{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:13:39Z","timestamp":1793204019536,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["QLK 2-CT-2001-01420"],"award-info":[{"award-number":["QLK 2-CT-2001-01420"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01 KI 0750"],"award-info":[{"award-number":["FKZ 01 KI 0750"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010570","name":"Nieders\u00e4chsisches Ministerium f\u00fcr Wissenschaft und Kultur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.vetmic.2008.01.014","type":"journal-article","created":{"date-parts":[[2008,2,9]],"date-time":"2008-02-09T07:42:17Z","timestamp":1202542937000},"page":"330-337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mycobacterium avium subsp. paratuberculosis-specific mpt operon expressed in M. bovis BCG as vaccine candidate"],"prefix":"10.1016","volume":"130","author":[{"given":"Julia","family":"Heinzmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirja","family":"Wilkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Dohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald-F.","family":"Gerlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2008.01.014_bib1","series-title":"Tuberculosis: Pathogenesis, Protection, and Control","first-page":"531","article-title":"The BCG experience: implications for future vaccines against tuberculosis","author":"Bloom","year":"1994"},{"key":"10.1016\/j.vetmic.2008.01.014_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0022-2836(69)90288-5","article-title":"A complementation analysis of the restriction and modification of DNA in Escherichia coli","volume":"41","author":"Boyer","year":"1969","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetmic.2008.01.014_bib3","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/IAI.70.2.672-678.2002","article-title":"Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis","volume":"70","author":"Brandt","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2008.01.014_bib4","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1016\/j.vaccine.2005.01.150","article-title":"Effect of oral vaccination of cattle with lipid-formulated BCG on immune responses and protection against bovine tuberculosis","volume":"23","author":"Buddle","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2008.01.014_bib5","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/iai.4.6.688-696.1971","article-title":"Immunogenicity of various mycobacteria and the corresponding levels of cross-protection developed between species","volume":"4","author":"Collins","year":"1971","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2008.01.014_bib6","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1016\/j.vaccine.2007.01.087","article-title":"Evaluation of recombinant BCG expressing rotavirus VP6 as an anti-rotavirus vaccine","volume":"25","author":"Dennehy","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2008.01.014_bib7","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.vaccine.2004.08.039","article-title":"Factors influencing the immune response to foreign antigen expressed in recombinant BCG vaccines","volume":"23","author":"Dennehy","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2008.01.014_bib8","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0264-410X(02)00577-7","article-title":"Mycobacterium bovis BCG-based vaccines against tuberculosis: novel developments","volume":"21","author":"Dietrich","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2008.01.014_bib9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1473-3099(07)70211-6","article-title":"Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis","volume":"7","author":"Feller","year":"2007","journal-title":"Lancet Infect Dis."},{"key":"10.1016\/j.vetmic.2008.01.014_bib10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.mimet.2004.01.010","article-title":"Recovery of Mycobacterium avium subspecies paratuberculosis from the natural host for the extraction and analysis in vivo-derived RNA","volume":"57","author":"Granger","year":"2004","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.vetmic.2008.01.014_bib11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/CMR.14.3.489-512.2001","article-title":"Mycobacterium avium subsp. paratuberculosis in veterinary medicine","volume":"14","author":"Harris","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.vetmic.2008.01.014_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.vetmic.2005.11.050","article-title":"Recent advances in our knowledge of Mycobacterium bovis: a feeling for the organism","volume":"112","author":"Hewinson","year":"2006","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2008.01.014_bib13","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0264-410X(00)00070-0","article-title":"Immune responses induced by recombinant BCG strains according to level of production of a foreign antigen: MalE","volume":"18","author":"Himmelrich","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2008.01.014_bib14","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1128\/IAI.73.10.6877-6884.2005","article-title":"Expression library immunization confers protection against Mycobacterium avium subsp. paratuberculosis infection","volume":"73","author":"Huntley","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2008.01.014_bib15","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1016\/j.vaccine.2005.12.019","article-title":"Mycobacterial 70kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis","volume":"24","author":"Koets","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2008.01.014_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1439-0450.2001.00443.x","article-title":"Immune