{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:48:31Z","timestamp":1788058111983,"version":"build-2784847793"},"reference-count":62,"publisher":"Elsevier BV","issue":"44","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.vaccine.2020.08.062","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T09:30:35Z","timestamp":1599384635000},"page":"6904-6913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Live attenuated Salmonella enterica serovar Choleraesuis vector delivering a conserved surface protein enolase induces high and broad protection against Streptococcus suis serotypes 2, 7, and 9 in mice"],"prefix":"10.1016","volume":"38","author":[{"given":"Quan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-an","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianfeng","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huoying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2020.08.062_b0005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tim.2009.12.003","article-title":"Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent","volume":"18","author":"Feng","year":"2010","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0010","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1023\/A:1005870317757","article-title":"Streptococcus suis: past and present","volume":"21","author":"Staats","year":"1997","journal-title":"Vet Res Commun"},{"key":"10.1016\/j.vaccine.2020.08.062_b0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/S1466252307001247","article-title":"Streptococcus suis infections in humans: the Chinese experience and the situation in North America","volume":"8","author":"Gottschalk","year":"2007","journal-title":"Animal Health Res Rev"},{"key":"10.1016\/j.vaccine.2020.08.062_b0020","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1038\/emi.2014.45","article-title":"Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing","volume":"3","author":"Goyette-Desjardins","year":"2014","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.vaccine.2020.08.062_b0025","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4161\/viru.28595","article-title":"Streptococcus suis infection: an emerging\/reemerging challenge of bacterial infectious diseases?","volume":"5","author":"Feng","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.vaccine.2020.08.062_b0030","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jprot.2013.03.035","article-title":"Surfomics: shaving live organisms for a fast proteomic identification of surface proteins","volume":"97","author":"Olaya-Abril","year":"2014","journal-title":"J Proteomics"},{"key":"10.1016\/j.vaccine.2020.08.062_b0035","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/CVI.00046-07","article-title":"Immunization with recombinant Sao protein confers protection against Streptococcus suis infection","volume":"14","author":"Li","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0040","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1086\/644602","article-title":"Streptococcus suis enolase functions as a protective antigen displayed on the bacterial cell surface","volume":"200","author":"Feng","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2020.08.062_b0045","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1574-6968.2009.01617.x","article-title":"Vaccination with Streptococcus suis serotype 2 recombinant 6PGD protein provides protection against S. suis infection in swine","volume":"296","author":"Tan","year":"2009","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.vaccine.2020.08.062_b0050","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/vr.148.15.473","article-title":"Protection of pigs against challenge with virulent Streptococcus suis serotype 2 strains by a muramidase-released protein and extracellular factor vaccine","volume":"148","author":"Wisselink","year":"2001","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaccine.2020.08.062_b0055","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1574-6968.2010.02200.x","article-title":"Induction of protective immune response against Streptococcus suis serotype 2 infection by the surface antigen HP0245","volume":"316","author":"Li","year":"2011","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.vaccine.2020.08.062_b0060","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1016\/j.vaccine.2009.06.074","article-title":"Identification of a surface protective antigen, HP0197 of Streptococcus suis serotype 2","volume":"27","author":"Zhang","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.08.062_b0065","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.jprot.2010.07.009","article-title":"A surface protein of Streptococcus suis serotype 2 identified by proteomics protects mice against infection","volume":"73","author":"Mandanici","year":"2010","journal-title":"J Proteomics"},{"key":"10.1016\/j.vaccine.2020.08.062_b0070","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.micres.2013.09.007","article-title":"Prevalent distribution and conservation of Streptococcus suis Lmb protein and its protective capacity against the Chinese highly virulent strain infection","volume":"169","author":"Zhang","year":"2014","journal-title":"Microbiol Res"},{"key":"10.1016\/j.vaccine.2020.08.062_b0075","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1016\/j.vaccine.2013.07.004","article-title":"The genetically modified suilysin, rSLY(P353L), provides a candidate vaccine that suppresses proinflammatory response and reduces fatality following infection with Streptococcus suis","volume":"31","author":"Du","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.08.062_b0080","first-page":"484","article-title":"Identification of the gene encoding a 38-kilodalton immunogenic and protective antigen of Streptococcus suis","volume":"12","author":"Okwumabua","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0085","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.micinf.2015.12.005","article-title":"Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2","volume":"18","author":"Fu","year":"2016","journal-title":"Microbes Infect"},{"key":"10.1016\/j.vaccine.2020.08.062_b0090","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.vaccine.2015.03.038","article-title":"Evaluation of the protective efficacy of four novel identified membrane associated proteins of Streptococcus suis serotype 2","volume":"33","author":"Zhou","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.08.062_b0095","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1574-6968.2010.02162.x","article-title":"HtpS, a novel immunogenic cell surface-exposed protein of Streptococcus suis, confers protection in mice","volume":"314","author":"Shao","year":"2011","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.vaccine.2020.08.062_b0100","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/21505594.2015.1056971","article-title":"The type II histidine triad protein HtpsC is a novel adhesion with the involvement of Streptococcus