{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:18:38Z","timestamp":1792801118110,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.vetimm.2005.02.023","type":"journal-article","created":{"date-parts":[[2005,4,16]],"date-time":"2005-04-16T11:28:33Z","timestamp":1113650913000},"page":"209-220","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of cell-mediated immune responses and bacterial clearance in 6\u201310 months old water buffalo (Bubalus bubalis) experimentally vaccinated with four dosages of commercial Brucella abortus strain RB51 vaccine"],"prefix":"10.1016","volume":"106","author":[{"given":"M.D.","family":"Diptee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Adesiyun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Asgarali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.T.","family":"Fosgate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2005.02.023_bib1","first-page":"42","article-title":"Bovine natural resistance macrophage protein 1 (NRAMP1) gene","volume":"42","author":"Adams","year":"1999","journal-title":"Archiv F\u00fcr Tierzucht"},{"key":"10.1016\/j.vetimm.2005.02.023_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.19182\/remvt.9541","article-title":"Seroprevalences of brucellosis. Q-fever and toxoplasmosis in slaughter livestock in Trinidad","volume":"49","author":"Adesiyun","year":"1996","journal-title":"Rev. Elev. Med. Vet. Pays. Trop."},{"issue":"10","key":"10.1016\/j.vetimm.2005.02.023_bib3","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.4049\/jimmunol.143.10.3330","article-title":"Temporal development of protective cell mediated and humoral immunity in BALB\/c mice infected with Brucella abortus","volume":"143","author":"Araya","year":"1989","journal-title":"J. Immunol."},{"issue":"2\u20133","key":"10.1016\/j.vetimm.2005.02.023_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0378-1135(90)90111-8","article-title":"An evaluation of the DTH test for diagnosing brucellosis in individual cattle: a field study","volume":"22","author":"Bercovich","year":"1990","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2005.02.023_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.20506\/rst.3.1.152","article-title":"Contribution of the OIE to controlling animal brucellosison a world-wide scale","volume":"3","author":"Blajan","year":"1984","journal-title":"Rev. Sci. Tech."},{"issue":"10","key":"10.1016\/j.vetimm.2005.02.023_bib6","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.2460\/ajvr.1992.53.10.1881","article-title":"Bacterial survival, lymph node changes and immunologic responses of cattle vaccinated with standard and mutant strains of Brucella abortus","volume":"53","author":"Cheville","year":"1992","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2005.02.023_bib7","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2460\/ajvr.1996.57.08.1153","article-title":"Effects of age at vaccination on efficacy of Brucella abortus strain RB51 to protect cattle against brucellosis","volume":"57","author":"Cheville","year":"1996","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2005.02.023_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","article-title":"Brucellosis: an overview","volume":"3","author":"Corbel","year":"1997","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetimm.2005.02.023_bib9","unstructured":"Diptee, M.D., 2004. Preliminary evaluation of the efficacy of Brucella abortus strain RB51 vaccine in domestic water buffalo (Bubalus bubalis). M.Phil. Thesis. University of the West Indies, St. Augustine, Trinidad, Tobago."},{"key":"10.1016\/j.vetimm.2005.02.023_bib10","series-title":"Animal Brucellosis","first-page":"301","article-title":"The pathogenesis and pathobiology of Brucella infection on domestic animals","author":"Enright","year":"1990"},{"key":"10.1016\/j.vetimm.2005.02.023_bib11","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/vr.151.9.272","article-title":"Isolation of Brucella abortus biovar 1 from cattle and water buffalo of Trinidad","volume":"151","author":"Fosgate","year":"2002","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetimm.2005.02.023_bib12","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.2460\/ajvr.2002.63.1598","article-title":"Bayesian comparison of brucellosis serologic tests without a gold standard in cattle and water buffalo (Bubalus bubalis) of Trinidad","volume":"63","author":"Fosgate","year":"2002","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2005.02.023_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0167-5877(03)00048-5","article-title":"Evaluation of brucellosis RB51 vaccine for domestic water buffalo (Bubalus bubalis) in Trinidad","volume":"15","author":"Fosgate","year":"2003","journal-title":"Prev. Vet. Med."