{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:22:29Z","timestamp":1777533749543,"version":"3.51.4"},"reference-count":81,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.vetimm.2015.09.014","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T00:57:01Z","timestamp":1443574621000},"page":"211-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation"],"prefix":"10.1016","volume":"168","author":[{"given":"Heidi","family":"Wyns","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Plessers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneleen","family":"Watteyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"van Bergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn","family":"Schauvliege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegrid","family":"De Baere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Devreese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"De Backer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siska","family":"Croubels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2015.09.014_bib0010","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1128\/AAC.35.10.2016","article-title":"Differential modulation of cytokine production by macrolides: interleukin-6 production is increased by spiramycin and erythromycin","volume":"35","author":"Bailly","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0015","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/BF00254925","article-title":"Role of thromboxane, prostaglandins and leukotrienes in endotoxic and septic shock","volume":"12","author":"Ball","year":"1986","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0020","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0167-5699(94)90137-6","article-title":"The acute phase response","volume":"15","author":"Baumann","year":"1994","journal-title":"Immunol. Today"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000014099","article-title":"Effects of dexamethasone on IL-1beta, IL-6, and TNF-alpha production by mononuclear cells of newborns and adults","volume":"75","author":"Bessler","year":"1999","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prostaglandins.2005.01.001","article-title":"Cytokines, PGE(2) and endotoxic fever: a re-assessment","volume":"76","author":"Blatteis","year":"2005","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0045","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.2527\/jas1988.6682084x","article-title":"Immunomodulation: a means of disease prevention in stressed livestock","volume":"66","author":"Blecha","year":"1988","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0060","doi-asserted-by":"crossref","first-page":"L146","DOI":"10.1152\/ajplung.1999.276.1.L146","article-title":"Pulmonary intravascular macrophages: their contribution to the mononuclear phagocyte system in 13 species","volume":"276","author":"Brain","year":"1999","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0070","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ijantimicag.2005.12.010","article-title":"Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes","volume":"27","author":"Cao","year":"2006","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0075","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.domaniend.2005.03.009","article-title":"Evaluation of the acute phase response in cloned pigs following a lipopolysaccharide challenge","volume":"29","author":"Carroll","year":"2005","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0080","doi-asserted-by":"crossref","first-page":"S506","DOI":"10.1097\/01.CCM.0000185502.21012.37","article-title":"Monocytes\/macrophages and sepsis","volume":"33","author":"Cavaillon","year":"2005","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0085","article-title":"Alfaxalone constant rate infusion in midazolam, morphine and ketamine premedicated pigs","author":"Cerasoli","year":"2014","journal-title":"Vet. Anaesth. Analg."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0095","first-page":"R527","article-title":"Multiple mechanisms mediate antipyretic action of glucocorticoids","volume":"269","author":"Coelho","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0105","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2741\/1341","article-title":"Cytokines and fever","volume":"9","author":"Conti","year":"2004","journal-title":"Front. Biosci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0003-2670(02)00753-5","article-title":"Recent developments in the use and abuse of growth promoters","volume":"473","author":"Courtheyn","year":"2002","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0115","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-2999(01)01321-8","article-title":"Anti-inflammatory effects of macrolide antibiotics","volume":"429","author":"\u010culi\u0107","year":"2001","journal-title":"Eur. J. Phar."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0120","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5326\/0410298","article-title":"Nonsteroidal antiinflammatory drugs: a review","volume":"41","author":"Curry","year":"2005","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0130","doi-asserted-by":"crossref","first-page":"321S","DOI":"10.1378\/chest.112.6_Supplement.321S","article-title":"Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock","volume":"112","author":"Dinarello","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0135","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1365-2885.2012.01396.x","article-title":"Effects of flunixin meglumine and ketoprofen on mediator production in ex vivo and in vitro models of inflammation in healthy dairy cows","volume":"36","author":"Donalisio","year":"2013","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0145","series-title":"Guideline for the Conduct of Efficacy Studies for Non-Steroidal Anti-Inflammatory Drugs. EMEA\/CVMP\/237\/01-FINAL","author":"EMA European Medicines Agency","year":"2001"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0150","series-title":"The European Agency for the Evaluation of Medicinal