{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:26:24Z","timestamp":1793651184356,"version":"4.5.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["CPRR23032387169"],"award-info":[{"award-number":["CPRR23032387169"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary and Animal Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.vas.2026.100764","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:23:03Z","timestamp":1783700583000},"page":"100764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Physiological and meat quality responses to phased and continuous hydrolyzed yeast (Saccharomyces cerevisiae) supplementation in densely stocked broiler chickens"],"prefix":"10.1016","volume":"34","author":[{"given":"Nicole","family":"Moreane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caven M.","family":"Mnisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victory O.","family":"Sumanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omolola E.","family":"Fayemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaneshree","family":"Moonsamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah G.","family":"Kiarie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-3899","authenticated-orcid":false,"given":"Victor","family":"Mlambo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.vas.2026.100764_bib0001","first-page":"317","article-title":"In vitro hydrolysis of yeast biomass and the effect of varying levels of hydrolyzed yeast on the production performance of broilers","volume":"77","author":"Abbas","year":"2025","journal-title":"Pakistan Journal of Scientific and Industrial Research"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0002","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1080\/09712119.2018.1454325","article-title":"Dietary supplementation of Bacillus subtilis, Saccharomyces cerevisiae & their symbiotic effect on serum biochemical parameters in broilers challenged with Clostridium perfringens","volume":"46","author":"Al-Baadani","year":"2018","journal-title":"Journal of Applied Animal Research"},{"key":"10.1016\/j.vas.2026.100764_bib0003","series-title":"Ross broiler: nutrition specifications","year":"2022"},{"key":"10.1016\/j.vas.2026.100764_bib0004","first-page":"362","article-title":"The impact of high stocking density & Saccharomyces cerevisiae boulardii on productive performance, intestinal microbiota & gut integrity of broiler chickens","author":"Awaad","year":"2019","journal-title":"International Journal of Veterinary Science"},{"issue":"2","key":"10.1016\/j.vas.2026.100764_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104664","article-title":"Precision biotic as an effective replacement of hydrolyzed yeast & butyrate in antibiotic free diets of broiler chickens raised under field conditions","volume":"104","author":"Bortoluzzi","year":"2025","journal-title":"Poultry Science"},{"issue":"17","key":"10.1016\/j.vas.2026.100764_bib0006","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.3390\/ani15172531","article-title":"Effects of Saccharomyces cerevisiae hydrolysate on broiler performance & gut health","volume":"15","author":"Comi","year":"2025","journal-title":"Animals"},{"issue":"8","key":"10.1016\/j.vas.2026.100764_bib0007","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/ps\/84.8.1332","article-title":"Stocking density effects on growth performance & processing yields of heavy broilers","volume":"84","author":"Dozier","year":"2005","journal-title":"Poultry Science"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0008","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2356278","article-title":"Untapped potential of gut microbiome for hypertension management","volume":"16","author":"Gao","year":"2024","journal-title":"Gut Microbes"},{"issue":"8","key":"10.1016\/j.vas.2026.100764_bib0009","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/asj.12522","article-title":"Comparison of active dry yeast (Saccharomyces cerevisiae) & yeast culture for growth performance, carcass traits, meat quality & blood indexes in finishing bulls","volume":"87","author":"Geng","year":"2016","journal-title":"Animal Science Journal"},{"key":"10.1016\/j.vas.2026.100764_bib0010","first-page":"385","article-title":"Effect of autolyzed yeast on performance & physiological indices of broiler chickens reared at high stock density","author":"Ghaseminejad","year":"2024","journal-title":"Iranian Journal of Animal Science"},{"key":"10.1016\/j.vas.2026.100764_bib0011","doi-asserted-by":"crossref","first-page":"972","DOI":"10.2307\/1590198","article-title":"Evaluation of the heterophil\/lymphocyte ratio as a measure of stress in chickens","volume":"27","author":"Gross","year":"1983","journal-title":"Avian Diseases"},{"issue":"10","key":"10.1016\/j.vas.2026.100764_bib0012","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3390\/ani15101398","article-title":"Enhancing laying hen productivity & health: influence of dietary probiotic Bacillus strains & prebiotic Saccharomyces cerevisiae yeast cell wall on production performance, egg quality & inflammatory responses","volume":"15","author":"Hakami","year":"2025","journal-title":"Animals"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0013","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/09712119.2021.1876705","article-title":"Effects of live yeast (Saccharomyces cerevisiae) as a substitute to antibiotic on growth performance, immune function, serum biochemical parameters & intestinal morphology of broilers","volume":"49","author":"He","year":"2021","journal-title":"Journal of Applied Animal Research"},{"issue":"3","key":"10.1016\/j.vas.2026.100764_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.japr.2025.100542","article-title":"Supplementation of live yeast (Saccharomyces cerevisiae) as