{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:14:49Z","timestamp":1794280489246,"version":"4.9.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.vaccine.2023.05.005","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T08:16:04Z","timestamp":1683792964000},"page":"3663-3672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Hepatitis B vaccine delivered by microneedle patch: Immunogenicity in mice and rhesus macaques"],"prefix":"10.1016","volume":"41","author":[{"given":"Youkyung","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Sanghee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"Mixson-Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungreem","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengning","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Prausnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleem","family":"Kamili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Purdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania A.","family":"Tohme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2023.05.005_b0005","unstructured":"WHO, Hepatitits B fact sheet https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b#:\u223c:text=WHO%20estimates%20that%20296%20million,carcinoma%20(primary%20liver%20cancer). 2022. (Accessed July 19, 2022)."},{"issue":"2","key":"10.1016\/j.vaccine.2023.05.005_b0010","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/oxfordjournals.aje.a112370","volume":"105","author":"Beasley","year":"1977","journal-title":"Am J Epidemiol"},{"issue":"1337","key":"10.1016\/j.vaccine.2023.05.005_b0015","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1098\/rspb.1993.0102","volume":"253","author":"Edmunds","year":"1993","journal-title":"Proc Biol Sci"},{"issue":"1","key":"10.1016\/j.vaccine.2023.05.005_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr6701a1","volume":"67","author":"Schillie","year":"2018","journal-title":"MMWR Recomm Rep"},{"issue":"4","key":"10.1016\/j.vaccine.2023.05.005_b0025","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cld.2016.06.006","volume":"20","author":"Nelson","year":"2016","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.vaccine.2023.05.005_b0030","unstructured":"WHO, Global Health Sector Strategy On Viral Hepatitis 2016\u20132021: Towards Ending Viral Hepatitis, http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/246177\/WHO-HIV-2016.06-eng.pdf, Geneva, 2016."},{"key":"10.1016\/j.vaccine.2023.05.005_b0035","unstructured":"Geneva: World Health Organization, Global guidance on criteria and processes for validation: elimination of mother-to-child transmission of HIV, syphilis and hepatitis B virus, 2021. https:\/\/www.who.int\/publications\/i\/item\/9789240039360.)."},{"key":"10.1016\/j.vaccine.2023.05.005_b0040","unstructured":"WHO\/UNICEF, WHO UNICEF Immunization Coverage Estimates in https:\/\/www.who.int\/docs\/default-source\/immunization\/immunization-coverage\/wuenic_notes.pdf?sfvrsn=88ff590d_6, 2021."},{"key":"10.1016\/j.vaccine.2023.05.005_b0045","first-page":"369","volume":"92","author":"WHO","year":"2017","journal-title":"Wkly Epidemiol Rec"},{"issue":"33","key":"10.1016\/j.vaccine.2023.05.005_b0050","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1016\/j.vaccine.2017.06.051","volume":"35","author":"Allison","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2023.05.005_b0055","unstructured":"WHO, Global compliance with Hepatitis B vaccine birth dose and factors related to timely schedule; 2016. http:\/\/www.who.int\/immunization\/sage\/meetings\/2016\/october\/7_Review_of_the_barriers_to_implement_the_birth_dose_of_hepb.pdf?ua=1.)."},{"issue":"12","key":"10.1016\/j.vaccine.2023.05.005_b0060","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nri1728","volume":"5","author":"Mitragotri","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.vaccine.2023.05.005_b0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-chembioeng-060816-101514","volume":"8","author":"Prausnitz","year":"2017","journal-title":"Annu Rev Chem Biomol Eng"},{"key":"10.1016\/j.vaccine.2023.05.005_b0070","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejpb.2022.02.013","volume":"173","author":"Moore","year":"2022","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.vaccine.2023.05.005_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113919","volume":"179","author":"Sheng","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"issue":"10095","key":"10.1016\/j.vaccine.2023.05.005_b0080","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0140-6736(17)30575-5","article-title":"TIV-MNP Study Group","volume":"390","author":"Rouphael","year":"2017","journal-title":"Lancet"},{"issue":"37","key":"10.1016\/j.vaccine.2023.05.005_b0085","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1016\/j.vaccine.2015.02.074","volume":"33","author":"Edens","year":"2015","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2023.05.005_b0090","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/infdis\/jiy139","volume":"218","author":"Joyce","year":"2018","journal-title":"J Infec Dis"},{"key":"10.1016\/j.vaccine.2023.05.005_b0095","unstructured":"I.A.E.A.M.Y.S.D.L.B.J.B.D.A.M.D.J.A.N.A.B.M.R.J.L. Goodson; Mark R Prausnitz; Devin McAllister; Paul A Rota; Sebastien Henry; Ed Clarke, Trials in press."},{"issue":"1","key":"10.1016\/j.vaccine.2023.05.005_b0100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41541-022-00443-7","volume":"7","author":"Moon","year":"2022","journal-title":"npj Vaccines"},{"issue":"3","key":"10.1016\/j.vaccine.2023.05.005_b0105","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/btm2.10098","volume":"3","author":"Perez Cuevas","year":"2018","journal-title":"Bioeng Transl Med"},{"issue":"12","key":"10.1016\/j.vaccine.2023.05.005_b0110","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1093\/infdis\/jiz399","volume":"220","author":"Choi","year":"2019","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1016\/j.vaccine.2023.05.005_b0115","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/CVI.00087-06","article-title":"Kulkarni","volume":"13","author":"Shivananda","year":"2006","journal-title":"Clin Vaccine Immunol"},{"issue":"RR-16","key":"10.1016\/j.vaccine.2023.05.005_b0120","first-page":"1","article-title":"C. Advisory Committee on Immunization Practices Centers for Disease, Prevention","volume":"55","author":"Mast","year":"2006","journal-title":"MMWR Recomm