{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:05:41Z","timestamp":1761091541527,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological and Toxicological Methods"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.vascn.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T02:32:17Z","timestamp":1462933937000},"page":"313-322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The \u201cinduced hyperactivity\u201d test for the de-risking of potential off-target activity of antihypertensive drugs"],"prefix":"10.1016","volume":"81","author":[{"given":"Herbert M.","family":"Himmel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vascn.2016.05.004_bb0005","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0896-6273(90)90135-3","article-title":"Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina","volume":"4","author":"Ahlijanian","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.vascn.2016.05.004_bb0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0014-2999(95)00292-S","article-title":"Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of d-amphetamine","volume":"283","author":"Arnt","year":"1985","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.vascn.2016.05.004_bb0015","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1460-9568.1994.tb00272.x","article-title":"Blockade of prefronto-cortical \u03b11-adrenergic receptors prevents locomotor hyperactivity induced by subcortical d-amphetamine injection","volume":"6","author":"Blanc","year":"1994","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.vascn.2016.05.004_bb0020","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbr.2009.09.037","article-title":"Role of ventral hippocampal nitric oxide\/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze","volume":"207","author":"Calixto","year":"2010","journal-title":"Behavioral Brain Research"},{"key":"10.1016\/j.vascn.2016.05.004_bb0025","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neuropharm.2005.05.011","article-title":"Differential effects of 7-OH-DPAT and apomorphine on hyperactivity induced by MK-801 (dizocilpine) in rats","volume":"49","author":"Clements","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.vascn.2016.05.004_bb0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/syn.10023","article-title":"Critical role of \u03b11-adrenergic receptors in acute and sensitized locomotor effects of d-amphetamine, cocaine, and GBR 12783: Influence of preexposure conditions and pharmacological characteristics","volume":"43","author":"Drouin","year":"2002","journal-title":"Synapse"},{"key":"10.1016\/j.vascn.2016.05.004_bb0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00005344-198303000-00012","article-title":"Tissue distribution and hypotensive effect of prazosin in the conscious rat","volume":"5","author":"Dynon","year":"1983","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"Suppl. 2","key":"10.1016\/j.vascn.2016.05.004_bb0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2165\/00003495-199300462-00007","article-title":"Influence of antihypertensive drugs on exercise capacity","volume":"46","author":"Fagard","year":"1993","journal-title":"Drugs"},{"key":"10.1016\/j.vascn.2016.05.004_bb0045","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0002-9149(79)90368-0","article-title":"Effect of isosorbide dinitrate on response to submaximal and maximal exercise in patients with congestive heart failure","volume":"43","author":"Franciosa","year":"1979","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.vascn.2016.05.004_bb0050","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1124\/jpet.109.155994","article-title":"Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia","volume":"331","author":"Grauer","year":"2009","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.vascn.2016.05.004_bb0055","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/0024-3205(86)90605-3","article-title":"Nifedipine and flunarizine block amphetamine-induced behavioral stimulation in mice","volume":"38","author":"Grebb","year":"1986","journal-title":"Life Sciences"},{"key":"10.1016\/j.vascn.2016.05.004_bb0060","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bbr.2007.06.018","article-title":"Modulation of stress-induced neurobehavioral changes and brain oxidative injury by nitric oxide (NO) mimetics in rats","volume":"183","author":"Gulati","year":"2007","journal-title":"Behavioral Brain Research"},{"key":"10.1016\/j.vascn.2016.05.004_bb0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.vascn.2008.06.001","article-title":"Safety pharmacology assessment of central nervous system function in juvenile and adult rats: Effects of pharmacological reference compounds","volume":"58","author":"Himmel","year":"2008","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"year":"2014","series-title":"The induced hyperactivity test for potential de-risking of anti-psychotic activity of drugs","author":"Himmel","key":"10.1016\/j.vascn.2016.05.004_bb0070"},{"key":"10.1016\/j.vascn.2016.05.004_bb0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/138161211795049624","article-title":"PDE10A inhibitors: Novel therapeutic drugs for