{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:28:31Z","timestamp":1793532511943,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT605810"],"award-info":[{"award-number":["GNT605810"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1150901"],"award-info":[{"award-number":["GNT1150901"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.vaccine.2021.03.032","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T10:09:51Z","timestamp":1616494191000},"page":"2264-2273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Nasopharyngeal carriage of otitis media pathogens in infants receiving 10-valent non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10), 13-valent pneumococcal conjugate vaccine (PCV13) or a mixed primary schedule of both vaccines: A randomised controlled trial"],"prefix":"10.1016","volume":"39","author":[{"given":"J.","family":"Beissbarth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Arrowsmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Binks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9505-7197","authenticated-orcid":false,"given":"V.M.","family":"Oguoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Llewellyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.K.","family":"Mulholland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Santosham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.C.","family":"Smith-Vaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Leach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.vaccine.2021.03.032_b0005","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/INF.0b013e3180621177","article-title":"The spectrum and management of otitis media in Australian indigenous and nonindigenous children: a national study","volume":"26","author":"Gunasekera","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2021.03.032_b0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2431-5-27","article-title":"Otitis media in young Aboriginal children from remote communities in Northern and Central Australia: a cross-sectional survey","volume":"5","author":"Morris","year":"2005","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.vaccine.2021.03.032_b0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1471-2431-14-200","article-title":"Otitis media in children vaccinated during consecutive 7-valent or 10-valent pneumococcal conjugate vaccination schedules","volume":"14","author":"Leach","year":"2014","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.vaccine.2021.03.032_b0020","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijporl.2016.05.011","article-title":"General health, otitis media, nasopharyngeal carriage and middle ear microbiology in Northern Territory Aboriginal children vaccinated during consecutive periods of 10-valent or 13-valent pneumococcal conjugate vaccines","volume":"86","author":"Leach","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"11","key":"10.1016\/j.vaccine.2021.03.032_b0025","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/00006454-199411000-00009","article-title":"Bacterial colonization of the nasopharynx predicts very early onset and persistence of otitis media in Australian aboriginal infants","volume":"13","author":"Leach","year":"1994","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2021.03.032_b0030","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/1471-2334-12-366","article-title":"Association between early bacterial carriage and otitis media in Aboriginal and non-Aboriginal children in a semi-arid area of Western Australia: a cohort study","volume":"12","author":"Sun","year":"2012","journal-title":"BMC Infect Dis"},{"issue":"1","key":"10.1016\/j.vaccine.2021.03.032_b0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1472-6815-13-12","article-title":"Dominance of Haemophilus influenzae in ear discharge from Indigenous Australian children with acute otitis media with tympanic membrane perforation","volume":"13","author":"Smith-Vaughan","year":"2013","journal-title":"BMC Ear Nose Throat Disord"},{"key":"10.1016\/j.vaccine.2021.03.032_b0040","doi-asserted-by":"crossref","unstructured":"Hull B, Mahajan D, Menzies R, McIntyre PB. Immunisation coverage annual report, 2009. Commun Dis Intellig 2011;36(3):132\u201348.","DOI":"10.33321\/cdi.2011.35.9"},{"key":"10.1016\/j.vaccine.2021.03.032_b0045","doi-asserted-by":"crossref","unstructured":"Hull B, Mahajan D, Menzies R, Brotherton JM, McIntyre PB. Immunisation coverage annual report, 2011. Communicable Dis Intellig 2013;37(4): E291\u2013E312.","DOI":"10.33321\/cdi.2013.37.48"},{"key":"10.1016\/j.vaccine.2021.03.032_b0050","doi-asserted-by":"crossref","unstructured":"Hull B, Mahajan D, Menzies R, Brotherton JM, McIntyre PB, Immunisation coverage, 2012. Commun Dis Intellig 2014;38(3):E208\u2013E231.","DOI":"10.33321\/cdi.2014.38.37"},{"key":"10.1016\/j.vaccine.2021.03.032_b0055","doi-asserted-by":"crossref","unstructured":"Hull B, Menzies R, McIntyre PB. Immunisation coverage annual report, 2007. Commun Dis Intellig 