{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:19:36Z","timestamp":1786997976059,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"American Quarter Horse Foundation and the Grayson Jockey Club Research Foundation"},{"name":"Geoffrey C. Hughes Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.vetimm.2016.03.009","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T14:22:08Z","timestamp":1457965328000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Equine herpesvirus-1 infection disrupts interferon regulatory factor-3 (IRF-3) signaling pathways in equine endothelial cells"],"prefix":"10.1016","volume":"173","author":[{"given":"Sanjay","family":"Sarkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udeni B.R.","family":"Balasuriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Horohov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2016.03.009_bib0005","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1128\/JVI.02075-06","article-title":"Capsid protein of eastern equine encephalitis virus inhibits host cell gene expression","volume":"81","author":"Aguilar","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0010","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1046\/j.1365-3083.1996.d01-317.x","article-title":"Sendai virus-induced IFN-alpha production analysed by immunocytochemistry and computerized image analysis","volume":"44","author":"Akerlund","year":"1996","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0015","first-page":"78","article-title":"Molecular epizootiology, pathogenesis, and prophylaxis of equine herpesvirus-1 infections","volume":"2","author":"Allen","year":"1986","journal-title":"Prog. Vet. Microbiol. Immunol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0020","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1128\/JVI.61.8.2454-2461.1987","article-title":"Use of lambda gt11 and monoclonal antibodies to map the genes for the six major glycoproteins of equine herpesvirus 1","volume":"61","author":"Allen","year":"1987","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0025","series-title":"Equine Infectious Diseases VIII: Proceedings of the Eighth International Conference","first-page":"129","article-title":"Advances in the understanding of the pathogenesis, epidemiology and immunological control of equine herpesvirus abortion","author":"Allen","year":"1998"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0030","first-page":"829","article-title":"Equid herpesvirus-1 (EHV-1) and -4 (EHV-4) infections","volume":"vol. 2","author":"Allen","year":"2004"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2746\/042516408X253127","article-title":"Prevalence of latent, neuropathogenic equine herpesvirus-1 in the Thoroughbred broodmare population of central Kentucky","volume":"40","author":"Allen","year":"2008","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0040","doi-asserted-by":"crossref","first-page":"7844","DOI":"10.1128\/JVI.00325-07","article-title":"Varicella-Zoster virus IE63, a major viral latency protein, is required to inhibit the alpha interferon-induced antiviral response","volume":"81","author":"Ambagala","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0045","doi-asserted-by":"crossref","first-page":"7945","DOI":"10.1128\/JVI.77.14.7945-7956.2003","article-title":"The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3","volume":"77","author":"Basler","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0050","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1128\/JVI.01326-09","article-title":"Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation","volume":"84","author":"Beura","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0055","doi-asserted-by":"crossref","first-page":"9798","DOI":"10.1128\/JVI.78.18.9798-9806.2004","article-title":"NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription","volume":"78","author":"Billecocq","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0060","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/cvr\/cvq076","article-title":"The nuclear factor-kappaB-interleukin-6 signalling pathway mediating vascular inflammation","volume":"86","author":"Brasier","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0065","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1128\/JVI.69.5.3024-3032.1995","article-title":"Detection and intracellular localization of equine herpesvirus 1 IR1 and IR2 gene products by using monoclonal antibodies","volume":"69","author":"Caughman","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0070","first-page":"31","article-title":"Epizootiology of equine viral rhinopneumonitis","volume":"142","author":"Doll","year":"1963","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0075","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1128\/JVI.70.12.8710-8718.1996","article-title":"Expression and function of the equine herpesvirus 1 virion-associated host shutoff homolog","volume":"70","author":"Feng","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0080","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.vetmic.2010.08.030","article-title":"Infection of central nervous system endothelial cells by cell-associated EHV-1","volume":"148","author":"Goehring","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0085","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1182\/blood.V94.5.1711","article-title":"IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells","volume":"94","author":"Hawiger","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0090","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1046\/j.1365-2567.2001.01262.x","article-title":"Characterization of equine E-selectin","volume":"103","author":"Hedges","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0095","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1939-1676.2007.tb02942.x","article-title":"Outbreak of neurologic disease caused by equine herpesvirus-1at a university equestrian center","volume":"21","author":"Henninger","year":"2007","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0100","series-title":"Confocal Microscopy for Biologists","first-page":"259","article-title":"Fluorescence immunolabelling","author":"Hibbs","year":"2004"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0105","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0168-1702(95)00027-N","article-title":"gp13 (EHV-gC): a complement receptor induced by equine herpesviruses","volume":"37","author":"Huemer","year":"1995","journal-title":"Virus Res."