{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:47:08Z","timestamp":1778251628956,"version":"3.51.4"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological and Toxicological Methods"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.vascn.2016.10.005","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T08:16:53Z","timestamp":1476951413000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Using Tiletamine-Zolazepam-Xylazine Anesthesia Compared to CO2-inhalation for Terminal Clinical Chemistry, Hematology, and Coagulation Analysis in Mice"],"prefix":"10.1016","volume":"84","author":[{"given":"Oksana N.","family":"Khokhlova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena A.","family":"Tukhovskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4662-4332","authenticated-orcid":false,"given":"Irina N.","family":"Kravchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5193-4343","authenticated-orcid":false,"given":"Elena S.","family":"Sadovnikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Pakhomova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-1124","authenticated-orcid":false,"given":"Elena A.","family":"Kalabina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander V.","family":"Lobanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira R.","family":"Shaykhutdinova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina M.","family":"Ismailova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arkady N.","family":"Murashev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vascn.2016.10.005_bb0005","author":"AVMA"},{"key":"10.1016\/j.vascn.2016.10.005_bb0010","first-page":"55","article-title":"Effects of xylazine-diazepam-ketamine and xylazine-tiletamine-zolazepam anesthesia on some coagulation parameters in horses","volume":"18","author":"Aydlek","year":"2007","journal-title":"Yyu Vet FakDerg"},{"key":"10.1016\/j.vascn.2016.10.005_bb0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1939-165X.1992.tb00576.x","article-title":"Effects of ketamine hydrochloride on serum biochemical and hematologic variables in rhesus monkeys (Macaccamulatta)","volume":"21","author":"Bennett","year":"1992","journal-title":"Veterinary Clinical Pathology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0020","first-page":"58","article-title":"Evaluation of injectable anesthetics for major surgical procedures in guinea pigs","volume":"37","author":"Buchanan","year":"1998","journal-title":"Contemporary Topics in Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0025","first-page":"67","article-title":"Blood reservoir function of dog spleen, liver, and intestine","volume":"232","author":"Carneiro","year":"1977","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0030","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1258\/la.2011.011136","article-title":"Influence of tail versus cardiac sampling on blood glucose and lipid profiles in mice","volume":"46","author":"Chan","year":"2012","journal-title":"Laboratory Animals"},{"key":"10.1016\/j.vascn.2016.10.005_bb0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1258\/0023677053739747","article-title":"Carbon dioxide for euthanasia: Concerns regarding pain and distress, with special reference to mice and rats","volume":"39","author":"Conlee","year":"2005","journal-title":"Laboratory Animals"},{"key":"10.1016\/j.vascn.2016.10.005_bb0040","first-page":"376","article-title":"Humane and practical implications of using carbon dioxide mixed with oxygen for anesthesia or euthanasia of rats","volume":"47","author":"Danneman","year":"1997","journal-title":"Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0045","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.fct.2007.03.005","article-title":"The effects of inhalation anaesthetics on common clinical pathology parameters in laboratory rats","volume":"45","author":"Deckardt","year":"2007","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0050","first-page":"455","article-title":"Anesthesie du lapin de Nouvelle-Zelande utilisant les combinaisons tiletamine-zolazepamet ketamine-midazolam avec ou sans xylazine (in French)","volume":"42","author":"Dupras","year":"2001","journal-title":"The Canadian Veterinary Journal"},{"key":"10.1016\/j.vascn.2016.10.005_bb0055","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1177\/0192623310374332","article-title":"Effects of hepatic drug-metabolizing enzyme induction on clinical pathology parameters in animals and man","volume":"38","author":"Ennulat","year":"2010","journal-title":"Toxicologic Pathology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0060","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF01852390","article-title":"A comparative study with various anesthetics in mice (pentobarbitone, ketamine-xylazine, carfentanyl-etomidate)","volume":"184","author":"Erhardt","year":"1984","journal-title":"Research in Experimental Medicine (Berlin)"},{"key":"10.1016\/j.vascn.2016.10.005_bb0065","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1638\/2009-0036.1","article-title":"Treatment of hypoxemia during anesthesia of brown bears (Ursus arctos)","volume":"41","author":"Fahlman","year":"2010","journal-title":"Journal of Zoo and Wildlife Medicine"},{"key":"10.1016\/j.vascn.2016.10.005_bb0070","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/ki.2008.33","article-title":"Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia","volume":"73","author":"Faroqui","year":"2008","journal-title":"Kidney