Products. Draxxin: EPAR \u2013 Product Information","author":"EMA European Medicines Agency","year":"2008"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0155","series-title":"The European Agency for the Evaluation of Medicinal Products. Zuprevo: EPAR \u2013 Product Information","author":"EMA European Medicines Agency","year":"2011"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0170","series-title":"Veterinary Pharmacology and Therapeutics","first-page":"771","article-title":"Glucocorticoids, mineralocorticoids, and adrenolytic drugs","author":"Ferguson","year":"2009"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0175","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0090-6980(80)90126-4","article-title":"The stability of 13,14-dihydro-15 keto-PGE2","volume":"19","author":"Fitzpatrick","year":"1980","journal-title":"Prostaglandins"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0180","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2885.2010.01236.x","article-title":"Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK\/PD modelling","volume":"34","author":"Fosse","year":"2011","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0185","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.2527\/2003.8151166x","article-title":"The effects of thermal environment and spray-dried plasma on the acute-phase response of pigs challenged with lipopolysaccharide","volume":"81","author":"Frank","year":"2003","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0195","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1136\/vr.159.17.552","article-title":"Clinical and anti-inflammatory effects of treating endotoxin-challenged pigs with meloxicam","volume":"159","author":"Friton","year":"2006","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0200","first-page":"85","article-title":"Repetitive intravenous catheterisation for pharmacokinetic studies in pigs","volume":"68","author":"Gasthuys","year":"1999","journal-title":"Vlaams Diergen. Tijds."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0205","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0022-3565(24)37889-9","article-title":"Differential contribution of R and S isomers in ketoprofen anti-inflammatory activity: role of cytokine modulation","volume":"287","author":"Ghezzi","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0210","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/AAC.33.3.277","article-title":"In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection","volume":"33","author":"Gladue","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0215","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0090-6980(80)90127-6","article-title":"Chemical instability of 15-keto-13,14-dihydro-PGE2: the reason for low assay reliability","volume":"19","author":"Granstr\u00f6m","year":"1980","journal-title":"Prostaglandins"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0225","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11908-007-0016-1","article-title":"Macrolide immunomodulation of chronic respiratory diseases","volume":"9","author":"Healy","year":"2007","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0230","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0305-0491(97)00362-3","article-title":"The porcine acute phase response to infection with Actinobacillus pleuropneumoniae. Haptoglobin, C-reactive protein, major acute phase protein and serum amyloid A protein are sensitive indicators of infection","volume":"119","author":"Heegaard","year":"1998","journal-title":"Comp. Biochem. Physiol. B: Biochem. Mol. Biol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0240","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2885.2009.01125.x","article-title":"Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity","volume":"33","author":"Huang","year":"2010","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0245","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0022-3565(24)35272-3","article-title":"Anti-inflammatory activity of macrolide antibiotics","volume":"292","author":"Ianaro","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0250","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.2741\/1383","article-title":"Prostaglandin E2 as a mediator of fever: synthesis and catabolism","volume":"9","author":"Ivanov","year":"2004","journal-title":"Front. Biosci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0260","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000107352","article-title":"Early effects of lipopolysaccharide on cytokine release, hemodynamic and renal function in newborn piglets","volume":"93","author":"John","year":"2008","journal-title":"Neonatology"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0265","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2527\/1994.722309x","article-title":"Lipopolysaccharide-induced sickness behavior in pigs is inhibited by pretreatment with indomethacin","volume":"72","author":"Johnson","year":"1994","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0270","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1128\/CMR.00078-09","article-title":"Mechanisms of action and clinical application of macrolides as immunomodulatory medications","volume":"23","author":"Kanoh","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0275","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0952-3278(92)90111-U","article-title":"The measurement of the main PGE metabolite, 13,14-dihydro-15-keto prostaglandin E by radioimmunoassay using methyl oxime stabilization","volume":"45","author":"Kelly","year":"1992","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0280","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/0006-2952(92)90167-H","article-title":"Time course of various inflammatory mediators during recurrent endotoxemia","volume":"43","author":"Klosterhalfen","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0295","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1016\/S0021-9258(18)60727-6","article-title":"Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression","volume":"263","author":"Kunkel","year":"1988","journal-title":"J. Biol. Chem."