{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:43:29Z","timestamp":1775263409199,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministerio de Econom\u00eda y Competitividad (MINECO)","award":["AGL2013-45868-R"],"award-info":[{"award-number":["AGL2013-45868-R"]}]},{"name":"MINECO"},{"DOI":"10.13039\/501100004687","name":"University of Murcia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.vetimm.2019.109887","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T08:09:09Z","timestamp":1561622949000},"page":"109887","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Effect of progesterone on the vaccination and immune response against Chlamydia abortus in sheep"],"prefix":"10.1016","volume":"213","author":[{"given":"A.","family":"Murcia-Belmonte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-0586","authenticated-orcid":false,"given":"E.","family":"G\u00f3mez-Luc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Buend\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4719-8926","authenticated-orcid":false,"given":"L.","family":"del R\u00edo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R.","family":"Caro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2019.109887_bib0005","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.tvjl.2015.04.036","article-title":"Intratracheal infection as an efficient route for testing vaccines against Chlamydia abortus in sheep","volume":"205","author":"\u00c1lvarez","year":"2015","journal-title":"Vet. J."},{"key":"10.1016\/j.vetimm.2019.109887_bib0010","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1471-2180-11-150","article-title":"Modulation of the Chlamydia trachomatis in vitro transcriptome response by the sex hormones estradiol and progesterone","volume":"11","author":"Amirshahi","year":"2011","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0015","doi-asserted-by":"crossref","first-page":"12564","DOI":"10.1128\/JVI.01559-10","article-title":"Suppression of innate immune pathology by regulatory T cells during Influenza A virus infection of immunodeficient mice","volume":"84","author":"Antunes","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0928-8244(03)00202-5","article-title":"Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone","volume":"38","author":"Beagley","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0025","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1073\/pnas.90.9.3998","article-title":"Morphologic and antigenic characterization of interferon gamma-mediated persistent Chlamydia trachomatis infection in vitro","volume":"90","author":"Beatty","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vetimm.2019.109887_bib0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.atherosclerosis.2007.09.026","article-title":"Evidence for persistent Chlamydia pneumoniae infection of human coronary atheromas","volume":"199","author":"Borel","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.vetimm.2019.109887_bib0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1471-2180-10-201","article-title":"Mixed infections with Chlamydia and porcine epidemic diarrhea virus - a new in vitro model of chlamydial persistence","volume":"10","author":"Borel","year":"2010","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0040","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1128\/IAI.66.5.2128-2134.1998","article-title":"Kinetics of infection and effects on placental cell populations in a murine model of Chlamydia psittaci-induced abortion","volume":"66","author":"Buend\u00eda","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0045","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1128\/IAI.67.5.2110-2116.1999","article-title":"Role of polymorphonuclear neutrophils in a murine model of Chlamydia psittaci-induced abortion","volume":"67","author":"Buend\u00eda","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0050","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1128\/IAI.00503-09","article-title":"B cells are essential for moderating the inflammatory response and controlling bacterial multiplication in a mouse model of vaccination against Chlamydophila abortus infection","volume":"77","author":"Buend\u00eda","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0055","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1016\/S0264-410X(03)00255-X","article-title":"Relationship between the immune response and protection conferred by new designed inactivated vaccines against ovine enzootic abortion in a mouse model","volume":"21","author":"Caro","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vetimm.2019.109887_bib0060","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1128\/IAI.63.12.4912-4916.1995","article-title":"An oligomer of the major outer membrane protein of Chlamydia psittaci is recognized by monoclonal antibodies which protect mice from abortion","volume":"63","author":"de Sa","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0065","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1462-5822.2005.00608.x","article-title":"Chlamydia trachomatis enters a viable but non-cultivable (persistent) state within herpes simplex virus type 2 (HSV-2) co-infected host cells","volume":"8","author":"Deka","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0070","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1053\/jcpa.2000.0411","article-title":"Chlamydophila abortus (Chlamydia psittaci serotype 1) clearance is associated with the early recruitment of neutrophils and CD8(+)T cells in a mouse