{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:19:06Z","timestamp":1787764746656,"version":"build-2784847793"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,8,18]],"date-time":"2027-08-18T00:00:00Z","timestamp":1818547200000},"content-version":"am","delay-in-days":351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K05988"],"award-info":[{"award-number":["22K05988"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26K09146"],"award-info":[{"award-number":["26K09146"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Immunology and Immunopathology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.vetimm.2026.111192","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:13:35Z","timestamp":1786547615000},"page":"111192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Increased mast cells in the thymus during acute thymic involution in Japanese Black calves with a poor prognosis"],"prefix":"10.1016","volume":"299","author":[{"given":"Sora","family":"Shirataki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0977-4518","authenticated-orcid":false,"given":"Shoichi","family":"Wakitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8384-8167","authenticated-orcid":false,"given":"Masahiro","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetimm.2026.111192_bib1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.15789\/1563-0625-TMC-2774","article-title":"Thymus mast cells as a component of neuro-endocrine-immune interactions under stress","volume":"25","author":"Artashyan","year":"2023","journal-title":"Med. Immunol. (Russ. )\/Meditsinskaya Immunol."},{"key":"10.1016\/j.vetimm.2026.111192_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1590\/S0074-02762005000900022","article-title":"Thymus involution in alloxan diabetes: analysis of mast cells","volume":"100","author":"Barreto","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.vetimm.2026.111192_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.tvjl.2024.106225","article-title":"Dynamics of the thymic transcriptome at stages of acute thymic involution in Japanese Black calves with a poor prognosis","volume":"307","author":"Furukawa","year":"2024","journal-title":"Vet. J."},{"key":"10.1016\/j.vetimm.2026.111192_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jdermsci.2007.09.009","article-title":"Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis","volume":"49","author":"Galli","year":"2008","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.vetimm.2026.111192_bib5","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fimmu.2018.00292","article-title":"Adrenomedullin and adrenomedullin-targeted therapy as treatment strategies relevant for sepsis","volume":"9","author":"Geven","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetimm.2026.111192_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.17691\/stm2021.13.4.10","article-title":"Modern imaging technologies of mast cells for biology and medicine (review)","volume":"13","author":"Grigorev","year":"2021","journal-title":"Sovrem. Tekhnol. Med."},{"key":"10.1016\/j.vetimm.2026.111192_bib7","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1189\/jlb.0108025","article-title":"Cytokines, leptin, and stress-induced thymic atrophy","volume":"84","author":"Gruver","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.vetimm.2026.111192_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fimmu.2012.00119","article-title":"Mast cell chemotaxis: chemoattractants and signaling pathways","volume":"3","author":"Halova","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetimm.2026.111192_bib9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.4103\/jomfp.JOMFP_267_19","article-title":"Quantification of mast cells in nonreactive and reactive lesions of gingiva: a comparative study using toluidine blue and immunohistochemical marker mast cell tryptase","volume":"25","author":"Jain","year":"2021","journal-title":"J. Oral. Maxillofac. Pathol."},{"key":"10.1016\/j.vetimm.2026.111192_bib10","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12016-019-08769-2","article-title":"Mast cell biology at molecular level: a comprehensive review","volume":"58","author":"Komi","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.vetimm.2026.111192_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s004410051103","article-title":"Bovine mast cells: distribution, density, heterogeneity, and influence of fixation techniques","volume":"293","author":"K\u00fcther","year":"1998","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.vetimm.2026.111192_bib12","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1016\/j.cell.2023.07.036","article-title":"TGF-\u03b2 signaling in health and disease","volume":"186","author":"Massagu\u00e9","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.vetimm.2026.111192_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/rda.14369","article-title":"Invited review: bovine neonatal morbidity and mortality: causes, risk factors, incidences, sequelae and prevention","volume":"58","author":"Mee","year":"2023","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.vetimm.2026.111192_bib14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.0959-4493.2001.00272.x","article-title":"The mast cell in wound healing","volume":"12","author":"Noli","year":"2001","journal-title":"Vet. Dermatol."},{"key":"10.1016\/j.vetimm.2026.111192_bib15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1439-0442.1999.00221.x","article-title":"Intrauterine growth retardation as a cause of perinatal mortality in Japanese Black beef calves","volume":"46","author":"Ogata","year":"1999","journal-title":"J. Vet. Med. A"},{"key":"10.1016\/j.vetimm.2026.111192_bib16","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1292\/jvms.65.793","article-title":"Changes in peripheral leukocyte populations of weak calf syndrome of Japanese Black calves","volume":"65","author":"Ohtsuka","year":"2003","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.vetimm.2026.111192_bib17","first-page":"11","article-title":"Increased mast cell density and microvessel density in the thymus of patients with myasthenia gravis","volume":"48","author":"Raica","year":"2007","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.vetimm.2026.111192_bib18","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1084\/jem.136.3.466","article-title":"Evidence for a blood-thymus barrier using electron-opaque tracers","volume":"136","author":"Raviola","year":"1972","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.vetimm.2026.111192_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0020062","article-title":"The thymus is a common target organ in infectious diseases","volume":"2","author":"Savino","year":"2006","journal-title":"PLoS. Pathog."},{"key":"10.1016\/j.vetimm.2026.111192_bib20","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1369\/0022155414545334","article-title":"Mast cell function: a new vision of an old cell","volume":"62","author":"da Silva","year":"2014","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.vetimm.2026.111192_bib21","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1292\/jvms.70.1173","article-title":"Thymic hypoplasia in Japanese Black calves with stillbirth\/perinatal weak calf syndrome","volume":"70","author":"Takasu","year":"2008","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.vetimm.2026.111192_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbadis.2010.12.014","article-title":"Mast cells and inflammation","volume":"1822","author":"Theoharides","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vetimm.2026.111192_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetimm.2021.110379","article-title":"Insufficiency of CD205-positive cortical thymic epithelial cells in immature Japanese Black cattle with severe thymic abnormalities and poor prognosis","volume":"245","author":"Wakitani","year":"2022","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetimm.2026.111192_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1292\/jvms.24-0413","article-title":"Distribution of keratin subtypes in the thymus of Japanese Black calves during acute thymic involution","volume":"87","author":"Wakitani","year":"2025","journal-title":"J. Vet. Med. Sci."}],"container-title":["Veterinary Immunology and Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242726001327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165242726001327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:32:09Z","timestamp":1787761929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165242726001327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":24,"alternative-id":["S0165242726001327"],"URL":"https:\/\/doi.org\/10.1016\/j.vetimm.2026.111192","relation":{},"ISSN":["0165-2427"],"issn-type":[{"value":"0165-2427","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased mast cells in the thymus during acute thymic involution in Japanese Black calves with a poor prognosis","name":"articletitle","label":"Article Title"},{"value":"Veterinary Immunology and Immunopathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetimm.2026.111192","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111192"}}