{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:50:36Z","timestamp":1762375836334},"reference-count":32,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.vetimm.2014.05.007","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T18:46:33Z","timestamp":1400697993000},"page":"230-234","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Polymorphisms at the 3\u2032 untranslated region of SLC11A1 gene are associated with protection to Brucella infection in goats"],"prefix":"10.1016","volume":"160","author":[{"given":"Paola A.","family":"Iacoboni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia C.","family":"Hasenauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eugenia","family":"Caffaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Analia","family":"Gaido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Rossetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto D.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Salatin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Bertoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario A.","family":"Poli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2014.05.007_bib0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1874318801004010061","article-title":"Natural resistance against brucellosis: a review","volume":"4","author":"Adams","year":"2010","journal-title":"Open Vet. Sci. J."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0010","series-title":"Animal Brucellosis","first-page":"383","article-title":"Brucella melitensis","author":"Alton","year":"1990"},{"key":"10.1016\/j.vetimm.2014.05.007_bib0015","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1128\/IAI.69.5.3110-3119.2001","article-title":"Stable transfection of the bovine NRAMP1 gene into murine RAW264.7 cells: effect on Brucella abortus survival","volume":"69","author":"Barthel","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0020","first-page":"145","article-title":"Control and eradication strategies for brucella melitensis infection in sheep and goats","volume":"31","author":"Blasco","year":"2010","journal-title":"Prilozi"},{"key":"10.1016\/j.vetimm.2014.05.007_bib0025","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1128\/IAI.74.4.2115-2120.2006","article-title":"Genetic resistance to Brucella abortus in the water buffalo (Bubalus bubalis)","volume":"74","author":"Borriello","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0030","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1128\/IAI.00948-06","article-title":"Protective effect of the Nramp1 BB genotype against Brucella abortus in the water buffalo (Bubalus bubalis)","volume":"75","author":"Capparelli","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00335-006-0103-x","article-title":"The Nramp1AA genotype confers susceptibility to Brucella abortus in water buffalo","volume":"18","author":"Capparelli","year":"2007","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.vetimm.2014.05.007_bib0040","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0378-1135(02)00223-7","article-title":"The innate immune response against Brucella in humans","volume":"90","author":"Dornand","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0045","series-title":"Animal Production and Health Proceedings. No. 10","first-page":"57","article-title":"Brucella melitensis en Eurasia and the Middle East","author":"FAO","year":"2010"},{"key":"10.1016\/j.vetimm.2014.05.007_bib0050","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1128\/IAI.63.3.1130-1133.1995","article-title":"Interleukin 10 down-regulates protective immunity to Brucella abortus","volume":"63","author":"Fern\u00e1ndez","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0055","series-title":"Brucellosis 2011: International Research Conference","article-title":"Goat brucellosis: a serological study in flocks from the east of Salta, Argentina","author":"Gaido","year":"2011"},{"key":"10.1016\/j.vetimm.2014.05.007_bib0060","doi-asserted-by":"crossref","first-page":"989","DOI":"10.20506\/rst.23.3.1545","article-title":"Serological diagnosis of bovine brucellosis: a review of test performance and cost comparison","volume":"23","author":"Gall","year":"2004","journal-title":"Rev. Sci. Tech."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0065","first-page":"95","article-title":"Bioedit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"Hall","year":"1999","journal-title":"Nucleic Acids Sympos."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0070","series-title":"Genetic control of host resistance to infection and malignancy","first-page":"345","article-title":"Macrophage function and immune response of naturally resistant and susceptible cattle to B. abortus","author":"Harmon","year":"1985"},{"key":"10.1016\/j.vetimm.2014.05.007_bib0075","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11033-012-2091-0","article-title":"Genetic analysis of the 3\u2032 untranslated region of the bovine SLC11A1 gene reveals novel polymorphisms","volume":"40","author":"Hasenauer","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0080","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-2052.2011.02203.x","article-title":"Polymorphisms of the SLC11A1 gene and resistance to bovine tuberculosis in African Zebu cattle","volume":"42","author":"Kadarmideen","year":"2011","journal-title":"Anim. Genet."