{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:31:34Z","timestamp":1782498694039,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000106","name":"Saskatchewan Health Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000106","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.vetimm.2015.06.003","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T17:07:52Z","timestamp":1434301672000},"page":"95-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Porcine retinal cell line VIDO R1 and Chlamydia suis to modelize ocular chlamydiosis"],"prefix":"10.1016","volume":"166","author":[{"given":"Tobias","family":"K\u00e4ser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cnudde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-131X","authenticated-orcid":false,"given":"Glenn","family":"Hamonic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghanne","family":"Rieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alex","family":"Pasternak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh K.","family":"Tikoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-0901","authenticated-orcid":false,"given":"Heather L.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Meurens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 3a","key":"10.1016\/j.vetimm.2015.06.003_bib0005","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/eye.1998.104","article-title":"Immunopathogenesis of conjunctival scarring in trachoma","volume":"12","author":"Abu el-Asrar","year":"1998","journal-title":"Eye"},{"key":"10.1016\/j.vetimm.2015.06.003_bib0010","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1067\/mob.2002.126850","article-title":"Chlamydia trachomatis enhances the expression of matrix metalloproteinases in an in vitro model of the human fallopian tube infection","volume":"187","author":"Ault","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0015","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tim.2014.04.013","article-title":"Chlamydia genomics: providing novel insights into chlamydial biology","volume":"22","author":"Bachmann","year":"2014","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1469-0691.2008.02669.x","article-title":"Zoonotic Chlamydophila psittaci infections from a clinical perspective","volume":"15","author":"Beeckman","year":"2009","journal-title":"Clin. Microbiol. Infect.: Off. Publ. Eur. Soc. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0255","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.dci.2009.12.017","article-title":"Epithelial induction of porcine suppressor of cytokine signaling 2 (SOCS2) gene expression in response to Entamoeba histolytica","volume":"34","author":"Bruel","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nri1551","article-title":"Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine","volume":"5","author":"Brunham","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0040","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1128\/IAI.05718-11","article-title":"Active trachoma is associated with increased conjunctival expression of IL17A and profibrotic cytokines","volume":"79","author":"Burton","year":"2011","journal-title":"Infect. Immun."},{"issue":"Suppl. 2","key":"10.1016\/j.vetimm.2015.06.003_bib0045","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1086\/652397","article-title":"Pathogenesis of genital tract disease due to Chlamydia trachomatis","volume":"201","author":"Darville","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0050","series-title":"The Minipig in Biomedical Research","first-page":"323","article-title":"A comparative assessment of the pig, mouse, and human genomes: structural and functional analysis of genes involved in immunity and inflammation","author":"Dawson","year":"2011"},{"key":"10.1016\/j.vetimm.2015.06.003_bib0055","doi-asserted-by":"crossref","first-page":"e96704","DOI":"10.1371\/journal.pone.0096704","article-title":"Development and validation of a real-time PCR for Chlamydia suis diagnosis in swine and humans","volume":"9","author":"De Puysseleyr","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vetimm.2015.06.003_bib0060","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.vetimm.2011.08.002","article-title":"Expression of SOCS1-7 and CIS mRNA in porcine tissues","volume":"144","author":"Delgado-Ortega","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0260","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.vetmic.2013.11.037","article-title":"In vitro and ex vivo analyses of co-infections with swine influenza and porcine reproductive and respiratory syndrome viruses","volume":"169","author":"Dobrescu","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1472-6750-6-41","article-title":"Development of a new set of reference genes for normalization of real-time RT-PCR data of porcine backfat and longissimus dorsi muscle, and evaluation with PPARGC1A","volume":"6","author":"Erkens","year":"2006","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0070","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2249.2005.02917.x","article-title":"Temporal cytokine gene expression patterns in subjects with trachoma identify distinct conjunctival responses associated with infection","volume":"142","author":"Faal","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/dmm.004861","article-title":"Primates as a model for research","volume":"3","author":"Garbarini","year":"2010","journal-title":"Dis. Models Mech."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0085","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1038\/ncomms6201","article-title":"Chlamydia infection depends on a functional MDM2-p53 axis","volume":"5","author":"Gonzalez","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0090","first-page":"126","article-title":"A pig model of Acanthamoeba keratitis: transmission via contaminated contact lenses","volume":"33","author":"He","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0095","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1186\/gb-2007-8-2-r19","article-title":"qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data","volume":"8","author":"Hellemans","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0100","doi-asserted-by":"crossref","first-page":"e2020","DOI":"10.1371\/journal.pntd.0002020","article-title":"Trachoma: protective and pathogenic ocular immune responses to Chlamydia trachomatis","volume":"7","author":"Hu","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1128\/IAI.05965-11","article-title":"Innate immune responses and modified extracellular matrix regulation characterize bacterial infection and cellular\/connective tissue changes in scarring trachoma","volume":"80","author":"Hu","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0110","first-page":"355","article-title":"Untersuchungen \u00fcber das Vorkommen von Miyagawanellen beim Schwein","volume":"56","author":"K\u00f6lbl","year":"1969","journal-title":"Wiener tier\u00e4rztliche Wochenschrift"},{"key":"10.1016\/j.vetimm.2015.06.003_bib0115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.dci.2014.03.022","article-title":"The porcine innate immune system: an update","volume":"45","author":"Mair","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0120","series-title":"Virologische Arbeitsmethoden","author":"Mayr","year":"1974"},{"key":"10.1016\/j.vetimm.2015.06.003_bib0125","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0130","doi-asserted-by":"crossref","first-page":"e677","DOI":"10.1371\/journal.pone.0000677","article-title":"Commensal bacteria and expression of two major intestinal chemokines. TECK\/CCL25 and MEC\/CCL28, and their receptors","volume":"2","author":"Meurens","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vetimm.2015.06.003_bib0265","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1051\/vetres:2008043","article-title":"Early immune response following Salmonella enterica subspecies enterica serovar Typhimurium infection in porcine jejunal gut loops","volume":"40","author":"Meurens","year":"2009","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0270","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.molimm.2008.09.036","article-title":"Broad early immune response of porcine epithelial jejunal IPI-2I cells to Entamoeba histolytica","volume":"46","author":"Meurens","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0135","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tim.2011.11.002","article-title":"The pig: a model for human infectious diseases","volume":"20","author":"Meurens","year":"2012","journal-title":"Trends Microbiol."