{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:04:32Z","timestamp":1791291872503,"version":"4.1.0"},"reference-count":121,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.vetmic.2007.11.023","type":"journal-article","created":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T20:17:55Z","timestamp":1196885875000},"page":"1-14","source":"Crossref","is-referenced-by-count":104,"title":["Brucella: A pathogen without classic virulence genes"],"prefix":"10.1016","volume":"129","author":[{"given":"Mohamed N.","family":"Seleem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nammalwar","family":"Sriranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2007.11.023_bib1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/IAI.66.3.1008-1016.1998","article-title":"Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival","volume":"66","author":"Allen","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/ni1202","article-title":"Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival","volume":"6","author":"Arellano-Reynoso","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1128\/jb.173.1.23-27.1991","article-title":"Identification of genes and gene products whose expression is activated during nitrogen-limited growth in Bacillus subtilis","volume":"173","author":"Atkinson","year":"1991","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1146\/annurev.bi.49.070180.003403","article-title":"Active oxygen species and the functions of phagocytic leukocytes","volume":"49","author":"Badwey","year":"1980","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.vetmic.2007.11.023_bib5","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1128\/JB.187.16.5767-5775.2005","article-title":"Carboxyl-terminal protease regulates Brucella suis morphology in culture and persistence in macrophages and mice","volume":"187","author":"Bandara","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2180-7-57","article-title":"Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB\/c mice","volume":"7","author":"Bandara","year":"2007","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.mi.38.100184.000331","article-title":"The role of oxygen and its derivatives in microbial pathogenesis and host defense","volume":"38","author":"Beaman","year":"1984","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib8","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1021\/bi00454a010","article-title":"A protein isolated from Brucella abortus is a Cu\u2013Zn superoxide dismutase","volume":"29","author":"Beck","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.vetmic.2007.11.023_bib9","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1128\/IAI.71.4.1794-1803.2003","article-title":"Genetic organization and iron-responsive regulation of the Brucella abortus 2,3-dihydroxybenzoic acid biosynthesis operon, a cluster of genes required for wild-type virulence in pregnant cattle","volume":"71","author":"Bellaire","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib10","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1128\/IAI.73.6.3702-3713.2005","article-title":"Opsonized virulent Brucella abortus replicates within nonacidic, endoplasmic reticulum-negative, LAMP-1-positive phagosomes in human monocytes","volume":"73","author":"Bellaire","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib11","doi-asserted-by":"crossref","first-page":"25310","DOI":"10.1016\/S0021-9258(18)47248-1","article-title":"Escherichia coli expresses a copper- and zinc-containing superoxide dismutase","volume":"269","author":"Benov","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2007.11.023_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1574-6968.2000.tb09075.x","article-title":"Osmoregulated periplasmic glucans in Proteobacteria","volume":"186","author":"Bohin","year":"2000","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.vetmic.2007.11.023_bib13","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1128\/AAC.49.9.3922-3925.2005","article-title":"Targeting of the virulence factor acetohydroxyacid synthase by sulfonylureas results in inhibition of intramacrophagic multiplication of Brucella suis","volume":"49","author":"Boigegrain","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2007.11.023_bib14","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1128\/IAI.58.9.2935-2939.1990","article-title":"Cloning, expression, and occurrence of the Brucella Cu\u2013Zn superoxide dismutase","volume":"58","author":"Bricker","year":"1990","journal-title":"Infect. Immun."},{"issue":"Pt 4","key":"10.1016\/j.vetmic.2007.11.023_bib15","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1099\/00221287-143-4-1115","article-title":"Periplasmic cyclic 1,2-beta-glucan in Brucella spp. is not osmoregulated","volume":"143","author":"Briones","year":"1997","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2007.11.023_bib16","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1128\/IAI.69.7.4528-4535.2001","article-title":"Brucella abortus cyclic beta-1,2-glucan mutants have reduced virulence in mice and are defective in intracellular replication in HeLa cells","volume":"69","author":"Briones","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib17","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1172\/JCI117750","article-title":"DNA repair is more important than catalase for Salmonella virulence in mice","volume":"95","author":"Buchmeier","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vetmic.2007.11.023_bib18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/jinf.2002.0996","article-title":"Bacteria in two-millennia-old cheese, and related epizoonoses in Roman populations","volume":"45","author":"Capasso","year":"2002","journal-title":"J. Infect."