{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:46:21Z","timestamp":1767861981240,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.vetimm.2017.06.004","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T04:32:44Z","timestamp":1497933164000},"page":"43-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Dietary cinnamaldehyde enhances acquisition of specific antibodies following helminth infection in pigs"],"prefix":"10.1016","volume":"189","author":[{"given":"Andrew R.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina V.A.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Krych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajar Fauzan Bin","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis S.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Skovgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig M.","family":"Thamsborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2017.06.004_bib0005","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0010","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1096\/fj.05-3936fje","article-title":"Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals","volume":"19","author":"Bethony","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0015","first-page":"543","article-title":"Thyme and cinnamon extracts induce anion secretion in piglet small intestine via cholinergic pathways","volume":"59","author":"Boudry","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0020","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.1038\/srep07919","article-title":"Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying","volume":"5","author":"Camacho","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0025","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.fct.2007.07.016","article-title":"Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes\/macrophages through suppression of intracellular signaling","volume":"46","author":"Chao","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0030","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1128\/IAI.73.2.1116-1128.2005","article-title":"Localized multigene expression patterns support an evolving th1\/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum","volume":"73","author":"Dawson","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0035","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1128\/IAI.00827-07","article-title":"Localized th1-, th2-, t regulatory cell-, and inflammation-associated hepatic and pulmonary immune responses in Ascaris suum-infected swine are increased by retinoic acid","volume":"77","author":"Dawson","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0040","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1128\/CDLI.12.12.1387-1392.2005","article-title":"Modulation of antibody-mediated immune response by probiotics in chickens","volume":"12","author":"Haghighi","year":"2005","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2527\/jas1985.601220x","article-title":"Influence of an experimental infection of Ascaris suum on performance of pigs","volume":"60","author":"Hale","year":"1985","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0050","series-title":"Advances in Parasitology","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/bs.apar.2016.02.025","article-title":"Chapter seven \u2013 interactions between nutrition and infections with Haemonchus contortus and related gastrointestinal nematodes in small ruminants","author":"Hoste","year":"2016"},{"key":"10.1016\/j.vetimm.2017.06.004_bib0055","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.rvsc.2015.04.002","article-title":"The influence of endoparasites on selected production parameters in pigs in various housing systems","volume":"100","author":"Jankowska-M\u0105kosa","year":"2015","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0060","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0192-0561(98)00064-2","article-title":"Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation","volume":"20","author":"Koh","year":"1998","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0065","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.vetpar.2015.06.008","article-title":"Serum antibody responses in pigs trickle-infected with Ascaris and Trichuris: heritabilities and associations with parasitological findings","volume":"211","author":"Kringel","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.vetpar.2011.05.003","article-title":"Effects of dietary supplementation with phytonutrients on vaccine-stimulated immunity against infection with Eimeria tenella","volume":"181","author":"Lee","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0075","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1017\/S0007114511001073","article-title":"Cinnamaldehyde enhances in vitro parameters of immunity and reduces in vivo infection against avian coccidiosis","volume":"106","author":"Lee","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0080","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.livsci.2012.01.005","article-title":"The effect of essential oils on performance, immunity and gut microbial population in weaner pigs","volume":"145","author":"Li","year":"2012","journal-title":"Livest. Sci."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0085","doi-asserted-by":"crossref","DOI":"10.2527\/jas.2011-4304","article-title":"Anti-inflammatory effects of several plant extracts on porcine alveolar macrophages in vitro","volume":"90","author":"Liu","year":"2012","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0090","doi-asserted-by":"crossref","DOI":"10.2527\/jas.2013-6496","article-title":"Effects of capsicum oleoresin, garlic botanical, and turmeric oleoresin on gene expression profile of ileal mucosa in weaned pigs","volume":"92","author":"Liu","year":"2014","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0095","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/CMR.00002-11","article-title":"Food animals and antimicrobials: impacts on human health","volume":"24","author":"Marshall","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0100","doi-asserted-by":"crossref","first-page":"e2588","DOI":"10.1371\/journal.pntd.0002588","article-title":"The intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time","volume":"7","author":"Masure","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0105","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.chom.2008.08.014","article-title":"Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection","volume":"4","author":"McCoy","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vetimm.2017.06.004_bib0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.anifeedsci.2009.01.004","article-title":"In