{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:11:46Z","timestamp":1773007906487,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.vetmic.2010.01.024","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T09:50:11Z","timestamp":1265104211000},"page":"487-492","source":"Crossref","is-referenced-by-count":36,"title":["Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy"],"prefix":"10.1016","volume":"144","author":[{"given":"Lucia","family":"Unger-Torroledo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reto","family":"Straub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea D.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Graber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Frey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinzenz","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Hoppeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Baum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2010.01.024_bib1","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1128\/IAI.72.6.3120-3128.2004","article-title":"Degeneration and regeneration of murine skeletal neuromuscular junctions after intramuscular injection with a sublethal dose of Clostridium sordellii lethal toxin","volume":"72","author":"Barbier","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2010.01.024_bib2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/10739680591003413","article-title":"Arteriolization of capillaries and FGF-2 upregulation in skeletal muscles of patients with chronic peripheral arterial disease","volume":"12","author":"Baum","year":"2005","journal-title":"Microcirculation"},{"key":"10.1016\/j.vetmic.2010.01.024_bib3","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1462-5822.2006.00687.x","article-title":"Modification of epithelial cell barrier permeability and intercellular junctions by Clostridium sordellii lethal toxins","volume":"8","author":"Boehm","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.vetmic.2010.01.024_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2746\/042516407X157765","article-title":"Morphological alterations in oxidative muscles and mitochondrial structure associated with equine atypical myopathy","volume":"39","author":"Cassart","year":"2007","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.vetmic.2010.01.024_bib5","first-page":"202","article-title":"C. sordellii and C. bifermentans toxicoinfection as a possible cause of \u201cAtypical Myoglobinuria\u201d in grazing horses","volume":"148","author":"Eberle","year":"2006","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"10.1016\/j.vetmic.2010.01.024_bib6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.tvjl.2008.03.023","article-title":"Prevention and treatment of equine atypical myopathy\u2014an acute, highly fatal disease of unknown etiology","volume":"178","author":"Finno","year":"2008","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2010.01.024_bib7","first-page":"178","article-title":"Zur aktuellen Problematik der atypische Weidemyopathie des Pferdes","volume":"86","author":"Gehlen","year":"2005","journal-title":"Prakt. Tierarzt."},{"key":"10.1016\/j.vetmic.2010.01.024_bib8","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.2353\/ajpath.2007.060583","article-title":"Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability","volume":"170","author":"Geny","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.vetmic.2010.01.024_bib9","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1024\/0036-7281.148.10.553","article-title":"Equine botulism and acute pasture myodystrophy: new soil-borne emerging diseases in Switzerland?","volume":"148","author":"Gerber","year":"2006","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"10.1016\/j.vetmic.2010.01.024_bib10","first-page":"603","article-title":"Atypical myoglobinuria alert","volume":"127","author":"Harris","year":"1990","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2010.01.024_bib11","doi-asserted-by":"crossref","first-page":"16134","DOI":"10.1074\/jbc.273.26.16134","article-title":"Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35","volume":"273","author":"Herrmann","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2010.01.024_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1152\/jappl.1985.59.2.320","article-title":"Endurance training in humans: aerobic capacity and structure of skeletal muscle","volume":"59","author":"Hoppeler","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.vetmic.2010.01.024_bib13","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/vr.119.18.444","article-title":"Acute myopathy in horses at grass in east and south east Scotland","volume":"119","author":"Hosie","year":"1986","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2010.01.024_bib14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1751-0813.2002.tb10839.x","article-title":"Malignant oedema associated with blood-sampling in sheep","volume":"80","author":"Morris","year":"2002","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetmic.2010.01.024_bib15","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1939-1676.2008.0167.x","article-title":"Glycogen synthase 1 (GYS1) mutation in diverse breeds with polysaccharide storage myopathy","volume":"22","author":"McCue","year":"2008","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.vetmic.2010.01.024_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1939-1676.1998.tb02114.x","article-title":"Electrolyte disturbances in foals with severe rhabdomyolysis","volume":"12","author":"Perkins","year":"1998","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.vetmic.2010.01.024_bib17","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1046\/j.1462-5822.2003.00309.x","article-title":"Lethal toxin from Clostridium sordellii induces apoptotic cell death by disruption of mitochondrial homeostasis in HL-60 cells","volume":"5","author":"Petit","year":"2003","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.vetmic.2010.01.024_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/IAI.55.1.35-43.1987","article-title":"Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile cytotoxin","volume":"55","author":"Popoff","year":"1987","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2010.01.024_bib19","first-page":"185","article-title":"Bacterial toxins modifying the actin cytoskeleton","volume":"2","author":"Richard","year":"1999","journal-title":"Int. Microbiol."},{"key":"10.1016\/j.vetmic.2010.01.024_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbagen.2004.03.014","article-title":"Large clostridial cytotoxins: cellular biology of Rho\/Ras-glucosylating toxins","volume":"1673","author":"Schirmer","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vetmic.2010.01.024_bib21","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1086\/344464","article-title":"Toxic shock syndrome due to Clostridium sordellii: a dramatic postpartum and postabortion disease","volume":"35","author":"Sinave","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.vetmic.2010.01.024_bib22","doi-asserted-by":"crossref","first-page":"R535","DOI":"10.1016\/S0960-9822(00)00588-1","article-title":"Adhesion signaling: PAK meets Rac on solid ground","volume":"10","author":"Symons","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.vetmic.2010.01.024_bib23","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1101\/gad.11.18.2295","article-title":"Rho GTPases and signaling networks","volume":"11","author":"Van Aelst","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.vetmic.2010.01.024_bib24","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.bbrc.2007.09.073","article-title":"Critical intermediate steps in Clostridium sordellii lethal toxin-induced apoptosis","volume":"363","author":"Voth","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vetmic.2010.01.024_bib25","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1111\/j.1939-1676.2007.tb01962.x","article-title":"History and clinical features of atypical myopathy in horses in Belgium (2000\u20132005)","volume":"21","author":"Votion","year":"2007","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.vetmic.2010.01.024_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.nmd.2008.02.007","article-title":"Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy","volume":"18","author":"Westermann","year":"2008","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.vetmic.2010.01.024_bib27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.2042-3306.1988.tb01545.x","article-title":"Atypical myoglobinuria: an acute myopathy in grazing horses","volume":"20","author":"Whitwell","year":"1988","journal-title":"Equine Vet. J."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811351000060X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811351000060X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T11:03:55Z","timestamp":1711191835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811351000060X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":27,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S037811351000060X"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2010.01.024","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}