{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:55:51Z","timestamp":1762505751058,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological and Toxicological Methods"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.vascn.2011.05.001","type":"journal-article","created":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T04:57:39Z","timestamp":1306040259000},"page":"134-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Keeping the rhythm \u2014 Pro-arrhythmic investigations in isolated G\u00f6ttingen minipig hearts"],"prefix":"10.1016","volume":"64","author":[{"given":"Morten","family":"Laursen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Grunnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren-Peter","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Jespersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Mow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vascn.2011.05.001_bb0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1472-8206.2004.00230.x","article-title":"Sex differences in ventricular repolarization: From cardiac electrophysiology to Torsades de Pointes","volume":"18","author":"Abi-Gerges","year":"2004","journal-title":"Fundamental and Clinical Pharmacology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0010","first-page":"1","article-title":"The QT interval","volume":"43","author":"Bednar","year":"2001","journal-title":"Progress in Cardiovascular Diseases"},{"key":"10.1016\/j.vascn.2011.05.001_bb0015","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1096\/fasebj.9.5.7896004","article-title":"Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes","volume":"9","author":"Belardinelli","year":"1995","journal-title":"The Federation of American Societies for Experimental Biology Journal"},{"key":"10.1016\/j.vascn.2011.05.001_bb0020","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.vascn.2010.05.009","article-title":"The utility of the minipig as an animal model in regulatory toxicology","volume":"62","author":"Bode","year":"2011","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2011.05.001_bb0025","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1540-8159.2006.00336.x","article-title":"Late-phase 3 EAD. A unique mechanism contributing to initiation of atrial fibrillation","volume":"29","author":"Burashikov","year":"2006","journal-title":"Pacing and Clinical Electrophysiology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0030","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00005344-199809000-00013","article-title":"Drug-related torsades de pointes in the isolated rabbit heart: Comparison of clofilium, d, l-sotalol, and erythromycin","volume":"32","author":"Eckardt","year":"1998","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0035","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1172\/JCI113706","article-title":"Cycle length dependence of human action potential duration in vivo. Effects of single extrastimuli, sudden sustained rate acceleration and deceleration, and different steady-state frequencies","volume":"82","author":"Franz","year":"1988","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.vascn.2011.05.001_bb0040","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cardiores.2007.06.019","article-title":"In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome","volume":"76","author":"Gallacher","year":"2007","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.vascn.2011.05.001_bb0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1152\/ajplegacy.1914.33.3.397","article-title":"The nature of fibrillatory contraction of the heart. Its relation to tissue mass and form","volume":"33","author":"Garrey","year":"1914","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0050","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/CIRCRESAHA.109.204891","article-title":"Transmural dispersion of repolarization in failing and nonfailing human ventricle","volume":"19;106","author":"Glukhov","year":"2010","journal-title":"Circulation Research"},{"key":"10.1016\/j.vascn.2011.05.001_bb0055","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1161\/01.CIR.103.15.2004","article-title":"Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic","volume":"103","author":"Hondeghem","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.vascn.2011.05.001_bb0060","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00210-010-0549-y","article-title":"Oscillations of cardiac wave length and proarrhythmia","volume":"382","author":"Hondeghem","year":"2010","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0210","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/00005344-200301000-00003","article-title":"Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: Importance of triangulation, reverse use dependence, and instability","volume":"41","author":"Hondeghem","year":"2003","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0065","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1540-8167.2003.02466.x","article-title":"Detection of proarrhythmia in the female rabbit heart: Blinded validation","volume":"14","author":"Hondeghem","year":"2003","journal-title":"Journal of Cardiovascular Electrophysiology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0070","unstructured":"ICH. (2005). ICH harmonised tripartite guideline S7B. The non-clinical evaluation of the potential for delayed repolarization (QT interval prolongation) by human pharmaceuticals. European Medicines Agency Step 5, http:\/\/www.ich.org\/products\/guidelines\/safety\/article\/safety-guidelines.html."},{"key":"10.1016\/j.vascn.2011.05.001_bb0075","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.yjmcc.2009.08.033","article-title":"IKs restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation","volume":"48","author":"Johnson","year":"2010","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0080","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCULATIONAHA.105.550111","article-title":"Restricting excessive cardiac action potential and QT prolongation: A vital role for IKs in human ventricular muscle","volume":"112","author":"Jost","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.vascn.2011.05.001_bb0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1161\/01.RES.72.1.75","article-title":"Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide","volume":"72","author":"Jurkiewicz","year":"1993","journal-title":"Circulation Research"},{"key":"10.1016\/j.vascn.2011.05.001_bb0090","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF01812150","article-title":"Untersuchungen am \u00fcberlebenden S\u00e4ugetierherzen","volume":"61","author":"Langendorff","year":"1895","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.vascn.2011.05.001_bb0095","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.vascn.2010.10.001","article-title":"Characterization of cardiac repolarization in the Gottingen minipig","volume":"63","author":"Laursen","year":"2011","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2011.05.001_bb0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.vascn.2004.10.004","article-title":"Both [beta]-adrenergic receptor stimulation and cardiac tissue type have important roles in elucidating the