{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:48:39Z","timestamp":1791053319355,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1016\/j.vetimm.2004.02.006","type":"journal-article","created":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T09:27:58Z","timestamp":1081934878000},"page":"179-192","source":"Crossref","is-referenced-by-count":30,"title":["The immunopathogenesis of flea allergy dermatitis in dogs, an experimental study"],"prefix":"10.1016","volume":"99","author":[{"given":"Melinda J","family":"Wilkerson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Bagladi-Swanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Floyd-Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dryden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2004.02.006_BIB1","doi-asserted-by":"crossref","unstructured":"Altman, D., 1991. Practical Statistics for Medical Research. Chapman & Hall, London.","DOI":"10.1201\/9780429258589"},{"key":"10.1016\/j.vetimm.2004.02.006_BIB2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0165-2427(99)00163-4","article-title":"A standardized gating technique for the generation of flow cytometry data for normal canine and normal feline blood lymphocytes","volume":"73","author":"Byrne","year":"2000","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2460\/javma.1995.206.03.325","article-title":"Identification of mast cells in buffy coat preparations from dogs with inflammatory skin diseases","volume":"206","author":"Cayatte","year":"1995","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB4","doi-asserted-by":"crossref","first-page":"768","DOI":"10.4049\/jimmunol.103.4.768","article-title":"Reaginic-type of antibody in mice stimulated by extracts of Bordetella pertussis","volume":"103","author":"Clausen","year":"1969","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB5","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2460\/javma.1993.202.05.739","article-title":"Comparison of intradermal allergy test and enzyme-linked immunosorbent assay in dogs with allergic skin disease","volume":"202","author":"Codner","year":"1993","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB6","first-page":"71","article-title":"The sensitivity of rat CD8+ and CD4+ T cells to ricin in vivo and in vitro and their relationship to IgE regulation","volume":"69","author":"Diaz-Sanchez","year":"1990","journal-title":"Immunology"},{"key":"10.1016\/j.vetimm.2004.02.006_BIB7","first-page":"297","article-title":"Generation of a long-lived IgE response in high and low responder strains of rat by co-administration of ricin and antigen","volume":"72","author":"Diaz-Sanchez","year":"1991","journal-title":"Immunology"},{"key":"10.1016\/j.vetimm.2004.02.006_BIB8","first-page":"226","article-title":"Ricin enhances IgE responses by inhibiting a subpopulation of early-activated IgE regulatory CD8+ T cells","volume":"78","author":"Diaz-Sanchez","year":"1993","journal-title":"Immunology"},{"key":"10.1016\/j.vetimm.2004.02.006_BIB9","first-page":"24","article-title":"Rate of kill of nienpyram tablets, imidacloprid spot-on and fipronil spot-on against flea infestations on dogs","volume":"23","author":"Dryden","year":"2002","journal-title":"Comp. Cont. Educ. Pract. Vet."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB10","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1046\/j.1365-2222.1999.00679.x","article-title":"Increased mast cell tryptase in sudden infant death-anaphylaxis, hypoxia or artefact","volume":"29","author":"Edston","year":"1999","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.vetimm.2004.02.006_BIB11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0165-2427(01)00337-3","article-title":"Lymphocyte subsets in peripheral blood of dogs\u2014a flow cytometric study","volume":"82","author":"Faldyna","year":"2001","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/030098588502200112","article-title":"Lesions of experimental flea bite hypersensitivity in the dog","volume":"22","author":"Gross","year":"1985","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000232995","article-title":"Boosterable IgE antibody response in mice without the use of adjuvant","volume":"67","author":"Hall","year":"1982","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB14","first-page":"1273","article-title":"Managing flea allergy dermatitis. 3","volume":"79","author":"Halliwell","year":"1984","journal-title":"Vet. Med."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB15","first-page":"1273","article-title":"Factors in the development of flea-bite allergy","volume":"79","author":"Halliwell","year":"1984","journal-title":"Vet. Med."