International"},{"key":"10.1016\/j.vascn.2016.10.005_bb0075","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1056\/NEJMra052529","article-title":"The biology of human sex differences","volume":"354","author":"Federman","year":"2006","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.vascn.2016.10.005_bb0080","first-page":"202","article-title":"Clinical biochemistry parameters in C57BL\/6J mice after blood collection from the submandibular vein and retroorbital plexus","volume":"49","author":"Fern\u00e1ndez","year":"2010","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0085","first-page":"256","article-title":"Evaluation of two combinations of Domitor, Zoletil 100, and Euthatal to obtain long-term nonrecovery anesthesia in Sprague-Dawley rats","volume":"55","author":"Ferrari","year":"2005","journal-title":"Comparative Medicine"},{"key":"10.1016\/j.vascn.2016.10.005_bb0090","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1476-511X-12-118","article-title":"Acute stress show great influences on liver function and the expression of hepatic genes associated with lipid metabolism in rats","volume":"12","author":"Gao","year":"2013","journal-title":"Lipids in Health and Disease"},{"key":"10.1016\/j.vascn.2016.10.005_bb0095","first-page":"199","article-title":"Comparison of tribromoethanol, ketamine\/acetylpromazine, telazol\/xylazine, pentobarbital, and methoxyflurane anesthesia in HSD:ICR mice","volume":"45","author":"Gardner","year":"1995","journal-title":"Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0100","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1258\/00236770360563804","article-title":"Effects of the anaesthetic\/tranquillizer treatments on selected plasma biochemical parameters in NZW rabbits","volume":"37","author":"Gil","year":"2003","journal-title":"Laboratory Animals"},{"key":"10.1016\/j.vascn.2016.10.005_bb0105","first-page":"52","article-title":"Serum biochemical response to inhalant anesthetics in New Zealand white rabbits","volume":"49","author":"Gil","year":"2010","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0110","first-page":"221","article-title":"Blood coagulation and fibrinolysis in rats after hypokinesia and hyperthermia","volume":"24","author":"Groza","year":"1987","journal-title":"Physiologie"},{"key":"10.1016\/j.vascn.2016.10.005_bb0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2131\/jts.36.211","article-title":"Alkaline phosphatase isoenzymes in mouse plasma detected by polyacrylamide-gel disk electrophoresis","volume":"36","author":"Hatayama","year":"2011","journal-title":"The Journal of Toxicological Sciences"},{"key":"10.1016\/j.vascn.2016.10.005_bb0120","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0024-3205(89)90290-7","article-title":"The effects of immobilization stress on serum triglycerides, nonesterified fatty acids, and total cholesterol in male rats after dietary modifications","volume":"45","author":"Hershock","year":"1989","journal-title":"Life Sciences"},{"key":"10.1016\/j.vascn.2016.10.005_bb0125","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/bja\/57.1.23","article-title":"Ionic changes in brain ischemia and alterations produced by drugs","volume":"57","author":"Heuser","year":"1985","journal-title":"British Journal Anesthesia"},{"key":"10.1016\/j.vascn.2016.10.005_bb0130","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0022-4804(69)90012-2","article-title":"Elevation of serum calcium concentration and changes in other blood parameters after death","volume":"9","author":"Hodgkinson","year":"1969","journal-title":"The Journal of Surgical Research"},{"key":"10.1016\/j.vascn.2016.10.005_bb0135","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/01480540802390247","article-title":"The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat","volume":"31","author":"Jackson","year":"2008","journal-title":"Drug and Chemical Toxicology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0140","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/hep.20182","article-title":"Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver","volume":"39","author":"Jadhao","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0145","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2754\/avb201483020145","article-title":"Effects of the tiletamine\/zolazepam-xylazine-tramadol combination on plasma oxidative status and haematological indicators in miniature pigs","volume":"83","author":"Jiang","year":"2014","journal-title":"Acta Veterinaria"},{"key":"10.1016\/j.vascn.2016.10.005_bb0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/1874609810902010067","article-title":"Effect of gender on main clinical chemistry parameters in aged rats","volume":"2","author":"Kayali","year":"2009","journal-title":"Current Aging Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1439-0442.1999.00215.x","article-title":"Effect of subarachnoid xylazine and medetomidine on haemodynamics and ECG in goats","volume":"46","author":"Kinjavdekar","year":"1999","journal-title":"Zentralblatt f\u00fcr Veterin\u00e4rmedizin. Reihe A"},{"key":"10.1016\/j.vascn.2016.10.005_bb0160","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/hep.27622","article-title":"Serum alkaline phosphatase levels accurately