functional effects of IKs channel blockers in vitro","volume":"51","author":"Lu","year":"2005","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2011.05.001_bb0105","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/sj.bjp.0701891","article-title":"Pharmacological classification of adenosine receptors in the sinoatrial and atrioventricular nodes of the guinea-pig","volume":"124","author":"Meester","year":"1998","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0110","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0140-6736(08)61307-0","article-title":"The QT syndromes: Long and short","volume":"372","author":"Morita","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.vascn.2011.05.001_bb0115","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1093\/europace\/eup314","article-title":"Ventricular arrhythmia in coronary artery disease: Limits of a risk stratification strategy based on the ejection fraction alone and impact of infarct localization","volume":"11","author":"Pascale","year":"2009","journal-title":"Europace"},{"key":"10.1016\/j.vascn.2011.05.001_bb0120","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1056\/NEJMra032426","article-title":"Drug-induced prolongation of the QT interval","volume":"350","author":"Roden","year":"2004","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.vascn.2011.05.001_bb0125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/hrt.57.1.32","article-title":"Relation of human cardiac action potential duration to the interval between beats: Implications for the validity of rate corrected QT interval (QTc)","volume":"57","author":"Seed","year":"1987","journal-title":"British Heart Journal"},{"key":"10.1016\/j.vascn.2011.05.001_bb0130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.drudis.2008.11.009","article-title":"The future of drug safety testing: expanding the view and narrowing the focus","volume":"14","author":"Stevens","year":"2009","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.vascn.2011.05.001_bb0135","first-page":"1","article-title":"Comparative anatomy and physiology of the pig","volume":"25","author":"Swindle","year":"1998","journal-title":"Scandinavian Journal of Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2011.05.001_bb0140","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00005344-200301000-00018","article-title":"HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current","volume":"41","author":"Thomas","year":"2003","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0145","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cardiores.2006.11.025","article-title":"Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation","volume":"73","author":"Thomsen","year":"2007","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.vascn.2011.05.001_bb0150","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1161\/01.CIR.0000145162.64183.C8","article-title":"Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs","volume":"19;110","author":"Thomsen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.vascn.2011.05.001_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vascn.2009.04.197","article-title":"Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?","volume":"60","author":"Towart","year":"2007","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2011.05.001_bb0160","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.vascn.2004.03.008","article-title":"Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs","volume":"49","author":"Valentin","year":"2004","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2011.05.001_bb0165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0160-5402(89)90015-6","article-title":"An improved method to correct the QT interval of the electrocardiogram for changes in heart rate","volume":"22","author":"Van de Water","year":"1989","journal-title":"Journal of Pharmacological Methods"},{"year":"2010","series-title":"The electro-mechanical window in the fentanyl\/etomidate-anaesthetised G\u00f6ttingen minipig (compared to FEAB dogs)","author":"van der Linde","key":"10.1016\/j.vascn.2011.05.001_bb0170"},{"key":"10.1016\/j.vascn.2011.05.001_bb0175","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1111\/j.1476-5381.2010.00934.x","article-title":"The electro-mechanical window: A risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias","volume":"161","author":"van der Linde","year":"2010","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0180","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vascn.2009.04.195","article-title":"The fentanyl\/etomidate-anaesthetised beagle (FEAB) dog: A versatile in vivo model in cardiovascular safety research","volume":"60","author":"Van Deuren","year":"2009","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.vascn.2011.05.001_bb0185","doi-asserted-by":"crossref","first-page":"H334","DOI":"10.1152\/ajpheart.2001.280.1.H334","article-title":"A partial agonist of the A1-adenosine receptor selectively slows AV conduction in guinea pig hearts","volume":"280","author":"Wu","year":"2001","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology"},{"key":"10.1016\/j.vascn.2011.05.001_bb0190","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1053\/eupc.1998.0022","article-title":"Electrophysiological profile after inward rectifier K channel blockade by barium in isolated rabbit hearts. Altered repolarization and unmasked decremental conduction property","volume":"1","author":"Wu","year":"1999","journal-title":"Europace"},{"key":"10.1016\/j.vascn.2011.05.001_bb0195","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1161\/01.CIR.98.18.1928","article-title":"Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome","volume":"98","author":"Yan","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.vascn.2011.05.001_bb0200","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1136\/heart.89.11.1363","article-title":"Drug induced QT prolongation and torsades de pointes","volume":"89","author":"Yap","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.vascn.2011.05.001_bb0205","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0006-3495(95)80271-7","article-title":"Early afterdepolarizations in cardiac myocytes: Mechanism and rate dependence","volume":"68","author":"Zeng","year":"1995","journal-title":"Biophysical Journal"}],"container-title":["Journal of Pharmacological and Toxicological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871911002449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871911002449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T23:55:57Z","timestamp":1761004557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056871911002449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S1056871911002449"],"URL":"https:\/\/doi.org\/10.1016\/j.vascn.2011.05.001","relation":{},"ISSN":["1056-8719"],"issn-type":[{"type":"print","value":"1056-8719"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Keeping the rhythm \u2014 Pro-arrhythmic investigations in isolated G\u00f6ttingen minipig hearts","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological and Toxicological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vascn.2011.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}