{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:48:32Z","timestamp":1761007712704,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological and Toxicological Methods"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.vascn.2012.03.005","type":"journal-article","created":{"date-parts":[[2012,4,6]],"date-time":"2012-04-06T06:40:12Z","timestamp":1333694412000},"page":"122-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel approach for generation of low calcium reagents for investigations of heavy metal effects on calcium signaling"],"prefix":"10.1016","volume":"65","author":[{"given":"Katelyn Y.","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel C.","family":"Noyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vascn.2012.03.005_bb0035","first-page":"131","article-title":"Permeability of the blood\u2013brain barrier to lead","volume":"14","author":"Bradbury","year":"1993","journal-title":"Neurotoxicology"},{"year":"2005","author":"Centers for Disease Control, Prevention","series-title":"Preventing lead poisoning in young children","key":"10.1016\/j.vascn.2012.03.005_bb0145"},{"key":"10.1016\/j.vascn.2012.03.005_bb0150","first-page":"40","article-title":"Lead hazards for pregnant women and children: Part 1: Immigrants and the poor shoulder most of the burden of lead exposure in this country. Part 1 of a two-part article details how exposure happens, whom it affects, and the harm it can do","volume":"108","author":"Cleveland","year":"2008","journal-title":"The American Journal of Nursing"},{"key":"10.1016\/j.vascn.2012.03.005_bb0135","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ceca.2006.01.005","article-title":"CaMKII inactivation by extracellular Ca(2+) depletion in dorsal root ganglion neurons","volume":"39","author":"Cohen","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1016\/j.vascn.2012.03.005_bb0055","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1073\/pnas.88.11.5061","article-title":"cAMP response element-binding protein is activated by Ca2+\/calmodulin- as well as cAMP-dependent protein kinase","volume":"88","author":"Dash","year":"1991","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.vascn.2012.03.005_bb0015","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1038\/sj.ki.5001809","article-title":"Lead-related nephrotoxicity: A review of the epidemiologic evidence","volume":"70","author":"Ekong","year":"2006","journal-title":"Kidney International"},{"key":"10.1016\/j.vascn.2012.03.005_bb0050","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(89)90013-5","article-title":"Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133","volume":"59","author":"Gonzalez","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.vascn.2012.03.005_bb0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00277816","article-title":"Lead and other metals can substitute for Ca2+ in calmodulin","volume":"54","author":"Habermann","year":"1983","journal-title":"Archives of Toxicology"},{"key":"10.1016\/j.vascn.2012.03.005_bb0125","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1085\/jgp.99.1.41","article-title":"Calmodulin activation of the Ca2+ pump revealed by fluorescent chelator dyes in human red blood cell ghosts","volume":"99","author":"James-Kracke","year":"1992","journal-title":"The Journal of General Physiology"},{"key":"10.1016\/j.vascn.2012.03.005_bb0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/taap.1995.1174","article-title":"Inorganic lead may inhibit neurite development in cultured rat hippocampal neurons through hyperphosphorylation","volume":"134","author":"Kern","year":"1995","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.vascn.2012.03.005_bb0130","doi-asserted-by":"crossref","first-page":"C56","DOI":"10.1152\/ajpcell.00377.2002","article-title":"Ca2+ transients activate calcineurin\/NFATc1 and initiate fast-to-slow transformation in a primary skeletal muscle culture","volume":"285","author":"Kubis","year":"2003","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"10.1016\/j.vascn.2012.03.005_bb0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/brain\/awg014","article-title":"Lead neurotoxicity in children: Basic mechanisms and clinical correlates","volume":"126","author":"Lidsky","year":"2003","journal-title":"Brain: A Journal of Neurology"},{"key":"10.1016\/j.vascn.2012.03.005_bb0120","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0006-8993(98)00536-8","article-title":"Sequence-dependent interactions between transient calcium and transmitter stimuli in activation of mammalian brain adenylyl cyclase","volume":"800","author":"Lin","year":"1998","journal-title":"Brain Research"},{"key":"10.1016\/j.vascn.2012.03.005_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrn753","article-title":"The molecular basis of CaMKII function in synaptic and behavioural