{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:42:38Z","timestamp":1790073758213,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["NCT02223637"],"award-info":[{"award-number":["NCT02223637"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005620","name":"North Carolina GlaxoSmithKline Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.vaccine.2020.02.008","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T07:45:30Z","timestamp":1581320730000},"page":"2683-2690","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety of MenACWY-CRM vaccine exposure during pregnancy"],"prefix":"10.1016","volume":"38","author":[{"given":"Tracy A.","family":"Becerra-Culqui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina S.","family":"Sy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley K.","family":"Ackerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lie Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Fischetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zendi","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes E.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Malvisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Curina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung Fu","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 2","key":"10.1016\/j.vaccine.2020.02.008_b0005","doi-asserted-by":"crossref","first-page":"B26","DOI":"10.1016\/j.vaccine.2011.12.032","article-title":"The changing and dynamic epidemiology of meningococcal disease","volume":"30","author":"Halperin","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.02.008_b0010","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/cid\/cix993","article-title":"Current epidemiology and trends in meningococcal disease-United States, 1996\u20132015","volume":"66","author":"MacNeil","year":"2018","journal-title":"Clin Infect Dis An Off Publ Infect Dis Soc Am"},{"key":"10.1016\/j.vaccine.2020.02.008_b0015","unstructured":"Cohn AC, MacNeil JR, Clark TA, Ortega-Sanchez IR, Briere EZ, Meissner HC, et al. Prevention and control of meningococcal disease: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recommendations and Reports: Morbidity and Mortality Weekly Report Recommendations and Reports. 2013;62:1-28. Retrieved on July 19, 2019 at https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/rr6202a1.htm."},{"key":"10.1016\/j.vaccine.2020.02.008_b0020","unstructured":"Sanofi Pasteur Inc. Menactra Package Insert: Highlights of Prescribing Information. 2018. Retrieved on July 19, 2019 at https:\/\/www.fda.gov\/files\/vaccines,%20blood%20&%20biologics\/published\/Package-Insert---Menactra.pdf."},{"key":"10.1016\/j.vaccine.2020.02.008_b0025","unstructured":"GlaxoSmithKline Biologicals S.A. MENVEO Package Insert: Highlights of Prescribing Information. Retrieved on July 19, 2019 at https:\/\/www.fda.gov\/media\/78514\/download."},{"issue":"478","key":"10.1016\/j.vaccine.2020.02.008_b0030","first-page":"e1","article-title":"Safety of meningococcal polysaccharide-protein conjugate vaccine in pregnancy: a review of the vaccine adverse event reporting system","volume":"208","author":"Zheteyeva","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.vaccine.2020.02.008_b0035","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/01.AOG.0000454932.15177.be","article-title":"Committee opinion No 611: method for estimating due date","volume":"124","author":"American College of Obstetricians and Gynecologists","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2020.02.008_b0040","unstructured":"GlaxoSmithKline Biologicals S.A. Meningococcal Quadrivalent CRM-197 Conjugate Vaccine Pregnancy Registry. Bethesda (MD): National Library of Medicine; 2019. p. 1. Retrieved on July 19, 2019 at https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02223637."},{"key":"10.1016\/j.vaccine.2020.02.008_b0045","doi-asserted-by":"crossref","unstructured":"American College of Obstetrics and Gynecology. ACOG Practice Bulletin No. 135: Second-trimester abortion. Obstetrics and Gynecology. 2013;121:1394-406. 10.1097\/01.AOG.0000431056.79334.cc.","DOI":"10.1097\/01.AOG.0000431056.79334.cc"},{"key":"10.1016\/j.vaccine.2020.02.008_b0050","unstructured":"National Center for Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention. Metropolitan Atlanta Congenital Defects Program (MACDP) 6-Digit Code Defect List 2018. Retrieved on December 5, 2019 at http:\/\/www.cdc.gov\/ncbddd\/birthdefects\/MACDP.html."},{"key":"10.1016\/j.vaccine.2020.02.008_b0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/ppe.12417","article-title":"Trends in risk of pregnancy loss among US Women, 1990\u20132011","volume":"32","author":"Rossen","year":"2018","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.vaccine.2020.02.008_b0060","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1016\/j.vaccine.2015.04.014","article-title":"Final report on exposure during pregnancy from a pregnancy registry for quadrivalent human papillomavirus vaccine","volume":"33","author":"Goss","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.02.008_b0065","first-page":"1","article-title":"Births: Final data for 2012","volume":"62","author":"Martin","year":"2013","journal-title":"Nat Vital Statist Rep Centers Dis Control Prevent Nat Center Health Stat Nat Vital Stat Syst"},{"key":"10.1016\/j.vaccine.2020.02.008_b0070","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.vaccine.2017.02.030","article-title":"Adverse events following quadrivalent meningococcal CRM-conjugate vaccine (Menveo(R)) reported to the vaccine adverse event reporting system (VAERS), 