{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:02:48Z","timestamp":1759104168848,"version":"3.44.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Australian Companion Animal Health Fund"},{"name":"University of Sydney Calico"},{"name":"Bi-colour Cat Club Feline Research Bequest"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.vetimm.2019.02.009","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T11:23:45Z","timestamp":1551180225000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Breed-specific variations in the coding region of toll-like receptor 4 in the domestic cat"],"prefix":"10.1016","volume":"209","author":[{"given":"J.","family":"Whitney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Haase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-7801","authenticated-orcid":false,"given":"J.","family":"Beatty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-8022","authenticated-orcid":false,"given":"V.R.","family":"Barrs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2019.02.009_bib0005","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0010","article-title":"Predicting functional effect of human missense mutations using PolyPhen-2","volume":"76","author":"Adzhubei","year":"2013","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0015","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.02379","article-title":"Pattern recognition receptors and the host cell death molecular machinery","volume":"9","author":"Amarante-Mendes","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0025","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/apha.12798","article-title":"Physiological aspects of Toll-like receptor 4 activation in sepsis-induced acute kidney injury","volume":"219","author":"Anderberg","year":"2017","journal-title":"Acta Physiol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0030","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/76048","article-title":"TLR4 mutations are associated with endotoxin hyporesponsiveness in humans","volume":"25","author":"Arbour","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0035","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-2427(03)00159-4","article-title":"Full-length cDNA cloning of Toll-like receptor 4 in dogs and cats","volume":"96","author":"Asahina","year":"2003","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0040","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0045","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.tvjl.2014.12.020","article-title":"Detection of Aspergillus-specific antibodies by agar gel double immunodiffusion and IgG ELISA in feline upper respiratory tract aspergillosis","volume":"203","author":"Barrs","year":"2015","journal-title":"Vet. J."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0050","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S1471-4906(03)00242-4","article-title":"Leucine-rich repeats and pathogen recognition in Toll-like receptors","volume":"24","author":"Bell","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0055","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1056\/NEJMoa0802629","article-title":"Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation","volume":"359","author":"Bochud","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/vde.12295","article-title":"Overexpression of TLR-2 and TLR-4 mRNA in feline polymorphonuclear neutrophils exposed to Microsporum canis","volume":"27","author":"Cambier","year":"2016","journal-title":"Vet. Dermatol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0065","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.exphem.2009.06.004","article-title":"Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation","volume":"37","author":"Carvalho","year":"2009","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0070","first-page":"1","article-title":"Association between TLR2 and TLR4 gene polymorphisms and the susceptibility to inflammatory bowel disease: a meta-analysis","volume":"10","author":"Cheng","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2052-6687-1-11","article-title":"Non-synonymous genetic variation in exonic regions of canine Toll-like receptors","volume":"1","author":"Cusc\u00f3","year":"2014","journal-title":"Canine Genet. Epidemiol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018403","article-title":"Influence of polymorphisms in innate immunity genes on susceptibility to invasive aspergillosis after stem cell transplantation","volume":"6","author":"de Boer","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0085","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2119\/2007-00135.Ferwerda","article-title":"Functional consequences of toll-like receptor 4 polymorphisms","volume":"14","author":"Ferwerda","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0090","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/ni777","article-title":"Human Toll-like receptor 4 recognizes host-specific LPS modifications","volume":"3","author":"Hajjar","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0095","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1128\/CMR.16.4.637-646.2003","article-title":"Role of toll-like receptors in pathogen recognition","volume":"16","author":"Janssens","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0100","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.theriogenology.2014.10.023","article-title":"The role of toll-like receptors 2 and 4 in the pathogenesis of feline pyometra","volume":"83","author":"Jursza","year":"2015","journal-title":"Theriogenology"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015740","article-title":"Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs","volume":"5","author":"Kathrani","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0110","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/age.12008","article-title":"Variation of cats under domestication: genetic assignment of domestic cats to breeds and worldwide random-bred populations","volume":"44","author":"Kurushima","year":"2013","journal-title":"Anim. Genet."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0115","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/myc.12052","article-title":"Minireview: host defence in invasive aspergillosis","volume":"56","author":"Lass-Florl","year":"2013","journal-title":"Mycoses"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0120","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.tvjl.2011.06.016","article-title":"Genetic diversity, inbreeding and breeding practices in dogs: results from pedigree analyses","volume":"189","author":"Leroy","year":"2011","journal-title":"Vet. J."