{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:26:41Z","timestamp":1793651201875,"version":"4.5.1"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004913","name":"University of Palermo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary and Animal Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.vas.2026.100870","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:05:32Z","timestamp":1789495532000},"page":"100870","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["From candidate genes to whole-genome approaches: current insights into the genetic architecture of ovine milk production and quality traits"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-1981","authenticated-orcid":false,"given":"Salvatore","family":"Mastrangelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Benanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-2490","authenticated-orcid":false,"given":"Serena","family":"Tumino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-1906","authenticated-orcid":false,"given":"Andrea","family":"Criscione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cesarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0001","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40104-025-01334-2","article-title":"Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats","volume":"17","author":"Akhatayeva","year":"2026","journal-title":"Journal of Animal Science and Biotechnology"},{"issue":"2","key":"10.1016\/j.vas.2026.100870_bib0002","doi-asserted-by":"crossref","first-page":"435","DOI":"10.14202\/vetworld.2022.435-441","article-title":"Single and combined effects of CSN1S1 and CSN2-casein genes on Awassi sheep milk quantity and quality","volume":"15","author":"Al-Amareen","year":"2022","journal-title":"Veterinary World"},{"key":"10.1016\/j.vas.2026.100870_bib0003","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smallrumres.2015.12.016","article-title":"Nutritional properties of small ruminant food products and their role on human health","volume":"135","author":"Albenzio","year":"2016","journal-title":"Small Ruminant Research"},{"issue":"3","key":"10.1016\/j.vas.2026.100870_bib0004","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0958-6946(00)00034-0","article-title":"Genetic polymorphism of ovine milk proteins: its influence on technological properties of milk\u2014A review","volume":"10","author":"Amigo","year":"2000","journal-title":"International Dairy Journal"},{"issue":"2","key":"10.1016\/j.vas.2026.100870_bib0005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1439-0388.2008.00764.x","article-title":"Searching for DNA markers for milk production and composition on chromosome 6 in sheep","volume":"126","author":"Arnyasi","year":"2009","journal-title":"Journal of Animal Breeding and Genetics"},{"issue":"2","key":"10.1016\/j.vas.2026.100870_bib0006","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/1541-4337.12250","article-title":"Sheep milk: Physicochemical characteristics and relevance for functional food development","volume":"16","author":"Balthazar","year":"2017","journal-title":"Comprehensive Reviews in Food Science and Food Safety"},{"issue":"6","key":"10.1016\/j.vas.2026.100870_bib0007","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1541-4337.2011.00163.x","article-title":"Nutritional value and technological suitability of milk from various animal species used for dairy production","volume":"10","author":"Bar\u0142owska","year":"2011","journal-title":"Comprehensive Reviews in Food Science and Food Safety"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0008","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/1471-2164-9-366","article-title":"Gene networks driving bovine milk fat synthesis during the lactation cycle","volume":"9","author":"Bionaz","year":"2008","journal-title":"BMC Genomics"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12711-018-0443-5","article-title":"Accuracy of imputation to whole-genome sequence in sheep","volume":"51","author":"Bolormaa","year":"2019","journal-title":"Genetics Selection Evolution"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.livsci.2013.06.014","article-title":"Structural and functional characterisation of the \u03b1S1-casein (CSN1S1) gene and association studies with milk traits in Assaf sheep breed","volume":"157","author":"Calvo","year":"2013","journal-title":"Livestock Science"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0011","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2052.2004.01169.x","article-title":"Association of the heart fatty acid-binding protein (FABP3) gene with milk traits in Manchega breed sheep","volume":"35","author":"Calvo","year":"2004","journal-title":"Animal Genetics"},{"issue":"5","key":"10.1016\/j.vas.2026.100870_bib0012","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.3168\/jds.2022-22579","article-title":"Understanding the phenotypic and genetic background of the lactose content in Sarda dairy