{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:11:13Z","timestamp":1781687473069,"version":"3.54.5"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RFA-FD-19-002"],"award-info":[{"award-number":["RFA-FD-19-002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacological and Toxicological Methods"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.vascn.2020.106895","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T12:09:47Z","timestamp":1593778187000},"page":"106895","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method"],"prefix":"10.1016","volume":"105","author":[{"given":"Mahnaz","family":"Maddah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Mandegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri","family":"Dame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Grafton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Loewke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre J.S.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vascn.2020.106895_bb0005","doi-asserted-by":"crossref","DOI":"10.1186\/s13036-019-0148-5","article-title":"Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity","volume":"13","author":"Ahn","year":"2019","journal-title":"Journal of Biological Engineering"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0010","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1358\/dof.2010.35.1.1452391","article-title":"Approaches to assessing drug safety in the discovery phase","volume":"35","author":"Allen","year":"2010","journal-title":"Drug Future"},{"key":"10.1016\/j.vascn.2020.106895_bb0015","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9737920","article-title":"Key challenges and opportunities associated with the use of in vitro models to detect human DILI: Integrated risk assessment and mitigation plans","volume":"2016","author":"Atienzar","year":"2016","journal-title":"BioMed Research International"},{"issue":"6","key":"10.1016\/j.vascn.2020.106895_bb0020","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s11906-010-0149-8","article-title":"Mitochondrial dysfunction and oxidative damage to sarcomeric proteins","volume":"12","author":"Bayeva","year":"2010","journal-title":"Current Hypertension Reports"},{"issue":"5","key":"10.1016\/j.vascn.2020.106895_bb0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00019052-200410000-00003","article-title":"Myopathies resulting from mutations in sarcomeric proteins","volume":"17","author":"Bonnemann","year":"2004","journal-title":"Current Opinion in Neurology"},{"issue":"6","key":"10.1016\/j.vascn.2020.106895_bb0030","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.cell.2015.11.007","article-title":"Microscopy-based high-content screening","volume":"163","author":"Boutros","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0035","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/19491034.2016.1260798","article-title":"Current insights into LMNA cardiomyopathies: Existing models and missing LINCs","volume":"8","author":"Brayson","year":"2017","journal-title":"Nucleus"},{"issue":"1750","key":"10.1016\/j.vascn.2020.106895_bb0040","article-title":"Microfabrication of liver and heart tissues for drug development","volume":"373","author":"Brown","year":"2018","journal-title":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences"},{"issue":"9","key":"10.1016\/j.vascn.2020.106895_bb0045","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nmeth.4397","article-title":"Data-analysis strategies for image-based cell profiling","volume":"14","author":"Caicedo","year":"2017","journal-title":"Nature Methods"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0050","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/CIRCULATIONAHA.108.776831","article-title":"Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics","volume":"118","author":"Chen","year":"2008","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.vascn.2020.106895_bb0055","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1124\/dmd.30.8.869","article-title":"Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formation of the 4-hydroxy, 4\u2032-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen","volume":"30","author":"Crewe","year":"2002","journal-title":"Drug Metabolism and Disposition"},{"issue":"7","key":"10.1016\/j.vascn.2020.106895_bb0060","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1139\/cjpp-2015-0459","article-title":"Toxicity testing and drug screening using iPSC-derived hepatocytes, cardiomyocytes, and neural