suis virulence","volume":"6","author":"Li","year":"2015","journal-title":"Virulence"},{"key":"10.1016\/j.vaccine.2020.08.062_b0105","doi-asserted-by":"crossref","first-page":"6992","DOI":"10.1016\/j.vaccine.2014.10.019","article-title":"A new recombinant SsnA protein combined with aluminum hydroxide protects mouse against Streptococcus suis","volume":"32","author":"Gomez-Gascon","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.08.062_b0110","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnz002","article-title":"Peptidyl isomerase PrsA is surface-associated on Streptococcus suis and offers cross-protection against serotype 9 strain","volume":"366","author":"Jiang","year":"2019","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.vaccine.2020.08.062_b0115","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1016\/j.vaccine.2010.01.009","article-title":"Immunoprotective activities of a Streptococcus suis pilus subunit in murine models of infection","volume":"28","author":"Garibaldi","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.08.062_b0120","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1128\/JCM.38.3.1156-1160.2000","article-title":"Efficacy of antimicrobial treatments and vaccination regimens for control of porcine reproductive and respiratory syndrome virus and Streptococcus suis coinfection of nursery pigs","volume":"38","author":"Halbur","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0125","first-page":"8","article-title":"Antibody response to an autogenous vaccine and serologic profile for Streptococcus suis capsular type 1\/2","volume":"66","author":"Lapointe","year":"2002","journal-title":"Can J Veterinary Res = Revue canadienne de recherche veterinaire"},{"key":"10.1016\/j.vaccine.2020.08.062_b0130","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2217\/fmb.11.149","article-title":"Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis","volume":"7","author":"Fittipaldi","year":"2012","journal-title":"Future Microbiol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0135","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1128\/CVI.00371-08","article-title":"Streptococcus suis bacterin and subunit vaccine immunogenicities and protective efficacies against serotypes 2 and 9","volume":"16","author":"Baums","year":"2009","journal-title":"Clin Vaccine Immunol : CVI"},{"key":"10.1016\/j.vaccine.2020.08.062_b0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.micpath.2014.02.002","article-title":"The protective protein Sao (surface antigen one) is not a critical virulence factor for Streptococcus suis serotype 2","volume":"67\u201368","author":"Roy","year":"2014","journal-title":"Microb Pathog"},{"key":"10.1016\/j.vaccine.2020.08.062_b0145","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1099\/mic.0.2008\/017145-0","article-title":"Isolation and characterization of alpha-enolase, a novel fibronectin-binding protein from Streptococcus suis","volume":"154","author":"Esgleas","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.vaccine.2020.08.062_b0150","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fcimb.2015.00082","article-title":"Identification of Novel Laminin- and Fibronectin-binding Proteins by Far-Western Blot: Capturing the Adhesins of Streptococcus suis Type 2","volume":"5","author":"Li","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0155","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.micres.2016.11.011","article-title":"Factor H specifically capture novel Factor H-binding proteins of Streptococcus suis and contribute to the virulence of the bacteria","volume":"196","author":"Li","year":"2017","journal-title":"Microbiol Res"},{"key":"10.1016\/j.vaccine.2020.08.062_b0160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fcimb.2015.00019","article-title":"Proteomics identification of novel fibrinogen-binding proteins of Streptococcus suis contributing to antiphagocytosis","volume":"5","author":"Pian","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0165","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.vaccine.2008.12.047","article-title":"Identification and characterization of a novel protective antigen, Enolase of Streptococcus suis serotype 2","volume":"27","author":"Zhang","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.08.062_b0170","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1574-6968.2009.01551.x","article-title":"Immunization with SsEno fails to protect mice against challenge with Streptococcus suis serotype 2","volume":"294","author":"Esgleas","year":"2009","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.vaccine.2020.08.062_b0175","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0264-410X(95)00173-X","article-title":"Evaluation of a phoP\/phoQ-deleted, aroA-deleted live oral Salmonella typhi vaccine strain in human volunteers","volume":"14","author":"Hohmann","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.08.062_b0180","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1016\/j.vaccine.2015.07.063","article-title":"Live attenuated Salmonella enterica serovar Choleraesuis vaccine vector displaying regulated delayed attenuation and regulated delayed antigen synthesis to confer protection against Streptococcus suis in mice","volume":"33","author":"Ji","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.08.062_b0185","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13567-017-0494-6","article-title":"Salmonella enterica serovar Choleraesuis vector delivering SaoA antigen confers protection against Streptococcus suis serotypes 2 and 7 in mice and pigs","volume":"48","author":"Li","year":"2017","journal-title":"Vet Res"},{"key":"10.1016\/j.vaccine.2020.08.062_b0190","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1128\/IAI.00693-08","article-title":"Salmonella enterica serovar typhimurium strains with regulated delayed attenuation in vivo","volume":"77","author":"Curtiss","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2020.08.062_b0195","doi-asserted-by":"crossref","first-page":"e11142","DOI":"10.1371\/journal.pone.0011142","article-title":"Live recombinant Salmonella Typhi vaccines constructed to investigate the role of rpoS in eliciting immunity to a heterologous antigen","volume":"5","author":"Shi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2020.08.062_b0200","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1128\/CVI.00412-09","article-title":"Construction of recombinant attenuated Salmonella enterica serovar typhimurium vaccine vector strains for safety in newborn and infant mice","volume":"17","author":"Gunn","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0205","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1128\/IAI.00444-10","article-title":"Salmonella vaccine vectors displaying delayed antigen synthesis in vivo to enhance