memory","volume":"3","author":"Lisman","year":"2002","journal-title":"Nature Reviews. Neuroscience"},{"key":"10.1016\/j.vascn.2012.03.005_bb0155","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-3-642-71248-7_78","article-title":"Lead does not affect calmodulin-induced activation of calcium-dependent adenosine triphosphatase in human red blood cell membranes","volume":"9","author":"MacDonald","year":"1986","journal-title":"Archives of Toxicology. Supplement"},{"volume":"1","year":"1974","author":"Martell","key":"10.1016\/j.vascn.2012.03.005_bb0160"},{"key":"10.1016\/j.vascn.2012.03.005_bb0005","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1289\/ehp.9785","article-title":"Lead exposure and cardiovascular disease\u2014A systematic review","volume":"115","author":"Navas-Acien","year":"2007","journal-title":"Environmental Health Perspectives"},{"unstructured":"Noyes, N., Niu, K. Y., & Abrams T. W. (in preparation). Bidirectional effects of lead on calmodulin-dependent enzymes involved in synaptic plasticity and learning.","key":"10.1016\/j.vascn.2012.03.005_bb0140"},{"key":"10.1016\/j.vascn.2012.03.005_bb0080","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF01870077","article-title":"Novel type of ion channel activated by Pb2+, Cd2+, and Al3+ in cultured mouse neuroblastoma cells","volume":"113","author":"Oortgiesen","year":"1990","journal-title":"The Journal of Membrane Biology"},{"key":"10.1016\/j.vascn.2012.03.005_bb0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.919117","article-title":"Cellular and molecular toxicity of lead in bone","volume":"91","author":"Pounds","year":"1991","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.vascn.2012.03.005_bb0115","first-page":"35","article-title":"Adenylate cyclase assay","volume":"10","author":"Salomon","year":"1979","journal-title":"Advances in Cyclic Nucleotide Research"},{"key":"10.1016\/j.vascn.2012.03.005_bb0045","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/exmp.1994.1026","article-title":"Effect of lead on the biological activity of calmodulin in rat brain","volume":"61","author":"Sandhir","year":"1994","journal-title":"Experimental and Molecular Pathology"},{"key":"10.1016\/j.vascn.2012.03.005_bb0085","first-page":"99","article-title":"Development of 19F NMR for measurement of [Ca2+]i and [Pb2+]i in cultured osteoblastic bone cells","volume":"84","author":"Schanne","year":"1990","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.vascn.2012.03.005_bb0060","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1096\/fj.00-0106com","article-title":"Calcium\/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons","volume":"15","author":"See","year":"2001","journal-title":"The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.vascn.2012.03.005_bb0040","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1471-4159.1987.tb04105.x","article-title":"Lead enters bovine adrenal medullary cells through calcium channels","volume":"48","author":"Simons","year":"1987","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.vascn.2012.03.005_bb0105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jat.2550090506","article-title":"Metal inhibition of calmodulin activity in monkey brain","volume":"9","author":"Vig","year":"1989","journal-title":"Journal of Applied Toxicology: JAT"},{"key":"10.1016\/j.vascn.2012.03.005_bb0065","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0896-6273(01)80036-2","article-title":"Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP","volume":"23","author":"Wong","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.vascn.2012.03.005_bb0095","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1111\/j.1471-4159.1992.tb11005.x","article-title":"A quantitative study of the Ca2+\/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and rat","volume":"59","author":"Yovell","year":"1992","journal-title":"Journal of Neurochemistry"}],"container-title":["Journal of Pharmacological and Toxicological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871912000366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871912000366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T23:56:07Z","timestamp":1761004567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056871912000366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S1056871912000366"],"URL":"https:\/\/doi.org\/10.1016\/j.vascn.2012.03.005","relation":{},"ISSN":["1056-8719"],"issn-type":[{"type":"print","value":"1056-8719"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel approach for generation of low calcium reagents for investigations of heavy metal effects on calcium signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological and Toxicological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vascn.2012.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}