model","volume":"123","author":"del R\u00edo","year":"2000","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0075","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1128\/IAI.69.8.4808-4815.2001","article-title":"Endogenous interleukin-12 is not required for resolution of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection in mice","volume":"69","author":"del R\u00edo","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.vetmic.2017.11.009","article-title":"Development of an in vivo model of Chlamydia abortus chronic infection in mice overexpressing IL-10","volume":"213","author":"del R\u00edo","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0085","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1210\/jc.2003-031647","article-title":"Interferon-related and other immune genes are downregulated in peripheral blood leukocytes in the luteal phase of the menstrual cycle","volume":"89","author":"Dosiou","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.vetimm.2019.109887_bib0090","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cimid.2011.12.001","article-title":"New challenges for vaccination to prevent chlamydial abortion in sheep","volume":"35","author":"Entrican","year":"2012","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.vetimm.2019.109887_bib0095","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s40588-015-0014-2","article-title":"Chlamydia abortus: new aspects of infectious abortion in sheep and potential risk for pregnant women","volume":"2","author":"Essig","year":"2015","journal-title":"Curr. Clin. Microbiol. Reports"},{"key":"10.1016\/j.vetimm.2019.109887_bib0100","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.vetmic.2004.01.015","article-title":"Efficacy of different commercial and new inactivated vaccines against ovine enzootic abortion","volume":"100","author":"Garc\u00eda de la Fuente","year":"2004","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0105","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1128\/AAC.48.4.1402-1405.2004","article-title":"First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae","volume":"48","author":"Gieffers","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetimm.2019.109887_bib0110","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1128\/IAI.71.8.4700-4710.2003","article-title":"Primary cultures of female swine genital epithelial cells in vitro: A new approach for the study of hormonal modulation of chlamydia infection","volume":"71","author":"Guseva","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0115","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/IAI.72.4.1843-1855.2004","article-title":"Chlamydial persistence: beyond the biphasic paradigm","volume":"72","author":"Hogan","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0120","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.molimm.2014.09.015","article-title":"CD4(+)Foxp3(+) Tregs protect against innate immune cell-mediated fulminant hepatitis in mice","volume":"63","author":"Hou","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0125","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1016\/j.ajpath.2015.07.019","article-title":"Endogenous Il10 alleviates the systemic antiviral cellular immune response and T cell-mediated immunopathology in select organs of acutely LCMV-infected mice","volume":"185","author":"Jakobshagen","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0130","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jneuroim.2016.04.010","article-title":"T cell-derived interleukin-10 is an important regulator of the Th17 response during lethal alphavirus encephalomyelitis","volume":"295\u2013296","author":"Kulcsar","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0135","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1053\/jcpa.2002.0629","article-title":"Animal chlamydioses and zoonotic implications","volume":"128","author":"Longbottom","year":"2003","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057950","article-title":"Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep","volume":"8","author":"Longbottom","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vetimm.2019.109887_bib0145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.1365-2249.2002.01780.x","article-title":"The strength of B cell immunity in female rhesus macaques is controlled by CD8+ T cells under the influence of ovarian steroid hormones","volume":"128","author":"L\u00fc","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0150","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jcpa.2005.12.002","article-title":"Relative importance of CD4+ and CD8+ T cells in the resolution of Chlamydophila abortus primary infection in mice","volume":"134","author":"Mart\u00ednez","year":"2006","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0155","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1128\/IAI.68.3.1746-1751.2000","article-title":"Polymorphonuclear neutrophils are necessary for the recruitment of CD8(+) T cells in the liver in a pregnant mouse model of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection","volume":"68","author":"Montes de Oca","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0160","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/infdis\/jiq176","article-title":"Murine Chlamydia trachomatis genital infection is unaltered by depletion of CD4 + T cells and diminished adaptive immunity","volume":"203","author":"Morrison","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vetimm.2019.109887_bib0165","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0889-1591(91)90013-Z","article-title":"Major