{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:42:22Z","timestamp":1791337342320,"version":"4.3.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.vetimm.2010.04.003","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T04:26:12Z","timestamp":1271219172000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anti-TNF-\u03b1 therapy does not ameliorate disease in a model of acute virus-endotoxin mediated respiratory disease in pigs"],"prefix":"10.1016","volume":"137","author":[{"given":"Kalina","family":"Atanasova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Van Gucht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristien","family":"Van Reeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2010.04.003_bib1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.micinf.2004.02.012","article-title":"What kind of message does IL-12\/IL-23 bring to macrophages and dendritic cells?","volume":"6","author":"Bastos","year":"2004","journal-title":"Microbes Infect."},{"key":"10.1016\/j.vetimm.2010.04.003_bib2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/sj.bjp.0706979","article-title":"Effects of etanercept, a tumour necrosis factor-alpha antagonist, in an experimental model of periodontitis in rats","volume":"150","author":"Di Paola","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vetimm.2010.04.003_bib3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7150\/ijms.5.169","article-title":"Infliximab and etanercept are equally effective in reducing enterocyte APOPTOSIS in experimental colitis","volume":"5","author":"Fries","year":"2008","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.vetimm.2010.04.003_bib4","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/eji.1830181010","article-title":"Functional discrimination between interleukin 6 and interleukin 1","volume":"18","author":"Helle","year":"1988","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.vetimm.2010.04.003_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1529-8019.2007.00138.x","article-title":"TNF-alpha inhibitors","volume":"20","author":"Jackson","year":"2007","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.vetimm.2010.04.003_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1135(02)00104-9","article-title":"Porcine reproductive-respiratory syndrome virus infection predisposes pigs for respiratory signs upon exposure to bacterial lipopolysaccharide","volume":"88","author":"Labarque","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2010.04.003_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1465-9921-7-125","article-title":"Role of TNF-alpha in pulmonary pathophysiology","volume":"7","author":"Mukhopadhyay","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.vetimm.2010.04.003_bib8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1089\/jir.2006.26.661","article-title":"Etanercept reduces late endotoxin-induced pulmonary hypertension in the pig","volume":"26","author":"Mutschler","year":"2006","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.vetimm.2010.04.003_bib9","doi-asserted-by":"crossref","DOI":"10.1089\/jir.2009.0035","article-title":"Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swine","volume":"29","author":"Niemann","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.vetimm.2010.04.003_bib10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cytogfr.2004.03.009","article-title":"The role of IL-12, IL-23 and IFN-gamma in immunity to viruses","volume":"15","author":"Novelli","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.vetimm.2010.04.003_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/mpat.1995.0056","article-title":"Tumor necrosis factor as a mediator of inflammation in influenza A viral pneumonia","volume":"19","author":"Peper","year":"1995","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetimm.2010.04.003_bib12","first-page":"560","article-title":"Blocking TNF-\u03b1 in mice reduces colorectal carcinogenesis associated with chronic colitis","volume":"118","author":"Popivanova","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vetimm.2010.04.003_bib13","first-page":"493","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"key":"10.1016\/j.vetimm.2010.04.003_bib14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s003900050238","article-title":"Cytokines and host defense in pneumonia","volume":"36","author":"Schultz","year":"1999","journal-title":"Intensivmedicine"},{"key":"10.1016\/j.vetimm.2010.04.003_bib15","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1128\/JCM.41.3.960-966.2003","article-title":"Interaction between porcine reproductive-respiratory syndrome virus and bacterial endotoxin in the lungs of pigs: potentiation of cytokine production and respiratory disease","volume":"41","author":"Van Gucht","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetimm.2010.04.003_bib16","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.micinf.2006.01.009","article-title":"Effect of porcine respiratory coronavirus infection on lipopolysaccharide recognition proteins and haptoglobin levels in the lungs","volume":"8","author":"Van Gucht","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.vetimm.2010.04.003_bib17","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2460\/ajvr.1994.55.09.1275","article-title":"Porcine respiratory coronavirus-mediated interference against influenza virus replication in the respiratory tract of feeder pigs","volume":"55","author":"Van Reeth","year":"1994","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2010.04.003_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/rvsc.1998.0277","article-title":"Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity","volume":"67","author":"Van Reeth","year":"1999","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetimm.2010.04.003_bib19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1099\/0022-1317-49-7-613","article-title":"A potential role for tumour necrosis factor-alpha in synergy between porcine respiratory coronavirus and bacterial lipopolysaccharide in the induction of respiratory disease in pigs","volume":"49","author":"Van Reeth","year":"2000","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.vetimm.2010.04.003_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00211.x","article-title":"Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4","volume":"202","author":"Watford","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetimm.2010.04.003_bib21","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/SHK.0b013e31817d42dd","article-title":"Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury","volume":"31","author":"Wolthuis","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.vetimm.2010.04.003_bib22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/00029330-200804010-00005","article-title":"Inhibition of tumor necrosis factor-alpha reduces alveolar septal cell apoptosis in passive smoking rats","volume":"121","author":"Zhang","year":"2008","journal-title":"Chin. Med. J."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242710001182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242710001182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:20:32Z","timestamp":1759044032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242710001182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":22,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0165242710001182"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2010.04.003","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-TNF-\u03b1 therapy does not ameliorate disease in a model of acute virus-endotoxin mediated respiratory disease in pigs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2010.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}