schizophrenia","volume":"17","author":"Kehler","year":"2011","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.vascn.2016.05.004_bb0080","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00210-011-0702-2","article-title":"Discovery of potential antipsychotic agents possessing pro-cognitive properties","volume":"385","author":"Lameh","year":"2012","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"key":"10.1016\/j.vascn.2016.05.004_bb0085","first-page":"1117","article-title":"Comparative antianginal, hemodynamic and pharmacokinetic effect of ISMN and ISDN in the rat","volume":"33","author":"Leitold","year":"1983","journal-title":"Drug Research"},{"key":"10.1016\/j.vascn.2016.05.004_bb0090","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S1734-1140(13)71464-6","article-title":"Role of nitric oxide in the regulation of motor function. An overview of behavioral, biochemical and histological studies in animal models","volume":"65","author":"Lorenc-Koci","year":"2013","journal-title":"Pharmacological Reports"},{"key":"10.1016\/j.vascn.2016.05.004_bb0095","doi-asserted-by":"crossref","first-page":"98A","DOI":"10.1016\/0002-9149(87)90184-6","article-title":"Exercise and antihypertensive therapy","volume":"59","author":"Lund-Johansen","year":"1987","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.vascn.2016.05.004_bb0100","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1378\/chest.80.6.692","article-title":"Antihypertensive therapy with prazosin in patients with left ventricular dysfunction","volume":"80","author":"Massie","year":"1981","journal-title":"Chest"},{"key":"10.1016\/j.vascn.2016.05.004_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(96)00315-9","article-title":"Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens","volume":"309","author":"Mathe","year":"1996","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.vascn.2016.05.004_bb0110","doi-asserted-by":"crossref","first-page":"95S","DOI":"10.1093\/ajh\/6.3.95S","article-title":"Beneficial effect of isradipine on the development of left ventricular hypertrophy in mild hypertension","volume":"6","author":"Mehlsen","year":"1993","journal-title":"American Journal of Hypertension"},{"key":"10.1016\/j.vascn.2016.05.004_bb0115","first-page":"54","article-title":"Phosphodiesterase 10A inhibitors: A novel approach to the treatment of the symptoms of schizophrenia","volume":"8","author":"Menniti","year":"2007","journal-title":"Current Opinion in Investigational Drugs"},{"issue":"S4A","key":"10.1016\/j.vascn.2016.05.004_bb0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0002-9343(89)90194-0","article-title":"Antitrophic properties of antihypertensive drugs may depend solely on their blood pressure-lowering capability","volume":"86","author":"Nielsen","year":"1989","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.vascn.2016.05.004_bb0125","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/jnr.20889","article-title":"Nitric oxide donor molsidomine attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801","volume":"84","author":"Pitsikas","year":"2006","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.vascn.2016.05.004_bb0130","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0893-133X(94)00080-J","article-title":"Isradipine suppresses amphetamine-induced conditioned place preference and locomotor stimulation in the rat","volume":"12","author":"Pucilowski","year":"1995","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.vascn.2016.05.004_bb0135","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0278-5846(86)90056-4","article-title":"The calcium entry blockers: Anti-manic drugs?","volume":"10","author":"Renwart","year":"1986","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"issue":"17","key":"10.1016\/j.vascn.2016.05.004_bb0140","first-page":"1","article-title":"Models for assessing antipsychotics: Antagonism of amphetamine-induced hyperactivity and stereotypies in mice","volume":"5","author":"Roux","year":"1999","journal-title":"Current Protocols Pharmacology"},{"key":"10.1016\/j.vascn.2016.05.004_bb0145","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s00213-003-1509-8","article-title":"On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization","volume":"169","author":"Vanderschuren","year":"2003","journal-title":"Psychopharmacology"}],"container-title":["Journal of Pharmacological and Toxicological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871916300430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871916300430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:02:30Z","timestamp":1761004950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056871916300430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":29,"alternative-id":["S1056871916300430"],"URL":"https:\/\/doi.org\/10.1016\/j.vascn.2016.05.004","relation":{},"ISSN":["1056-8719"],"issn-type":[{"type":"print","value":"1056-8719"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The \u201cinduced hyperactivity\u201d test for the de-risking of potential off-target activity of antihypertensive drugs","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological and Toxicological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vascn.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}