sheep","volume":"106","author":"Carta","year":"2023","journal-title":"Journal of Dairy Science"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0013","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.3168\/jds.2018-15333","article-title":"Genomic selection of milk fatty acid composition in Sarda dairy sheep: Effect of different phenotypes and relationship matrices on heritability and breeding value accuracy","volume":"102","author":"Cesarani","year":"2019","journal-title":"Journal of Dairy Science"},{"issue":"5","key":"10.1016\/j.vas.2026.100870_bib0014","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S1050-1738(00)00066-9","article-title":"DGAT and triglyceride synthesis: A new target for obesity treatment?","volume":"10","author":"Chen","year":"2000","journal-title":"Trends in Cardiovascular Medicine"},{"issue":"15","key":"10.1016\/j.vas.2026.100870_bib0015","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1016\/S0021-9258(17)33235-0","article-title":"Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols","volume":"251","author":"Coleman","year":"1976","journal-title":"Journal of Biological Chemistry"},{"issue":"1-3","key":"10.1016\/j.vas.2026.100870_bib0016","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.livsci.2010.01.007","article-title":"Associations between milk protein genetic polymorphisms and milk production traits in Merino sheep breed","volume":"129","author":"Corral","year":"2010","journal-title":"Livestock Science"},{"issue":"1-3","key":"10.1016\/j.vas.2026.100870_bib0017","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.livsci.2013.01.008","article-title":"Detection and genetic characterization of ovine CSN1S2\u204e B polymorphisms and their associations with milk production traits","volume":"153","author":"Corral","year":"2013","journal-title":"Livestock Science"},{"issue":"3","key":"10.1016\/j.vas.2026.100870_bib0018","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1017\/S1751731118001659","article-title":"Genetic parameters of milk fatty acid profile in sheep: Comparison between gas chromatographic measurements and Fourier-transform IR spectroscopy predictions","volume":"13","author":"Correddu","year":"2019","journal-title":"Animal"},{"key":"10.1016\/j.vas.2026.100870_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.idairyj.2020.104895","article-title":"Effect of altitude of flock location, season of milk production and ripening time on the fatty acid profile of Pecorino Sardo cheese","volume":"113","author":"Correddu","year":"2021","journal-title":"International Dairy Journal"},{"issue":"8","key":"10.1016\/j.vas.2026.100870_bib0020","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.3168\/jds.2009-3014","article-title":"Exploring polymorphisms and effects of candidate genes on milk fat quality in dairy sheep","volume":"93","author":"Cris\u00e0","year":"2010","journal-title":"Journal of Dairy Science"},{"issue":"1-3","key":"10.1016\/j.vas.2026.100870_bib0021","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.smallrumres.2007.06.007","article-title":"Genetic polymorphism of \u03b2-lactoglobulin gene and effect on milk composition in Leccese sheep","volume":"74","author":"Dario","year":"2008","journal-title":"Small Ruminant Research"},{"issue":"12","key":"10.1016\/j.vas.2026.100870_bib0022","doi-asserted-by":"crossref","first-page":"8469","DOI":"10.3168\/jds.2023-23403","article-title":"Consumer acceptance for sheep milk\u2013based yogurt\u2014Evidence from a large sample of Italian consumers","volume":"106","author":"De Devitiis","year":"2023","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.vas.2026.100870_bib0023","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.smallrumres.2015.08.015","article-title":"Structural characterisation of the acyl CoA: diacylglycerol acyltransferase 1 (DGAT1) gene and association studies with milk traits in Assaf sheep breed","volume":"131","author":"Dervishi","year":"2015","journal-title":"Small Ruminant Research"},{"issue":"3","key":"10.1016\/j.vas.2026.100870_bib0024","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1017\/S0022029901004988","article-title":"Mapping quantitative trait loci for milk production traits on ovine chromosome 6","volume":"68","author":"Diez-Tasc\u00f3n","year":"2001","journal-title":"Journal of Dairy Research"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0025","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1017\/S0022029906001932","article-title":"Effects of genetic polymorphisms at the growth hormone gene on milk yield in Serra da Estrela sheep","volume":"73","author":"do Ros\u00e1rio Marques","year":"2006","journal-title":"Journal of Dairy Research"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0026","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00335-025-10107-1","article-title":"Genome-wide study for signatures of selection identifies genomic regions and candidate genes associated with milk traits in sheep","volume":"36","author":"Ebrahimi","year":"2025","journal-title":"Mammalian