{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T01:08:01Z","timestamp":1775956081727,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.vetimm.2012.05.007","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T22:16:46Z","timestamp":1336688206000},"page":"260-266","source":"Crossref","is-referenced-by-count":17,"title":["Canine cerebral leishmaniasis: Potential role of matrix metalloproteinase-2 in the development of neurological disease"],"prefix":"10.1016","volume":"148","author":[{"given":"Guilherme D.","family":"Melo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Marcondes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele F.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2012.05.007_bib0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.semcdb.2007.06.003","article-title":"MMPs in the central nervous system: where the good guys go bad","volume":"19","author":"Agrawal","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0010","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pt.2008.04.001","article-title":"Canine leishmaniasis \u2013 new concepts and insights on an expanding zoonosis. Part one","volume":"24","author":"Baneth","year":"2008","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0015","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.2460\/ajvr.2002.63.1359","article-title":"Characterization of matrix metalloproteinase-2 and -9 in cerebrospinal fluid of clinically normal dogs","volume":"63","author":"Bergman","year":"2002","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0167-4838(99)00279-4","article-title":"Tissue inhibitors of metalloproteinases: evolution, structure and function","volume":"1477","author":"Brew","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vetimm.2012.05.007_bib0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/1531-8249(199909)46:3<391::AID-ANA15>3.0.CO;2-0","article-title":"Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia","volume":"46","author":"Conant","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0030","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1128\/IAI.71.10.5739-5749.2003","article-title":"gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection","volume":"71","author":"Cuevas","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tvjl.2007.11.024","article-title":"The function, composition and analysis of cerebrospinal fluid in companion animals. Part II. Analysis","volume":"180","author":"Di Terlizzi","year":"2009","journal-title":"Vet. J."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0040","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.febslet.2004.03.070","article-title":"Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain","volume":"567","author":"Dzwonek","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2249.2005.02840.x","article-title":"The paradox of matrix metalloproteinases in infectious disease","volume":"142","author":"Elkington","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0050","first-page":"61","article-title":"Cerebrospinal fluid (CSF) evaluation in dogs naturally infected with visceral leishmaniasis, with and without neurological symptoms","volume":"11","author":"Feitosa","year":"2005","journal-title":"Vet. Not."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0055","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1365-3024.1996.d01-28.x","article-title":"Presence of antibodies in the aqueous humour and cerebrospinal fluid during Leishmania infections in dogs. Pathological features at the central nervous system","volume":"18","author":"Garcia-Alonso","year":"1996","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0060","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1371\/journal.ppat.0030150","article-title":"A function for a specific zinc metalloprotease of African trypanosomes","volume":"3","author":"Grandgenett","year":"2007","journal-title":"PLoS Pathol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0065","doi-asserted-by":"crossref","first-page":"5","DOI":"10.11606\/issn.1678-4456.bjvras.2007.26653","article-title":"Histological and immunohistochemical study of the central nervous system of dogs naturally infected by Leishmania (Leishmania) chagasi","volume":"44","author":"Ikeda","year":"2007","journal-title":"Braz. J. Vet. Res. Anim. Sci."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0070","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/abio.1994.1186","article-title":"Quantitative zymography: detection of picogram quantities of gelatinases","volume":"218","author":"Kleiner","year":"1994","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0075","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1128\/IAI.01542-08","article-title":"Trypanosoma cruzi gp63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection","volume":"77","author":"Kulkarni","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0080","first-page":"215","article-title":"Serological diagnosis of visceral leishmaniasis by an enzyme immunoassay using protein A in naturally infected dogs","volume":"25","author":"Lima","year":"2005","journal-title":"Braz. J. Vet. Res. Anim. Sci."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0085","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1590\/S0100-879X2003000400010","article-title":"Anti-Leishmania antibodies in cerebrospinal fluid from dogs with visceral leishmaniasis","volume":"36","author":"Lima","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0090","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.vetimm.2010.03.024","article-title":"Differential alterations in the activity of matrix metalloproteinases within the nervous tissue of dogs in distinct manifestations of visceral leishmaniasis","volume":"136","author":"Machado","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0009-8981(03)00015-9","article-title":"Zymographic analysis of latent and activated forms of matrix metalloproteinase-2 and -9 in synovial fluid: correlation to polymorphonuclear leukocyte infiltration and in response to infection","volume":"329","author":"Makowski","year":"2003","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.vetimm.2012.05.007_bib0100","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/0035-9203(88)90510-X","article-title":"Studies on canine leishmaniasis control. 1. Evolution of infection of different clinical forms of canine leishmaniasis following antimonial treatment","volume":"82","author":"Mancianti","year":"1988","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0105","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-3024.2011.01285.x","article-title":"Levels of matrix metalloproteinase-2 and -9 in the cerebrospinal fluid of dogs with visceral leishmaniasis","volume":"33","author":"Marangoni","year":"2011","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0110","first-page":"20","article-title":"Evaluation of serum proteinogram of dogs naturally infected with Leishmania chagasi with and without neurological symptoms","volume":"13","author":"Marcondes","year":"2006","journal-title":"Rev. Bras. Cienc. Vet."