reflect cholestasis in mice","volume":"62","author":"Krones","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0165","series-title":"Duncan and Prasse's Veterinary Laboratory Medicine: Clinical Pathology","author":"Latimer","year":"2003"},{"key":"10.1016\/j.vascn.2016.10.005_bb0170","first-page":"63","article-title":"Tiletamine\u2013zolazepam and xylazine is a potent cardiodepressive combination: A case report","volume":"46","author":"Lefkov","year":"2007","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0175","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-2885.1993.tb00206.x","article-title":"Telazol - a review of its pharmacology and use in veterinary medicine","volume":"16","author":"Lin","year":"1993","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.vascn.2016.10.005_bb0180","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bone.2012.12.048","article-title":"Isozyme profile and tissue-origin of alkaline phosphatases in mouse serum","volume":"53","author":"Linder","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.vascn.2016.10.005_bb0185","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0684.2009.00394.x","article-title":"Effects of serial anesthesia using ketamine or ketamine\/medetomidine on hematology and serum biochemistry values in rhesus macaques (Macaca mulatta)","volume":"39","author":"Lugo-Roman","year":"2010","journal-title":"Journal of Medical Primatology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0190","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1590\/S0100-879X2009005000030","article-title":"Effects of different general anesthetics on serum hemolysis and hepatic and muscular glycogenolysis in rats","volume":"42","author":"Machado","year":"2009","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.vascn.2016.10.005_bb0195","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.applanim.2009.04.003","article-title":"Rat aversion to induction with inhalant anaesthetics","volume":"119","author":"Makowska","year":"2009","journal-title":"Applied Animal Behaviour Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0200","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.applanim.2009.10.001","article-title":"Evaluating methods of gas euthanasia for laboratory mice","volume":"121","author":"Makowska","year":"2009","journal-title":"Applied Animal Behaviour Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0205","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1467-2995.2006.00341.x","article-title":"Effects of anesthetic agents on serum parathyroid hormone and calcium concentrations in mice","volume":"34","author":"Mallya","year":"2007","journal-title":"Veterinary Anaesthesia and Analgesia"},{"issue":"11","key":"10.1016\/j.vascn.2016.10.005_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003772","article-title":"Age-related reference intervals of the main biochemical and hematological parameters in C57BL\/6J, 129SV\/EV and C3H\/HeJ mouse strains","volume":"3","author":"Mazzaccara","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.vascn.2016.10.005_bb0215","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1113\/expphysiol.1998.sp004134","article-title":"Blood mobilization from the liver of the anaesthetized dog","volume":"83","author":"Noble","year":"1998","journal-title":"Experimental Physiology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0220","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0006-8993(93)90648-7","article-title":"In vivo and in vitro responses of neurons in the ventrolateral medulla to hypoxia","volume":"630","author":"Nolan","year":"1993","journal-title":"Brain Research"},{"key":"10.1016\/j.vascn.2016.10.005_bb0225","first-page":"117","article-title":"Serum lipids, proteins and electrolyte profiles in rats following total body irradiation","volume":"61","author":"Nwokocha","year":"2012","journal-title":"The West Indian Medical Journal"},{"issue":"2","key":"10.1016\/j.vascn.2016.10.005_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117232","article-title":"Impact of anesthesia and euthanasia on metabolomics of mammalian tissues: Studies in a C57BL\/6J mouse model","volume":"10","author":"Overmyer","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.vascn.2016.10.005_bb0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1152\/physiolgenomics.00077.2002","article-title":"Large-scale, high-throughput screening for coagulation and hematologic phenotypes in mice","volume":"11","author":"Peters","year":"2002","journal-title":"Physiological Genomics"},{"key":"10.1016\/j.vascn.2016.10.005_bb0240","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4102\/jsava.v69i1.803","article-title":"Stability of cardiodynamic and some blood parameters in the baboon following intravenous anaesthesia with ketamine and diazepam","volume":"69","author":"du Plooy","year":"1998","journal-title":"Journal of the South African Veterinary Association"},{"key":"10.1016\/j.vascn.2016.10.005_bb0245","first-page":"51","article-title":"Comparison of xylazine with tiletamine-zolazepam (Telazol) and xylazine-ketamine anesthesia in rabbits","volume":"41","author":"Popilskis","year":"1991","journal-title":"Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0250","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/0192623312447550","article-title":"Metabolic adaptive ALT isoenzyme response in livers of C57\/BL6 mice treated with dexamethasone","volume":"40","author":"Reagan","year":"2012","journal-title":"Toxicologic Pathology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0255","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1210\/en.2008-1408","article-title":"Carbon dioxide-induced anesthesia results in a rapid increase in plasma levels of vasopressin","volume":"150","author":"Reed","year":"2009","journal-title":"Endocrinology"},{"issue":"Suppl. 