{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:56:09Z","timestamp":1768794969466,"version":"3.49.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marine Biotechnology Program","award":["PJT200620"],"award-info":[{"award-number":["PJT200620"]}]},{"name":"Genome Analysis of Marine Organisms and Development of Functional Applications"},{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.vetimm.2017.02.008","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T22:37:36Z","timestamp":1488839856000},"page":"29-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["A homolog of teleostean signal transducer and activator of transcription 3 (STAT3) from rock bream, Oplegnathus fasciatus : Structural insights, transcriptional modulation, and subcellular localization"],"prefix":"10.1016","volume":"186","author":[{"given":"S.D.N.K.","family":"Bathige","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Shanthakumar","family":"Thulasitha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navaneethaiyer","family":"Umasuthan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.H.E.","family":"Jayasinghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Hye","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jehee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2017.02.008_bib0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1196\/annals.1378.063","article-title":"Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution","volume":"1091","author":"Aggarwal","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0010","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bbrc.2005.05.106","article-title":"Ultraviolet B exposure activates Stat3 signaling via phosphorylation at tyrosine705 in skin of SKH1 hairless mouse: a target for the management of skin cancer?","volume":"333","author":"Ahsan","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0092-8674(94)90235-6","article-title":"Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway","volume":"77","author":"Akira","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0020","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1128\/MCB.21.5.1621-1632.2001","article-title":"Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver","volume":"21","author":"Alonzi","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0025","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0030","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.fsi.2012.07.017","article-title":"Interferon regulatory factors 4 and 8 in rock bream, Oplegnathus fasciatus: structural and expressional evidence for their antimicrobial role in teleosts","volume":"33","author":"Bathige","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0035","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.fsi.2014.05.012","article-title":"Antibacterial activity and immune responses of a molluscan macrophage expressed gene-1 from disk abalone, Haliotis discus discus","volume":"39","author":"Bathige","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0040","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0045","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0050","doi-asserted-by":"crossref","first-page":"17580","DOI":"10.1074\/jbc.274.25.17580","article-title":"Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes","volume":"274","author":"Carballo","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0055","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2011.09.017","article-title":"An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells","volume":"35","author":"Cui","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0060","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1038\/sj.onc.1208469","article-title":"Stat3 regulates genes common to both wound healing and cancer","volume":"24","author":"Dauer","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0065","series-title":"The PyMOL Molecular Graphics System. DeLano Scientific","author":"DeLano","year":"2002"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0070","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1128\/MCB.16.9.4710","article-title":"A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9","volume":"16","author":"Demoulin","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.09.074","article-title":"Involvement of Stat3 in mouse brain development and sexual dimorphism: a proteomics approach","volume":"1362","author":"Di Domenico","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0080","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jbiotec.2008.03.021","article-title":"The Genome Sequencer FLX System-longer reads, more applications, straight forward bioinformatics and more complete data sets","volume":"136","author":"Droege","year":"2008","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0085","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1515\/REVNEURO.2008.19.4-5.341","article-title":"Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration","volume":"19","author":"Dziennis","year":"2008","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0090","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1128\/MCB.25.4.1215-1227.2005","article-title":"GATA1 function, a paradigm for transcription factors in hematopoiesis","volume":"25","author":"Ferreira","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0095","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/iwj.12473","article-title":"The expression of inflammatory cytokines, TAM tyrosine kinase receptors and their ligands is upregulated in venous leg ulcer patients: a novel insight into chronic wound immunity","volume":"13","author":"Filkor","year":"2015","journal-title":"Int. Wound J."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0100","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jlb.63.2.139","article-title":"Transcriptional regulation in the immune system: all roads lead to AP-1","volume":"63","author":"Foletta","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0105","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.4049\/jimmunol.172.12.7703","article-title":"Stat3 activation in acute lung injury","volume":"172","author":"Gao","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0110","doi-asserted-by":"crossref","first-page":"22962","DOI":"10.1074\/jbc.273.36.22962","article-title":"Activation of the Janus kinase\/signal transducer and activator of transcription pathway by osmotic shock","volume":"273","author":"Gatsios","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0115","first-page":"171","article-title":"In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3","volume":"9","author":"Gronowski","year":"1995","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0120","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.fsi.2009.06.001","article-title":"The JAK and STAT family members of the mandarin fish Siniperca chuatsi: molecular cloning, tissues distribution and immunobiological activity","volume":"27","author":"Guo","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0125","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.fsi.2013.09.012","article-title":"Cloning, molecular characterization, and expression analysis of the signal transducer and activator of transcription 3 (STAT(3)) gene from grass carp (Ctenopharyngodon