cells","volume":"94","author":"Csobonyeiova","year":"2016","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"issue":"11","key":"10.1016\/j.vascn.2020.106895_bb0065","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/CIRCRESAHA.108.173989","article-title":"Nuclear shape, mechanics, and mechanotransduction","volume":"102","author":"Dahl","year":"2008","journal-title":"Circulation Research"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15337-2","article-title":"Stem cell-derived polarized hepatocytes","volume":"11","author":"Dao Thi","year":"2020","journal-title":"Nature Communications"},{"issue":"3","key":"10.1016\/j.vascn.2020.106895_bb0075","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/cvr\/cvn281","article-title":"Subcellular remodelling may induce cardiac dysfunction in congestive heart failure","volume":"81","author":"Dhalla","year":"2009","journal-title":"Cardiovascular Research"},{"issue":"6","key":"10.1016\/j.vascn.2020.106895_bb0080","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/1389200216888150915112039","article-title":"Role of drug metabolism in the cytotoxicity and clinical efficacy of anthracyclines","volume":"16","author":"Edwardson","year":"2015","journal-title":"Current Drug Metabolism"},{"issue":"8","key":"10.1016\/j.vascn.2020.106895_bb0085","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/2472555218775028","article-title":"Clinical trials in a dish: A perspective on the coming revolution in drug development","volume":"23","author":"Fermini","year":"2018","journal-title":"SLAS Discovery"},{"issue":"3","key":"10.1016\/j.vascn.2020.106895_bb0090","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.pharmthera.2013.03.005","article-title":"Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity","volume":"138","author":"Ferri","year":"2013","journal-title":"Pharmacology & Therapeutics"},{"issue":"3","key":"10.1016\/j.vascn.2020.106895_bb0095","first-page":"196","article-title":"Nuclear architecture remodelling in cardiomyocytes with Lamin a deficiency","volume":"46","author":"Fidzianska","year":"2008","journal-title":"Folia Neuropathologica"},{"key":"10.1016\/j.vascn.2020.106895_bb0100","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfz154","article-title":"Novel mechanisms of valproate hepatotoxicity: Impaired Mrp2 trafficking and hepatocyte depolarization","author":"Fu","year":"2019","journal-title":"Toxicological Sciences"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0105","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3892\/br.2015.536","article-title":"Tamoxifen induces hepatotoxicity and changes to hepatocyte morphology at the early stage of endocrinotherapy in mice","volume":"4","author":"Gao","year":"2016","journal-title":"Biomedical Reports"},{"issue":"4","key":"10.1016\/j.vascn.2020.106895_bb0110","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10565-017-9383-z","article-title":"A transcriptomic study suggesting human iPSC-derived hepatocytes potentially offer a better in vitro model of hepatotoxicity than most hepatoma cell lines","volume":"33","author":"Gao","year":"2017","journal-title":"Cell Biology and Toxicology"},{"key":"10.1016\/j.vascn.2020.106895_bb0115","first-page":"2696","article-title":"A computational study of the role of mitochondrial organization on cardiac bioenergetics","volume":"2017","author":"Ghosh","year":"2017","journal-title":"Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"issue":"12","key":"10.1016\/j.vascn.2020.106895_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006640","article-title":"Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture","volume":"14","author":"Ghosh","year":"2018","journal-title":"PLoS Computational Biology"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0125","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/sj.clpt.6100367","article-title":"Tamoxifen pharmacogenomics: The role of CYP2D6 as a predictor of drug response","volume":"83","author":"Goetz","year":"2008","journal-title":"Clinical Pharmacology and Therapeutics"},{"issue":"9","key":"10.1016\/j.vascn.2020.106895_bb0130","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1089\/adt.2015.659","article-title":"High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes","volume":"13","author":"Grimm","year":"2015","journal-title":"Assay and Drug Development Technologies"},{"key":"10.1016\/j.vascn.2020.106895_bb0135","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399411002110","article-title":"Molecular mechanisms underlying chemical liver injury","volume":"14","author":"Gu","year":"2012","journal-title":"Expert Reviews in Molecular Medicine"},{"issue":"8","key":"10.1016\/j.vascn.2020.106895_bb0140","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1161\/CIRCRESAHA.119.315862","article-title":"Cardiomyocyte