},{"issue":"3\u20134","key":"10.1016\/j.vetimm.2005.02.023_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-2427(03)00063-1","article-title":"Analysis of repeated tests for interferon-gamma (IFN-gamma) response and faecal excretion for diagnosis of subclinical paratuberculosis in Danish cattle","volume":"94","author":"Huda","year":"2003","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"4","key":"10.1016\/j.vetimm.2005.02.023_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0378-1135(97)00110-7","article-title":"Serological crossreactivity between Brucella abortus and Yersinia enterocolitica O:9. III. Specificity of the in vitro antigen-specific gamma interferon test for bovine brucellosis diagnosis in experimentally Yersinia enterocolitica 0:9-infected cattle","volume":"57","author":"Kittelberger","year":"1997","journal-title":"Vet. Microbiol."},{"issue":"1","key":"10.1016\/j.vetimm.2005.02.023_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-1135(97)00202-2","article-title":"Serological cross-reactivity between Brucella abortus and Yersinia enterocolitica O:9. IV. Evaluation of the M- and C-epitope antibody response for the specific detection of B. abortus infections","volume":"60","author":"Kittelberger","year":"1998","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2005.02.023_bib17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.7589\/0090-3558-36.3.477","article-title":"Safety and efficacy of Brucella abortus strain RB51 vaccine in captive pregnant elk","volume":"36","author":"Kreeger","year":"2000","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.vetimm.2005.02.023_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7589\/0090-3558-38.1.27","article-title":"Brucella abortus strain RB51 vaccination in elk. II. Failure of high dosage to prevent abortion","volume":"38","author":"Kreeger","year":"2002","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.vetimm.2005.02.023_bib19","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.2460\/ajvr.1998.59.08.1016","article-title":"Field study of vaccination of cattle with Brucella abortus strains RB51 and 19 under high and low prevalence","volume":"59","author":"Lord","year":"1998","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2005.02.023_bib20","first-page":"19","article-title":"The evaluation of tests","volume":"41","author":"Martin","year":"1997","journal-title":"Can. J. Comp. Med."},{"issue":"10","key":"10.1016\/j.vetimm.2005.02.023_bib21","first-page":"2147","article-title":"Identification of Brucella abortus in formalin-fixed, paraffin-embedded tissues of cows, goats and mice with an avidin-biotin-peroxidase complex immunoenzymatic staining technique","volume":"47","author":"Meador","year":"1986","journal-title":"Am. J. Vet. Res."},{"issue":"5","key":"10.1016\/j.vetimm.2005.02.023_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/030098588902600501","article-title":"Pathogenesis of Brucella abortus infection of the mammary gland and supramammary lymph node of the goat","volume":"26","author":"Meador","year":"1989","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.vetimm.2005.02.023_bib23","first-page":"647","article-title":"Diseases and parasites of buffaloes","volume":"38","author":"Mohan","year":"1968","journal-title":"Vet. Bull."},{"key":"10.1016\/j.vetimm.2005.02.023_bib24","unstructured":"Office International Des Epizooties (OIE), 2000. International Animal Health Code, 2.3.1, Accessed March 14, 2004. Available at: http:\/\/www.oie.int\/."},{"key":"10.1016\/j.vetimm.2005.02.023_bib25","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/eji.1830250922","article-title":"CD8+ type 1 CD44hi CD45 RB1o T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I- and class II-deficient mice","volume":"25","author":"Oliveira","year":"1995","journal-title":"Eur. J. Immunol."},{"issue":"1\u20134","key":"10.1016\/j.vetimm.2005.02.023_bib26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0378-1135(02)00225-0","article-title":"Molecular and cellular interactions between Brucella abortus antigens and host immune responses","volume":"90","author":"Oliveira","year":"2002","journal-title":"Vet. Microbiol."},{"issue":"4","key":"10.1016\/j.vetimm.2005.02.023_bib27","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2460\/ajvr.1998.59.04.410","article-title":"Evaluation of serologic responses, lymphocyte proliferative responses and clearance from lymphatic organs after vaccination of bison with Brucella abortus strain RB51","volume":"59","author":"Olsen","year":"1998","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2005.02.023_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1053\/rvsc.1998.0251","article-title":"Responses of cattle to two dosages of Brucella abortus strain RB51: serology, clearance and efficacy","volume":"66","author":"Olsen","year":"1999","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetimm.2005.02.023_bib29","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2460\/ajvr.1999.60.07.905","article-title":"Biosafety and antibody responses of adult bison bulls after vaccination with Brucella abortus strain RB51","volume":"60","author":"Olsen","year":"1999","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2005.02.023_bib30","first-page":"183","article-title":"Immune responses and efficacy after