},{"key":"10.1016\/j.vetmic.2007.11.023_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1475-2859-5-13","article-title":"Brucella spp. noncanonical LPS: structure, biosynthesis, and interaction with host immune system","volume":"5","author":"Cardoso","year":"2006","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.vetmic.2007.11.023_bib20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1128\/IAI.46.2.384-388.1984","article-title":"Antigenic S-type lipopolysaccharide of Brucella abortus 1119-3","volume":"46","author":"Caroff","year":"1984","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib21","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1128\/IAI.00486-07","article-title":"Role of the Omp25\/Omp31 family in outer membrane properties and virulence of Brucella ovis","volume":"75","author":"Caro-Hernandez","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrmicro753","article-title":"The versatile bacterial type IV secretion systems","volume":"1","author":"Cascales","year":"2003","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mib.2003.11.001","article-title":"Organelle robbery: Brucella interactions with the endoplasmic reticulum","volume":"7","author":"Celli","year":"2004","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.20030088","article-title":"Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum","volume":"198","author":"Celli","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.vetmic.2007.11.023_bib25","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1073\/pnas.0406873102","article-title":"Brucella coopts the small GTPase Sar1 for intracellular replication","volume":"102","author":"Celli","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2007.11.023_bib26","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.1073\/pnas.91.15.7017","article-title":"Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes","volume":"91","author":"Chae","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2007.11.023_bib27","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1097-2765(00)80079-9","article-title":"Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates","volume":"1","author":"Chen","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.vetmic.2007.11.023_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbamcr.2004.02.013","article-title":"Type IV secretion: the Agrobacterium VirB\/D4 and related conjugation systems","volume":"1694","author":"Christie","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vetmic.2007.11.023_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.micro.58.030603.123630","article-title":"Biogenesis, architecture, and function of bacterial type IV secretion systems","volume":"59","author":"Christie","year":"2005","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2958.1993.tb01215.x","article-title":"Identification of a nitrogen-regulated promoter controlling expression of Klebsiella pneumoniae urease genes","volume":"8","author":"Collins","year":"1993","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib31","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1128\/JB.188.5.1929-1934.2006","article-title":"Brucella abortus synthesizes phosphatidylcholine from choline provided by the host","volume":"188","author":"Comerci","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib32","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1128\/IAI.56.12.3251-3261.1988","article-title":"Killing of Brucella abortus by bovine serum","volume":"56","author":"Corbeil","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib33","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/jb.179.10.3371-3373.1997","article-title":"The Bacillus subtilis ureABC operon","volume":"179","author":"Cruz-Ramos","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0891-5849(88)90015-9","article-title":"Degradation of oxidatively denatured proteins in Escherichia coli","volume":"5","author":"Davies","year":"1988","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.vetmic.2007.11.023_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0378-1097(96)00528-9","article-title":"A novel mechanism of urease regulation in Yersinia enterocolitica","volume":"147","author":"de Koning-Ward","year":"1997","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.vetmic.2007.11.023_bib36","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.micinf.2005.11.008","article-title":"Brucella outer membrane protein Omp31 is a haemin-binding protein","volume":"8","author":"Delpino","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.vetmic.2007.11.023_bib37","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1462-5822.2001.00131.x","article-title":"Identification of Brucella spp. genes involved in intracellular trafficking","volume":"3","author":"Delrue","year":"2001","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib38","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1462-5822.2005.00543.x","article-title":"A quorum-sensing regulator controls expression of both the type IV secretion system and the flagellar apparatus of Brucella melitensis","volume":"7","author":"Delrue","year":"2005","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.221575398","article-title":"The genome sequence of the facultative intracellular pathogen Brucella melitensis","volume":"99","author":"DelVecchio","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2007.11.023_bib40","first-page":"205","article-title":"Alkylation and oxidative damages to DNA: constitutive and inducible repair systems","volume":"39","author":"Demple","year":"1986","journal-title":"Basic Life Sci."