maturation: New phase in development","volume":"126","author":"Guo","year":"2020","journal-title":"Circulation Research"},{"issue":"6","key":"10.1016\/j.vascn.2020.106895_bb0145","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1517\/17425250902932915","article-title":"Cardionomics: A new integrative approach for screening cardiotoxicity of drug candidates","volume":"5","author":"Gwathmey","year":"2009","journal-title":"Expert Opinion on Drug Metabolism & Toxicology"},{"key":"10.1016\/j.vascn.2020.106895_bb0150","series-title":"Deep residual learning for image recognition. Paper presented at the 2016 IEEE conference on computer vision and pattern recognition (CVPR)","article-title":"27-30 June 2016","author":"He","year":"2016"},{"key":"10.1016\/j.vascn.2020.106895_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2019.121765","article-title":"Simultaneous UHPLC-MS\/MS method of estradiol metabolites to support the evaluation of Phase-2 metabolic activity of induced pluripotent stem cell derived hepatocytes","volume":"1126-1127","author":"Indapurkar","year":"2019","journal-title":"Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences"},{"issue":"3","key":"10.1016\/j.vascn.2020.106895_bb0160","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/bit.25115","article-title":"Automated method for the rapid and precise estimation of adherent cell culture characteristics from phase contrast microscopy images","volume":"111","author":"Jaccard","year":"2014","journal-title":"Biotechnology and Bioengineering"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2004.12.003","article-title":"Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin","volume":"209","author":"Kalender","year":"2005","journal-title":"Toxicology"},{"issue":"Suppl. 2","key":"10.1016\/j.vascn.2020.106895_bb0170","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1086\/381446","article-title":"Drug-induced liver injury","volume":"38","author":"Kaplowitz","year":"2004","journal-title":"Clinical Infectious Diseases"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0175","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.117.305365","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes: Insights into molecular, cellular, and functional phenotypes","volume":"117","author":"Karakikes","year":"2015","journal-title":"Circulation Research"},{"key":"10.1016\/j.vascn.2020.106895_bb0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mito.2016.10.008","article-title":"Effects of doxorubicin on cardiac muscle subsarcolemmal and intermyofibrillar mitochondria","volume":"34","author":"Kavazis","year":"2017","journal-title":"Mitochondrion"},{"key":"10.1016\/j.vascn.2020.106895_bb0185","article-title":"The sarcomeric Z-disc and Z-discopathies","volume":"2011","author":"Knoll","year":"2011","journal-title":"Journal of Biomedicine & Biotechnology"},{"issue":"20","key":"10.1016\/j.vascn.2020.106895_bb0190","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1016\/0006-2952(88)90069-X","article-title":"Different cytotoxicity and metabolism of doxorubicin, daunorubicin, epirubicin, esorubicin and idarubicin in cultured human and rat hepatocytes","volume":"37","author":"Le Bot","year":"1988","journal-title":"Biochemical Pharmacology"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0195","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0009-2797(99)00088-5","article-title":"Cryopreserved human hepatocytes: Characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential","volume":"121","author":"Li","year":"1999","journal-title":"Chemico-Biological Interactions"},{"issue":"16","key":"10.1016\/j.vascn.2020.106895_bb0200","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1161\/CIRCULATIONAHA.113.001883","article-title":"Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity","volume":"127","author":"Liang","year":"2013","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0205","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/toxsci\/kfr339","article-title":"Evaluation of drugs with specific organ toxicities in organ-specific cell lines","volume":"126","author":"Lin","year":"2012","journal-title":"Toxicological Sciences"},{"issue":"5","key":"10.1016\/j.vascn.2020.106895_bb0210","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.yjmcc.2010.06.012","article-title":"Role of mitochondrial dysfunction in cardiac glycoside toxicity","volume":"49","author":"Liu","year":"2010","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0215","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/toxsci\/kfv117","article-title":"Morphological and functional characterization