reactions in cattle after immunization with a Mycobacterium paratuberculosis vaccine and implications for the diagnosis of M. paratuberculosis and M. bovis infections","volume":"48","author":"Kohler","year":"2001","journal-title":"J. Vet. Med. B Infect. Dis. Vet. Public Health"},{"key":"10.1016\/j.vetmic.2008.01.014_bib17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/104063879100300425","article-title":"Ruminant paratuberculosis\u2014a century of progress and frustration","volume":"3","author":"Kreeger","year":"1991","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.vetmic.2008.01.014_bib18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.vetimm.2006.03.009","article-title":"The safety and immunogenicity of Bacillus Calmette-Gu\u00e9rin (BCG) vaccine in European badgers (Meles meles)","volume":"112","author":"Lesellier","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2008.01.014_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.micinf.2005.03.012","article-title":"Improved protection by recombinant BCG","volume":"7","author":"Nasser","year":"2005","journal-title":"Microbes Infect."},{"key":"10.1016\/j.vetmic.2008.01.014_bib20","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2460\/javma.1988.192.09.1197","article-title":"Accidental self-inoculation with Mycobacterium paratuberculosis bacterin (Johne's bacterin) by veterinarians in Wisconsin","volume":"192","author":"Patterson","year":"1988","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.vetmic.2008.01.014_bib21","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1128\/JB.181.16.4780-4789.1999","article-title":"Comparison of the construction of unmarked deletion mutations in Mycobacterium smegmatis, Mycobacterium bovis bacillus Calmette-Guerin, and Mycobacterium tuberculosis H37Rv by allelic exchange","volume":"181","author":"Pavelka","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2008.01.014_bib22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nm859","article-title":"Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis","volume":"9","author":"Pym","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.vetmic.2008.01.014_bib23","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1099\/13500872-141-9-2131","article-title":"Species-specific identification of Mycobacterium bovis by PCR","volume":"141","author":"Rodriguez","year":"1995","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2008.01.014_bib24","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1128\/IAI.01521-05","article-title":"Development of luminescent Mycobacterium avium subsp. paratuberculosis for rapid screening of vaccine candidates in mice","volume":"74","author":"Rosseels","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2008.01.014_bib25","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1128\/IAI.01742-05","article-title":"Identification of novel virulence determinants in Mycobacterium paratuberculosis by screening a library of insertional mutants","volume":"74","author":"Shin","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2008.01.014_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1084\/jem.178.1.197","article-title":"Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine","volume":"178","author":"Stover","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.vetmic.2008.01.014_bib27","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/351456a0","article-title":"New use of BCG for recombinant vaccines","volume":"351","author":"Stover","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2008.01.014_bib28","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1128\/AEM.00590-06","article-title":"Peptide aMptD-mediated capture PCR for detection of Mycobacterium avium subsp. paratuberculosis in bulk milk samples","volume":"72","author":"Stratmann","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.vetmic.2008.01.014_bib29","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1128\/IAI.72.3.1265-1274.2004","article-title":"A 38-kilobase pathogenicity island specific for Mycobacterium avium subsp paratuberculosis encodes cell surface proteins expressed in the host","volume":"72","author":"Stratmann","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2008.01.014_bib30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/01652176.2001.9695094","article-title":"Present and future of veterinary viral vaccinology: a review","volume":"23","author":"van Oirschot","year":"2001","journal-title":"Vet. Q."},{"key":"10.1016\/j.vetmic.2008.01.014_bib31","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1128\/IAI.01826-06","article-title":"Environmental strains of Mycobacterium avium interfere with immune responses associated with BCG vaccination","volume":"75","author":"Young","year":"2007","journal-title":"Infect. Immun."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113508000540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113508000540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T22:56:34Z","timestamp":1759877794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113508000540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":31,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0378113508000540"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2008.01.014","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mycobacterium avium subsp. paratuberculosis-specific mpt operon expressed in M. bovis BCG as vaccine candidate","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2008.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}