10","key":"10.1016\/j.vascn.2016.10.005_bb0260","first-page":"S159","article-title":"Sympatho-excitatory neurons of the rostral ventrolateral medulla are oxygen sensors and essential elements in the tonic and reflex control of the systemic and cerebral circulation","volume":"12","author":"Reis","year":"1994","journal-title":"Journal of Hypertension"},{"key":"10.1016\/j.vascn.2016.10.005_bb0265","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1053\/meta.2002.33353","article-title":"Immobilization stress alters intermediate metabolism and circulating lipoproteins in the rat","volume":"51","author":"Ricart-Jan\u00e9","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.vascn.2016.10.005_bb0270","first-page":"74","article-title":"Comparison of cardiovascular effects of tiletamine-zolazepam, pentobarbital, and ketamine-xylazine in male rats","volume":"46","author":"Saha","year":"2007","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0275","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1177\/153537020523001012","article-title":"Acute hyperglycemia induced by ketamine\/xylazine anesthesia in rats: Mechanisms and implications for preclinical models","volume":"230","author":"Saha","year":"2005","journal-title":"Experimental Biology and Medicine (Maywood, N.J.)"},{"key":"10.1016\/j.vascn.2016.10.005_bb0280","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/archinte.1985.00360040069016","article-title":"The hypersplenic spleen. A contractile reservoir of granulocytes and platelets","volume":"145","author":"Schaffner","year":"1985","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.vascn.2016.10.005_bb0285","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/10430340152712700","article-title":"Effect of blood collection technique in mice on clinical pathology parameters","volume":"13","author":"Schnell","year":"2002","journal-title":"Human Gene Therapy"},{"key":"10.1016\/j.vascn.2016.10.005_bb0290","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/jcbfm.1981.18","article-title":"Cell damage in the brain: A speculative synthesis","volume":"1","author":"Siesjo","year":"1981","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.vascn.2016.10.005_bb0295","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1161\/CIRCRESAHA.112.277962","article-title":"Acute psychological stress accelerates reverse cholesterol transport via corticosterone-dependent inhibition of intestinal cholesterol absorption","volume":"111","author":"Silvennoinen","year":"2012","journal-title":"Circulation Research"},{"key":"10.1016\/j.vascn.2016.10.005_bb5000","first-page":"885","article-title":"A review of the physiological effects of \u03b12-agonists related to the clinical use of medetomidine in small animal practice","volume":"44","author":"Sinclair","year":"2003","journal-title":"The Canadian Veterinary Journal"},{"key":"10.1016\/j.vascn.2016.10.005_bb0300","first-page":"349","article-title":"High doses of ketamine-xylazine anesthesia reduce cardiac ischemia-reperfusion injury in guinea pigs","volume":"50","author":"Sloan","year":"2011","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0305","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0034-5288(93)90104-N","article-title":"Biochemical and haematological changes following prolonged halothane anaesthesia in horses","volume":"55","author":"Steffey","year":"1993","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0310","first-page":"430","article-title":"Effects of two injectable anesthetic agents on coagulation assays in the rat","volume":"46","author":"Stringer","year":"1996","journal-title":"Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0315","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.physbeh.2007.03.027","article-title":"Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content","volume":"91","author":"Tordoff","year":"2007","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.vascn.2016.10.005_bb0320","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1177\/1076029613483168","article-title":"Construction noise induces hypercoagulability and elevated plasma corticosteroids in rats","volume":"7","author":"Toukh","year":"2014","journal-title":"Clinical and Applied Thrombosis\/Hemostasis"},{"key":"10.1016\/j.vascn.2016.10.005_bb0325","first-page":"316","article-title":"Euthanasia by CO\u2082 inhalation affects potassium levels in mice","volume":"49","author":"Traslavina","year":"2010","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0330","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1477-9560-3-21","article-title":"Systemic coagulation parameters in mice after treatment with vascular targeting agents","volume":"3","author":"Unruh","year":"2005","journal-title":"Thrombosis Journal"},{"key":"10.1016\/j.vascn.2016.10.005_bb0335","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1152\/ajpendo.00122.2005","article-title":"Comparative