immunogenicity","volume":"78","author":"Wang","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2020.08.062_b0210","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1073\/pnas.0811697106","article-title":"Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA","volume":"106","author":"Li","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2020.08.062_b0215","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/JB.01142-08","article-title":"Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar Typhimurium","volume":"191","author":"Baek","year":"2009","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0220","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1128\/CVI.00003-13","article-title":"Evaluation of regulated delayed attenuation strategies for Salmonella enterica serovar Typhi vaccine vectors in neonatal and infant mice","volume":"20","author":"Shi","year":"2013","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0225","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1128\/CVI.00413-09","article-title":"Immunogenicity of a live recombinant Salmonella enterica serovar typhimurium vaccine expressing pspA in neonates and infant mice born from naive and immunized mothers","volume":"17","author":"Shi","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0230","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1128\/IAI.70.4.1739-1749.2002","article-title":"Immune responses to recombinant pneumococcal PspA antigen delivered by live attenuated Salmonella enterica serovar typhimurium vaccine","volume":"70","author":"Kang","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2020.08.062_b0235","first-page":"1","article-title":"The non-conserved region of MRP is involved in the virulence of Streptococcus suis serotype 2","author":"Li","year":"2017","journal-title":"Virulence"},{"key":"10.1016\/j.vaccine.2020.08.062_b0240","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/vr.139.10.225","article-title":"Protection of experimentally infected pigs by suilysin, the thiol-activated haemolysin of Streptococcus suis","volume":"139","author":"Jacobs","year":"1996","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaccine.2020.08.062_b0245","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1574-6968.2010.01944.x","article-title":"Evaluation of the protective efficacy of a newly identified immunogenic protein, HP0272, of Streptococcus suis","volume":"307","author":"Chen","year":"2010","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.vaccine.2020.08.062_b0250","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1128\/IAI.06294-11","article-title":"Fhb, a novel factor H-binding surface protein, contributes to the antiphagocytic ability and virulence of Streptococcus suis","volume":"80","author":"Pian","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2020.08.062_b0255","unstructured":"Busque P, Higgins R, Caya F, Quessy S. Immunization of pigs against Streptococcus suis serotype 2 infection using a live avirulent strain. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 1997;61:275\u20139."},{"key":"10.1016\/j.vaccine.2020.08.062_b0260","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0378-1135(01)00452-7","article-title":"Assessment of protective efficacy of live and killed vaccines based on a non-encapsulated mutant of Streptococcus suis serotype 2","volume":"84","author":"Wisselink","year":"2002","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0265","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.vaccine.2015.03.047","article-title":"The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is a highly protective antigen against serotype 2","volume":"33","author":"Seele","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.08.062_b0270","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2217\/fmb.14.14","article-title":"Latest developments on Streptococcus suis: an emerging zoonotic pathogen: part 1","volume":"9","author":"Segura","year":"2014","journal-title":"Future Microbiol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0275","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2217\/fmb.14.15","article-title":"Latest developments on Streptococcus suis: an emerging zoonotic pathogen: part 2","volume":"9","author":"Segura","year":"2014","journal-title":"Future Microbiol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0280","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1128\/IAI.74.1.694-702.2006","article-title":"A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity","volume":"74","author":"Lee","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2020.08.062_b0285","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1126\/science.1138963","article-title":"The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4","volume":"316","author":"Mata-Haro","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2020.08.062_b0290","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1046\/j.1365-2567.2000.00015.x","article-title":"Bacterial lipopolysaccharide acts as an adjuvant to induce autoimmune arthritisin mice","volume":"99","author":"Yoshino","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.vaccine.2020.08.062_b0295","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/pmic.200600930","article-title":"Proteome analysis of Streptococcus suis serotype 2","volume":"8","author":"Jing","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.vaccine.2020.08.062_b0300","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s10753-015-0298-7","article-title":"Enolase of Streptococcus Suis Serotype 2 Enhances Blood-Brain Barrier Permeability by Inducing IL-8 Release","volume":"39","author":"Sun","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.vaccine.2020.08.062_b0305","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.tim.2017.02.005","article-title":"Critical streptococcus suis virulence factors: are they all really critical?","volume":"25","author":"Segura","year":"2017","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.vaccine.2020.08.062_b0310","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.4049\/jimmunol.179.3.1842","article-title":"Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection","volume":"179","author":"Dominguez-Punaro","year":"2007","journal-title":"J Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X20311142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X20311142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:47:40Z","timestamp":1759402060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X20311142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":62,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0264410X20311142"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2020.08.062","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Live attenuated Salmonella enterica serovar Choleraesuis vector delivering a conserved surface protein enolase induces high and broad protection against Streptococcus suis serotypes 2, 7, and 9 in mice","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2020.08.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}