and assessment of iPSC-derived hepatocytes for in vitro toxicity testing","volume":"147","author":"Lu","year":"2015","journal-title":"Toxicological Sciences"},{"issue":"4","key":"10.1016\/j.vascn.2020.106895_bb0220","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.stemcr.2015.02.007","article-title":"A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing","volume":"4","author":"Maddah","year":"2015","journal-title":"Stem Cell Reports"},{"issue":"12","key":"10.1016\/j.vascn.2020.106895_bb0225","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/s41592-019-0403-1","article-title":"Deep learning for cellular image analysis","volume":"16","author":"Moen","year":"2019","journal-title":"Nature Methods"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0230","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12265-012-9423-2","article-title":"A review of human pluripotent stem cell-derived cardiomyocytes for high-throughput drug discovery, cardiotoxicity screening, and publication standards","volume":"6","author":"Mordwinkin","year":"2013","journal-title":"Journal of Cardiovascular Translational Research"},{"issue":"6","key":"10.1016\/j.vascn.2020.106895_bb0235","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/CIRCRESAHA.119.314996","article-title":"Physiological biomimetic culture system for pig and human heart slices","volume":"125","author":"Ou","year":"2019","journal-title":"Circulation Research"},{"issue":"7","key":"10.1016\/j.vascn.2020.106895_bb0240","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.yexcr.2009.02.001","article-title":"Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes","volume":"315","author":"Pentassuglia","year":"2009","journal-title":"Experimental Cell Research"},{"issue":"14","key":"10.1016\/j.vascn.2020.106895_bb0245","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1091\/mbc.E16-01-0038","article-title":"Biology of the cardiac myocyte in heart disease","volume":"27","author":"Peter","year":"2016","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.vascn.2020.106895_bb0250","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fphys.2013.00102","article-title":"Mitochondrial dynamics in the adult cardiomyocytes: Which roles for a highly specialized cell?","volume":"4","author":"Piquereau","year":"2013","journal-title":"Frontiers in Physiology"},{"issue":"2","key":"10.1016\/j.vascn.2020.106895_bb0255","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/toxsci\/kft005","article-title":"Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity","volume":"132","author":"Pointon","year":"2013","journal-title":"Toxicological Sciences"},{"issue":"9","key":"10.1016\/j.vascn.2020.106895_bb0260","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1162\/neco_a_00990","article-title":"Deep convolutional neural networks for image classification: A comprehensive review","volume":"29","author":"Rawat","year":"2017","journal-title":"Neural Computation"},{"key":"10.1016\/j.vascn.2020.106895_bb0265","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3389\/fphar.2019.00934","volume":"10","author":"Ribeiro","year":"2019","journal-title":"Frontiers in Pharmacology"},{"issue":"21","key":"10.1016\/j.vascn.2020.106895_bb0270","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1091\/mbc.e17-03-0209","article-title":"Systematic gene tagging using CRISPR\/Cas9 in human stem cells to illuminate cell organization","volume":"28","author":"Roberts","year":"2017","journal-title":"Molecular Biology of the Cell"},{"issue":"6","key":"10.1016\/j.vascn.2020.106895_bb0275","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00424-014-1456-8","article-title":"Focal adhesion signaling in heart failure","volume":"466","author":"Samarel","year":"2014","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"5","key":"10.1016\/j.vascn.2020.106895_bb0280","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/stem.631","article-title":"Concise review: Human pluripotent stem cell-based models for cardiac and hepatic toxicity assessment","volume":"29","author":"Sartipy","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.vascn.2020.106895_bb0285","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.coisb.2018.05.004","article-title":"Machine learning and image-based profiling in drug discovery","volume":"10","author":"Scheeder","year":"2018","journal-title":"Current Opinion in Systems Biology"},{"issue":"27","key":"10.1016\/j.vascn.2020.106895_bb0290","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.2174\/138161205774414510","article-title":"Why drugs fail--a study on side effects in new chemical