analysis of ACTH and corticosterone sampling methods in rats","volume":"289","author":"Vahl","year":"2005","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"10.1016\/j.vascn.2016.10.005_bb0340","first-page":"50","article-title":"Sedation or inhalant anesthesia before euthanasia with CO2 does not reduce behavioral or physiologic signs of pain and stress in mice","volume":"51","author":"Valentine","year":"2012","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0345","first-page":"125","article-title":"Effects of certain anaesthetics on plasma metabolite concentrations in the baboon (Papioursinus)","volume":"58","author":"Van der Merwe","year":"1987","journal-title":"Journal of the South African Veterinary Association"},{"key":"10.1016\/j.vascn.2016.10.005_bb0350","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2460\/ajvr.1991.52.05.651","article-title":"Cardiovascular effects of xylazine and detomidine in horses","volume":"52","author":"Wagner","year":"1991","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.vascn.2016.10.005_bb0355","first-page":"481","article-title":"Comparison of ketamine\u2013xylazine and ketamine\u2013dexmedetomidine anesthesia and intraperitoneal tolerance in rats","volume":"52","author":"Wellington","year":"2013","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"10.1016\/j.vascn.2016.10.005_bb0360","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0091-3057(92)90492-X","article-title":"Antinociceptive properties of tiletamine-zolazepam improved by addition of xylazine or butorphanol","volume":"43","author":"Wilson","year":"1992","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"10.1016\/j.vascn.2016.10.005_bb0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0091-3057(93)90274-W","article-title":"Cardiovascular and respiratory effects of tiletamine-zolazepam","volume":"44","author":"Wilson","year":"1993","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"10.1016\/j.vascn.2016.10.005_bb0370","first-page":"159","article-title":"Selected blood serum biochemical indicators in twelve inbred strains of laboratory mice","volume":"27","author":"Wirth-Dzi\u0119cio\u0142owska","year":"2009","journal-title":"Animal Science Papers and Reports"},{"key":"10.1016\/j.vascn.2016.10.005_bb0375","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/PSY.0b013e31816e03a5","article-title":"Coagulation activity before and after acute psychosocial stress increases with age","volume":"70","author":"Wirtz","year":"2008","journal-title":"Psychosomatic Medicine"},{"key":"10.1016\/j.vascn.2016.10.005_bb0380","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/hep.22657","article-title":"Alanine aminotransferase isoenzymes: Molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity","volume":"49","author":"Yang","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.vascn.2016.10.005_bb0385","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1101\/gr.5217506","article-title":"Tissue-specific expression and regulation of sexually dimorphic genes in mice","volume":"16","author":"Yang","year":"2006","journal-title":"Genome Research"},{"key":"10.1016\/j.vascn.2016.10.005_bb0390","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tvjl.2004.01.005","article-title":"Levels of glutathione peroxidase, lipoperoxidase and some biochemical and haematological parameters in gazelles anaesthetised with a tiletamin\u2013zolazepam\u2013xylazine combination","volume":"169","author":"Yaralioglu-Gurgoze","year":"2005","journal-title":"Veterinary Journal"},{"key":"10.1016\/j.vascn.2016.10.005_bb0395","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/sj.sc.3101400","article-title":"The effect of ketamine\/xylazine anesthesia on sensory and motor evoked potentials in the rat","volume":"41","author":"Zandieh","year":"2003","journal-title":"Spinal Cord"},{"key":"10.1016\/j.vascn.2016.10.005_bb0400","first-page":"973","article-title":"Plasma corticosterone, insulin and glucose changes induced by brief exposure to isoflurane, diethyl ether and CO2 in male rats","volume":"59","author":"Zardooz","year":"2010","journal-title":"Physiological Research"},{"key":"10.1016\/j.vascn.2016.10.005_bb0405","first-page":"176","article-title":"Effect of sex and age on serum biochemical reference ranges in C57BL\/6J mice","volume":"54","author":"Zhou","year":"2004","journal-title":"Comparative Medicine"}],"container-title":["Journal of Pharmacological and Toxicological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871916301344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871916301344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:05Z","timestamp":1761004805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056871916301344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":82,"alternative-id":["S1056871916301344"],"URL":"https:\/\/doi.org\/10.1016\/j.vascn.2016.10.005","relation":{},"ISSN":["1056-8719"],"issn-type":[{"value":"1056-8719","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Using Tiletamine-Zolazepam-Xylazine Anesthesia Compared to CO2-inhalation for Terminal Clinical Chemistry, Hematology, and Coagulation Analysis in Mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological and Toxicological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vascn.2016.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}