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.genrep.2016.11.005","article-title":"Predicting the effect of non synonymous SNPs in bovine TLR4 gene","volume":"6","author":"Mishra","year":"2017","journal-title":"Gene Rep."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0130","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bjid.2015.10.011","article-title":"TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review","volume":"20","author":"Mukherjee","year":"2016","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0135","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-11-406","article-title":"Light whole genome sequence for SNP discovery across domestic cat breeds","volume":"11","author":"Mullikin","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/2407137","article-title":"The bottleneck effect and genetic variability in populations","volume":"29","author":"Nei","year":"1975","journal-title":"Evolution"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01523","article-title":"Toll-like receptors, associated biological roles, and signaling networks in non-mammals","volume":"9","author":"Nie","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfms.2005.04.003","article-title":"Prevalence of feline infectious peritonitis in specific cat breeds","volume":"8","author":"Pesteanu-Somogyi","year":"2006","journal-title":"J. Feline Med. Surg."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0155","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.coi.2016.10.005","article-title":"Early innate immune responses to bacterial LPS","volume":"44","author":"Rosadini","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0160","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30865-0","article-title":"Toll-like receptor 4 pathway polymorphisms interact with pollution to influence asthma diagnosis and severity","volume":"8","author":"Schurman","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0165","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/318686","article-title":"Association of toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients","author":"Singh","year":"2013","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0170","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1093\/genetics\/165.3.1465","article-title":"The contribution of genetic diversity to the spread of infectious diseases in livestock populations","volume":"165","author":"Springbett","year":"2003","journal-title":"Genetics"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0175","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jhevol.2017.03.004","article-title":"An evolutionary medicine perspective on Neandertal extinction","volume":"108","author":"Sullivan","year":"2017","journal-title":"J. Hum. Evol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0180","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0185","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/v3060920","article-title":"Pattern recognition receptors and the innate immune response to viral infection","volume":"3","author":"Thompson","year":"2011","journal-title":"VirusesBasel"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0190","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4168\/aair.2015.7.2.130","article-title":"Association of single nucleotide polymorphisms in Toll-like receptor genes with asthma risk: a systematic review and meta-analysis","volume":"7","author":"Tizaoui","year":"2015","journal-title":"Allergy Asthma Immunol. Res."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00316","article-title":"A comparative review of toll-like receptor 4 expression and functionality in different animal species","volume":"5","author":"Vaure","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0200","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13567-014-0123-6","article-title":"Polymorphisms in the feline TNFA and CD209 genes are associated with the outcome of feline coronavirus infection","volume":"45","author":"Wang","year":"2014","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0205","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13567-018-0578-y","article-title":"Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq","volume":"49","author":"Watanabe","year":"2018","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0210","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1177\/1098612X12441875","article-title":"Risk factors for feline infectious peritonitis in Australian cats","volume":"14","author":"Worthing","year":"2012","journal-title":"J. Feline Med. Surg."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0215","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1007\/s10096-015-2461-3","article-title":"Possible role of TLR4 and TLR9 SNPs in protection against congenital toxoplasmosis","volume":"34","author":"Wujcicka","year":"2015","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.vetimm.2019.02.009_bib0220","article-title":"Association of polymorphisms in TLR2 and TLR4 with asthma risk An update meta-analysis","volume":"96","author":"Zhao","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.vetimm.2019.02.009_bib0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081047","article-title":"The Role of TLR4 896 A&G and 1196 C&T in susceptibility to infections: a review and meta-analysis of genetic association studies","volume":"8","author":"Ziakas","year":"2013","journal-title":"PLoS One"}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242718304355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242718304355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:25:35Z","timestamp":1759044335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242718304355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":45,"alternative-id":["S0165242718304355"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2019.02.009","relation":{},"ISSN":["0165-2427"],"issn-type":[{"type":"print","value":"0165-2427"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Breed-specific variations in the coding region of toll-like receptor 4 in the domestic cat","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2019.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}