vitro characterisation of the antimicrobial activity of selected essential oil components and binary combinations against the pig gut flora","volume":"151","author":"Michiels","year":"2009","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0115","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-3024.2005.00752.x","article-title":"Host immune reactions and worm kinetics during the expulsion of Ascaris suum in pigs","volume":"27","author":"Miquel","year":"2005","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0120","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/avj.12305","article-title":"Effect of the route of administration on the mucosal and systemic immune responses to Lawsonia intracellularis vaccine in pigs","volume":"93","author":"Nogueira","year":"2015","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0125","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.immuni.2014.08.009","article-title":"TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination","volume":"41","author":"Oh","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.vetimm.2017.06.004_bib0130","doi-asserted-by":"crossref","first-page":"e76695","DOI":"10.1371\/journal.pone.0076695","article-title":"Organization and biology of the porcine serum amyloid a (SAA) gene cluster: isoform specific responses to bacterial infection","volume":"8","author":"Olsen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vetimm.2017.06.004_bib0135","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.vaccine.2015.11.034","article-title":"Efficacy of a new bivalent vaccine of porcine circovirus type 2 and Mycoplasma hyopneumoniae (Fostera\u2122 PCV MH) under experimental conditions","volume":"34","author":"Park","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vetimm.2017.06.004_bib0140","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.biochi.2010.10.006","article-title":"Effects of cinnamaldehyde on the glucose transport activity of GLUT1","volume":"93","author":"Plaisier","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.vetimm.2017.06.004_bib0145","doi-asserted-by":"crossref","first-page":"e89977","DOI":"10.1371\/journal.pone.0089977","article-title":"The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing","volume":"9","author":"R\u00f6der","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.vetimm.2017.06.004_bib0150","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.4315\/0362-028X-71.6.1145","article-title":"Plant-derived compounds inactivate antibiotic-resistant campylobacter jejuni strains","volume":"71","author":"Ravishankar","year":"2008","journal-title":"J. Food Prot."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0155","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1017\/S0031182097001480","article-title":"Experimental Ascaris suum infection in the pig: worm population kinetics following single inoculations with three doses of infective eggs","volume":"115","author":"Roepstorff","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.vetimm.2017.06.004_bib0160","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1515\/ap-2017-0017","article-title":"Profiling gene expression in mesenteric lymph nodes in pigs wuth different levels of resistance to Ascaris suum","volume":"62","author":"Skallerup","year":"2017","journal-title":"Acta Parasitol"},{"key":"10.1016\/j.vetimm.2017.06.004_bib0165","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1177\/1753425912473668","article-title":"Expression of innate immune genes, proteins and microRNAs in lung tissue of pigs infected experimentally with influenza virus (H1N2)","volume":"19","author":"Skovgaard","year":"2013","journal-title":"Innate Immun."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0175","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.3382\/ps.2012-02690","article-title":"In vitro sensitivity of poultry Brachyspira intermedia isolates to essential oil components and in vivo reduction of Brachyspira intermedia in rearing pullets with cinnamaldehyde feed supplementation","volume":"92","author":"Verlinden","year":"2013","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0180","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.vetpar.2015.04.012","article-title":"Serological examination of fattening pigs reveals associations between Ascaris suum, lung pathogens and technical performance parameters","volume":"210","author":"Vlaminck","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0185","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/2162-3619-1-36","article-title":"CD19: a biomarker for B cell development, lymphoma diagnosis and therapy","volume":"1","author":"Wang","year":"2012","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0190","doi-asserted-by":"crossref","first-page":"14791","DOI":"10.1038\/srep14791","article-title":"Anthelmintic activity of trans-cinnamaldehyde and A- and B-type proanthocyanidins derived from cinnamon (Cinnamomum verum)","volume":"5","author":"Williams","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0195","doi-asserted-by":"crossref","first-page":"9253","DOI":"10.1038\/srep09253","article-title":"Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection","volume":"5","author":"Wlodarska","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0200","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.5713\/ajas.2012.12111","article-title":"Effect of eugenol and cinnamaldehyde on the growth performance, nutrient digestibility, blood characteristics, fecal microbial shedding and fecal noxious gas content in growing pigs","volume":"25","author":"Yan","year":"2012","journal-title":"Asian-Aust. J. Anim. Sci."},{"key":"10.1016\/j.vetimm.2017.06.004_bib0205","doi-asserted-by":"crossref","first-page":"927","DOI":"10.4315\/0362-028X.JFP-13-497","article-title":"Inhibitory effects of citral, cinnamaldehyde, and tea polyphenols on mixed biofilm formation by foodborne staphylococcus aureus and Salmonella enteritidis","volume":"77","author":"Zhang","year":"2014","journal-title":"J. Food Prot."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242716303397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242716303397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T12:11:03Z","timestamp":1602331863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242716303397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":41,"alternative-id":["S0165242716303397"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2017.06.004","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary cinnamaldehyde enhances acquisition of specific antibodies following helminth infection in pigs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2017.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}