natural feed additives on growth performance, meat quality & physiological status of broiler chickens","volume":"34","author":"Hossain","year":"2025","journal-title":"Journal of Applied Poultry Research"},{"key":"10.1016\/j.vas.2026.100764_bib0015","series-title":"Reproducible omics workflow (Version 0.1) [R software]","author":"Idowu","year":"2026"},{"key":"10.1016\/j.vas.2026.100764_bib0016","first-page":"1","article-title":"The role of added feed enzymes in promoting gut health in swine & poultry","volume":"34","author":"Kiarie","year":"2013","journal-title":"Nutrition Research Reviews"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0017","first-page":"191","article-title":"Effect of yeast (Saccharomyces cerevisiae) supplementation on growth performance, haematological & serum biochemical parameters of broiler chicken","volume":"20","author":"Lawrence-Azua","year":"2018","journal-title":"Nigerian Journal of Animal Science"},{"key":"10.1016\/j.vas.2026.100764_bib0018","series-title":"Clinical Biochemistry of Domestic Animals","first-page":"839","article-title":"Avian clinical biochemistry","author":"Lumeij","year":"2008"},{"issue":"3","key":"10.1016\/j.vas.2026.100764_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103383","article-title":"Response of broiler breeder pullets when fed hydrolyzed whole yeast from placement to 22 wk of age","volume":"103","author":"Maina","year":"2024","journal-title":"Poultry Science"},{"key":"10.1016\/j.vas.2026.100764_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.vas.2020.100141","article-title":"Growth performance, serum biochemistry & meat quality traits of Jumbo quails fed with mopane worm (Imbrasia belina) meal-containing diets","volume":"10","author":"Marareni","year":"2020","journal-title":"Veterinary and Animal Science"},{"key":"10.1016\/j.vas.2026.100764_bib0021","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1079\/WPS19980012","article-title":"The avian heterophil leukocyte: a review","volume":"54","author":"Maxwell","year":"1998","journal-title":"World\u2019s Poultry Science Journal"},{"key":"10.1016\/j.vas.2026.100764_bib0022","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-22944-w","article-title":"The effect of probiotic baker\u2019s yeast on egg quality, tibia characteristics & hepatic lipid peroxidation in laying hens","volume":"15","author":"Mazur-Ku\u015bnirek","year":"2025","journal-title":"Scientific Reports"},{"issue":"2","key":"10.1016\/j.vas.2026.100764_bib0023","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.aninu.2018.03.002","article-title":"Use of antibiotics in broiler production: global impacts & alternatives","volume":"4","author":"Mehdi","year":"2018","journal-title":"Animal Nutrition"},{"issue":"2","key":"10.1016\/j.vas.2026.100764_bib0024","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3382\/ps.0710337","article-title":"Determination of blood constituents reference values in broilers","volume":"71","author":"Meluzzi","year":"1992","journal-title":"Poultry Science"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0026","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11250-025-04801-0","article-title":"Effects of Moringa oleifera & Saccharomyces cerevisiae on growth performance, meat quality & fatty acids profile of meat in broiler chickens","volume":"58","author":"Nastoh","year":"2026","journal-title":"Tropical Animal Health and Production"},{"key":"10.1016\/j.vas.2026.100764_bib0027","article-title":"The effect of yeast-derived prebiotics on mitigating colonization & fecal shedding of Salmonella & modifying the microbiome of laying hens in a Salmonella Enteritidis challenge","author":"Ovi","year":"2025","journal-title":"Journal of Applied Poultry Research"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0028","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4161\/gmic.26945","article-title":"Intestinal microbiome of poultry & its interaction with host & diet","volume":"5","author":"Pan","year":"2014","journal-title":"Gut Microbes"},{"issue":"11","key":"10.1016\/j.vas.2026.100764_bib0029","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1016\/j.psj.2020.08.038","article-title":"Research note: comparison of 3 methods used for estimating cook loss in broiler breast meat","volume":"99","author":"Pang","year":"2020","journal-title":"Poultry Science"},{"issue":"11","key":"10.1016\/j.vas.2026.100764_bib0030","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3390\/ani12111426","article-title":"Yeast-derived products: the role of hydrolyzed yeast & yeast culture in poultry nutrition\u2014a review","volume":"12","author":"Perricone","year":"2022","journal-title":"Animals"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0031","first-page":"57","article-title":"Exploration of Saccharomyces cerevisiae as a feed additive in poultry","volume":"15","author":"Pratama","year":"2026","journal-title":"International Journal of Agriculture and Biosciences"},{"key":"10.1016\/j.vas.2026.100764_bib0032","first-page":"1","article-title":"The environmental and economic impact of withdrawing antibiotics from US broiler production","volume":"1","author":"Salois","year":"2016","journal-title":"Journal of Food Distribution Research"},{"issue":"3","key":"10.1016\/j.vas.2026.100764_bib0033","doi-asserted-by":"crossref","first-page":"563","DOI":"10.5187\/jast.2021.e61","article-title":"Influence of yeast hydrolysate supplement on growth performance, nutrient digestibility, microflora, gas emission, blood profile & meat quality in broilers","volume":"63","author":"Sampath","year":"2021","journal-title":"Journal of Animal Science and Technology"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3923\/ajpsaj.2016.1.29","article-title":"Review on natural growth promoters available for