{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:32:03Z","timestamp":1793133123541,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-182A-085-"],"award-info":[{"award-number":["111-2314-B-182A-085-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-182A-066"],"award-info":[{"award-number":["NSTC 112-2314-B-182A-066"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 114-2314-B-182A-027"],"award-info":[{"award-number":["NSTC 114-2314-B-182A-027"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG1P0081"],"award-info":[{"award-number":["CMRPG1P0081"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CPRPG1N0011"],"award-info":[{"award-number":["CPRPG1N0011"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary and Animal Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.vas.2026.100747","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:40:05Z","timestamp":1782146405000},"page":"100747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Exploration of extracellular vesicles from porcine endometrial cells for enhancing the development of parthenogenetic embryos"],"prefix":"10.1016","volume":"34","author":[{"given":"Shao-Yu","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Chang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Wen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perng-Chih","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Tai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Jen","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3931-7297","authenticated-orcid":false,"given":"Steven W.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vas.2026.100747_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196817","article-title":"Knockdown of CDK2AP1 in human embryonic stem cells reduces the threshold of differentiation","volume":"13","author":"Alsayegh","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.vas.2026.100747_bib0002","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0303-7207(94)90053-1","article-title":"Differential gene expression of fibroblast growth factor receptor isoforms in rat ovary","volume":"104","author":"Asakai","year":"1994","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.vas.2026.100747_bib0003","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12964-022-00876-6","article-title":"Follicular fluid-derived exosomal miR-143-3p\/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome","volume":"20","author":"Cao","year":"2022","journal-title":"Cell Communication and Signaling: CCS"},{"key":"10.1016\/j.vas.2026.100747_bib0004","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1071\/RD11318","article-title":"The fibroblast growth factor family: Involvement in the regulation of folliculogenesis","volume":"24","author":"Chaves","year":"2012","journal-title":"Reproduction, Fertility, and Development"},{"key":"10.1016\/j.vas.2026.100747_bib0005","first-page":"48","article-title":"Function and molecular mechanism of mitogen-activated protein kinase (MAPK) in regulating oocyte meiotic maturation and ovulation","volume":"72","author":"Chen","year":"2020","journal-title":"Sheng Li Xue Bao: [Acta Physiologica Sinica]"},{"key":"10.1016\/j.vas.2026.100747_bib0006","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.ebiom.2015.09.003","article-title":"Human blastocyst secreted microRNA regulate endometrial epithelial cell adhesion","volume":"2","author":"Cuman","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.vas.2026.100747_bib0007","first-page":"12","article-title":"Effect of miR-143-3p from extracellular vesicles of porcine uterine luminal fluid on porcine trophoblast cells","author":"Ding","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.vas.2026.100747_bib0008","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12964-019-0448-x","article-title":"Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk","volume":"17","author":"Es-Haghi","year":"2019","journal-title":"Cell Communication and Signaling: CCS"},{"issue":"3","key":"10.1016\/j.vas.2026.100747_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1095\/biolreprod.103.022830","article-title":"Involvement of mitogen\u2013activated protein kinase cascade during oocyte maturation and fertilization in mammals","volume":"70","author":"Fan","year":"2004","journal-title":"Biology of Reproduction"},{"key":"10.1016\/j.vas.2026.100747_bib0009","series-title":"Transgenic Animal Technology","first-page":"581","article-title":"Assisted reproductive technologies and embryo culture methods for farm animals","author":"Godke","year":"2014"},{"key":"10.1016\/j.vas.2026.100747_bib0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.placenta.2016.12.011","article-title":"Review: Embryo- and endometrium-derived exosomes and their potential role in assisted reproductive treatments \u2014 Liquid biopsies for endometrial receptivity","volume":"54","author":"Homer","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.vas.2026.100747_bib0011","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mce.2013.05.017","article-title":"Divergence of intracellular signaling pathways and early response genes of two closely related fibroblast growth factors, FGF8 and FGF18, in bovine ovarian granulosa cells","volume":"375","author":"Jiang","year":"2013","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.vas.2026.100747_bib0012","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.theriogenology.2017.09.015","article-title":"Effect of co-culture canine cumulus and oviduct cells with porcine oocytes during maturation and subsequent embryo development of parthenotes in vitro","volume":"106","author":"Lee","year":"2018","journal-title":"Theriogenology"},{"key":"10.1016\/j.vas.2026.100747_bib0013","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1530\/REP-16-0384","article-title":"Effect of bovine oviductal extracellular vesicles on embryo development and quality in vitro","volume":"153","author":"Lopera-Vasquez","year":"2017","journal-title":"Reproduction (Cambridge, England)"},{"key":"10.1016\/j.vas.2026.100747_bib0014","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00441-012-1330-y","article-title":"The balance of proangiogenic and antiangiogenic VEGFA isoforms regulate follicle development","volume":"349","author":"McFee","year":"2012","journal-title":"Cell and Tissue Research"},{"key":"10.1016\/j.vas.2026.100747_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4684","article-title":"Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif-mediated interactions","volume":"32","author":"Mihali\u010d","year":"2023","journal-title":"Protein Science: a Publication of the Protein Society"},{"key":"10.1016\/j.vas.2026.100747_bib0016","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/rda.12556","article-title":"Bovine oviduct epithelial cells dedifferentiate partly in culture, while maintaining their ability to improve early embryo development rate and quality","volume":"50","author":"Schmaltz-Panneau","year":"2015","journal-title":"Reproduction in Domestic Animals"},{"key":"10.1016\/j.vas.2026.100747_bib0017","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0012-1606(03)00437-8","article-title":"Oocyte-dependent activation of mitogen-activated protein kinase (ERK1\/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex","volume":"263","author":"Su","year":"2003","journal-title":"Developmental Biology"},{"key":"10.1016\/j.vas.2026.100747_bib0018","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1242\/dev.006882","article-title":"Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells","volume":"134","author":"Sugiura","year":"2007","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.vas.2026.100747_bib0019","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/cmi.2014.42","article-title":"Extracellular vesicles and reproduction \u2014 Promotion of successful pregnancy","volume":"11","author":"Tannetta","year":"2014","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.vas.2026.100747_bib0020","first-page":"11","article-title":"Clinical relevance of secreted small noncoding RNAs in an embryo implantation potential prediction at morula and blastocyst development stages","author":"Timofeeva","year":"2021","journal-title":"Life (Basel, Switzerland)"},{"key":"10.1016\/j.vas.2026.100747_bib0022","first-page":"2514","article-title":"Angiogenesis in the human corpus luteum: Localization and changes in angiopoietins, tie-2, and vascular endothelial growth factor messenger ribonucleic acid","volume":"86","author":"Wulff","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"}],"container-title":["Veterinary and Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451943X26001778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451943X26001778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:32:54Z","timestamp":1793129574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451943X26001778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":22,"alternative-id":["S2451943X26001778"],"URL":"https:\/\/doi.org\/10.1016\/j.vas.2026.100747","relation":{},"ISSN":["2451-943X"],"issn-type":[{"value":"2451-943X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration of extracellular vesicles from porcine endometrial cells for enhancing the development of parthenogenetic embryos","name":"articletitle","label":"Article Title"},{"value":"Veterinary and Animal Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vas.2026.100747","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100747"}}