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0115","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-3940(98)00674-0","article-title":"Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains","volume":"254","author":"Marshall","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0120","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.molmed.2007.09.001","article-title":"Matrix metalloproteinase dysregulation in HIV infection: implications for therapeutic strategies","volume":"13","author":"Mastroianni","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0125","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/IAI.71.2.1008-1010.2003","article-title":"Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63","volume":"71","author":"McGwire","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0130","first-page":"69","article-title":"Choroid plexus involvement in dogs with spontaneous visceral leishmaniasis: a histopathological investigation","volume":"2","author":"Melo","year":"2009","journal-title":"Braz. J. Vet. Pathol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0135","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.vetpar.2009.03.002","article-title":"Leukocyte entry into the CNS of Leishmania chagasi naturally infected dogs","volume":"162","author":"Melo","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00441-011-1290-7","article-title":"Glial reactivity in dogs with visceral leishmaniasis: correlation with T lymphocyte infiltration and with cerebrospinal fluid anti-Leishmania antibody titres","volume":"346","author":"Melo","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0145","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tvjl.2010.03.017","article-title":"High levels of serum matrix metalloproteinases in dogs with natural visceral leishmaniasis: a preliminary report","volume":"188","author":"Melo","year":"2011","journal-title":"Vet. J."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0150","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1152\/ajpregu.1998.274.5.R1203","article-title":"Gelatinase B modulates selective opening of the blood\u2013brain barrier during inflammation","volume":"274","author":"Mun-Bryce","year":"1998","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0155","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0160","first-page":"16","article-title":"Canine leishmaniasis","volume":"9","author":"Noli","year":"1999","journal-title":"Waltham Focus"},{"key":"10.1016\/j.vetimm.2012.05.007_bib0165","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1471-4906(01)02023-3","article-title":"Gelatinase B: a tuner and amplifier of immune functions","volume":"22","author":"Opdenakker","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0170","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodeling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0175","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jneuroim.2009.09.016","article-title":"Polyclonal immunoglobulins (IVIg) induce expression of MMP-9 in microglia","volume":"217","author":"Pul","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0180","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bcp.2007.07.004","article-title":"Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease","volume":"75","author":"Raffetto","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0185","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1016\/j.vaccine.2008.09.005","article-title":"Comparison of the immunomodulatory effects of L. donovani and L. major excreted-secreted antigens, particulate and soluble extracts and viable parasites on human dendritic cells","volume":"26","author":"Revest","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vetimm.2012.05.007_bib0190","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/glia.10108","article-title":"Matrix metalloproteinases in neuroinflammation","volume":"39","author":"Rosenberg","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.vetimm.2012.05.007_bib0195","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1161\/01.STR.29.10.2189","article-title":"Matrix metalloproteinases and TIMPs are associated with blood\u2013brain barrier opening after reperfusion in rat brain","volume":"29","author":"Rosenberg","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.vetimm.2012.05.007_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2007\/85154","article-title":"Immune response regulation by Leishmania secreted and nonsecreted antigens","volume":"2007","author":"Santar\u00e9m","year":"2007","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0205","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.nbd.2005.09.007","article-title":"In bacterial meningitis cortical brain damage is associated with changes in parenchymal MMP-9\/TIMP-1 ratio and increased collagen type IV degradation","volume":"21","author":"Sellner","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0210","series-title":"Clinical Microbiology and Infectious Diseases of the Dog and Cat","first-page":"450","article-title":"Leishmaniasis","author":"Slappendel","year":"1998"},{"key":"10.1016\/j.vetimm.2012.05.007_bib0215","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/jnen\/62.12.1254","article-title":"Pro-inflammatory cytokines modulate matrix metalloproteinase secretion and organic anion transport at the blood\u2013cerebrospinal fluid barrier","volume":"62","author":"Strazielle","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0225","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cca.2008.02.023","article-title":"Preanalytical factors affecting the stability of matrix metalloproteinase-2 concentrations in cerebrospinal fluid","volume":"392","author":"Sulik","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.vetimm.2012.05.007_bib0230","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/labinvest.3700454","article-title":"Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria","volume":"86","author":"Van den Steen","year":"2006","journal-title":"Lab. Invest."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0235","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0240","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1189\/jlb.0306152","article-title":"Matrix metalloproteinases, their production by monocytes and macrophages and their potential role in HIV-related diseases","volume":"80","author":"Webster","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0245","doi-asserted-by":"crossref","first-page":"17119","DOI":"10.1074\/jbc.271.29.17119","article-title":"The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase a and initiates autoproteolytic activation","volume":"271","author":"Will","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2012.05.007_bib0250","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0166-2236(97)01169-7","article-title":"Matrix metalloproteinases and diseases of the CNS","volume":"21","author":"Yong","year":"1998","journal-title":"Trends Neurosci."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242712001559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242712001559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T10:32:34Z","timestamp":1561717954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242712001559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":49,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0165242712001559"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2012.05.007","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}