},{"issue":"Suppl. B","key":"10.1016\/j.vetimm.2015.09.014_bib0300","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jac\/41.suppl_2.37","article-title":"Anti-inflammatory activity of macrolides: a new therapeutic potential?","volume":"41","author":"Labro","year":"1998","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0310","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0739-7240(99)00064-8","article-title":"Physiological response to acute endotoxemia in swine: effect of genotype on energy metabolites and leptin","volume":"18","author":"Leininger","year":"2000","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0315","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1378\/chest.07-3056","article-title":"Effects of telithromycin in in vitro and in vivo models of lipopolysaccharide-induced airway inflammation","volume":"134","author":"Leiva","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0325","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1079\/ASC200665","article-title":"Pro-inflammatory cytokine and acute phase protein responses to low-dose lipopolysaccharide (LPS) challenge in pigs","volume":"82","author":"Llamas Moya","year":"2006","journal-title":"Anim. Sci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0330","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.vetimm.2009.09.003","article-title":"Validation of immunoassays for the candidate renal markers C-reactive protein, immunoglobulin G, thromboxane B2 and retinol binding protein in canine urine","volume":"134","author":"Maddens","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0335","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2567.2000.00065.x","article-title":"Cyclooxygenase-independent inhibition of dendritic cell maturation by aspirin","volume":"101","author":"Matasi\u0107","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0340","series-title":"Macrolide Antibiotics","first-page":"25","article-title":"Pharmacokinetics\/pharmacodynamics of macrolides","author":"Mattoes","year":"2002"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0345","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1128\/AAC.40.6.1366","article-title":"Modulatory effect of antibiotics on cytokine production by human monocytes in vitro","volume":"40","author":"Morikawa","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0350","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/vr.100431","article-title":"Dose\u2013response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin","volume":"171","author":"Mustonen","year":"2012","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0355","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1567-5769(03)00048-1","article-title":"Inflammatory mediator production in swine following endotoxin challenge with or without co-administration of dexamethasone","volume":"3","author":"Myers","year":"2003","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.vetimm.2015.09.014_bib0370","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1292\/jvms.59.927","article-title":"Circulating tumor necrosis factor and interleukin-1 after administration of LPS in adult cows","volume":"59","author":"Ohtsuka","year":"1997","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0380","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2567.2004.01976.x","article-title":"Signal transduction by the lipopolysaccharide receptor. Toll-like receptor-4","volume":"113","author":"P\u00e5lsson-McDermott","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0385","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1365-2885.2011.01308.x","article-title":"Development and validation of a tissue cage model of acute inflammation in the cat","volume":"35","author":"Pelligand","year":"2012","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0390","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1042\/BST0381390","article-title":"Exploring the LPS\/TLR4 signal pathway with small molecules","volume":"38","author":"Peri","year":"2010","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0395","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.vetimm.2012.05.001","article-title":"In vivo characterization of inflammatory biomarkers in swine and the impact of flunixin meglumine administration","volume":"148","author":"Peters","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0405","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/1043-4666(94)90077-9","article-title":"Cyclooxygenase inhibitors enhance tumour necrosis factor production and mortality in murine endotoxic shock","volume":"6","author":"Pettipher","year":"1994","journal-title":"Cytokine"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0410","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.vetimm.2014.11.005","article-title":"Characterization of an intravenous lipopolysaccharide inflammation model in calves with respect to the acute phase response","volume":"163","author":"Plessers","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0415","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2460\/ajvr.69.1.108","article-title":"Evaluation of bioequivalence after oral, intramuscular, and intravenous administration of racemic ketoprofen in pigs","volume":"69","author":"Raekallio","year":"2008","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0420","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s004240100718","article-title":"Influence of systemic treatment with cyclooxygenase inhibitors on lipopolysaccharide-induced fever and circulating levels of cytokines and cortisol in guinea-pigs","volume":"443","author":"Roth","year":"2002","journal-title":"Pfl\u00fcgers Archiv. Eur. J. Physiol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0430","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1365-2885.2011.01314.x","article-title":"Comparison of the antipyretic efficacy of ketoprofen, acetylsalicylic acid, and paracetamol, orally administered to