administration of a commercial Brucella abortus strain vaccine to cattle","volume":"1","author":"Olsen","year":"2000","journal-title":"Vet. Therapeutics"},{"key":"10.1016\/j.vetimm.2005.02.023_bib31","doi-asserted-by":"crossref","first-page":"746","DOI":"10.7589\/0090-3558-38.4.746","article-title":"Immune responses of elk to vaccination with Brucella abortus strain RB51","volume":"38","author":"Olsen","year":"2002","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.vetimm.2005.02.023_bib32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0034-5288(02)00146-7","article-title":"Efficacy of calfhood vaccination with Brucella abortus strain RB51 in protecting bison against brucellosis","volume":"74","author":"Olsen","year":"2003","journal-title":"Res. Vet. Sci."},{"issue":"6","key":"10.1016\/j.vetimm.2005.02.023_bib33","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1177\/030098589603300607","article-title":"Experimental infection of pregnant cattle with the vaccine candidate Brucella abortus strain RB51: pathologic, bacteriologic and serologic findings","volume":"33","author":"Palmer","year":"1996","journal-title":"Vet. Pathol."},{"issue":"2","key":"10.1016\/j.vetimm.2005.02.023_bib34","first-page":"491","article-title":"Effect of exogenous interleukin-18 (IL-18) and IL-12 in the course of Brucella abortus 2308 infection in mice","volume":"9","author":"Pasquali","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"issue":"8","key":"10.1016\/j.vetimm.2005.02.023_bib35","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/vr.145.8.214","article-title":"Diagnosis of bovine brucellosis by skin test: conditions for the test and evaluation of its performance","volume":"145","author":"Saegerman","year":"1999","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetimm.2005.02.023_bib36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-1135(91)90091-S","article-title":"Biological properties of RB51; a stable rough strain of Brucella abortus","volume":"28","author":"Schurig","year":"1991","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2005.02.023_bib37","article-title":"Physiological responses and adaptation of water buffalo","volume":"vol. 2","author":"Shafie","year":"1985"},{"key":"10.1016\/j.vetimm.2005.02.023_bib38","series-title":"Veterinary Clinical Epidemiology","first-page":"234","year":"1991"},{"key":"10.1016\/j.vetimm.2005.02.023_bib39","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1128\/JCM.32.4.1065-1066.1994","article-title":"Serologic responses in diagnostic tests for brucellosis in cattle vaccinated with Brucella abortus 19 or RB51","volume":"32","author":"Stevens","year":"1994","journal-title":"J. Clin. Microbiol."},{"issue":"3\u20134","key":"10.1016\/j.vetimm.2005.02.023_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0165-2427(94)05311-F","article-title":"Comparative analysis of immune responses in cattle vaccinated with Brucella abortus strain 19 or strain RB51","volume":"44","author":"Stevens","year":"1995","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2005.02.023_bib41","first-page":"766","article-title":"Brucella abortus strain RB51: a new brucellosis vaccine for cattle","volume":"19","author":"Stevens","year":"1997","journal-title":"Compend. Continuing Edu. Pract. Veterinarian"},{"issue":"3","key":"10.1016\/j.vetimm.2005.02.023_bib42","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1128\/JCM.33.3.706-712.1995","article-title":"Specific bovine brucellosis diagnosis based on in vitro antigen-specific gamma interferon production","volume":"33","author":"Weynants","year":"1995","journal-title":"J. Clin. Microbiol."},{"issue":"3\u20134","key":"10.1016\/j.vetimm.2005.02.023_bib43","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0165-2427(98)00205-0","article-title":"Quantitative assessment by flow cytometry of T-lymphocytes producing antigen-specific gamma-interferon in Brucella immune cattle","volume":"66","author":"Weynants","year":"1998","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2005.02.023_bib44","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/clinids\/21.2.283","article-title":"An overview of human brucellosis","volume":"5","author":"Young","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.vetimm.2005.02.023_bib45","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1128\/IAI.64.7.2782-2786.1996","article-title":"Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms","volume":"64","author":"Zhan","year":"1996","journal-title":"Infect. Immun."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242705000991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242705000991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T23:03:16Z","timestamp":1706137396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242705000991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":45,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0165242705000991"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2005.02.023","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}