},{"key":"10.1016\/j.vetmic.2007.11.023_bib41","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0014-5793(95)00189-G","article-title":"Cloning and sequencing of the bacterioferritin gene of Brucella melitensis 16M strain","volume":"361","author":"Denoel","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.vetmic.2007.11.023_bib42","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1111\/j.1462-5822.2006.00749.x","article-title":"The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB","volume":"8","author":"Dozot","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib43","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2460\/ajvr.2001.62.1461","article-title":"Attenuation of a Brucella abortus mutant lacking a major 25kDa outer membrane protein in cattle","volume":"62","author":"Edmonds","year":"2001","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2007.11.023_bib44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0378-1135(02)00110-4","article-title":"Brucella species lacking the major outer membrane protein Omp25 are attenuated in mice and protect against Brucella melitensis and Brucella ovis","volume":"88","author":"Edmonds","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1053\/rvsc.2002.0555","article-title":"Pathogenicity and protective activity in pregnant goats of a Brucella melitensis Deltaomp25 deletion mutant","volume":"72","author":"Edmonds","year":"2002","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2007.11.023_bib46","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.2460\/ajvr.1995.56.12.1592","article-title":"Serum sensitivity of field isolates and laboratory strains of Brucella abortus","volume":"56","author":"Eisenschenk","year":"1995","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2007.11.023_bib47","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1128\/JB.183.8.2454-2462.2001","article-title":"Interruption of the cydB locus in Brucella abortus attenuates intracellular survival and virulence in the mouse model of infection","volume":"183","author":"Endley","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib48","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1128\/mr.55.4.561-585.1991","article-title":"Oxidative stress responses in Escherichia coli and Salmonella typhimurium","volume":"55","author":"Farr","year":"1991","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.vetmic.2007.11.023_bib49","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1128\/IAI.71.4.2110-2119.2003","article-title":"Interactions between Brucella melitensis and human phagocytes: bacterial surface O-polysaccharide inhibits phagocytosis, bacterial killing, and subsequent host cell apoptosis","volume":"71","author":"Fernandez-Prada","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib50","doi-asserted-by":"crossref","first-page":"6784","DOI":"10.4049\/jimmunol.162.11.6784","article-title":"Lysosomal accumulation and recycling of lipopolysaccharide to the cell surface of murine macrophages, an in vitro and in vivo study","volume":"162","author":"Forestier","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib51","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.4049\/jimmunol.165.9.5202","article-title":"Brucella abortus lipopolysaccharide in murine peritoneal macrophages acts as a down-regulator of T cell activation","volume":"165","author":"Forestier","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib52","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1128\/jb.178.20.5867-5876.1996","article-title":"Brucella\u2013Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts","volume":"178","author":"Freer","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib53","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1462-5822.2005.00502.x","article-title":"The sheathed flagellum of Brucella melitensis is involved in persistence in a murine model of infection","volume":"7","author":"Fretin","year":"2005","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib54","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.bi.64.070195.000525","article-title":"Superoxide radical and superoxide dismutases","volume":"64","author":"Fridovich","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.vetmic.2007.11.023_bib55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.vetmic.2004.05.009","article-title":"Role of catalase in the virulence of Brucella melitensis in pregnant goats","volume":"102","author":"Gee","year":"2004","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib56","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1128\/IAI.73.5.2873-2880.2005","article-title":"The Brucella abortus Cu, Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice","volume":"73","author":"Gee","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib57","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1051\/vetres:2005003","article-title":"From the discovery of the Malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis","volume":"36","author":"Godfroid","year":"2005","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2007.11.023_bib58","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1432-1033.1980.tb04635.x","article-title":"Heterogeneity of antigenic-side-chain length in lipopolysaccharide from Escherichia coli 0111 and Salmonella typhimurium LT2","volume":"107","author":"Goldman","year":"1980","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.vetmic.2007.11.023_bib59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0378-1135(02)00214-6","article-title":"Brucella intracellular life: from invasion to intracellular replication","volume":"90","author":"Gorvel","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib60","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1128\/IAI.66.4.1309-1316.1998","article-title":"Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages","volume":"66","author":"Gross","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib61","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1128\/IAI.68.1.342-351.2000","article-title":"In vitro Brucella suis infection prevents the programmed cell death of human monocytic cells","volume":"68","author":"Gross","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib62","doi-asserted-by":"crossref","first-page":"12375","DOI":"10.1073\/pnas.192439399","article-title":"The two-component system