entities","volume":"11","author":"Schuster","year":"2005","journal-title":"Current Pharmaceutical Design"},{"issue":"2","key":"10.1016\/j.vascn.2020.106895_bb0295","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbamem.2013.07.011","article-title":"The physiological role of cardiac cytoskeleton and its alterations in heart failure","volume":"1838","author":"Sequeira","year":"2014","journal-title":"Biochimica et Biophysica Acta"},{"issue":"377","key":"10.1016\/j.vascn.2020.106895_bb0300","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf2584","article-title":"High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells","volume":"9","author":"Sharma","year":"2017","journal-title":"Science Translational Medicine"},{"issue":"11","key":"10.1016\/j.vascn.2020.106895_bb0305","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.3748\/wjg.v16.i11.1358","article-title":"Alcohol-induced alterations of the hepatocyte cytoskeleton","volume":"16","author":"Shepard","year":"2010","journal-title":"World Journal of Gastroenterology"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0310","doi-asserted-by":"crossref","DOI":"10.1186\/s40537-019-0197-0","article-title":"A survey on image data augmentation for deep learning","volume":"6","author":"Shorten","year":"2019","journal-title":"Journal of Big Data"},{"issue":"10","key":"10.1016\/j.vascn.2020.106895_bb0315","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0196-0644(05)81352-6","article-title":"Acetaminophen overdose: A 48-hour intravenous N-acetylcysteine treatment protocol","volume":"20","author":"Smilkstein","year":"1991","journal-title":"Annals of Emergency Medicine"},{"issue":"Pt 24","key":"10.1016\/j.vascn.2020.106895_bb0320","first-page":"5529","article-title":"Machine learning in cell biology - teaching computers to recognize phenotypes","volume":"126","author":"Sommer","year":"2013","journal-title":"Journal of Cell Science"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0325","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10974-014-9395-8","article-title":"Pathomechanisms in heart failure: The contractile connection","volume":"36","author":"Stienen","year":"2015","journal-title":"Journal of Muscle Research and Cell Motility"},{"issue":"6","key":"10.1016\/j.vascn.2020.106895_bb0330","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00418-008-0431-x","article-title":"Intermediate filament cytoskeleton of the liver in health and disease","volume":"129","author":"Strnad","year":"2008","journal-title":"Histochemistry and Cell Biology"},{"issue":"3","key":"10.1016\/j.vascn.2020.106895_bb0335","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3109\/03602530903491881","article-title":"Sandwich-cultured hepatocytes: An in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity","volume":"42","author":"Swift","year":"2010","journal-title":"Drug Metabolism Reviews"},{"issue":"12","key":"10.1016\/j.vascn.2020.106895_bb0340","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1109\/JPROC.2017.2761740","article-title":"Efficient processing of deep neural networks: A tutorial and survey","volume":"105","author":"Sze","year":"2017","journal-title":"Proceedings of the IEEE"},{"issue":"6","key":"10.1016\/j.vascn.2020.106895_bb0345","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/stem.2368","article-title":"Concise review: Advances in generating hepatocytes from pluripotent stem cells for translational medicine","volume":"34","author":"Szkolnicka","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.vascn.2020.106895_bb0350","series-title":"A survey on deep transfer learning","author":"Tan","year":"2018"},{"issue":"7","key":"10.1016\/j.vascn.2020.106895_bb0355","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/FPC.0b013e32833ffb56","article-title":"Doxorubicin pathways: Pharmacodynamics and adverse effects","volume":"21","author":"Thorn","year":"2011","journal-title":"Pharmacogenetics and Genomics"},{"issue":"1\u20132","key":"10.1016\/j.vascn.2020.106895_bb0360","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10616-009-9238-4","article-title":"The role of cell death and myofibrillar damage in contractile dysfunction of long-term cultured adult cardiomyocytes exposed to doxorubicin","volume":"61","author":"Timolati","year":"2009","journal-title":"Cytotechnology"},{"key":"10.1016\/j.vascn.2020.106895_bb0365","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-3-319-55330-6_15","article-title":"Mitochondria in structural and functional cardiac remodeling","volume":"982","author":"Torrealba","year":"2017","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0370","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/j.2040-4603.2013.tb00490.x","article-title":"Hepatocyte