Rep"},{"issue":"D1","key":"10.1016\/j.vaccine.2023.05.005_b0125","doi-asserted-by":"crossref","first-page":"D351","DOI":"10.1093\/nar\/gky1100","volume":"47","author":"Mitchell","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"10.1016\/j.vaccine.2023.05.005_b0130","doi-asserted-by":"crossref","first-page":"D492","DOI":"10.1093\/nar\/gkp858","volume":"38","author":"Geer","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"10.1016\/j.vaccine.2023.05.005_b0135","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.vaccine.2023.05.005_b0140","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","volume":"46","author":"Fabregat","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.vaccine.2023.05.005_b0145","doi-asserted-by":"crossref","first-page":"D661","DOI":"10.1093\/nar\/gkx1064","volume":"46","author":"Slenter","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.vaccine.2023.05.005_b0150","doi-asserted-by":"crossref","first-page":"e10266","DOI":"10.1371\/journal.pone.0010266","volume":"5","author":"Fernando","year":"2010","journal-title":"PLoS One"},{"issue":"34","key":"10.1016\/j.vaccine.2023.05.005_b0155","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1016\/j.vaccine.2012.11.027","volume":"31","author":"Moon","year":"2013","journal-title":"Vaccine"},{"issue":"37","key":"10.1016\/j.vaccine.2023.05.005_b0160","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1016\/j.vaccine.2015.01.089","volume":"33","author":"Edens","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2023.05.005_b0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2018.03.010","volume":"127","author":"Zhao","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"10.1016\/j.vaccine.2023.05.005_b0170","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/17425247.2021.1823964","volume":"18","author":"Korkmaz","year":"2021","journal-title":"Expert Opin Drug Deliv"},{"issue":"1","key":"10.1016\/j.vaccine.2023.05.005_b0175","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7326\/0003-4819-101-1-34","volume":"101","author":"Dienstag","year":"1984","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.vaccine.2023.05.005_b0180","doi-asserted-by":"crossref","first-page":"356","DOI":"10.7326\/0003-4819-105-3-356","volume":"105","author":"Craven","year":"1986","journal-title":"Ann Intern Med"},{"issue":"15","key":"10.1016\/j.vaccine.2023.05.005_b0185","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1056\/NEJM198010093031501","volume":"303","author":"Szmuness","year":"1980","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.vaccine.2023.05.005_b0190","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0264-410X(94)00044-N","volume":"13","author":"Martinetti","year":"1995","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2023.05.005_b0195","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1399-0039.1997.tb02827.x","volume":"50","author":"McDermott","year":"1997","journal-title":"Tissue Antigens"},{"issue":"6","key":"10.1016\/j.vaccine.2023.05.005_b0200","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/BF00163994","volume":"41","author":"Salazar","year":"1995","journal-title":"Immunogenetics"},{"issue":"1","key":"10.1016\/j.vaccine.2023.05.005_b0205","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0198-8859(97)00209-7","volume":"58","author":"Chedid","year":"1997","journal-title":"Hum Immunol"},{"issue":"8581","key":"10.1016\/j.vaccine.2023.05.005_b0210","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0140-6736(88)91119-1","volume":"1","author":"Yamauchi","year":"1988","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.vaccine.2023.05.005_b0215","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4049\/jimmunol.154.2.520","volume":"154","author":"Desombere","year":"1995","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2023.05.005_b0220","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4049\/immunohorizons.1700015","volume":"1","author":"Gelinas","year":"2017","journal-title":"ImmunoHorizons"},{"issue":"22","key":"10.1016\/j.vaccine.2023.05.005_b0225","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.3748\/wjg.14.3534","volume":"14","author":"Velu","year":"2008","journal-title":"World J Gastroenterol"},{"issue":"44","key":"10.1016\/j.vaccine.2023.05.005_b0230","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1016\/j.vaccine.2011.07.098","volume":"29","author":"Zhu","year":"2011","journal-title":"Vaccine"},{"issue":"3\u20134","key":"10.1016\/j.vaccine.2023.05.005_b0235","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.vaccine.2003.07.020","volume":"22","author":"Ota","year":"2004","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2023.05.005_b0240","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.vaccine.2012.11.029","volume":"31","author":"Carollo","year":"2013","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2023.05.005_b0245","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1182\/blood-2007-09-110858","volume":"111","author":"Belnoue","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2023.05.005_b0250","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"10.1016\/j.vaccine.2023.05.005_b0255","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000034","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"2","key":"10.1016\/j.vaccine.2023.05.005_b0260","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41577-020-00479-7","volume":"21","author":"Pollard","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2023.05.005_b0265","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/21645515.2016.1259043","volume":"13","author":"Donnelly","year":"2017","journal-title":"Hum Vaccin Immunother"},{"issue":"3","key":"10.1016\/j.vaccine.2023.05.005_b0270","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.immuni.2008.07.013","volume":"29","author":"Klechevsky","year":"2008","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.vaccine.2023.05.005_b0275","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.immuni.2014.08.006","volume":"41","author":"McGovern","year":"2014","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.vaccine.2023.05.005_b0280","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4049\/jimmunol.1701005","volume":"200","author":"Lin","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2023.05.005_b0285","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.586124","volume":"11","author":"Sanchez","year":"2020","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2023.05.005_b0290","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/ars.2010.3241","volume":"14","author":"Messaoudi","year":"2011","journal-title":"Antioxid Redox Signal"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X23005248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X23005248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:26:46Z","timestamp":1759404406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X23005248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":58,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0264410X23005248"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2023.05.005","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatitis B vaccine delivered by microneedle patch: Immunogenicity in mice and rhesus macaques","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2023.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 US Centers for Disease Control and Prevention. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}