idellus)","volume":"35","author":"Guo","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0130","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1038\/sj.onc.1203551","article-title":"Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors","volume":"19","author":"Hirano","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/1742-2094-9-227","article-title":"Interferon regulatory factor 8\/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia","volume":"9","author":"Horiuchi","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0140","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.fsi.2014.09.011","article-title":"Involvement of fish signal transducer and activator of transcription 3 (STAT3) in SGIV replication and virus induced paraptosis","volume":"41","author":"Huang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0145","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.fsi.2014.12.031","article-title":"Involvement of fish signal transducer and activator of transcription 3 (STAT3) in nodavirus infection induced cell death","volume":"43","author":"Huang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0150","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)81277-5","article-title":"STATs: signal transducers and activators of transcription","volume":"84","author":"Ihle","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0155","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1084\/jem.181.5.1755","article-title":"Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4","volume":"181","author":"Jacobson","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0160","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.1365-2761.2000.00212.x","article-title":"Iridovirus-like infection associated with high mortalitiesof striped beakperch,Oplegnathus fasciatus(Temmincket Schlegel), in southern coastal areas of the Koreanpeninsula","volume":"23","author":"Jung","year":"2000","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0165","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0167-4781(00)00168-8","article-title":"Structure and functional analysis of the human STAT3 gene promoter: alteration of chromatin structure as a possible mechanism for the upregulation in cisplatin-resistant cells","volume":"1493","author":"Kato","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0170","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1096\/fasebj.4.5.2407588","article-title":"Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression","volume":"4","author":"Kemler","year":"1990","journal-title":"FASEB J."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(02)00398-0","article-title":"Signaling through the JAK\/STAT pathway, recent advances and future challenges","volume":"285","author":"Kisseleva","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0180","series-title":"The Immune System Drugs in Fish: Immune Function, Immunoassay, Drugs","author":"Kum","year":"2011"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0185","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1073\/pnas.97.13.7278","article-title":"Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors","volume":"97","author":"Lau","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0190","doi-asserted-by":"crossref","first-page":"28545","DOI":"10.1074\/jbc.273.44.28545","article-title":"Biological role of the CCAAT\/enhancer-binding protein family of transcription factors","volume":"273","author":"Lekstrom-Himes","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0195","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1172\/JCI0215650","article-title":"What does stat3 do","volume":"109","author":"Levy","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0200","first-page":"158","article-title":"[Characterization of an iridovirus detected in rock bream (Oplegnathus fasciatus; Temminck and Schlegel)]","volume":"27","author":"Li","year":"2011","journal-title":"Bing Du Xue Bao"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0205","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.4049\/jimmunol.1300765","article-title":"IL-21 enhances the activity of the TLR-MyD88-STAT3 pathway but not the classical TLR-MyD88-NF-kappaB pathway in human B cells to boost antibody production","volume":"191","author":"Liu","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0210","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0215","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/hep.26496","article-title":"Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus","volume":"58","author":"McCartney","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0220","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine","volume":"226","author":"Mosser","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0225","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.4049\/jimmunol.178.5.2623","article-title":"The JAK-STAT signaling pathway: input and output integration","volume":"178","author":"Murray","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0230","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/(SICI)1097-0177(199908)215:4<352::AID-AJA7>3.0.CO;2-J","article-title":"Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line","volume":"215","author":"Oates","year":"1999","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0235","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0240","doi-asserted-by":"crossref","first-page":"e71932","DOI":"10.1371\/journal.pone.0071932","article-title":"STAT3 activation promotes oncolytic HSV1 replication in glioma cells","volume":"8","author":"Okemoto","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1297-9716-43-67","article-title":"Pathogenesis of and strategies for preventing Edwardsiella tarda infection in fish","volume":"43","author":"Park","year":"2012","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0250","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3147\/jsfp.44.19","article-title":"Disease control in korean aquaculture","volume":"44","author":"Park","year":"2009","journal-title":"Fish Pathol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0255","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4049\/jimmunol.1402093","article-title":"Carp il10 has anti-inflammatory activities on phagocytes, promotes proliferation of memory T cells, and regulates B cell differentiation and antibody secretion","volume":"194","author":"Piazzon","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0260","doi-asserted-by":"crossref","first-page":"874","DOI":"10.5604\/17322693.1162989","article-title":"Stem cells and growth factors in wound healing","volume":"69","author":"Pikula","year":"2015","journal-title":"Postepy Hig Med. Dosw (Online)"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0265","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.vph.2015.02.007","article-title":"The innate immune system, toll-like receptors and dermal wound healing: a