{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:14:28Z","timestamp":1777461268395,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.vetmic.2008.12.018","type":"journal-article","created":{"date-parts":[[2008,12,26]],"date-time":"2008-12-26T09:33:49Z","timestamp":1230284029000},"page":"111-119","source":"Crossref","is-referenced-by-count":31,"title":["A reverse vaccinology approach to swine dysentery vaccine development"],"prefix":"10.1016","volume":"137","author":[{"given":"Yong","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"La","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nyree D.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew I.","family":"Bellgard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Hampson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2008.12.018_bib1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2008.12.018_bib2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/nar\/30.1.276","article-title":"The Pfam protein families database","volume":"30","author":"Bateman","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2008.12.018_bib3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0","volume":"340","author":"Bendtsen","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetmic.2008.12.018_bib4","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1128\/JCM.32.8.1976-1979.1994","article-title":"Evaluation of microagglutination test for differentiation between Serpulina (Treponema) hyodysenteriae and S. innocens and serotyping of S. hyodysenteriae","volume":"32","author":"Diarra","year":"1994","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2008.12.018_bib5","first-page":"604","article-title":"Multiresistant Brachyspira hyodysenteriae in a Dutch sow herd","volume":"133","author":"Duinhof","year":"2008","journal-title":"Tijdschr. Diergeneeskd."},{"key":"10.1016\/j.vetmic.2008.12.018_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1101\/gr.8.3.175","article-title":"Base-calling of automated sequencer traces using phred. I. Accuracy assessment","volume":"8","author":"Ewing","year":"1998","journal-title":"Genome Res."},{"key":"10.1016\/j.vetmic.2008.12.018_bib7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1128\/IAI.63.1.142-148.1995","article-title":"Isolation of extracytoplasmic proteins from Serpulina hyodysenteriae B204 and molecular cloning of the flaB1 gene encoding a 38-kilodalton flagellar protein","volume":"63","author":"Gabe","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2008.12.018_bib8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/bioinformatics\/bti057","article-title":"PSORTb v.2. 0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis","volume":"21","author":"Gardy","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.vetmic.2008.12.018_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1101\/gr.8.3.195","article-title":"Consed: a graphical tool for sequence finishing","volume":"8","author":"Gordon","year":"1998","journal-title":"Genome Res."},{"key":"10.1016\/j.vetmic.2008.12.018_bib10","series-title":"Diseases of Swine","first-page":"785","article-title":"Swine dysentery","author":"Hampson","year":"2006"},{"key":"10.1016\/j.vetmic.2008.12.018_bib11","doi-asserted-by":"crossref","first-page":"215219","DOI":"10.1093\/nar\/27.1.215","article-title":"The PROSITE database, its status in 1999","volume":"27","author":"Hofmann","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2008.12.018_bib12","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1128\/JCM.24.4.669-671.1986","article-title":"Autoclaved liquid medium for propagation of Treponema hyodysenteriae","volume":"24","author":"Kunkle","year":"1986","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2008.12.018_bib13","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1128\/JCM.41.7.3372-3375.2003","article-title":"Development of a duplex PCR assay for detection of Brachyspira hyodysenteriae and Brachyspira pilosicoli in pig feces","volume":"41","author":"La","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2008.12.018_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.vetmic.2004.06.004","article-title":"Protection of pigs from swine dysentery by vaccination with recombinant BmpB, a 29.7kDa outer-membrane lipoprotein of Brachyspira hyodysenteriae","volume":"102","author":"La","year":"2004","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2008.12.018_bib15","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/nar\/26.4.1107","article-title":"GeneMark.hmm: new solutions for gene finding","volume":"26","author":"Lukashin","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2008.12.018_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2008.02.011","article-title":"New ways to identify novel bacterial antigens for vaccine development","volume":"131","author":"Movahedi","year":"2008","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2008.12.018_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0065-3233(00)54009-1","article-title":"Protein sorting signals and prediction of subcellular localization","volume":"54","author":"Nakai","year":"2000","journal-title":"Adv. Protein Chem."},{"key":"10.1016\/j.vetmic.2008.12.018_bib18","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1126\/science.287.5459.1816","article-title":"Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing","volume":"287","author":"Pizza","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.vetmic.2008.12.018_bib19","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1016\/S0264-410X(00)00554-5","article-title":"Reverse vaccinology, a genome-based approach to vaccine development","volume":"19","author":"Rappuoli","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2008.12.018_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0034-5288(18)31217-7","article-title":"Antibody production by the pig colon during infection with Treponema hyodysenteriae","volume":"47","author":"Rees","year":"1989","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2008.12.018_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/geno.1999.5854","article-title":"Interpolated Markov models for eukaryotic gene finding","volume":"59","author":"Salzberg","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.vetmic.2008.12.018_bib22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1099\/mic.0.28317-0","article-title":"Lipoprotein computational prediction in spirochaetal genomes","volume":"152","author":"Setubal","year":"2006","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2008.12.018_bib23","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1001\/jama.281.16.1520","article-title":"Immunogenicity of 2 serogroup B outer-membrane protein meningococcal vaccines: a randomized controlled trial in Chile","volume":"281","author":"Tappero","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.vetmic.2008.12.018_bib24","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2008.12.018_bib25","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1128\/IAI.56.12.3032-3039.1988","article-title":"Characterization of the major outer membrane antigens of Treponema hyodysenteriae","volume":"56","author":"Wannemuehler","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2008.12.018_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/nar\/29.1.11","article-title":"Database resources of the National Center for Biotechnology Information","volume":"29","author":"Wheeler","year":"2001","journal-title":"Nucleic Acids Res."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113508005890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113508005890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T04:08:02Z","timestamp":1589429282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113508005890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":26,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0378113508005890"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2008.12.018","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}