2010\u20132015","volume":"35","author":"Myers","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.02.008_b0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ajog.2004.06.099","article-title":"Age-specific risk of fetal loss observed in a second trimester serum screening population","volume":"192","author":"Wyatt","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2020.02.008_b0080","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0301-2115(01)00613-3","article-title":"Risk factors in miscarriage: a review","volume":"102","author":"Garcia-Enguidanos","year":"2002","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.vaccine.2020.02.008_b0085","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0015-0282(16)58144-8","article-title":"Estimates of human fertility and pregnancy loss","volume":"65","author":"Zinaman","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.vaccine.2020.02.008_b0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1472-6483(10)60300-8","article-title":"Early risk factors for miscarriage: a prospective cohort study in pregnant women","volume":"17","author":"Arck","year":"2008","journal-title":"Reproduct Biomed Online"},{"key":"10.1016\/j.vaccine.2020.02.008_b0095","doi-asserted-by":"crossref","first-page":"518","DOI":"10.5468\/ogs.2014.57.6.518","article-title":"Spontaneous abortion and recurrent miscarriage: a comparison of cytogenetic diagnosis in 250 cases","volume":"57","author":"Choi","year":"2014","journal-title":"Obstet Gynecol Sci"},{"key":"10.1016\/j.vaccine.2020.02.008_b0100","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet (Lond England)"},{"key":"10.1016\/j.vaccine.2020.02.008_b0105","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/phar.1649","article-title":"A review of antibiotic use in pregnancy","volume":"35","author":"Bookstaver","year":"2015","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.vaccine.2020.02.008_b0110","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/jog.13687","article-title":"Maternal and perinatal complications in pregnant women with urinary tract infection caused by Escherichia coli","volume":"44","author":"Dautt-Leyva","year":"2018","journal-title":"J Obstetr Gynaecol Res"},{"issue":"1","key":"10.1016\/j.vaccine.2020.02.008_b0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.15585\/mmwr.mm6701a4","article-title":"Antibiotics dispensed to privately insured pregnant women with urinary tract infections \u2014 United States, 2014","volume":"67","author":"Ailes","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"37","key":"10.1016\/j.vaccine.2020.02.008_b0120","first-page":"907","article-title":"Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring","volume":"2013","author":"Vidal","year":"2005","journal-title":"Int J Obesit"},{"key":"10.1016\/j.vaccine.2020.02.008_b0125","first-page":"713","article-title":"Urinary tract infections during pregnancy","volume":"61","author":"Delzell","year":"2000","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.vaccine.2020.02.008_b0130","doi-asserted-by":"crossref","first-page":"E625","DOI":"10.1503\/cmaj.161020","article-title":"Use of antibiotics during pregnancy and risk of spontaneous abortion","volume":"189","author":"Muanda","year":"2017","journal-title":"CMAJ"},{"key":"10.1016\/j.vaccine.2020.02.008_b0135","unstructured":"Office of Population Affairs. California Adolescent Reproductive Health Facts. U.S. Department of Health & Human Services; 2016. Accessed on November 15, 2019 at https:\/\/www.hhs.gov\/ash\/oah\/facts-and-stats\/national-and-state-data-sheets\/adolescent-reproductive-health\/california\/index.html."},{"issue":"13","key":"10.1016\/j.vaccine.2020.02.008_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6713a1","article-title":"Abortion Surveillance \u2014 United States, 2015","volume":"67","author":"Jatlaoui","year":"2018","journal-title":"MMWR Surveill Summ"},{"key":"10.1016\/j.vaccine.2020.02.008_b0145","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.contraception.2011.07.013","article-title":"Unintended pregnancy in the United States: Incidence and disparities, 2006","volume":"84","author":"Finer","year":"2011","journal-title":"Contraception"},{"key":"10.1016\/j.vaccine.2020.02.008_b0150","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.pcl.2016.11.007","article-title":"Adolescent pregnancy","volume":"64","author":"Leftwich","year":"2017","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.vaccine.2020.02.008_b0155","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1177\/002214650905000305","article-title":"Investigating the relationship between teenage childbearing and psychological distress using longitudinal evidence","volume":"50","author":"Mollborn","year":"2009","journal-title":"J Health Soc Behav"},{"key":"10.1016\/j.vaccine.2020.02.008_b0160","unstructured":"Correa AC, JD; Kucik J. Metropolitan Atlanta Congenital Defects Program 40th anniversary edition surveillance report: reporting birth defects surveillance data 1968-2003. Birth Defects Res A. 2007;79:65-93. Accessed on July 19, 2019 at 10.1002\/bdra.20351."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X20301754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X20301754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:40:45Z","timestamp":1759401645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X20301754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0264410X20301754"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2020.02.008","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of MenACWY-CRM vaccine exposure during pregnancy","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2020.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}