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0110","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/nature09118","article-title":"Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus","volume":"465","author":"Iannacone","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0115","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1098\/rspb.1957.0048","article-title":"Virus interference. I. The interferon","volume":"147","author":"Isaacs","year":"1957","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.virol.2004.10.015","article-title":"Thogoto virus ML protein suppresses IRF3 function","volume":"331","author":"Jennings","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0125","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1128\/JVI.01956-05","article-title":"Inhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo","volume":"80","author":"Jones","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0301-0082(95)00046-1","article-title":"Endothelial cells of the brain and other organ systems: some similarities and differences","volume":"48","author":"Joo","year":"1996","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0135","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1128\/IAI.7.6.911-917.1973","article-title":"Interferon sensitivity of Venezuelan equine encephalomyelitis virus","volume":"7","author":"Jordan","year":"1973","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0140","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.2042-3306.1994.tb04052.x","article-title":"Distribution of equid herpesvirus-1 (EHV-1) in respiratory tract associated lymphoid tissue: implications for cellular immunity","volume":"26","author":"Kydd","year":"1994","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0145","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.2042-3306.1994.tb04051.x","article-title":"Distribution of equid herpesvirus-1 (EHV-1) in the respiratory tract of ponies: implications for vaccination strategies","volume":"26","author":"Kydd","year":"1994","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0150","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vetimm.2006.01.005","article-title":"The equine immune response to equine herpesvirus-1: the virus and its vaccines","volume":"111","author":"Kydd","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0155","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1099\/vir.0.83538-0","article-title":"Mouse cytomegalovirus inhibits beta interferon (IFN-beta) gene expression and controls activation pathways of the IFN-beta enhanceosome","volume":"89","author":"Le","year":"2008","journal-title":"J Gen. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0160","doi-asserted-by":"crossref","DOI":"10.1007\/s00705-015-2733-3","article-title":"Conserved arginine residues in the carboxyl terminus of the equine arteritis virus E protein may play a role in heparin binding but may not affect viral infectivity in equine endothelial cells","author":"Lu","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0165","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1939-1676.2009.0304.x","article-title":"Equine herpesvirus-1 consensus statement","volume":"23","author":"Lunn","year":"2009","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0170","first-page":"452","article-title":"Isolation and propagation of equine arteritis virus in monolayer cell cultures of rabbit kidney","volume":"52","author":"McCollum","year":"1962","journal-title":"Cornell Vet."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0175","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.virol.2006.10.028","article-title":"Recruitment of activated IRF-3 and CBP\/p300 to herpes simplex virus ICP0 nuclear foci: potential role in blocking IFN-beta induction","volume":"360","author":"Melroe","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0180","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/vim.2005.18.267","article-title":"Herpesviruses and the innate immune response","volume":"18","author":"Mossman","year":"2005","journal-title":"Viral Immunol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0185","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1128\/JVI.75.2.750-758.2001","article-title":"Herpes simplex virus triggers and then disarms a host antiviral response","volume":"75","author":"Mossman","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.tvjl.2008.12.002","article-title":"Equine herpesvirus myeloencephalopathy: unravelling the enigma","volume":"180","author":"Nugent","year":"2009","journal-title":"Vet. J."