BvrR\/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae","volume":"99","author":"Guzman-Verri","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2007.11.023_bib63","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1128\/JB.187.8.2715-2726.2005","article-title":"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis","volume":"187","author":"Halling","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib64","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/nar\/22.11.2010","article-title":"Recognition of oxidized abasic sites by repair endonucleases","volume":"22","author":"Haring","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2007.11.023_bib65","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1128\/IAI.68.7.4102-4107.2000","article-title":"Identification of genes required for chronic persistence of Brucella abortus in mice","volume":"68","author":"Hong","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib66","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1128\/JB.188.4.1295-1300.2006","article-title":"The Brucella abortus xthA-1 gene product participates in base excision repair and resistance to oxidative killing but is not required for wild-type virulence in the mouse model","volume":"188","author":"Hornback","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib67","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1096\/fasebj.6.3.1740238","article-title":"Relationship of resistance to oxygen free radicals to CuZn-superoxide dismutase activity in transgenic, transfected, and trisomic cells","volume":"6","author":"Huang","year":"1992","journal-title":"FASEB J."},{"key":"10.1016\/j.vetmic.2007.11.023_bib68","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0021-9258(18)94214-6","article-title":"An alkyl hydroperoxide reductase from Salmonella typhimurium involved in the defense of DNA against oxidative damage. Purification and properties","volume":"264","author":"Jacobson","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2007.11.023_bib69","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/IAI.61.1.124-134.1993","article-title":"Effects of cytokines on intracellular growth of Brucella abortus","volume":"61","author":"Jiang","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib70","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/cimm.1993.1241","article-title":"Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide","volume":"151","author":"Jiang","year":"1993","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib71","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0264-410X(93)90340-4","article-title":"Evaluation of vaccines and of antigen therapy in a mouse model for Brucella ovis","volume":"11","author":"Jimenez de Bagues","year":"1993","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2007.11.023_bib72","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1128\/IAI.72.4.2429-2433.2004","article-title":"Different responses of macrophages to smooth and rough Brucella spp.: relationship to virulence","volume":"72","author":"Jimenez de Bagues","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib73","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1128\/IAI.73.5.3178-3183.2005","article-title":"Regulation of the mitogen-activated protein kinases by Brucella spp. expressing a smooth and rough phenotype: relationship to pathogen invasiveness","volume":"73","author":"Jimenez de Bagues","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib74","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1128\/IAI.01185-06","article-title":"Different roles of the two high-oxygen-affinity terminal oxidases of Brucella suis: cytochrome c oxidase, but not ubiquinol oxidase, is required for persistence in mice","volume":"75","author":"Jimenez de Bagues","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib75","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1128\/IAI.69.8.4823-4830.2001","article-title":"Major outer membrane protein Omp25 of Brucella suis is involved in inhibition of tumor necrosis factor alpha production during infection of human macrophages","volume":"69","author":"Jubier-Maurin","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib76","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1016\/S0021-9258(18)62675-4","article-title":"Superoxide dismutase from Escherichia coli B. A new manganese-containing enzyme","volume":"245","author":"Keele","year":"1970","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2007.11.023_bib77","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1574-6968.2006.00253.x","article-title":"Brucella abortus-d-alanyl-d-alanine carboxypeptidase contributes to its intracellular replication and resistance against nitric oxide","volume":"259","author":"Kikuchi","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.vetmic.2007.11.023_bib78","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1128\/IAI.68.7.3861-3866.2000","article-title":"Regulation of Brucella abortus catalase","volume":"68","author":"Kim","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib79","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1128\/IAI.71.6.3020-3027.2003","article-title":"Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells","volume":"71","author":"Kim","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib80","series-title":"Proceedings of the National Academy of Sciences of the United States of America, vol. 99","first-page":"15711","article-title":"The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell","author":"Kohler","year":"2002"},{"key":"10.1016\/j.vetmic.2007.11.023_bib81","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mib.2004.12.003","article-title":"Brucella lipopolysaccharide acts as a virulence factor","volume":"8","author":"Lapaque","year":"2005","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib82","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0882-4010(92)90113-3","article-title":"Brucella abortus deficient in copper\/zinc superoxide dismutase is virulent in BALB\/c