{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:53:07Z","timestamp":1782409987557,"version":"3.54.5"},"reference-count":21,"publisher":"Elsevier BV","issue":"2-4","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.vetimm.2010.08.007","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T09:48:23Z","timestamp":1282902503000},"page":"245-249","source":"Crossref","is-referenced-by-count":22,"title":["A preliminary study to understand the effect of Fasciola hepatica tegument on na\u00efve macrophages and humoral responses in an ovine model"],"prefix":"10.1016","volume":"139","author":[{"given":"O.","family":"Ha\u00e7ar\u0131z","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sayers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mulcahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2010.08.007_bib0005","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1128\/IAI.67.10.5372-5378.1999","article-title":"Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis","volume":"67","author":"Brady","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0010","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1074\/jbc.M308831200","article-title":"Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells","volume":"279","author":"Collins","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0015","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1128\/IAI.64.12.5066-5074.1996","article-title":"Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin","volume":"64","author":"Dalton","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0020","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1128\/IAI.73.1.166-173.2005","article-title":"Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages","volume":"73","author":"Donnelly","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0025","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1096\/fj.08-106278","article-title":"Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages","volume":"22","author":"Donnelly","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0030","series-title":"Fasciolosis","first-page":"47","article-title":"Development of Fasciola hepatica in the mammalian host","author":"Fairweather","year":"1999"},{"key":"10.1016\/j.vetimm.2010.08.007_bib0035","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1128\/IAI.01445-06","article-title":"Experimental Fasciola hepatica infection alters responses to tests used for diagnosis of bovine tuberculosis","volume":"75","author":"Flynn","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.vetimm.2007.07.003","article-title":"Alternative activation of ruminant macrophages by Fasciola hepatica","volume":"120","author":"Flynn","year":"2007","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0045","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1128\/IAI.00732-07","article-title":"Possible role for Toll-like receptors in interaction of Fasciola hepatica excretory\/secretory products with bovine macrophages","volume":"76","author":"Flynn","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0110","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1016\/j.vaccine.2010.06.039","article-title":"Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1)","volume":"28","author":"Golden","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vetimm.2010.08.007_bib0055","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vaccine.2008.10.035","article-title":"The effect of Quil A adjuvant on the course of experimental Fasciola hepatica infection in sheep","volume":"27","author":"Ha\u00e7ar\u0131z","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vetimm.2010.08.007_bib0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1365-3024.2009.01135.x","article-title":"IL-10 and TGF-\u03b21 are associated with variations in fluke burdens following experimental fasciolosis in sheep","volume":"31","author":"Ha\u00e7ar\u0131z","year":"2009","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0065","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/JCM.12.5.695-699.1980","article-title":"Isolation of Fasciola hepatica tegument antigens","volume":"12","author":"Hillyer","year":"1980","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0070","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.coi.2007.07.002","article-title":"Alternatively activated macrophages in helminth infections","volume":"19","author":"Kreider","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0075","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1074\/mcp.M600375-MCP200","article-title":"Comparative proteomics of excretory\u2013secretory proteins released by the liver fluke Fasciola hepatica in sheep host bile and during in vitro culture ex host","volume":"6","author":"Morphew","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.vetimm.2010.08.007_bib0080","series-title":"Fasciolosis","first-page":"341","article-title":"Immunology of Fasciola hepatica infection","author":"Mulcahy","year":"1999"},{"key":"10.1016\/j.vetimm.2010.08.007_bib0085","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1128\/IAI.73.6.3251-3260.2005","article-title":"Changes in lipopolysaccharide O antigen distinguish acute versus chronic Leptospira interrogans infections","volume":"73","author":"Nally","year":"2005","journal-title":"Infect. Immun."},{"issue":"Suppl. 1","key":"10.1016\/j.vetimm.2010.08.007_bib0090","doi-asserted-by":"crossref","first-page":"S226","DOI":"10.1002\/pmic.200500420","article-title":"Proteomic analysis of the tegument and excretory\u2013secretory products of adult Schistosoma bovis worms","volume":"6","author":"P\u00e9rez-S\u00e1nchez","year":"2006","journal-title":"Proteomics"},{"issue":"Pt. 3","key":"10.1016\/j.vetimm.2010.08.007_bib0095","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S0031182000081877","article-title":"Glycans with N-acetyllactosamine type 2-like residues covering adult Schistosoma mansoni, and glycomimesis as a putative mechanism of immune evasion","volume":"111","author":"Schmidt","year":"1995","journal-title":"Parasitology"},{"key":"10.1016\/j.vetimm.2010.08.007_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-6851(93)90171-S","article-title":"Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica","volume":"62","author":"Smith","year":"1993","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetimm.2010.08.007_bib0105","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0003-2697(84)90782-6","article-title":"A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids","volume":"138","author":"Wessel","year":"1984","journal-title":"Anal. Biochem."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242710002850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242710002850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:07:39Z","timestamp":1591834059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242710002850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":21,"journal-issue":{"issue":"2-4","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0165242710002850"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2010.08.007","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}