{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:23:40Z","timestamp":1776270220275,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological and Toxicological Methods"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.vascn.2017.10.004","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T14:15:21Z","timestamp":1508422521000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Characterization of immune cell, endothelial, and renal responses upon experimental human endotoxemia"],"prefix":"10.1016","volume":"89","author":[{"given":"Eveline P.","family":"van Poelgeest","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlous R.","family":"Dillingh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke","family":"de Kam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen E.","family":"Malone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen","family":"Kemper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik S.G.","family":"Stroes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobus","family":"Burggraaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs","family":"Moerland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vascn.2017.10.004_bb0005","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1289\/ehp.6683","article-title":"Identification of putative gene based markers of renal toxicity","volume":"112","author":"Amin","year":"2004","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.vascn.2017.10.004_bb0010","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2174\/092986708784872393","article-title":"Human endotoxemia as a model of systemic inflammation","volume":"15","author":"Andreasen","year":"2008","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.vascn.2017.10.004_bb0015","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00134-007-0656-5","article-title":"Urinary biomarkers in septic acute kidney injury","volume":"33","author":"Bagshaw","year":"2007","journal-title":"Intensive Care Medicine"},{"key":"10.1016\/j.vascn.2017.10.004_bb0020","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/01.ATV.0000051384.43104.FC","article-title":"Endothelial dysfunction - a marker of atherosclerotic risk","volume":"23","author":"Bonetti","year":"2003","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0025","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2147\/DDDT.S54956","article-title":"Characterization of renal biomarkers for use in clinical trials: Biomarker evaluation in healthy volunteers","volume":"8","author":"Brott","year":"2014","journal-title":"Drug Design, Development and Therapy"},{"key":"10.1016\/j.vascn.2017.10.004_bb0030","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s002040050613","article-title":"Glutathione transferase alpha as a marker for tubular damage after trichloroethylene exposure","volume":"73","author":"Bruning","year":"1999","journal-title":"Archives of Toxicology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0035","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1167\/iovs.12-9505","article-title":"Anti-inflammatory effect of the proteasome inhibitor bortezomib on endotoxin-induced uveitis in rats","volume":"53","author":"Chen","year":"2012","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.vascn.2017.10.004_bb0040","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","article-title":"The immunopathogenesis of sepsis","volume":"420","author":"Cohen","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.vascn.2017.10.004_bb0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1084\/jem.191.1.189","article-title":"P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice","volume":"191","author":"Collins","year":"2000","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.vascn.2017.10.004_bb0050","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1172\/JCI11871","article-title":"A major role for VCAM-1, but not ICAM-1, in early atherosclerosis","volume":"107","author":"Cybulsky","year":"2001","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.vascn.2017.10.004_bb0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1084\/jem.175.1.185","article-title":"Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes","volume":"175","author":"de Fougerolles","year":"1992","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.vascn.2017.10.004_bb0060","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1172\/JCI118074","article-title":"Nitric-oxide decreases cytokine-induced endothelial activation - nitric-oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines","volume":"96","author":"Decaterina","year":"1995","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.vascn.2017.10.004_bb0065","first-page":"11","article-title":"Characterization of inflammation and immune cell modulation induced by low-dose LPS administration to healthy volunteers","author":"Dillingh","year":"2014","journal-title":"Journal of Inflammation-London"},{"key":"10.1016\/j.vascn.2017.10.004_bb0070","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/00003246-200204000-00021","article-title":"Inhibition of p38 mitogen-activated protein kinase: Dose-dependent suppression of leukocyte and endothelial response after endotoxin challenge in humans","volume":"30","author":"Fijen","year":"2002","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.vascn.2017.10.004_bb0075","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/01.shk.0000054369.40802.35","article-title":"Enalapril does not alter adhesion molecule levels in human endotoxemia","volume":"19","author":"Graninger","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.vascn.2017.10.004_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1871529X1401140724093325","article-title":"Editorial: Renal endothelial dysfunction: Evolving concepts and perspectives","volume":"14","author":"Guerrot","year":"2014","journal-title":"Cardiovascular & Hematological Disorders Drug Targets"},{"key":"10.1016\/j.vascn.2017.10.004_bb0085","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/sj.ki.5002715","article-title":"Urinary biomarkers in the early diagnosis of acute kidney injury","volume":"73","author":"Han","year":"2008","journal-title":"Kidney International"},{"key":"10.1016\/j.vascn.2017.10.004_bb0090","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2215\/CJN.00490206","article-title":"Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury","volume":"1","author":"Heemskerk","year":"2006","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tox.2010.08.013","article-title":"Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity","volume":"277","author":"Hoffmann","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0100","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1164\/ajrccm.159.3.9805087","article-title":"Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin","volume":"159","author":"Jilma","year":"1999","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.vascn.2017.10.004_bb0105","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1182\/blood.V88.9.3259.bloodjournal8893259","article-title":"Selectins and their ligands: Current concepts and controversies","volume":"88","author":"Kansas","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.vascn.2017.10.004_bb0110","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1097\/CCM.0b013e3182190d5d","article-title":"Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia","volume":"39","author":"Kox","year":"2011","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.vascn.2017.10.004_bb0115","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.2215\/CJN.00740110","article-title":"Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury","volume":"5","author":"Koyner","year":"2010","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0120","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"More accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of diet in renal disease study group","volume":"130","author":"Levey","year":"1999","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.vascn.2017.10.004_bb0125","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.vascn.2017.10.004_bb0130","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1681\/ASN.V871043","article-title":"Ultrastructural localization of osteopontin in the kidney: Induction by lipopolysaccharide","volume":"8","author":"Madsen","year":"1997","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0135","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.1992.263.4.C767","article-title":"Induction of ICAM-1 by TNF-alpha, IL-1 beta, and LPS in human endothelial cells after downregulation of PKC","volume":"263","author":"Myers","year":"1992","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0140","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1007\/s00467-007-0470-x","article-title":"Biomarkers for the early detection of acute kidney injury","volume":"23","author":"Nguyen","year":"2008","journal-title":"Pediatric Nephrology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0145","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.1365-2613.2000.00163.x","article-title":"Osteopontin: A key cytokine in cell-mediated and granulomatous inflammation","volume":"81","author":"O'Regan","year":"2000","journal-title":"International Journal of Experimental Pathology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0150","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/jcla.21549","article-title":"Urinary N-acetyl-beta-d-glucosaminidase levels are positively correlated with 2-hr plasma glucose levels during oral glucose tolerance testing in prediabetes","volume":"26","author":"Ouchi","year":"2012","journal-title":"Journal of Clinical Laboratory Analysis"},{"key":"10.1016\/j.vascn.2017.10.004_bb0155","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/ATVBAHA.114.304455","article-title":"Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases","volume":"35","author":"Patel","year":"2015","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0160","first-page":"465","article-title":"Intercellular adhesion molecule-3 on endothelial cells. Expression in tumors but not in inflammatory responses","volume":"148","author":"Patey","year":"1996","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0165","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7150\/ijbs.7502","article-title":"The vascular endothelium and human diseases","volume":"9","author":"Rajendran","year":"2013","journal-title":"International Journal of Biological Sciences"},{"key":"10.1016\/j.vascn.2017.10.004_bb0170","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1189\/jlb.0607373","article-title":"Inflammation, endothelium, and coagulation in sepsis","volume":"83","author":"Schouten","year":"2008","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0175","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1681\/ASN.2005121296","article-title":"Endothelial health and diversity in the kidney","volume":"17","author":"Segal","year":"2006","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0180","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00280-015-2880-y","article-title":"Urinary kidney injury molecule-1 and monocyte chemotactic protein-1 are noninvasive biomarkers of cisplatin-induced nephrotoxicity in lung cancer patients","volume":"76","author":"Shinke","year":"2015","journal-title":"Cancer Chemotherapy and Pharmacology"},{"issue":"Suppl. 3","key":"10.1016\/j.vascn.2017.10.004_bb0185","first-page":"293","article-title":"Glutathione transferases in the urine: Sensitive methods for detection of kidney damage induced by nephrotoxic agents in humans","volume":"102","author":"Sundberg","year":"1994","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.vascn.2017.10.004_bb0190","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1161\/01.CIR.0000089093.75585.98","article-title":"Biomarkers of vascular disease linking inflammation to endothelial activation - part II","volume":"108","author":"Szmitko","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.vascn.2017.10.004_bb0195","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1752-8062.2008.00053.x","article-title":"Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans","volume":"1","author":"Vaidya","year":"2008","journal-title":"Clinical and Translational Science"},{"key":"10.1016\/j.vascn.2017.10.004_bb0200","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1093\/infdis\/174.6.1356","article-title":"Changes in endotoxin-induced cytokine production by whole blood after in vivo exposure of normal humans to endotoxin","volume":"174","author":"van der Poll","year":"1996","journal-title":"The Journal of Infectious Diseases"},{"key":"10.1016\/j.vascn.2017.10.004_bb0205","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s00134-004-2477-0","article-title":"Severe vagal response after endotoxin administration in humans","volume":"30","author":"van Eijk","year":"2004","journal-title":"Intensive Care Medicine"},{"key":"10.1016\/j.vascn.2017.10.004_bb0210","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/bcp.12282","article-title":"Urinary kidney biomarkers for early detection of nephrotoxicity in clinical drug development","volume":"77","author":"van","year":"2014","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/apc.2008.0106","article-title":"Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males","volume":"23","author":"Wood","year":"2009","journal-title":"AIDS Patient Care and STDs"},{"key":"10.1016\/j.vascn.2017.10.004_bb0220","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1681\/ASN.2015040460","article-title":"Endothelial Kruppel-like factor 4 mediates the protective effect of statins against ischemic AKI","volume":"27","author":"Yoshida","year":"2016","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.vascn.2017.10.004_bb0225","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.phrs.2015.09.013","article-title":"PAPep, a small peptide derived from human pancreatitis-associated protein, attenuates corneal inflammation in vivo and in vitro through the IKKalpha\/beta\/IkappaBalpha\/NF-kappaB signaling pathway","volume":"102","author":"Zhu","year":"2015","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.vascn.2017.10.004_bb0230","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/09680519040100060401","article-title":"p38-MAPK inhibition and endotoxin induced tubular dysfunction in men","volume":"10","author":"Zijlstra","year":"2004","journal-title":"Journal of Endotoxin Research"}],"container-title":["Journal of Pharmacological and Toxicological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871917300795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871917300795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:01:25Z","timestamp":1761004885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056871917300795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":46,"alternative-id":["S1056871917300795"],"URL":"https:\/\/doi.org\/10.1016\/j.vascn.2017.10.004","relation":{},"ISSN":["1056-8719"],"issn-type":[{"value":"1056-8719","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of immune cell, endothelial, and renal responses upon experimental human endotoxemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological and Toxicological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vascn.2017.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}