcine circovirus type 2a or 2b based experimental vaccines provide protection against PCV2d\/porcine parvovirus 2 co-challenge","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2020.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}