polarity","volume":"3","author":"Treyer","year":"2013","journal-title":"Comprehensive Physiology"},{"key":"10.1016\/j.vascn.2020.106895_bb0375","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cbi.2015.12.013","article-title":"In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries","volume":"255","author":"Utkarsh","year":"2016","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.vascn.2020.106895_bb0380","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cbi.2015.12.013","article-title":"In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries","volume":"255","author":"Utkarsh","year":"2016","journal-title":"Chemico-Biological Interactions"},{"issue":"5","key":"10.1016\/j.vascn.2020.106895_bb0385","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cels.2019.03.009","article-title":"Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming","volume":"8","author":"Wang","year":"2019","journal-title":"Cell Systems"},{"issue":"2","key":"10.1016\/j.vascn.2020.106895_bb0390","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/toxsci\/kfy270","article-title":"Today\u2019s challenges to de-risk and predict drug safety in human \u201cmind-the-gap\u201d","volume":"167","author":"Weaver","year":"2019","journal-title":"Toxicological Sciences"},{"issue":"9","key":"10.1016\/j.vascn.2020.106895_bb0395","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.biocel.2005.04.011","article-title":"Cardiomyocytes structure, function and associated pathologies","volume":"37","author":"Woodcock","year":"2005","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0400","first-page":"84","article-title":"Doxorubicin, DNA torsion, and chromatin dynamics","volume":"1845","author":"Yang","year":"2014","journal-title":"Biochimica et Biophysica Acta"},{"issue":"5","key":"10.1016\/j.vascn.2020.106895_bb0405","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1248\/bpb.b17-00913","article-title":"Comparison of drug metabolism and its related hepatotoxic effects in HepaRG, cryopreserved human hepatocytes, and HepG2 cell cultures","volume":"41","author":"Yokoyama","year":"2018","journal-title":"Biological & Pharmaceutical Bulletin"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0410","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.vascn.2020.106895_bb0415","series-title":"Madame Curie Bioscience Database [Internet]","article-title":"Keratins as targets in and modulators of liver diseases","author":"Zatloukal","year":"2000"},{"issue":"4","key":"10.1016\/j.vascn.2020.106895_bb0420","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/path.1649","article-title":"The keratin cytoskeleton in liver diseases","volume":"204","author":"Zatloukal","year":"2004","journal-title":"The Journal of Pathology"},{"issue":"1","key":"10.1016\/j.vascn.2020.106895_bb0425","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.yexcr.2016.11.027","article-title":"Functional properties of hepatocytes in vitro are correlated with cell polarity maintenance","volume":"350","author":"Zeigerer","year":"2017","journal-title":"Experimental Cell Research"},{"issue":"3","key":"10.1016\/j.vascn.2020.106895_bb0430","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.toxlet.2014.04.003","article-title":"A mutually beneficial relationship between hepatocytes and cardiomyocytes mitigates doxorubicin-induced toxicity","volume":"227","author":"Zhang","year":"2014","journal-title":"Toxicology Letters"},{"issue":"2","key":"10.1016\/j.vascn.2020.106895_bb0435","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1021\/tx8004295","article-title":"Differences in metabolite-mediated toxicity of tamoxifen in rodents versus humans elucidated with DNA\/microsome electro-optical arrays and nanoreactors","volume":"22","author":"Zhao","year":"2009","journal-title":"Chemical Research in Toxicology"}],"container-title":["Journal of Pharmacological and Toxicological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871920302240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056871920302240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:05:38Z","timestamp":1761005138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056871920302240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":87,"alternative-id":["S1056871920302240"],"URL":"https:\/\/doi.org\/10.1016\/j.vascn.2020.106895","relation":{},"ISSN":["1056-8719"],"issn-type":[{"value":"1056-8719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmacological and Toxicological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vascn.2020.106895","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106895"}}