mice","volume":"12","author":"Latimer","year":"1992","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2007.11.023_bib83","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1128\/IAI.73.9.5524-5529.2005","article-title":"Identification of a new virulence factor, BvfA, in Brucella suis","volume":"73","author":"Lavigne","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib84","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0378-1135(02)00208-0","article-title":"Fun stories about Brucella: the \u201cfurtive nasty bug\u201d","volume":"90","author":"Letesson","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib85","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1128\/IAI.73.11.7768-7771.2005","article-title":"Differential use of the two high-oxygen-affinity terminal oxidases of Brucella suis for in vitro and intramacrophagic multiplication","volume":"73","author":"Loisel-Meyer","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib86","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1128\/IAI.74.3.1973-1976.2006","article-title":"Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection","volume":"74","author":"Loisel-Meyer","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib87","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1128\/IAI.60.11.4496-4503.1992","article-title":"Identification of 2,3-dihydroxybenzoic acid as a Brucella abortus siderophore","volume":"60","author":"Lopez-Goni","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib88","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1128\/IAI.00439-07","article-title":"BvrR\/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence","volume":"75","author":"Manterola","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib89","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1128\/IAI.63.8.3054-3061.1995","article-title":"The outer membranes of Brucella spp. are resistant to bactericidal cationic peptides","volume":"63","author":"Martinez de Tejada","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib90","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1073\/pnas.68.5.1024","article-title":"An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase","volume":"68","author":"McCord","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2007.11.023_bib91","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1128\/IAI.67.8.3830-3835.1999","article-title":"Genetic characterization of a Tn5-disrupted glycosyltransferase gene homolog in Brucella abortus and its effect on lipopolysaccharide composition and virulence","volume":"67","author":"McQuiston","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/jb.174.1.1-7.1992","article-title":"Environmental signals controlling expression of virulence determinants in bacteria","volume":"174","author":"Mekalanos","year":"1992","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib93","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/MMBR.59.3.451-480.1995","article-title":"Molecular biology of microbial ureases","volume":"59","author":"Mobley","year":"1995","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.vetmic.2007.11.023_bib94","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1128\/JB.182.23.6845-6849.2000","article-title":"A Xanthomonas alkyl hydroperoxide reductase subunit C (ahpC) mutant showed an altered peroxide stress response and complex regulation of the compensatory response of peroxide detoxification enzymes","volume":"182","author":"Mongkolsuk","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.022622699","article-title":"Brucella melitensis: a nasty bug with hidden credentials for virulence","volume":"99","author":"Moreno","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2007.11.023_bib96","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/IAI.31.1.362-370.1981","article-title":"Biological activities of Brucella abortus lipopolysaccharides","volume":"31","author":"Moreno","year":"1981","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib97","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1574-695X.2001.tb00536.x","article-title":"Immune control of Brucella abortus 2308 infections in BALB\/c mice","volume":"32","author":"Murphy","year":"2001","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib98","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1046\/j.1365-2958.1999.01569.x","article-title":"A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis","volume":"33","author":"O\u2019Callaghan","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib99","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1128\/IAI.67.2.986-988.1999","article-title":"Vaccination with live Escherichia coli expressing Brucella abortus Cu\/Zn superoxide dismutase protects mice against virulent B. abortus","volume":"67","author":"Onate","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib100","doi-asserted-by":"crossref","first-page":"13148","DOI":"10.1073\/pnas.192319099","article-title":"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts","volume":"99","author":"Paulsen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2007.11.023_bib101","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1128\/IAI.74.5.2667-2675.2006","article-title":"Brucella abortus rough mutants induce macrophage oncosis that requires bacterial protein synthesis and direct interaction with the macrophage","volume":"74","author":"Pei","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib102","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1128\/IAI.60.4.1699-1702.1992","article-title":"Effect of Brucella abortus lipopolysaccharide on oxidative metabolism and lysozyme release by human neutrophils","volume":"60","author":"Rasool","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib103","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1128\/IAI.46.1.231-236.1984","article-title":"Brucellacidal activity of human and bovine polymorphonuclear leukocyte granule extracts against smooth and rough strains of Brucella abortus","volume":"46","author":"Riley","year":"1984","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib104","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1365-2958.2004.04017.x","article-title":"Adaptation of the Brucellae to their intracellular niche","volume":"52","author":"Roop","year":"2004","journal-title":"Mol. Microbiol."