swine","volume":"35","author":"Salichs","year":"2012","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0435","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.2527\/jas.2012-6165","article-title":"Efficacy of ketoprofen administered in drinking water at a low dose for the treatment of porcine respiratory disease complex","volume":"91","author":"Salichs","year":"2013","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0445","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF00343248","article-title":"Escherichia coli sepsis and endotoxemia in conscious young pigs","volume":"12","author":"Schrauwen","year":"1988","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0455","first-page":"5","article-title":"The Seldinger technique \u2013 catheter replacement of the needle in percutaneous arteriography \u2013 a new technique","volume":"142","author":"Seldinger","year":"1984","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0465","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/0192-0561(92)90149-F","article-title":"Differential sensitivity of in vivo TNF and IL-6 production to modulation by anti-inflammatory drugs in mice","volume":"14","author":"Sironi","year":"1992","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0475","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2460\/AJVR.2002.63.91","article-title":"Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood","volume":"63","author":"Streppa","year":"2002","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0480","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2249.2007.03299.x","article-title":"Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells","volume":"147","author":"Sugiyama","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0485","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2885.1994.tb00249.x","article-title":"Effects of ketoprofen and flunixin in pigs experimentally infected with Actinobacillus pleuropneumoniae","volume":"17","author":"Swinkels","year":"1994","journal-title":"J. Vet. Pharmacol. Ther."},{"issue":"Suppl. 9A","key":"10.1016\/j.vetimm.2015.09.014_bib0490","first-page":"5S","article-title":"Clinical implications of the immunomodulatory effects of macrolides","volume":"117","author":"Tamaoki","year":"2004","journal-title":"Am. J. Med."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0495","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/1874467210801010068","article-title":"Immunomodulatory properties of antibiotics","volume":"1","author":"Tauber","year":"2008","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0500","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bbi.2009.11.006","article-title":"The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: implications for a role of COX-1","volume":"24","author":"Teeling","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0515","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0530","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1210\/endo.138.6.5180","article-title":"Coincidental changes in behavior and plasma cortisol in unrestrained pigs after intracerebroventricular injection of tumor necrosis factor-alpha","volume":"138","author":"Warren","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.vetimm.2015.09.014_bib0535","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.domaniend.2009.04.004","article-title":"Temporal pattern and effect of sex on lipopolysaccharide-induced stress hormone and cytokine response in pigs","volume":"37","author":"Williams","year":"2009","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0540","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/aja.1001810302","article-title":"Pulmonary intravascular macrophages in domestic animal species \u2013 review of structural and functional properties","volume":"181","author":"Winkler","year":"1988","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0545","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/jlb.38.4.471","article-title":"Monocytic origin and postnatal mitosis of intravascular macrophages in the porcine lung","volume":"38","author":"Winkler","year":"1985","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0550","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.2527\/2000.7871892x","article-title":"Integrated adrenal, somatotropic, and immune responses of growing pigs to treatment with lipopolysaccharide","volume":"78","author":"Wright","year":"2000","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0560","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.rvsc.2013.11.012","article-title":"Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in pigs","volume":"96","author":"Wyns","year":"2014","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0565","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.vetimm.2015.06.001","article-title":"In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs","volume":"166","author":"Wyns","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0570","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.270.52.31315","article-title":"Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells","volume":"270","author":"Yamamoto","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2015.09.014_bib0575","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2165\/00003495-200161040-00003","article-title":"Review of macrolides and ketolides: focus on respiratory tract infections","volume":"61","author":"Zhanel","year":"2001","journal-title":"Drugs"}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242715002202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242715002202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T21:29:20Z","timestamp":1748640560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242715002202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":81,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0165242715002202"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2015.09.014","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2015.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}