Genome"},{"issue":"5","key":"10.1016\/j.vas.2026.100870_bib0027","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3168\/jds.S0022-0302(05)72860-5","article-title":"Effect of heat stress on production of Mediterranean dairy sheep","volume":"88","author":"Finocchiaro","year":"2005","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.vas.2026.100870_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047782","article-title":"GWA analysis for milk production traits in dairy sheep and genetic support for a QTN influencing milk protein percentage in the LALBA gene","volume":"7","author":"Garc\u00eda-G\u00e1mez","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vas.2026.100870_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fanim.2022.889797","article-title":"Multivariate and genome-wide analysis of mid-infrared spectra of non-coagulating milk of Sarda sheep breed","volume":"3","author":"Gaspa","year":"2022","journal-title":"Frontiers in Animal Science"},{"key":"10.1016\/j.vas.2026.100870_bib0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2527\/jam2016-0331","article-title":"Genome-wide association study of milk coagulation properties in dairy sheep","volume":"94","author":"Gaspa","year":"2016","journal-title":"Journal of Animal Science"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0031","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/ani10010033","article-title":"Review on genomic regions and candidate genes associated with economically important production and reproduction traits in sheep (Ovies aries)","volume":"10","author":"Gebreselassie","year":"2019","journal-title":"Animals"},{"issue":"2","key":"10.1016\/j.vas.2026.100870_bib0032","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/genetics\/139.2.907","article-title":"Mapping quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing","volume":"139","author":"Georges","year":"1995","journal-title":"Genetics"},{"issue":"2-3","key":"10.1016\/j.vas.2026.100870_bib0033","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.smallrumres.2014.09.001","article-title":"Milk protein variants are highly associated with milk performance traits in East Friesian Dairy and Lacaune sheep","volume":"121","author":"Giambra","year":"2014","journal-title":"Small Ruminant Research"},{"key":"10.1016\/j.vas.2026.100870_bib0034","series-title":"Proceedings of the 9th World Congress on Genetics Applied to Livestock Production (WCGALP)","first-page":"36","article-title":"Association study between milk protein variants and milk performance traits in East Friesian dairy sheep","author":"Giambra","year":"2010"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-animal-020518-114913","article-title":"Functional annotation of animal genomes (FAANG): current achievements and roadmap","volume":"7","author":"Giuffra","year":"2019","journal-title":"Annual Review of Animal Biosciences"},{"issue":"6","key":"10.1016\/j.vas.2026.100870_bib0036","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nrg2575","article-title":"Mapping genes for complex traits in domestic animals and their use in breeding programmes","volume":"10","author":"Goddard","year":"2009","journal-title":"Nature Reviews Genetics"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0037","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.21897\/rmvz.23","article-title":"Relationship between gene polymorphism and milk production traits in Teleorman Black Head sheep breed","volume":"21","author":"Gras","year":"2016","journal-title":"Revista MVZ C\u00f3rdoba"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0038","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2052.2009.01856.x","article-title":"Quantitative trait loci underlying milk production traits in sheep","volume":"40","author":"Guti\u00e9rrez-Gil","year":"2009","journal-title":"Animal Genetics"},{"issue":"2","key":"10.1016\/j.vas.2026.100870_bib0039","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1017\/S1751731118001374","article-title":"Estimates of genetic parameters and genetic trends for growth, reproduction, milk production and milk composition traits of Awassi sheep","volume":"13","author":"Haile","year":"2019","journal-title":"Animal"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0040","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biology"},{"issue":"3","key":"10.1016\/j.vas.2026.100870_bib0041","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1297-9686-33-3-209","article-title":"The distribution of the effects of genes affecting quantitative traits in livestock","volume":"33","author":"Hayes","year":"2001","journal-title":"Genetics Selection Evolution"},{"issue":"11","key":"10.1016\/j.vas.2026.100870_bib0042","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1139\/G10-076","article-title":"Genome-wide association and genomic selection in animal