2009;33(2):170\u2013187.","DOI":"10.33321\/cdi.2009.33.16"},{"key":"10.1016\/j.vaccine.2021.03.032_b0060","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12887-015-0483-8","article-title":"Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine","volume":"15","author":"Leach","year":"2015","journal-title":"BMC Pediatr"},{"issue":"1","key":"10.1016\/j.vaccine.2021.03.032_b0065","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.vaccine.2009.09.113","article-title":"Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae-derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age","volume":"28","author":"Prymula","year":"2009","journal-title":"Vaccine"},{"issue":"9512","key":"10.1016\/j.vaccine.2021.03.032_b0070","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0140-6736(06)68304-9","article-title":"Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study","volume":"367","author":"Prymula","year":"2006","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.vaccine.2021.03.032_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21645515.2017.1287640","article-title":"Efficacy of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine against acute otitis media and nasopharyngeal carriage in Panamanian children \u2013 a randomized controlled trial","volume":"13","author":"Saez-Llorens","year":"2017","journal-title":"Hum Vaccin Immunother"},{"issue":"12","key":"10.1016\/j.vaccine.2021.03.032_b0080","doi-asserted-by":"crossref","first-page":"e82280","DOI":"10.1371\/journal.pone.0082280","article-title":"High nasopharyngeal carriage of non-vaccine serotypes in Western Australian aboriginal people following 10 years of pneumococcal conjugate vaccination","volume":"8","author":"Collins","year":"2013","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.vaccine.2021.03.032_b0085","doi-asserted-by":"crossref","first-page":"E151","DOI":"10.33321\/cdi.2012.36.10","article-title":"Invasive pneumococcal disease in Australia 2007 and 2008","volume":"36","author":"Barry","year":"2012","journal-title":"Commun Dis Intell Q Rep"},{"issue":"1","key":"10.1016\/j.vaccine.2021.03.032_b0090","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-007247","article-title":"Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk Indigenous infants (PREV-IX_COMBO): protocol of a randomised controlled trial","volume":"5","author":"Leach","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.vaccine.2021.03.032_b0095","article-title":"Interchangeability, immunogenicity and safety of a combined 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (Synflorix) and 13-valent-PCV (Prevenar13) schedule at 1-2-4-6 months: PREVIX_COMBO, a 3-arm randomised controlled trial","author":"Leach","year":"2021","journal-title":"Vaccine: X"},{"issue":"1","key":"10.1016\/j.vaccine.2021.03.032_b0100","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.vaccine.2013.08.062","article-title":"Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: updated recommendations from the World Health Organization Pneumococcal Carriage Working Group","volume":"32","author":"Satzke","year":"2013","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2021.03.032_b0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s13104-018-3429-z","article-title":"Recommendations for application of Haemophilus influenzae PCR diagnostics to respiratory specimens for children living in northern Australia: a retrospective re-analysis","volume":"11","author":"Beissbarth","year":"2018","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.vaccine.2021.03.032_b0110","unstructured":"Bell SM, et al. Antibiotic susceptibility testing by the CDS method. 9th ed.; 2019."},{"key":"10.1016\/j.vaccine.2021.03.032_b0115","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2431-8-23","article-title":"Compared to placebo, long-term antibiotics resolve otitis media with effusion (OME) and prevent acute otitis media with perforation (AOMwiP) in a high-risk population: a randomized controlled trial","volume":"8","author":"Leach","year":"2008","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.vaccine.2021.03.032_b0120","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2334-9-121","article-title":"Emerging pneumococcal carriage serotypes in a high-risk population receiving universal 7-valent pneumococcal conjugate vaccine and 23-valent polysaccharide vaccine since 2001","volume":"9","author":"Leach","year":"2009","journal-title":"BMC Infect Dis"},{"issue":"7","key":"10.1016\/j.vaccine.2021.03.032_b0125","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/INF.0000000000001180","article-title":"The antibody response following a booster with either a 10- or 13-valent Pneumococcal conjugate vaccine in toddlers primed with a 13-valent pneumococcal conjugate vaccine in early infancy","volume":"35","author":"Truck","year":"2016","journal-title":"Pediatr Infect Dis J"},{"issue":"38","key":"10.1016\/j.vaccine.2021.03.032_b0130","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1016\/j.vaccine.2017.07.103","article-title":"Immunogenicity and safety of a booster dose of the 13-valent pneumococcal conjugate vaccine in children primed with the 10-valent or 13-valent pneumococcal conjugate vaccine in the Czech