{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:04:17Z","timestamp":1761091457622,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological and Toxicological Methods"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.vascn.2006.05.002","type":"journal-article","created":{"date-parts":[[2006,5,14]],"date-time":"2006-05-14T07:11:36Z","timestamp":1147590696000},"page":"94-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Safety pharmacology in focus: New methods developed in the light of the ICH S7B guidance document"],"prefix":"10.1016","volume":"54","author":[{"given":"Michael K.","family":"Pugsley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vascn.2006.05.002_bib1","unstructured":"Anon (2001). U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER). Guidance for Industry. S7A: Safety Pharmacology Studies for Human Pharmaceuticals (ICH S7A)."},{"key":"10.1016\/j.vascn.2006.05.002_bib2","first-page":"61133","article-title":"S7B: The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) By Human Pharmaceuticals (S7B)","volume":"70","author":"Anon","year":"2005","journal-title":"Federal Register"},{"key":"10.1016\/j.vascn.2006.05.002_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.vascn.2004.02.007","article-title":"Origins, practices and future of safety pharmacology","volume":"49","author":"Bass","year":"2004","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.vascn.2004.02.004","article-title":"Introduction to Nonclinical safety pharmacology and the safety pharmacology society","volume":"49","author":"Bass","year":"2004","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.04.001","article-title":"The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity","author":"Bertaina-Anglade","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.02.003","article-title":"Validation of Ionworks\u00ae HT as a Medium-Throughput, Electrophysiology Assay for hERG Activity","author":"Bridgland-Taylor","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib7","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.hrthm.2004.09.019","article-title":"Clinical trial design to evaluate the effects of drugs on cardiac repolarization: current state of the art","volume":"2","author":"Camm","year":"2005","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.vascn.2006.05.002_bib8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1517\/14740338.4.3.509","article-title":"ICH S7B draft guideline on the non-clinical strategy for testing delayed cardiac repolarization risk of drugs: a critical analysis","volume":"4","author":"Cavero","year":"2005","journal-title":"Expert Opinion Drug Safety"},{"key":"10.1016\/j.vascn.2006.05.002_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.03.004","article-title":"Cardiovascular Monkey Telemetry: Sensitivity to detect QT interval prolongation","author":"Chaves","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.02.004","article-title":"A One-step Approach to the Analysis of the QT Interval in Conscious Telemetrized Dogs","author":"Chiang","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.bjp.0706231","article-title":"Phase 2 ventricular arrhythmias in acute myocardial infarction: a neglected target for therapeutic drug development and safety pharmacology evaluation","volume":"145","author":"Clements-Jewery","year":"2005","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.vascn.2006.05.002_bib12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1472-8206.2002.00081.x","article-title":"In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity","volume":"16","author":"De Clerck","year":"2002","journal-title":"Fundamentals of Clinical Pharmacology"},{"key":"10.1016\/j.vascn.2006.05.002_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.03.002","article-title":"Dimethyl sulfoxide effects on hERG channels expressed in HEK293 cells","author":"Du","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.vascn.2005.04.002","article-title":"Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation","volume":"52","author":"Guo","year":"2005","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.05.001","article-title":"ILSI-HESI Cardiovascular Safety Subcommittee Initiative: Evaluation of Three Non-clinical Models of QT Prolongation","author":"Hanson","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.02.013","article-title":"Can optical recordings of membrane potential be used to screen for drug-induced action potential prolongation in single cardiac myocytes?","author":"Hardy","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1254\/jphs.FP0040774","article-title":"Effects of AF-DX116 and other muscarinic receptor antagonists on orthostatic hypotension in autonomic imbalanced (SART-stressed) rats","volume":"97","author":"Hata","year":"2005","journal-title":"Journal of Pharmacological Sciences"},{"key":"10.1016\/j.vascn.2006.05.002_bib18","article-title":"Invasive and Noninvasive Lung Function Measurements in Rodents","author":"Hoymann","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.vascn.2004.03.007","article-title":"New preclinical guidelines on drug effects on ventricular repolarization: safety pharmacology comes of age","volume":"49","author":"Kinter","year":"2004","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib20","article-title":"Optimizing the experimental environment for dog telemetry studies","author":"Klumpp","year":"2006","journal-title":"Journal of Pharmacological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0160-5402(82)90054-7","article-title":"A model for evaluation of postural hypotension induced by drugs in conscious restrained normotensive rats","volume":"7","author":"Lee","year":"1982","journal-title":"Journal of Pharmacological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.02.011","article-title":"Age Dependent Effects on Cisapride Induced QTc Prolongation in the Isolated Guinea Pig Heart","author":"Mittelstadt","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.03.001","article-title":"A model of orthostatic hypotension in the conscious monkey using lower body negative pressure","author":"Murphy","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0160-5402(83)90037-2","article-title":"A nonhuman primate model for evaluating the potential of antihypertensive drugs to cause orthostatic hypotension","volume":"9","author":"Pals","year":"1983","journal-title":"Journal of Pharmacological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.02.006","article-title":"Effect of Commonly Used Vehicles on Gastrointestinal, Renal and Liver Function in Rats","author":"Pestel","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib26","first-page":"18","article-title":"An overview of some pharmacological methods used in safety pharmacology studies","volume":"47","author":"Pugsley","year":"2004","journal-title":"Proceedings of the Western Pharmacology Society"},{"key":"10.1016\/j.vascn.2006.05.002_bib27","doi-asserted-by":"crossref","first-page":"H1548","DOI":"10.1152\/ajpheart.2000.279.4.H1548","article-title":"Orthostatic hypotension in aging humans","volume":"279","author":"Shi","year":"2000","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.vascn.2006.05.002_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0160-5402(81)90102-9","article-title":"A method for evaluating postural hypotension in conscious rabbits as a model to predict effects of drugs in man","volume":"5","author":"Sponer","year":"1981","journal-title":"Journal of Pharmacological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.vascn.2005.04.009","article-title":"Challenges and lessons learned since implementation of the safety pharmacology guidance ICH S7A","volume":"52","author":"Valentin","year":"2005","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2006.05.002_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2006.03.011","article-title":"Safety pharmacology Assessment of drug-induced QT-Prolongation in Dogs with Reduced Repolarization Reserve","author":"Vormberge","year":"2006","journal-title":"Journal of Pharmacological and Toxicological Methods"}],"container-title":["Journal of Pharmacological and Toxicological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871906000621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871906000621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T23:52:05Z","timestamp":1761004325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056871906000621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S1056871906000621"],"URL":"https:\/\/doi.org\/10.1016\/j.vascn.2006.05.002","relation":{},"ISSN":["1056-8719"],"issn-type":[{"type":"print","value":"1056-8719"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety pharmacology in focus: New methods developed in the light of the ICH S7B guidance document","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological and Toxicological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vascn.2006.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}