{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:51:32Z","timestamp":1792511492254,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.vaccine.2020.12.077","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T14:27:32Z","timestamp":1610548052000},"page":"915-925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques"],"prefix":"10.1016","volume":"39","author":[{"given":"Ruoheng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2020.12.077_b0005","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1056\/NEJMra1602113","article-title":"Zika Virus","volume":"374","author":"Petersen","year":"2016","journal-title":"New Engl J Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0010","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of zika virus associated with an epidemic, Yap State, Micronesia, 2007","volume":"14","author":"Lanciotti","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2020.12.077_b0015","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"New Engl J Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0020","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(16)00562-6","article-title":"Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study","volume":"387","author":"Cao-Lormeau","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2020.12.077_b0025","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika virus and birth defects - reviewing the evidence for causality","volume":"374","author":"Rasmussen","year":"2016","journal-title":"New Engl J Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0030","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJMp1600297","article-title":"Zika virus in the Americas - yet another arbovirus threat","volume":"374","author":"Fauci","year":"2016","journal-title":"New Engl J Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0035","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. 1. Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"T Roy Soc Trop Med H"},{"key":"10.1016\/j.vaccine.2020.12.077_b0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2807\/1560-7917.ES.2016.21.32.30314","article-title":"Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveller returning from Haiti to Italy, February 2016","volume":"21","author":"Nicastri","year":"2016","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.vaccine.2020.12.077_b0045","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00952-17","article-title":"Zika virus persistently infects and is basolaterally released from primary human brain microvascular endothelial cells","volume":"8","author":"Mladinich","year":"2017","journal-title":"Mbio"},{"key":"10.1016\/j.vaccine.2020.12.077_b0050","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMc1604449","article-title":"Evidence of sexual transmission of Zika virus","volume":"374","author":"D'Ortenzio","year":"2016","journal-title":"New Engl J Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0055","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3201\/eid2102.141363","article-title":"Potential sexual transmission of Zika virus","volume":"21","author":"Musso","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2020.12.077_b0060","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nature18952","article-title":"Vaccine protection against Zika virus from Brazil","volume":"536","author":"Larocca","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2020.12.077_b0065","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.aah6157","article-title":"Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys","volume":"353","author":"Abbink","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2020.12.077_b0070","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nm.4322","article-title":"A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models","volume":"23","author":"Shan","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00737-8","article-title":"A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage","volume":"8","author":"Shan","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.vaccine.2020.12.077_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.02.017","article-title":"Modified mRNA vaccines protect against Zika virus infection","volume":"168","author":"Richner","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2020.12.077_b0085","article-title":"E90 subunit vaccine protects mice from Zika virus infection and microcephaly","volume":"6","author":"Zhu","year":"2018","journal-title":"Acta Neuropathol Com"},{"key":"10.1016\/j.vaccine.2020.12.077_b0090","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.1038\/s41598-017-10595-5","article-title":"Immunization with truncated envelope protein of Zika virus induces protective immune response in mice","volume":"7","author":"Han","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.vaccine.2020.12.077_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194860","article-title":"Recombinant Zika virus envelope protein elicited protective immunity against Zika virus in immunocompetent mice","volume":"13","author":"Liang","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2020.12.077_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2019.104578","article-title":"Yeast-produced subunit protein vaccine elicits broadly neutralizing antibodies that protect mice against Zika virus lethal infection","volume":"170","author":"Zhang","year":"2019","journal-title":"Antiviral Res"},{"key":"10.1016\/j.vaccine.2020.12.077_b0105","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai8336","article-title":"Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus","volume":"8","author":"Wang","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0110","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2017.04.024","article-title":"Recurrent potent human neutralizing antibodies to Zika virus in Brazil and Mexico","volume":"169","author":"Robbiani","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2020.12.077_b0115","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191792","article-title":"Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge","volume":"217","author":"Zhao","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0120","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaf8505","article-title":"Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection","volume":"353","author":"Stettler","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2020.12.077_b0125","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1128\/JVI.00316-08","article-title":"Antibodies to envelope glycoprotein of dengue virus during the natural course of infection are predominantly cross-reactive and recognize epitopes containing highly conserved residues at the fusion loop of domain II","volume":"82","author":"Lai","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0130","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12204","article-title":"A rhesus macaque model of Asian-lineage Zika virus infection","volume":"7","author":"Dudley","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.vaccine.2020.12.077_b0135","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93042","article-title":"Delineating antibody recognition against Zika virus during