},{"issue":"Pt 2","key":"10.1016\/j.vetmic.2007.11.023_bib105","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1099\/00221287-146-2-487","article-title":"The genes for erythritol catabolism are organized as an inducible operon in Brucella abortus","volume":"146","author":"Sangari","year":"2000","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2007.11.023_bib106","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1128\/IAI.01244-06","article-title":"Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium","volume":"75","author":"Sangari","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib107","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1128\/JB.183.24.7173-7181.2001","article-title":"Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli","volume":"183","author":"Seaver","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib108","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.1128\/jb.176.23.7375-7377.1994","article-title":"Brucella abortus catalase is a periplasmic protein lacking a standard signal sequence","volume":"176","author":"Sha","year":"1994","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib109","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1126\/science.272.5268.1641","article-title":"Compensatory ahpC gene expression in isoniazid-resistant mycobacterium tuberculosis","volume":"272","author":"Sherman","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.vetmic.2007.11.023_bib110","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1128\/JB.182.17.4849-4855.2000","article-title":"A homologue of an operon required for DNA transfer in agrobacterium is required in Brucella abortus for virulence and intracellular multiplication","volume":"182","author":"Sieira","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib111","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0003-9969(93)90187-Q","article-title":"Urease activity in Streptococcus salivarius at low pH","volume":"38","author":"Sissons","year":"1993","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib112","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1128\/jb.175.11.3253-3258.1993","article-title":"Hydrolysis of urea by ureaplasma urealyticum generates a transmembrane potential with resultant ATP synthesis","volume":"175","author":"Smith","year":"1993","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib113","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1365-2958.1998.00913.x","article-title":"A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence","volume":"29","author":"Sola-Landa","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib114","series-title":"Proceedings of the National Academy of Sciences of the United States of America, vol. 103","first-page":"16514","article-title":"A B lymphocyte mitogen is a Brucella abortus virulence factor required for persistent infection","author":"Spera","year":"2006"},{"key":"10.1016\/j.vetmic.2007.11.023_bib115","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1128\/IAI.73.6.3322-3329.2005","article-title":"Nitric oxide detoxification systems enhance survival of Neisseria meningitidis in human macrophages and in nasopharyngeal mucosa","volume":"73","author":"Stevanin","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib116","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1128\/jb.171.4.2049-2055.1989","article-title":"An alkyl hydroperoxide reductase induced by oxidative stress in Salmonella typhimurium and Escherichia coli: genetic characterization and cloning of ahp","volume":"171","author":"Storz","year":"1989","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib117","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1128\/IAI.60.7.2863-2869.1992","article-title":"Construction of Cu\u2013Zn superoxide dismutase deletion mutants of Brucella abortus: analysis of survival in vitro in epithelial and phagocytic cells and in vivo in mice","volume":"60","author":"Tatum","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2007.11.023_bib118","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1348-0421.2006.tb03810.x","article-title":"Characterization of biological activities of Brucella melitensis lipopolysaccharide","volume":"50","author":"Tumurkhuu","year":"2006","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib119","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1128\/JB.00265-07","article-title":"Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis","volume":"189","author":"Uzureau","year":"2007","journal-title":"J. Bacterial."},{"key":"10.1016\/j.vetmic.2007.11.023_bib120","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.vetmic.2005.01.018","article-title":"Role of HdeA in acid resistance and virulence in Brucella abortus 2308","volume":"107","author":"Valderas","year":"2005","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2007.11.023_bib121","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1016\/S0021-9258(19)43649-1","article-title":"An iron-containing superoxide dismutase from Escherichia coli","volume":"248","author":"Yost","year":"1973","journal-title":"J. Biol. Chem."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113507005810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113507005810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T02:07:28Z","timestamp":1708394848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113507005810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":121,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0378113507005810"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2007.11.023","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}