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0085","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.vetmic.2010.01.009","article-title":"Investigation of the association of the SLC11A1 gene with resistance\/sensitivity of goats (Capra hircus) to paratuberculosis","volume":"144","author":"Korou","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0090","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1590\/S1415-47572010000300014","article-title":"Effect of polymorphisms in the Slc11a1 coding region on resistance to brucellosis by macrophages in vitro and after challenge in two Bos breeds (Blanco Orejinegro and Zebu)","volume":"33","author":"Martinez","year":"2010","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1439-0388.2008.00727.x","article-title":"Bovine SLC11A1 3\u2032 UTR SSCP genotype evaluated by a macrophage in vitro killing assay employing a Brucella abortus strain","volume":"125","author":"Martinez","year":"2008","journal-title":"J. Anim. Breed. Genet."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0100","volume":"vol. 2","author":"OIE (World Organisation for Animal Health)","year":"2008"},{"key":"10.1016\/j.vetimm.2014.05.007_bib0105","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0378-1135(02)00225-0","article-title":"Molecular and cellular interaction between Brucella abortus antigens and host immune responses","volume":"90","author":"Oliveira","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0110","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1590\/S0102-09352012000400041","article-title":"Polymorphisms of the coding region of Slc11a1 (Nramp1) gene associated to natural resistance against bovine brucellosis","volume":"64","author":"Paixao","year":"2012","journal-title":"Arq. Bras. Med. Vet. Zootec."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0115","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.prevetmed.2009.05.020","article-title":"Candidate gene polymorphisms (BoIFNG, TLR4, SLC11A1) as risk factors for paratuberculosis infection in cattle","volume":"91","author":"Pinedo","year":"2009","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0120","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1751-0813.2005.tb13087.x","article-title":"A preliminary study of possible genetic influences on the susceptibility of sheep to Johne's disease","volume":"83","author":"Reddacliff","year":"2005","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0125","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1128\/IAI.00203-08","article-title":"Inactivation of the type IV secretion system reduces the Th1 polarization of the immune response to Brucella abortus infection","volume":"76","author":"Rol\u00e1n","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.rvsc.2010.09.002","article-title":"Comparative analysis of the early transcriptome of Brucella abortus-infected monocyte-derived macrophages from cattle naturally resistant or susceptible to brucellosis","volume":"91","author":"Rossetti","year":"2011","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0135","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0140","series-title":"Manual de Diagnostico Serologico de Brucelosis Bovina","first-page":"95","author":"SENASA","year":"2009"},{"key":"10.1016\/j.vetimm.2014.05.007_bib0145","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1128\/IAI.66.5.1910-1917.1998","article-title":"Genetic control of immune response to recombinant antigens carried by an attenuated Salmonella typhimurium vaccine strain: Nramp1 influences T-helper subset responses and protection against leishmanial challenge","volume":"66","author":"Soo","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0150","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.meegid.2013.03.033","article-title":"In vitro expression of the SLC11A1 gene in goat monocyte-derived macrophages challenged with Mycobacterium avium subsp paratuberculosis","volume":"17","author":"Taka","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0155","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tvjl.2010.09.028","article-title":"Chromosomal localisation and genetic variation of the SLC11A1 gene in goats (Capra hircus)","volume":"190","author":"Vacca","year":"2011","journal-title":"Vet. J."},{"key":"10.1016\/j.vetimm.2014.05.007_bib0160","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1111\/j.1462-5822.2008.01155.x","article-title":"Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection","volume":"10","author":"Valdez","year":"2008","journal-title":"Cell. Microbiol."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242714001202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242714001202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T19:30:41Z","timestamp":1597865441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242714001202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":32,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0165242714001202"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2014.05.007","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymorphisms at the 3\u2032 untranslated region of SLC11A1 gene are associated with protection to Brucella infection in goats","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2014.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}