natural infection","volume":"2","author":"Yu","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.vaccine.2020.12.077_b0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006487","article-title":"Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques","volume":"13","author":"McCracken","year":"2017","journal-title":"Plos Pathog"},{"key":"10.1016\/j.vaccine.2020.12.077_b0145","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2017.04.008","article-title":"Zika virus persistence in the central nervous system and lymph nodes of rhesus monkeys","volume":"169","author":"Aid","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2020.12.077_b0150","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni.3515","article-title":"Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus","volume":"17","author":"Dejnirattisai","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0155","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1007\/s11427-017-9192-0","article-title":"Both structure and function of human monoclonal antibodies contribute to enhancement of Zika virus infectivity in vitro","volume":"60","author":"Li","year":"2017","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.vaccine.2020.12.077_b0160","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1099\/vir.0.055178-0","article-title":"Dengue virus envelope domain III immunization elicits predominantly cross-reactive, poorly neutralizing antibodies localized to the AB loop: implications for dengue vaccine design","volume":"94","author":"Li","year":"2013","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0165","doi-asserted-by":"crossref","DOI":"10.1038\/emi.2017.79","article-title":"Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III","volume":"6","author":"Wu","year":"2017","journal-title":"Emerg Microbes Infec"},{"key":"10.1016\/j.vaccine.2020.12.077_b0170","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao4163","article-title":"Durability and correlates of vaccine protection against Zika virus in rhesus monkeys","volume":"9","author":"Abbink","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0175","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan8184","article-title":"Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques","volume":"9","author":"Magnani","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0180","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41594-017-0010-8","article-title":"Structural biology of Zika virus and other flaviviruses","volume":"25","author":"Hasan","year":"2018","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0185","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/intimm\/dxv011","article-title":"A novel tetravalent formulation combining the four aggregated domain III-capsid proteins from dengue viruses induces a functional immune response in mice and monkeys","volume":"27","author":"Suzarte","year":"2015","journal-title":"Int Immunol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0190","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00705-013-1639-1","article-title":"A consensus envelope protein domain III can induce neutralizing antibody responses against serotype 2 of dengue virus in non-human primates","volume":"158","author":"Chen","year":"2013","journal-title":"Arch Virol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0195","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/icb.2014.63","article-title":"The protein DIIIC-2, aggregated with a specific oligodeoxynucleotide and adjuvanted in alum, protects mice and monkeys against DENV-2","volume":"93","author":"Gil","year":"2015","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0200","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1016\/j.vaccine.2016.03.108","article-title":"Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold\/DNA vaccine in non-human primates","volume":"34","author":"McBurney","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2020.12.077_b0205","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02187-18","article-title":"Rational design of Zika virus subunit vaccine with enhanced efficacy","volume":"93","author":"Tai","year":"2019","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0210","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.antiviral.2018.04.010","article-title":"Insect cell-produced recombinant protein subunit vaccines protect against Zika virus infection","volume":"154","author":"Qu","year":"2018","journal-title":"Antiviral Res"},{"key":"10.1016\/j.vaccine.2020.12.077_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02464","article-title":"A recombinant subunit based Zika virus vaccine is efficacious in non-human primates","volume":"9","author":"Medina","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0220","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1056\/NEJMoa1506223","article-title":"Efficacy and long-term safety of a dengue vaccine in regions of endemic disease","volume":"373","author":"Hadinegoro","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0225","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01023-18","article-title":"Engineered dengue virus domain III proteins elicit cross-neutralizing antibody responses in mice","volume":"92","author":"Frei","year":"2018","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0230","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature17994","article-title":"Structure of the thermally stable Zika virus","volume":"533","author":"Kostyuchenko","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2020.12.077_b0235","doi-asserted-by":"crossref","first-page":"12766","DOI":"10.1128\/JVI.01420-07","article-title":"Epitope determinants of a chimpanzee dengue virus type 4 (DENV-4) -neutralizing antibody and protection against DENV-4 challenge in mice and rhesus monkeys by passively transferred humanized antibody","volume":"81","author":"Lai","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2020.12.077_b0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007716","article-title":"Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes","volume":"15","author":"Li","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.vaccine.2020.12.077_b0245","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/emmm.201303404","article-title":"A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface","volume":"6","author":"Fibriansah","year":"2014","journal-title":"Embo Mol Med"},{"key":"10.1016\/j.vaccine.2020.12.077_b0250","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/s41590-019-0477-z","article-title":"A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection","volume":"20","author":"Slon-Campos","year":"2019","journal-title":"Nat Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X20316741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X20316741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:51:01Z","timestamp":1759402261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X20316741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0264410X20316741"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2020.12.077","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2020.12.077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}