breeding","volume":"53","author":"Hayes","year":"2010","journal-title":"Genome"},{"issue":"5","key":"10.1016\/j.vas.2026.100870_bib0043","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jssas.2021.09.006","article-title":"Genome-wide association study for milk production of Awassi sheep in Jordan","volume":"21","author":"Jawasreh","year":"2022","journal-title":"Journal of the Saudi Society of Agricultural Sciences"},{"issue":"6","key":"10.1016\/j.vas.2026.100870_bib0044","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/ani9060382","article-title":"Effect and interaction of \u03b2-lactoglobulin, kappa casein, and prolactin genes on milk production and composition of awassi sheep","volume":"9","author":"Jawasreh","year":"2019","journal-title":"Animals"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0045","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/09712119.2011.565223","article-title":"Genetic polymorphism of \u03b2-lactoglobulin in sheep raised for milk production","volume":"39","author":"Kawecka","year":"2011","journal-title":"Journal of Applied Animal Research"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0046","article-title":"Investigation on relationships of the FABP3 AND SLC27A3 genes with milk production traits in sheep","volume":"22","author":"Kowalewska-\u0141uczak","year":"2017","journal-title":"Journal of Elementology"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0047","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.3168\/jds.2024-25681","article-title":"Genomic selection and weighted single-step genome-wide association study of sheep body weight and milk yield: Imputing low-coverage sequencing data with similar genetic background panels","volume":"108","author":"Li","year":"2025","journal-title":"Journal of Dairy Science"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0048","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/age.12956","article-title":"Genome-wide association study of milk production traits in a crossbred dairy sheep population using three statistical models","volume":"51","author":"Li","year":"2020","journal-title":"Animal Genetics"},{"key":"10.1016\/j.vas.2026.100870_bib0049","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.3390\/ani13101654","article-title":"Genome-wide signal selection analysis revealing genes potentially related to sheep-milk-production traits","volume":"13","author":"Li","year":"2023","journal-title":"Animals"},{"issue":"3","key":"10.1016\/j.vas.2026.100870_bib0050","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1101\/gr.277372.12","article-title":"A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypes","volume":"33","author":"Li","year":"2023","journal-title":"Genome Research"},{"key":"10.1016\/j.vas.2026.100870_bib0051","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.1034211","article-title":"Whole genome re-sequencing reveals artificial and natural selection for milk traits in East Friesian sheep","volume":"9","author":"Li","year":"2022","journal-title":"Frontiers in Veterinary Science"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0052","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s40104-025-01294-7","article-title":"Exploring cattle structural variation in the era of long reads, pangenome graphs, and near-complete assemblies","volume":"16","author":"Liu","year":"2025","journal-title":"Journal of Animal Science and Biotechnology"},{"issue":"7265","key":"10.1016\/j.vas.2026.100870_bib0053","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.vas.2026.100870_bib0054","doi-asserted-by":"crossref","first-page":"11850","DOI":"10.3168\/jds.2021-20510","article-title":"Genome-wide association studies (GWAS) and post-GWAS analyses for technological traits in Assaf and Churra dairy breeds","volume":"104","author":"Marina","year":"2021","journal-title":"Journal of Dairy Science"},{"issue":"9","key":"10.1016\/j.vas.2026.100870_bib0055","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3390\/ani10091542","article-title":"Analysis of whole genome resequencing datasets from a worldwide sample of sheep breeds to identify potential causal mutations influencing milk composition traits","volume":"10","author":"Marina","year":"2020","journal-title":"Animals"},{"issue":"7","key":"10.1016\/j.vas.2026.100870_bib0056","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3390\/genes11070715","article-title":"Gene networks driving genetic variation in milk and cheese-making traits of Spanish Assaf sheep","volume":"11","author":"Marina","year":"2020","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0057","doi-asserted-by":"crossref","DOI":"10.1080\/10495398.2025.2516688","article-title":"Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock","volume":"36","author":"Marshall","year":"2025","journal-title":"Animal Biotechnology"},{"key":"10.1016\/j.vas.2026.100870_bib0058","series-title":"Uncovering the genomic basis of lactose content in Valle del Belice dairy sheep","author":"Mastrangelo","year":"2026"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0059","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s11033-011-0794-2","article-title":"Study