reproduction hormones as regulators of cell-to-cell interactions in humoral immune responses","volume":"5","author":"Nikolaevich","year":"1991","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0170","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.rvsc.2006.07.016","article-title":"Role of polymorphonuclear neutrophils (PMNs) and NK cells in the protection conferred by different vaccines against Chlamydophila abortus infection","volume":"82","author":"Ortega","year":"2007","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetimm.2019.109887_bib0175","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cimid.2009.08.002","article-title":"Detection of all Chlamydophila and Chlamydia spp. of veterinary interest using species-specific real-time PCR assays","volume":"33","author":"Pantchev","year":"2010","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.vetimm.2019.109887_bib0180","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1128\/IAI.62.9.3786-3792.1994","article-title":"Abortion and subsequent excretion of chlamydiae from the reproductive tract of sheep during estrus","volume":"62","author":"Papp","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0185","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1128\/IAI.64.4.1116-1125.1996","article-title":"Pregnancy failure following vaginal infection of sheep with Chlamydia psittaci prior to breeding","volume":"64","author":"Papp","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0190","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.micinf.2012.07.017","article-title":"Chlamydia muridarum enters a viable but non-infectious state in amoxicillin-treated BALB\/c mice","volume":"14","author":"Phillips Campbell","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/j.vetimm.2019.109887_bib0195","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vetmic.2008.09.035","article-title":"Aberrant chlamydial developmental forms in the gastrointestinal tract of pigs spontaneously and experimentally infected with Chlamydia suis","volume":"135","author":"Pospischil","year":"2009","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0200","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1128\/IAI.00200-11","article-title":"In vivo ultrastructural analysis of the intimate relationship between polymorphonuclear leukocytes and the chlamydial developmental cycle","volume":"79","author":"Rank","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0205","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1128\/IAI.65.11.4539-4547.1997","article-title":"Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins","volume":"65","author":"Raulston","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetimm.2019.109887_bib0210","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/cmi.12060","article-title":"A novel co-infection model with Toxoplasma and Chlamydia trachomatis highlights the importance of host cell manipulation for nutrient scavenging","volume":"15","author":"Romano","year":"2013","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0215","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0952-7915(02)00361-8","article-title":"The role of IFN-gamma in the outcome of chlamydial infection","volume":"14","author":"Rottenberg","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0220","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/107155769700400505","article-title":"Expression of interleukin-10 in human gestational tissues","volume":"4","author":"Trautman","year":"1997","journal-title":"J. Soc. Gynecol. Investig."},{"key":"10.1016\/j.vetimm.2019.109887_bib0225","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1046\/j.0019-2805.2001.01281.x","article-title":"Medroxyprogesterone acetate enhances in vivo and in vitro antibody production","volume":"104","author":"Vermeulen","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.vetimm.2019.109887_bib0230","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/aji.12168","article-title":"Progesterone activates multiple innate immune pathways in Chlamydia trachomatis-Infected endocervical cells","volume":"71","author":"Wan","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0235","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jri.2010.11.009","article-title":"Effect of menstrual cycle variation in female sex hormones on cellular immunity and regulation","volume":"89","author":"Weinberg","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.vetimm.2019.109887_bib0240","first-page":"40","article-title":"Breeding performance of sheep infected with Chlamydia psittaci (ovis) during their preceding pregnancy","volume":"126","author":"Wilsmore","year":"1990","journal-title":"Vet. Rec."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242718304501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242718304501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T04:16:55Z","timestamp":1610079415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242718304501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":48,"alternative-id":["S0165242718304501"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2019.109887","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of progesterone on the vaccination and immune response against Chlamydia abortus in sheep","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2019.109887","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109887"}}