},{"issue":"Suppl. 2","key":"10.1016\/j.vetimm.2015.06.003_bib0140","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1086\/652393","article-title":"Duration of untreated chlamydial genital infection and factors associated with clearance: review of animal studies","volume":"201","author":"Miyairi","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0145","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1471-2350-10-138","article-title":"Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians","volume":"10","author":"Natividad","year":"2009","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-2199-8-67","article-title":"Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR","volume":"8","author":"Nygard","year":"2007","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0155","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1074\/jbc.M510182200","article-title":"Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen","volume":"281","author":"O\u2019Connell","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0160","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.4049\/jimmunol.1400120","article-title":"CD8+ T cells define an unexpected role in live-attenuated vaccine protective immunity against Chlamydia trachomatis infection in macaques","volume":"192","author":"Olivares-Zavaleta","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0165","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1128\/IAI.02764-14","article-title":"Transcriptional profiling of human epithelial cells infected with plasmid-bearing and plasmid-deficient Chlamydia trachomatis","volume":"83","author":"Porcella","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0175","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1172\/JCI119136","article-title":"Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis","volume":"99","author":"Rasmussen","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0275","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-3083.2011.02586.x","article-title":"Reverse transcription real-time PCR for detection of porcine interferon alpha and beta genes","volume":"74","author":"Razzuoli","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0180","doi-asserted-by":"crossref","first-page":"9137","DOI":"10.1128\/JVI.73.11.9137-9144.1999","article-title":"Replication-defective bovine adenovirus type 3 as an expression vector","volume":"73","author":"Reddy","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0190","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1297-9716-42-29","article-title":"Chlamydiaceae infections in pig","volume":"42","author":"Schautteet","year":"2011","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0195","doi-asserted-by":"crossref","DOI":"10.1002\/9780471729259.mc11a01s00","article-title":"Cultivation and laboratory maintenance of Chlamydia trachomatis","author":"Scidmore","year":"2005","journal-title":"Curr. Protoc. Microbiol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0200","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mcp.2014.01.006","article-title":"Chlamydia trachomatis infection increases the expression of inflammatory tumorigenic cytokines and chemokines as well as components of the Toll-like receptor and NF-kappaB pathways in human prostate epithelial cells","volume":"28","author":"Sellami","year":"2014","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.vetimm.2015.06.003_bib0205","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.1371\/journal.pntd.0000264","article-title":"Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease","volume":"2","author":"Skwor","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0215","doi-asserted-by":"crossref","first-page":"e1001605","DOI":"10.1371\/journal.pmed.1001605","article-title":"Effect of water, sanitation, and hygiene on the prevention of trachoma: a systematic review and meta-analysis","volume":"11","author":"Stocks","year":"2014","journal-title":"PLoS Med."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0220","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/0300985811402846","article-title":"Swine as models in biomedical research and toxicology testing","volume":"49","author":"Swindle","year":"2012","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0280","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.molimm.2007.09.029","article-title":"Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine","volume":"45","author":"Tohno","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0225","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0230","first-page":"105","article-title":"Diagnosis of avian chlamydiosis: specificity of the modified Gimenez staining on smears and comparison of the sensitivity of isolation in eggs and three different cell cultures","volume":"39","author":"Vanrompay","year":"1992","journal-title":"Zentralbl Veterinarmed B"},{"key":"10.1016\/j.vetimm.2015.06.003_bib0235","doi-asserted-by":"crossref","first-page":"8317","DOI":"10.1128\/IAI.73.12.8317-8321.2005","article-title":"Specific-pathogen-free pigs as an animal model for studying Chlamydia trachomatis genital infection","volume":"73","author":"Vanrompay","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0240","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s11259-007-3501-y","article-title":"Reactivity of equine airways \u2013 a study on precision-cut lung slices","volume":"31","author":"Vietmeier","year":"2007","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0245","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1444-0938.2007.00218.x","article-title":"Trachoma and poverty: unnecessary blindness further disadvantages the poorest people in the poorest countries","volume":"90","author":"Wright","year":"2007","journal-title":"Clin. Exp. Optom.: J. Aust. Optom. Assoc."},{"key":"10.1016\/j.vetimm.2015.06.003_bib0250","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1089\/cmb.2005.12.1047","article-title":"Comprehensive algorithm for quantitative real-time polymerase chain reaction","volume":"12","author":"Zhao","year":"2005","journal-title":"J. Comput. Biol."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242715001294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242715001294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T11:58:07Z","timestamp":1599134287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242715001294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":50,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0165242715001294"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2015.06.003","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porcine retinal cell line VIDO R1 and Chlamydia suis to modelize ocular chlamydiosis","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2015.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}