of polymorphisms in the promoter region of ovine \u03b2-lactoglobulin gene and phylogenetic analysis among the Valle del Belice breed and other sheep breeds considered as ancestors","volume":"39","author":"Mastrangelo","year":"2012","journal-title":"Molecular Biology Reports"},{"issue":"5","key":"10.1016\/j.vas.2026.100870_bib0060","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1365-2052.2010.02045.x","article-title":"Genetic mapping of quantitative trait loci for milk production in sheep","volume":"41","author":"Mateescu","year":"2010","journal-title":"Animal Genetics"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0061","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12711-015-0175-8","article-title":"Accuracy of genotype imputation based on random and selected reference sets in purebred and crossbred sheep populations and its effect on accuracy of genomic prediction","volume":"47","author":"Moghaddar","year":"2015","journal-title":"Genetics Selection Evolution"},{"issue":"9","key":"10.1016\/j.vas.2026.100870_bib0062","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3390\/ani12091155","article-title":"Weighted single-step genome-wide association study uncovers known and novel candidate genomic regions for milk production traits and somatic cell score in Valle del Belice dairy sheep","volume":"12","author":"Mohammadi","year":"2022","journal-title":"Animals"},{"issue":"1-2","key":"10.1016\/j.vas.2026.100870_bib0063","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.smallrumres.2006.09.008","article-title":"Candidate genes affecting sheep and goat milk quality","volume":"68","author":"Moioli","year":"2007","journal-title":"Small Ruminant Research"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0064","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2156-14-76","article-title":"Signatures of selection identify loci associated with milk yield in sheep","volume":"14","author":"Moioli","year":"2013","journal-title":"BMC Genetics"},{"issue":"1-2","key":"10.1016\/j.vas.2026.100870_bib0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.smallrumres.2006.09.019","article-title":"Influence of farming and feeding systems on composition and quality of goat and sheep milk","volume":"68","author":"Morand-Fehr","year":"2007","journal-title":"Small Ruminant Research"},{"issue":"6; SPI","key":"10.1016\/j.vas.2026.100870_bib0066","first-page":"114","article-title":"Sheep milk protein polymorphism and its effect on milk performance of Polish Merino","volume":"47","author":"Mroczkowski","year":"2004","journal-title":"Archiv fur Tierzucht"},{"issue":"3","key":"10.1016\/j.vas.2026.100870_bib0067","first-page":"53","article-title":"Nutritional value and factors affecting milk production and milk composition from dairy sheep: A review","volume":"14","author":"Nguyen","year":"2022","journal-title":"CTU Journal of Innovation and Sustainable Development"},{"issue":"6","key":"10.1016\/j.vas.2026.100870_bib0068","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/age.12474","article-title":"Variations at regulatory regions of the milk protein genes are associated with milk traits and coagulation properties in the Sarda sheep","volume":"47","author":"Noce","year":"2016","journal-title":"Animal Genetics"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0069","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/dairy2010008","article-title":"Functional odd-and branched-chain fatty acid in sheep and goat milk and cheeses","volume":"2","author":"Nudda","year":"2021","journal-title":"Dairy"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0070","first-page":"331","article-title":"Polymorphism of sheep POU1F1 gene exon 6 and 3\u2032UTR region and their association with milk production traits","volume":"15","author":"Ozmen","year":"2014","journal-title":"Iranian Journal of Veterinary Research"},{"key":"10.1016\/j.vas.2026.100870_bib0071","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.livsci.2018.09.012","article-title":"Polymorphisms of \u03b1-lactoalbumin, \u03b2-lactoglobulin and prolactin genes are highly associated with milk composition traits in Spanish Merino sheep","volume":"217","author":"Padilla","year":"2018","journal-title":"Livestock Science"},{"issue":"1-2","key":"10.1016\/j.vas.2026.100870_bib0072","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.smallrumres.2006.09.013","article-title":"Physico-chemical characteristics of goat and sheep milk","volume":"68","author":"Park","year":"2007","journal-title":"Small Ruminant Research"},{"issue":"2","key":"10.1016\/j.vas.2026.100870_bib0073","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0378-1119(94)00755-H","article-title":"Complete sequence of the ovine \u03b2-casein-encoding gene and interspecies comparison","volume":"154","author":"Provot","year":"1995","journal-title":"Gene"},{"issue":"8","key":"10.1016\/j.vas.2026.100870_bib101","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.3168\/jds.2017-14015","article-title":"Invited