Republic and Slovakia","volume":"35","author":"Urbancikova","year":"2017","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2021.03.032_b0135","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/jpids\/piw010","article-title":"Effectiveness of the 10-valent Pneumococcal Nontypeable Haemophilus influenzae Protein D-Conjugated Vaccine (PHiD-CV) against carriage and acute otitis media-a double-blind randomized clinical trial in Finland","volume":"5","author":"Vesikari","year":"2016","journal-title":"J Pediatric Infect Dis Soc"},{"issue":"4","key":"10.1016\/j.vaccine.2021.03.032_b0140","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1473-3099(15)70007-1","article-title":"Comparison of two-dose priming plus 9-month booster with a standard three-dose priming schedule for a ten-valent pneumococcal conjugate vaccine in Nepalese infants: a randomised, controlled, open-label, non-inferiority trial","volume":"15","author":"Hamaluba","year":"2015","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2021.03.032_b0145","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1093\/cid\/cis922","article-title":"Effects of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine on nasopharyngeal bacterial colonization in young children: a randomized controlled trial","volume":"56","author":"van den Bergh","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"12","key":"10.1016\/j.vaccine.2021.03.032_b0150","doi-asserted-by":"crossref","first-page":"e1375","DOI":"10.1016\/S2214-109X(18)30383-8","article-title":"Effect of ten-valent pneumococcal conjugate vaccine introduction on pneumococcal carriage in Fiji: results from four annual cross-sectional carriage surveys","volume":"6","author":"Dunne","year":"2018","journal-title":"Lancet Glob Health"},{"issue":"7","key":"10.1016\/j.vaccine.2021.03.032_b0155","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1016\/S2214-109X(14)70224-4","article-title":"Population effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi, Kenya: findings from cross-sectional carriage studies","volume":"2","author":"Hammitt","year":"2014","journal-title":"Lancet Glob Health"},{"issue":"46","key":"10.1016\/j.vaccine.2021.03.032_b0160","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1016\/j.vaccine.2016.09.027","article-title":"Effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae among children in Sao Paulo, Brazil","volume":"34","author":"Brandileone","year":"2016","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2021.03.032_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056698","article-title":"Safety and immunogenicity of neonatal pneumococcal conjugate vaccination in Papua New Guinean children: a randomised controlled trial","volume":"8","author":"Pomat","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2021.03.032_b0170","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.vacrep.2016.08.002","article-title":"Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination on nasopharyngeal carriage of Streptococcus pneumoniae in Papua New Guinean children: a randomized controlled trial","volume":"6","author":"Aho","year":"2016","journal-title":"Vaccine Rep"},{"issue":"48","key":"10.1016\/j.vaccine.2021.03.032_b0175","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.1016\/j.vaccine.2015.10.101","article-title":"PneuMum: impact from a randomised controlled trial of maternal 23-valent pneumococcal polysaccharide vaccination on middle ear disease amongst Indigenous infants, Northern Territory, Australia","volume":"33","author":"Binks","year":"2015","journal-title":"Vaccine"},{"issue":"51","key":"10.1016\/j.vaccine.2021.03.032_b0180","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1016\/j.vaccine.2014.10.060","article-title":"Maternal immunization with pneumococcal 9-valent conjugate vaccine and early infant otitis media","volume":"32","author":"Daly","year":"2014","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2021.03.032_b0185","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1574-6976.2009.00200.x","article-title":"Recent findings on the viable but nonculturable state in pathogenic bacteria","volume":"34","author":"Oliver","year":"2010","journal-title":"FEMS Microbiol Rev"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X2100311X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X2100311X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:16:40Z","timestamp":1777537000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X2100311X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":37,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0264410X2100311X"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2021.03.032","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nasopharyngeal carriage of otitis media pathogens in infants receiving 10-valent non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10), 13-valent pneumococcal conjugate vaccine (PCV13) or a mixed primary schedule of both vaccines: A randomised controlled trial","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2021.03.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}