{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:07:15Z","timestamp":1785773235915,"version":"3.56.0"},"reference-count":9,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary and Animal Science"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.vas.2024.100414","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T23:35:33Z","timestamp":1732664133000},"page":"100414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Development of a sensitive disease-screening model using comprehensive circulating microRNA profiles in dogs: A pilot study"],"prefix":"10.1016","volume":"27","author":[{"given":"Kohei","family":"Omura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Ide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Furusawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Fujiwara-Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Teshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Momoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7006","key":"10.1016\/j.vas.2024.100414_bib0001","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.vas.2024.100414_bib0002","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1534\/g3.118.200947","article-title":"Integrated Analysis of miRNA and mRNA Expression Profiles Reveals Functional miRNA-Targets in Development Testes of Small Tail Han Sheep","volume":"9","author":"Bai","year":"2019","journal-title":"G3 (Bethesda, Md.)"},{"issue":"2","key":"10.1016\/j.vas.2024.100414_bib0003","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1261\/rna.046060.114","article-title":"Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data","volume":"21","author":"Campbell","year":"2015","journal-title":"RNA (New York, N.Y.),"},{"key":"10.1016\/j.vas.2024.100414_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.146237","article-title":"Micro RNA differential expression profile in canine mammary gland tumor by next generation sequencing","volume":"818","author":"Chen","year":"2022","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.vas.2024.100414_bib0005","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/vco.12848","article-title":"Blood biomarkers for canine cancer, from human to veterinary oncology","volume":"20","author":"Colombe","year":"2022","journal-title":"Veterinary and Comparative Oncology"},{"issue":"1","key":"10.1016\/j.vas.2024.100414_bib0006","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/jvim.16616","article-title":"Cancer detection in clinical practice and using blood-based liquid biopsy: A retrospective audit of over 350 dogs","volume":"37","author":"Flory","year":"2023","journal-title":"Journal of Veterinary Internal Medicine"},{"issue":"11","key":"10.1016\/j.vas.2024.100414_bib0007","doi-asserted-by":"crossref","first-page":"8297","DOI":"10.1007\/s00432-023-04728-9","article-title":"Comprehensive circulating microRNA profile as a supersensitive biomarker for early-stage lung cancer screening","volume":"149","author":"Inagaki","year":"2023","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"key":"10.1016\/j.vas.2024.100414_bib0008","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Frontiers in Endocrinology"},{"issue":"1","key":"10.1016\/j.vas.2024.100414_bib0009","doi-asserted-by":"crossref","first-page":"15107","DOI":"10.1038\/s41598-021-94501-0","article-title":"Automated machine learning optimizes and accelerates predictive modeling from COVID-19 high throughput datasets","volume":"11","author":"Papoutsoglou","year":"2021","journal-title":"Scientific Reports"}],"container-title":["Veterinary and Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451943X24000814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451943X24000814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T10:29:32Z","timestamp":1741602572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451943X24000814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":9,"alternative-id":["S2451943X24000814"],"URL":"https:\/\/doi.org\/10.1016\/j.vas.2024.100414","relation":{},"ISSN":["2451-943X"],"issn-type":[{"value":"2451-943X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a sensitive disease-screening model using comprehensive circulating microRNA profiles in dogs: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Veterinary and Animal Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vas.2024.100414","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100414"}}