review: Current production trends, farm structures, and economics of the dairy sheep and goat sectors","volume":"101","author":"Pulina","year":"2018","journal-title":"Journal of dairy science"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0074","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/jbg.12846","article-title":"Genome-wide detection of structural variation in some sheep breeds using whole-genome long-read sequencing data","volume":"141","author":"Qiao","year":"2024","journal-title":"Journal of Animal Breeding and Genetics"},{"issue":"2-3","key":"10.1016\/j.vas.2026.100870_bib0075","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.smallrumres.2009.02.007","article-title":"Candidate genes for milk production traits in Portuguese dairy sheep","volume":"82","author":"Ramos","year":"2009","journal-title":"Small Ruminant Research"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0076","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.smallrumres.2008.07.009","article-title":"Composition of goat and sheep milk products: An update","volume":"79","author":"Raynal-Ljutovac","year":"2008","journal-title":"Small Ruminant Research"},{"issue":"3","key":"10.1016\/j.vas.2026.100870_bib0077","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/vms3.731","article-title":"Detection of candidate genes affecting milk production traits in sheep using whole-genome sequencing analysis","volume":"8","author":"Rezvannejad","year":"2022","journal-title":"Veterinary Medicine and Science"},{"issue":"3","key":"10.1016\/j.vas.2026.100870_bib0078","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1046\/j.1439-0388.2002.00337.x","article-title":"Genotype by environment interaction for milk yield in Sarda dairy sheep","volume":"119","author":"Sanna","year":"2002","journal-title":"Journal of Animal Breeding and Genetics"},{"issue":"5","key":"10.1016\/j.vas.2026.100870_bib0079","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1365-2052.2009.01909.x","article-title":"Ovine acyl CoA: Diacylglycerol acyltransferase 1\u2013molecular characterization, polymorphisms and association with milk traits","volume":"40","author":"Scat\u00e0","year":"2009","journal-title":"Animal Genetics"},{"issue":"1-2","key":"10.1016\/j.vas.2026.100870_bib0080","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.smallrumres.2006.09.005","article-title":"Typicity and biodiversity of goat and sheep milk products","volume":"68","author":"Scintu","year":"2007","journal-title":"Small Ruminant Research"},{"key":"10.1016\/j.vas.2026.100870_bib0081","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1017\/S0022029916000765","article-title":"Environmental and genetic factors affecting milk yield and quality in three Italian sheep breeds","volume":"84","author":"Selvaggi","year":"2017","journal-title":"Journal of Dairy Research"},{"issue":"15","key":"10.1016\/j.vas.2026.100870_bib0082","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1002\/jsfa.6750","article-title":"Investigating the genetic polymorphism of sheep milk proteins: A useful tool for dairy production","volume":"94","author":"Selvaggi","year":"2014","journal-title":"Journal of the Science of Food and Agriculture"},{"issue":"10","key":"10.1016\/j.vas.2026.100870_bib0083","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.5713\/ajas.14.0715","article-title":"Stories and challenges of genome wide association studies in livestock\u2014A review","volume":"28","author":"Sharma","year":"2015","journal-title":"Asian-Australasian Journal of Animal Sciences"},{"key":"10.1016\/j.vas.2026.100870_bib0084","series-title":"eQTL Analysis","author":"Shi","year":"2020"},{"issue":"4","key":"10.1016\/j.vas.2026.100870_bib0085","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.3168\/jds.2009-2630","article-title":"Effect of prolactin, \u03b2-lactoglobulin, and \u03ba-casein genotype on milk yield in East Friesian sheep","volume":"93","author":"Staiger","year":"2010","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.vas.2026.100870_bib0086","article-title":"Comprehensive RNA-Seq profiling to evaluate lactating sheep mammary gland transcriptome","volume":"2","author":"Suarez-Vega","year":"2015","journal-title":"Scientific Data"},{"key":"10.1016\/j.vas.2026.100870_bib0087","doi-asserted-by":"crossref","DOI":"10.1177\/1177932219899051","article-title":"Multi-omics data integration, interpretation, and its application","volume":"14","author":"Subramanian","year":"2020","journal-title":"Bioinformatics and Biology Insights"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0088","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12711-016-0217-x","article-title":"Multi-omic data integration and analysis using systems genomics approaches: Methods and applications in animal production, health and welfare","volume":"48","author":"Suravajhala","year":"2016","journal-title":"Genetics