{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:08:04Z","timestamp":1787933284294,"version":"build-2784847793"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2021jcyj-msxmX0884"],"award-info":[{"award-number":["cstc2021jcyj-msxmX0884"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX1262"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX1262"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.vetimm.2025.110910","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T16:18:45Z","timestamp":1740500325000},"page":"110910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["TRIM21 interacts with I\u03baB\u03b1 and negatively regulates NF-\u03baB activation in Corynebacterium pseudotuberculosis-infected macrophages"],"prefix":"10.1016","volume":"282","author":[{"given":"Chanyu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoyong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2025.110910_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.coi.2012.12.005","article-title":"Regulation of NF-\u03baB by ubiquitination","volume":"25","author":"Chen","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.vetimm.2025.110910_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1051\/vetres:2005056","article-title":"Corynebacterium pseudotuberculosis: microbiology, biochemical properties, pathogenesis and molecular studies of virulence","volume":"37","author":"Dorella","year":"2006","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetimm.2025.110910_bib3","doi-asserted-by":"crossref","first-page":"10014","DOI":"10.1073\/pnas.1507534112","article-title":"Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21","volume":"112","author":"Fletcher","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.vetimm.2025.110910_bib4","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1038\/s41598-017-05487-7","article-title":"TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles","volume":"7","author":"Foltz","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetimm.2025.110910_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-\u03baB activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.vetimm.2025.110910_bib6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1165\/rcmb.2018-0366OC","article-title":"TRIM21 Mitigates Human Lung Microvascular Endothelial Cells\u2019 Inflammatory Responses to LPS","volume":"61","author":"Li","year":"2019","journal-title":"Am. J. Resp. Cell Mol."},{"key":"10.1016\/j.vetimm.2025.110910_bib7","article-title":"Multiple roles of TRIM21 in virus infection","volume":"24","author":"Li","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.vetimm.2025.110910_bib8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ccr.2014.05.015","article-title":"Ubiquitylation of autophagy receptor optineurin by HACE1 activates selective autophagy for tumor suppression","volume":"26","author":"Liu","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.vetimm.2025.110910_bib9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ni.2548","article-title":"Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21","volume":"14","author":"McEwan","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetimm.2025.110910_bib10","article-title":"Isolation, characterization, and pathogenicity assessment of Corynebacterium pseudotuberculosis biovar equi strains from alpacas (Vicugna pacos) in China","volume":"14","author":"Meng","year":"2023","journal-title":"Fornt. Microbiol."},{"issue":"11","key":"10.1016\/j.vetimm.2025.110910_bib11","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.4690","article-title":"Cycloheximide (CHX) chase assay to examine protein half-life","volume":"13","author":"Miao","year":"2023","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.vetimm.2025.110910_bib12","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/emboj.2012.354","article-title":"Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?","volume":"32","author":"Nathan","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.vetimm.2025.110910_bib13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.2065","article-title":"Crosstalk in NF-\u03baB signaling pathways","volume":"12","author":"Oeckinghaus","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetimm.2025.110910_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1751-0813.2003.tb11443.x","article-title":"Prevalence of caseous lymphadenitis and usage of caseous lymphadenitis vaccines in sheep flocks","volume":"81","author":"Paton","year":"2003","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetimm.2025.110910_bib15","first-page":"149","article-title":"Cytokine gene expression in sheep following experimental infection with various strains of Corynebacterium pseudotuberculosis differing in virulence","volume":"28","author":"P\u00e9pin","year":"1997","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetimm.2025.110910_bib16","first-page":"4794","article-title":"TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation","volume":"12","author":"Qin","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetimm.2025.110910_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2019.108461","article-title":"Cofilin-1, peroxiredoxin-1, and galectin-3: Major proteins released by macrophages infected with Corynebacterium pseudotuberculosis","volume":"239","author":"Shi","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2025.110910_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109209","article-title":"TRIM21 negatively regulates Corynebacterium pseudotuberculosis-induced inflammation and is critical for the survival of C. pseudotuberculosis infected C57BL6 mice","volume":"261","author":"Tan","year":"2021","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetimm.2025.110910_bib19","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/j.jid.2018.05.016","article-title":"E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis","volume":"138","author":"Yang","year":"2018","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.vetimm.2025.110910_bib20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s10753-020-01394-8","article-title":"TRIM Proteins in Inflammation: from Expression to Emerging Regulatory Mechanisms","volume":"44","author":"Yang","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.vetimm.2025.110910_bib21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/bjd.19057","article-title":"Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-\u03baB p65 subunit and promotes inflammation in keratinocytes","volume":"184","author":"Yang","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.vetimm.2025.110910_bib22","first-page":"1","article-title":"TRIM21-mediated ubiquitination of SQSTM1\/p62 abolishes its Ser403 phosphorylation and enhances palmitic acid cytotoxicity","author":"Yang","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.vetimm.2025.110910_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.685913","article-title":"Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape","volume":"9","author":"Yao","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.vetimm.2025.110910_bib24","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.4049\/jimmunol.0804121","article-title":"Gene Disruption Study Reveals a Nonredundant Role for TRIM21\/Ro52 in NF-\u03baB-Dependent Cytokine Expression in Fibroblasts","volume":"182","author":"Yoshimi","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetimm.2025.110910_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","article-title":"30 Years of NF-\u03baB: A Blossoming of Relevance to Human Pathobiology","volume":"168","author":"Zhang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.vetimm.2025.110910_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.molimm.2019.09.016","article-title":"Critical roles of NLRP3 inflammasome in IL-1\u03b2 secretion induced by Corynebacterium pseudotuberculosis in vitro","volume":"116","author":"Zhou","year":"2019","journal-title":"Mol. Immunol."},{"issue":"10","key":"10.1016\/j.vetimm.2025.110910_bib27","first-page":"3947","article-title":"Mechanism of IL-1\u03b1 expression, maturation and secretion in macrophages infected with Corynebacterium pseudotuberculosis","volume":"62","author":"Wang","year":"2022","journal-title":"Acta Microbiol. Sin."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242725000303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242725000303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T04:30:21Z","timestamp":1744086621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242725000303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":27,"alternative-id":["S0165242725000303"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2025.110910","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRIM21 interacts with I\u03baB\u03b1 and negatively regulates NF-\u03baB activation in Corynebacterium pseudotuberculosis-infected macrophages","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2025.110910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110910"}}