{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:41:44Z","timestamp":1775198504641,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological and Toxicological Methods"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.vascn.2010.02.015","type":"journal-article","created":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T04:56:25Z","timestamp":1267505785000},"page":"157-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs"],"prefix":"10.1016","volume":"61","author":[{"given":"R.","family":"Venkatasamy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.P.","family":"Page","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Spina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vascn.2010.02.015_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.bjp.0705056","article-title":"RSD931, a novel anti-tussive agent acting on airway sensory nerves","volume":"138","author":"Adcock","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vascn.2010.02.015_bib2","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.1476-5381.2009.00438.x","article-title":"Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents","volume":"158","author":"Andre","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vascn.2010.02.015_bib3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1124\/jpet.107.127258","article-title":"Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs","volume":"323","author":"Bhattacharya","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.vascn.2010.02.015_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pupt.2008.10.012","article-title":"Developing antitussives: The ideal clinical trial","volume":"22","author":"Birring","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.vascn.2010.02.015_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/uog.122","article-title":"Applying the right statistics: Analyses of measurement studies","volume":"22","author":"Bland","year":"2003","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.vascn.2010.02.015_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/sj.bjp.0705605","article-title":"Antitussive activity of sigma-1 receptor agonists in the guinea-pig","volume":"141","author":"Brown","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vascn.2010.02.015_bib7","first-page":"781","article-title":"Current and future prospects for drugs to suppress cough","volume":"6","author":"Chung","year":"2003","journal-title":"IDrugs"},{"key":"10.1016\/j.vascn.2010.02.015_bib8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.pupt.2006.10.012","article-title":"The effect of codeine on the urge-to-cough response to inhaled capsaicin","volume":"20","author":"Davenport","year":"2007","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.vascn.2010.02.015_bib9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pupt.2008.11.013","article-title":"The urge-to-cough and cough motor response modulation by the central effects of nicotine","volume":"22","author":"Davenport","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.vascn.2010.02.015_bib10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pupt.2008.08.002","article-title":"Currently available antitussives","volume":"22","author":"Dicpinigaitis","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.vascn.2010.02.015_bib11","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/thx.2009.113183","article-title":"Nerve growth factor enhances cough and airway obstruction via TrkA receptor- and TRPV1-dependent mechanisms","volume":"64","author":"El-Hashim","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.vascn.2010.02.015_bib12","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1152\/japplphysiol.01558.2005","article-title":"Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs","volume":"101","author":"Gatti","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.vascn.2010.02.015_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ygcen.2006.07.010","article-title":"Are lungfish living fossils? Observation on the evolution of the opioid\/orphanin gene family","volume":"148","author":"Lee","year":"2006","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.vascn.2010.02.015_bib14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1745-9974-3-10","article-title":"Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig","volume":"3","author":"Leung","year":"2007","journal-title":"Cough"},{"key":"10.1016\/j.vascn.2010.02.015_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pupt.2008.11.003","article-title":"Are there clinical features of a sensitized cough reflex?","volume":"22","author":"McGarvey","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.vascn.2010.02.015_bib16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1164\/rccm.200607-892OC","article-title":"Opiate therapy in chronic cough","volume":"175","author":"Morice","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.vascn.2010.02.015_bib17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/bmj.324.7333.329","article-title":"Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults","volume":"324","author":"Schroeder","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.vascn.2010.02.015_bib18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/thx.2003.012930","article-title":"Antitussive activity of iodo-resiniferatoxin in guinea pigs","volume":"59","author":"Trevisani","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.vascn.2010.02.015_bib19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1096\/fj.04-1990fje","article-title":"Theobromine inhibits sensory nerve activation and cough","volume":"19","author":"Usmani","year":"2005","journal-title":"Faseb J."}],"container-title":["Journal of Pharmacological and Toxicological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871910000316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871910000316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T23:55:12Z","timestamp":1761004512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056871910000316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S1056871910000316"],"URL":"https:\/\/doi.org\/10.1016\/j.vascn.2010.02.015","relation":{},"ISSN":["1056-8719"],"issn-type":[{"value":"1056-8719","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological and Toxicological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vascn.2010.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}