Selection Evolution"},{"issue":"3","key":"10.1016\/j.vas.2026.100870_bib0089","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/age.12789","article-title":"Genome-wide association studies for milk production traits in Valle del Belice sheep using repeated measures","volume":"50","author":"Sutera","year":"2019","journal-title":"Animal Genetics"},{"issue":"5","key":"10.1016\/j.vas.2026.100870_bib0090","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/jbg.12552","article-title":"Detection of genomic regions underlying milk production traits in Valle del Belice dairy sheep using regional heritability mapping","volume":"138","author":"Sutera","year":"2021","journal-title":"Journal of Animal Breeding and Genetics"},{"key":"10.1016\/j.vas.2026.100870_bib0091","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.643531","article-title":"Genome-wide association study identifies new candidate markers for somatic cells score in a local dairy sheep","volume":"12","author":"Sutera","year":"2021","journal-title":"Frontiers in Genetics"},{"issue":"2","key":"10.1016\/j.vas.2026.100870_bib0092","first-page":"281","article-title":"Identification of polymorphism in goat and sheep DGAT1 gene associated with milk production traits","volume":"71","author":"T\u0103b\u0103ran","year":"2014","journal-title":"Bulletin UASVM Veterinary Medicine"},{"issue":"1-3","key":"10.1016\/j.vas.2026.100870_bib0093","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.smallrumres.2011.09.021","article-title":"Popular ovine and caprine fermented milks","volume":"101","author":"Tamime","year":"2011","journal-title":"Small Ruminant Research"},{"issue":"2","key":"10.1016\/j.vas.2026.100870_bib0094","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1515\/aoas-2016-0058","article-title":"Effect of \u03b2-lactoglobulin gene polymorphism, lactation stage and breed on milk traits in Chios and Karagouniko sheep breeds","volume":"17","author":"Triantaphyllopoulos","year":"2017","journal-title":"Annals of Animal Science"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0095","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12711-021-00682-7","article-title":"A comprehensive genome-wide scan detects genomic regions related to local adaptation and climate resilience in Mediterranean domestic sheep","volume":"53","author":"Tsartsianidou","year":"2021","journal-title":"Genetics Selection Evolution"},{"key":"10.1016\/j.vas.2026.100870_bib0096","series-title":"Proceedings, 10th World Congress of Genetics Applied to Livestock Production","article-title":"Genome wide association study on milk production traits in a nucleus flock of Sarda breed sheep using a novel method combining linkage and linkage disequilibrium mapping","author":"Usai","year":"2014"},{"issue":"11","key":"10.1016\/j.vas.2026.100870_bib0097","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.3168\/jds.2007-0980","article-title":"Efficient methods to compute genomic predictions","volume":"91","author":"VanRaden","year":"2008","journal-title":"Journal of Dairy Science"},{"issue":"11","key":"10.1016\/j.vas.2026.100870_bib0098","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.3168\/jds.2022-21894","article-title":"Consumer attitudes toward dairy products from sheep and goats: A cross-continental perspective","volume":"105","author":"Vargas-Bello-P\u00e9rez","year":"2022","journal-title":"Journal of Dairy Science"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0099","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1038\/s41467-026-70382-7","article-title":"Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome","volume":"17","author":"Xie","year":"2026","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/j.vas.2026.100870_bib0100","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7482\/0003-9438-56-021","article-title":"Effect of \u03b2-lactoglobulin and \u03ba-casein genes polymorphism on milk composition in indigenous Zel sheep","volume":"56","author":"Yousefi","year":"2013","journal-title":"Archives Animal Breeding"}],"container-title":["Veterinary and Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451943X26002991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451943X26002991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:42:12Z","timestamp":1793648532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451943X26002991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":101,"alternative-id":["S2451943X26002991"],"URL":"https:\/\/doi.org\/10.1016\/j.vas.2026.100870","relation":{},"ISSN":["2451-943X"],"issn-type":[{"value":"2451-943X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From candidate genes to whole-genome approaches: current insights into the genetic architecture of ovine milk production and quality traits","name":"articletitle","label":"Article Title"},{"value":"Veterinary and Animal Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vas.2026.100870","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100870"}}