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0195","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1089\/jir.2009.0074","article-title":"Mechanisms employed by herpes simplex virus 1 to inhibit the interferon response","volume":"29","author":"Paladino","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0200","doi-asserted-by":"crossref","first-page":"e10428","DOI":"10.1371\/journal.pone.0010428","article-title":"Cellular localization of the herpes simplex virus ICP0 protein dictates its ability to block IRF3-mediated innate immune responses","volume":"5","author":"Paladino","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0205","series-title":"Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses","article-title":"Order: herpesvirales","author":"Pellett","year":"2012"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0210","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.immuni.2007.08.012","article-title":"Innate recognition of viruses","volume":"27","author":"Pichlmair","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0215","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.tvjl.2008.08.004","article-title":"Equine herpesvirus-1 myeloencephalopathy: a review of recent developments","volume":"180","author":"Pusterla","year":"2009","journal-title":"Vet. J."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0220","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1099\/vir.0.18612-0","article-title":"Down-regulation of MHC class I expression by equine herpesvirus-1","volume":"84","author":"Rappocciolo","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0225","doi-asserted-by":"crossref","first-page":"9760","DOI":"10.1128\/JVI.01051-10","article-title":"Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex","volume":"84","author":"Rodriguez-Madoz","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0230","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1128\/JVI.02514-09","article-title":"Dengue virus inhibits the production of type I interferon in primary human dendritic cells","volume":"84","author":"Rodriguez-Madoz","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0235","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1128\/JVI.02064-06","article-title":"The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) induces degradation of interferon response factor 3 and, consequently, inhibits beta interferon promoter activity","volume":"81","author":"Saira","year":"2007","journal-title":"J. Virol."},{"issue":"3-4","key":"10.1016\/j.vetimm.2016.03.009_bib0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetimm.2015.07.015","article-title":"Equine herpesvirus-1 suppresses type-I interferon induction in equine endothelial cells","volume":"167","author":"Sarkar","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0245","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.vetmic.2015.12.011","article-title":"The neuropathogenic T953 strain of equine herpesvirus-1 inhibits type-I IFN mediated antiviral activity in equine endothelial cells","volume":"183","author":"Sarkar","year":"2016","journal-title":"Vet. Microbiol."},{"issue":"7","key":"10.1016\/j.vetimm.2016.03.009_bib0250","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1128\/JVI.02455-15","article-title":"Equine arteritis virus uses equine CXCL16 (EqCXCL16) as an entry receptor","volume":"90","author":"Sarkar","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0255","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.virol.2010.08.025","article-title":"Nonstructural protein 1alpha subunit-based inhibition of NF-kappaB activation and suppression of interferon-beta production by porcine reproductive and respiratory syndrome virus","volume":"407","author":"Song","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0260","unstructured":"USDA-APHIS, 2007. Equine Herpesvirus Myeloencephalopathy: A Potential Emerging Disease"},{"key":"10.1016\/j.vetimm.2016.03.009_bib0265","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.1128\/JVI.00226-08","article-title":"West Nile virus nonstructural protein 1 inhibits TLR3 signal transduction","volume":"82","author":"Wilson","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0270","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/cmi.2010.84","article-title":"IFN-alpha production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and -independent pathways","volume":"8","author":"Yu","year":"2011","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0275","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.1128\/JVI.00155-10","article-title":"Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus","volume":"84","author":"Zhou","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0280","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.virusres.2011.06.003","article-title":"Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits beta interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels","volume":"160","author":"da Silva","year":"2011","journal-title":"Virus Res."},{"key":"10.1016\/j.vetimm.2016.03.009_bib0285","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.vetimm.2006.01.006","article-title":"Immune escape of equine herpesvirus 1 and other herpesviruses of veterinary importance","volume":"111","author":"van der Meulen","year":"2006","journal-title":"Vet. Immunol. Immunopathol."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242716300344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242716300344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:07:58Z","timestamp":1600301278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242716300344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":57,"alternative-id":["S0165242716300344"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2016.03.009","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Equine herpesvirus-1 infection disrupts interferon regulatory factor-3 (IRF-3) signaling pathways in equine endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2016.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}