review","volume":"71","author":"Portou","year":"2015","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0270","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.20184","article-title":"Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation","volume":"39","author":"Radaeva","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0275","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.antiviral.2013.09.011","article-title":"Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection","volume":"100","author":"Reitsma","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0280","doi-asserted-by":"crossref","first-page":"16513","DOI":"10.1074\/jbc.274.23.16513","article-title":"Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action","volume":"274","author":"Riley","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0285","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.cub.2008.03.055","article-title":"Polarized subcellular localization of Jak\/STAT components is required for efficient signaling","volume":"18","author":"Sotillos","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0290","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1016\/S0002-9610(98)00183-4","article-title":"Physiology and healing dynamics of chronic cutaneous wounds","volume":"176","author":"Stadelmann","year":"1998","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0295","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2012.03.013","article-title":"The JAK-STAT pathway at twenty","volume":"36","author":"Stark","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0300","doi-asserted-by":"crossref","first-page":"6409","DOI":"10.4049\/jimmunol.173.10.6409","article-title":"IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils","volume":"173","author":"Stout","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0305","doi-asserted-by":"crossref","first-page":"28049","DOI":"10.1074\/jbc.273.43.28049","article-title":"Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation","volume":"273","author":"Strehlow","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0310","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.fsi.2011.06.025","article-title":"A multivalent killed whole-cell vaccine induces effective protection against Edwardsiella tarda and Vibrio anguillarum","volume":"31","author":"Sun","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0315","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1073\/pnas.94.8.3801","article-title":"Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality","volume":"94","author":"Takeda","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0320","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.4049\/jimmunol.161.9.4652","article-title":"Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice","volume":"161","author":"Takeda","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0325","doi-asserted-by":"crossref","first-page":"10750","DOI":"10.1158\/0008-5472.CAN-05-2399","article-title":"The octamer binding transcription factor Oct-1 is a stress sensor","volume":"65","author":"Tantin","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0330","doi-asserted-by":"crossref","first-page":"447","DOI":"10.4049\/jimmunol.1203516","article-title":"Activated STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells","volume":"192","author":"Trilling","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0335","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.fsi.2012.01.019","article-title":"A teleostean angiotensinogen from Oplegnathus fasciatus responses to immune and injury challenges","volume":"32","author":"Umasuthan","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0340","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ng0996-95","article-title":"Leptin activation of Stat3 in the hypothalamus of wild-type and ob\/ob mice but not db\/db mice","volume":"14","author":"Vaisse","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0345","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.fsi.2012.07.018","article-title":"Molecular cloning and functional characterization of two duplicated two-cysteine containing type I interferon genes in rock bream Oplegnathus fasciatus","volume":"33","author":"Wan","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0350","doi-asserted-by":"crossref","first-page":"536","DOI":"10.7150\/ijbs.7.536","article-title":"Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target","volume":"7","author":"Wang","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0355","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.fsi.2010.10.017","article-title":"Signal transducer and activator of transcription 3 (STAT3) homologue in turbot (Scophthalmus maximus): molecular characterization and expression analysis","volume":"30","author":"Wang","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0360","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0171-2985(11)80541-3","article-title":"The C\/EBP family of transcription factors","volume":"193","author":"Wedel","year":"1995","journal-title":"Immunobiology"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0365","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0014-5793(96)00990-8","article-title":"IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes","volume":"394","author":"Wehinger","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0370","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1167\/iovs.10-5670","article-title":"Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats","volume":"52","author":"Xu","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0375","doi-asserted-by":"crossref","first-page":"G175","DOI":"10.1152\/ajpgi.00396.2004","article-title":"NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene","volume":"288","author":"Xu","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0380","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1534-5807(02)00126-0","article-title":"Stat3 controls cell movements during zebrafish gastrulation","volume":"2","author":"Yamashita","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.vetimm.2017.02.008_bib0385","doi-asserted-by":"crossref","first-page":"9358","DOI":"10.1074\/jbc.C600321200","article-title":"STAT3 regulates cytokine-mediated generation of inflammatory helper T cells","volume":"282","author":"Yang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0390","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1084\/jem.20012127","article-title":"Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation","volume":"196","author":"Yoshida","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.vetimm.2017.02.008_bib0395","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.8140422","article-title":"Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6","volume":"264","author":"Zhong","year":"1994","journal-title":"Science"}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242717301150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242717301150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T13:57:44Z","timestamp":1692712664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242717301150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":79,"alternative-id":["S0165242717301150"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2017.02.008","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A homolog of teleostean signal transducer and activator of transcription 3 (STAT3) from rock bream, Oplegnathus fasciatus: Structural insights, transcriptional modulation, and subcellular localization","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2017.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}