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0165-2427(85)90082-0","article-title":"IgE and IgG antibodies to flea antigen in differing dog populations","volume":"8","author":"Halliwell","year":"1985","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0165-2427(87)90164-4","article-title":"Aspects of the immunopathogenesis of flea allergy dermatitis in dogs","volume":"17","author":"Halliwell","year":"1987","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0165-2427(87)90083-3","article-title":"The role of basophils in the immunopathogenesis of hypersensitivity to fleas (Ctenocephalides felis) in dogs","volume":"15","author":"Halliwell","year":"1987","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-2427(97)00119-0","article-title":"Auto IgG anti-IgE and IgG\u00d7IgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodectic acariasis and helminthiasis","volume":"60","author":"Hammerberg","year":"1997","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0165-2427(01)00313-0","article-title":"The ACVD task force on canine atopic dermatitis. XVII. Intradermal testing","volume":"81","author":"Hillier","year":"2001","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000053662","article-title":"Unexpected functions of FcepsilonRI on antigen-presenting cells","volume":"124","author":"Kraft","year":"2001","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB22","unstructured":"Kwochka, K.W., McCall, C.A., Hillier, A., Stedman, K.E., Riester, L.E., Cole, L.C., Bevier, D.E., Wassom, D.L., 1998. Flea salivary antigen rush immunotherapy for flea allergy dermatitis in dogs: a double-blinded, placebo-controlled clinical study. In: Proceedings of the 14th AAVD\/ACVD Meeting, pp. 107\u2013108."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4049\/jimmunol.168.1.290","article-title":"Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes","volume":"168","author":"Mellon","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB24","first-page":"326","article-title":"Elimination of IgE regulatory rat CD8+ T cells in vivo increases the co-ordinate expression of Th2 cytokines IL-4, IL-5 and IL-10","volume":"80","author":"Noble","year":"1993","journal-title":"Immunology"},{"key":"10.1016\/j.vetimm.2004.02.006_BIB25","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.4049\/jimmunol.146.11.3929","article-title":"Initiation of delayed-type hypersensitivity by low doses of monoclonal IgE antibody. Mediation by serotonin and inhibition by histamine","volume":"146","author":"Ptak","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB26","unstructured":"Reedy, L., Miller, W., Willemse, T., 2003. Arthropod hypersensitivity disorders. In: Allergic Skin Diseases of Dogs and Cats. W.B. Saunders, London, pp. 202\u2013233."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB27","first-page":"4","article-title":"A brief introduction to nitenpyram: a new systemic flea adulticide for cats and dogs","volume":"23","author":"Schenker","year":"2002","journal-title":"Comp. Cont. Educ. Pract. Vet."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB28","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1348-0421.1983.tb00656.x","article-title":"Effects of Bordetella pertussis components on IgE and IgG1 responses","volume":"27","author":"Sekiya","year":"1983","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0165-2427(01)00242-2","article-title":"Measurement of canine IgE using the alpha chain of the human high affinity IgE receptor","volume":"78","author":"Stedman","year":"2001","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB30","first-page":"307","article-title":"The effect of the castor bean toxin, ricin, on rat IgE and IgG responses","volume":"68","author":"Thorpe","year":"1989","journal-title":"Immunology"},{"key":"10.1016\/j.vetimm.2004.02.006_BIB31","unstructured":"Tizard, I., 2000. Antibodies: soluble forms of BCR. In: Veterinary Immunology: An Introduction. W.B. Saunders, Philadelphia, pp. 155\u2013159."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB32","unstructured":"von Tscharner, C., Halliwell, R., 1990. Clinical and immunological aspects of allergic skin diseases in domestic animals. In: von Tscharner, C., Halliwell, R. (Eds.), Advances in Veterinary Dermatology. Bailliere Tindall, London, pp. 105\u2013115."},{"key":"10.1016\/j.vetimm.2004.02.006_BIB33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0165-2427(96)05634-6","article-title":"Immunisation regimes used to elevate serum IgE in sheep","volume":"55","author":"Yilmaz","year":"1996","journal-title":"Vet. Immunol. Immunopathol."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242704000534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242704000534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T22:31:52Z","timestamp":1705098712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242704000534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":33,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0165242704000534"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2004.02.006","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}