improving gut health of poultry: an alternative to antibiotic growth promoters","volume":"10","author":"Sethiya","year":"2016","journal-title":"Asian Journal of Poultry Science"},{"issue":"12","key":"10.1016\/j.vas.2026.100764_bib0036","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1099\/ijsem.0.000617","article-title":"Alistipes inops sp. nov. & Coprobacter secundus sp. nov., isolated from human faeces","volume":"65","author":"Shkoporov","year":"2015","journal-title":"International Journal of Systematic and Evolutionary Microbiology"},{"issue":"2","key":"10.1016\/j.vas.2026.100764_bib0037","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/ps\/79.2.205","article-title":"The effects of dietary mannanoligosaccharides on caecal parameters & concentrations of enteric bacteria in broiler chicks","volume":"79","author":"Spring","year":"2000","journal-title":"Poultry Science"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0038","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5194\/aab-65-21-2022","article-title":"Dietary strategies to alleviate high-stocking-density-induced stress in broiler chickens\u2014a comprehensive review","volume":"65","author":"Sugiharto","year":"2022","journal-title":"Archives Animal Breeding"},{"issue":"21","key":"10.1016\/j.vas.2026.100764_bib0039","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3390\/ani13213407","article-title":"A technical report on the potential effects of heat stress on antioxidant enzymes, performance & intestinal morphology in broilers","volume":"13","author":"Sumanu","year":"2023","journal-title":"Animals"},{"issue":"4","key":"10.1016\/j.vas.2026.100764_bib0040","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.17582\/journal.jahp\/2025\/13.4.1046.1054","article-title":"Growth performance, meat quality & economic efficiency of chickens fed fermented cassava root by Saccharomyces cerevisiae","volume":"13","author":"Thao","year":"2025","journal-title":"Journal of Animal Health and Production"},{"issue":"6706","key":"10.1016\/j.vas.2026.100764_bib0041","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1126\/science.adi3338","article-title":"Host control of the microbiome: mechanisms, evolution & disease","volume":"385","author":"Wilde","year":"2024","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.vas.2026.100764_bib0042","first-page":"43","article-title":"Mannan oligosaccharides (MOS) from Saccharomyces cerevisiae in broilers: effects on performance & blood biochemistry","volume":"32","author":"Yalcinkaya","year":"2008","journal-title":"Turkish Journal of Veterinary and Animal Sciences"},{"issue":"5","key":"10.1016\/j.vas.2026.100764_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105019","article-title":"Optimization of processing parameters of 50% aged paddy rice replacing corn in feed formula: effects on broiler performance & serum biochemical parameters","volume":"104","author":"Yang","year":"2025","journal-title":"Poultry Science"},{"key":"10.1016\/j.vas.2026.100764_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.vas.2025.100465","article-title":"Blood biochemical parameter intervals & dynamics in modern broiler chickens","volume":"29","author":"Z\u00e1le\u0161\u00e1kov\u00e1","year":"2025","journal-title":"Veterinary and Animal Science"},{"issue":"6","key":"10.1016\/j.vas.2026.100764_bib0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.21608\/mjapfp.2025.391542.1031","article-title":"Effect of yeast (Saccharomyces cerevisiae) supplementation on productive performance, immune response, caecal microbial count & intestinal histomorphology in broiler chicks","volume":"9","author":"Zanaty","year":"2025","journal-title":"Menoufia Journal of Animal, Poultry and Fish Production"},{"issue":"7","key":"10.1016\/j.vas.2026.100764_bib0046","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/ps\/84.7.1015","article-title":"Effects of yeast (Saccharomyces cerevisiae) cell components on growth performance, meat quality & ileal mucosa development of broiler chicks","volume":"84","author":"Zhang","year":"2005","journal-title":"Poultry Science"},{"issue":"6","key":"10.1016\/j.vas.2026.100764_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102671","article-title":"Effect of dietary Saccharomyces-derived prebiotic functional carbohydrates on growth performance & intestinal health of broilers","volume":"102","author":"Zhen","year":"2023","journal-title":"Poultry Science"},{"key":"10.1016\/j.vas.2026.100764_bib0048","doi-asserted-by":"crossref","first-page":"skae325","DOI":"10.1093\/jas\/skae325","article-title":"Effects of combined Bacillus coagulans & yeast fermentation culture on growth performance, plasma biochemical indices, intestinal morphology & microbiota of broilers","volume":"103","author":"Zi","year":"2025","journal-title":"Journal of Animal Science"}],"container-title":["Veterinary and Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451943X26001948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451943X26001948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:40:40Z","timestamp":1793648440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451943X26001948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":46,"alternative-id":["S2451943X26001948"],"URL":"https:\/\/doi.org\/10.1016\/j.vas.2026.100764","relation":{},"ISSN":["2451-943X"],"issn-type":[{"value":"2451-943X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiological and meat quality responses to phased and continuous hydrolyzed yeast (Saccharomyces cerevisiae) supplementation in densely stocked broiler chickens","name":"articletitle","label":"Article Title"},{"value":"Veterinary and Animal Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vas.2026.100764","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100764"}}