{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:39:11Z","timestamp":1791344351113,"version":"4.3.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Spain MICINN projects Consolider Ingenio","award":["CSD2007-00002"],"award-info":[{"award-number":["CSD2007-00002"]}]},{"name":"Spain MICINN projects Consolider Ingenio","award":["AGL2008-03519-C04"],"award-info":[{"award-number":["AGL2008-03519-C04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.vetmic.2010.10.017","type":"journal-article","created":{"date-parts":[[2010,11,5]],"date-time":"2010-11-05T08:21:36Z","timestamp":1288945296000},"page":"48-55","source":"Crossref","is-referenced-by-count":21,"title":["Characterization of an infectious pancreatic necrosis (IPN) virus carrier cell culture with resistance to superinfection with heterologous viruses"],"prefix":"10.1016","volume":"149","author":[{"given":"Inmaculada","family":"Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Galiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Falc\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Estepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2010.10.017_bib0005","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s007050050534","article-title":"Viral coinfection in salmonids: infectious pancreatic necrosis virus interferes with infectious hematopoietic necrosis virus","volume":"144","author":"Alonso","year":"1999","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0010","doi-asserted-by":"crossref","first-page":"7815","DOI":"10.1128\/JVI.00404-09","article-title":"Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses","volume":"83","author":"Biacchesi","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0015","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1099\/0022-1317-77-12-3053","article-title":"Persistent infection of mammalian cells by Rift Valley fever virus","volume":"77","author":"Billecocq","year":"1996","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0020","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.virol.2004.08.032","article-title":"Markedly reduced severity of Dengue virus infection in mosquito cell cultures persistently infected with Aedes albopictus densovirus (AalDNV)","volume":"329","author":"Burivong","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2010.10.017_bib0025","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.fsi.2007.08.010","article-title":"Study of the viral interference between infectious pancreatic necrosis virus (IPNV) and infectious haematopoietic necrosis virus (IHNV) in rainbow trout (Oncorrhynchus mykiss)","volume":"24","author":"Byrne","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0030","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.virol.2003.08.040","article-title":"In vitro inhibition of fish rhabdoviruses by Japanese flounder, Paralichthys olivaceus Mx","volume":"317","author":"Caipang","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2010.10.017_bib0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3354\/dao065091","article-title":"Persistent infection of betanodavirus in a novel cell line derived from the brain tissue of barramundi Lates calcarifer","volume":"65","author":"Chi","year":"2005","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3354\/dao033077","article-title":"Channel catfish reovirus (CRV) inhibits replication of channel catfish herpesvirus (CCV) by two distinct mechanisms: viral interference and induction of an anti-viral factor","volume":"33","author":"Chinchar","year":"1998","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.fsi.2006.03.011","article-title":"Infectious pancreatic necrosis virus suppresses type I interferon signalling in rainbow trout gonad cell line but not in Atlantic salmon macrophages","volume":"22","author":"Collet","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0050","series-title":"Interferon and Viral Interference in Viroses in Salmonid Fish","first-page":"241","author":"de Kinkelin","year":"1992"},{"key":"10.1016\/j.vetmic.2010.10.017_bib0055","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00705-003-0227-1","article-title":"Resistance to superinfection of Vero cells persistently infected with Junin virus","volume":"149","author":"Ellenberg","year":"2004","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0060","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1099\/vir.0.83041-0","article-title":"Superinfection exclusion in BHK-21 cells persistently infected with Junin virus","volume":"88","author":"Ellenberg","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0065","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.antiviral.2007.06.006","article-title":"Dual antiviral activity of human alpha-defensin-1 against viral haemorrhagic septicaemia rhabdovirus (VHSV): inactivation of virus particles and induction of a type I interferon-related response","volume":"76","author":"Falco","year":"2007","journal-title":"Antiviral Res."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0070","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.molimm.2007.06.358","article-title":"Expression and antiviral activity of a \u03b2-defensin-like peptide identified in the rainbow trout (Oncorhynchus mykiss) EST sequences","volume":"45","author":"Falco","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.vetimm.2007.09.008","article-title":"Expression analysis of Mx protein and evaluation of its antiviral activity against sole aquabirnavirus in SAF-1 and TV-1 cell lines","volume":"121","author":"Garc\u00eda-Rosado","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0080","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2761.1978.tb00034.x","article-title":"Persistent infection in salmonid fish cells with infectious pancreatic necrosis virus (IPNV)","volume":"1","author":"Hedrick","year":"1978","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/fsim.2001.0397","article-title":"Effect of double-stranded RNA and interferon on the antiviral activity of Atlantic salmon cells against infectious salmon anemia virus and infectious pancreatic necrosis virus","volume":"13","author":"Jensen","year":"2002","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3354\/dao02066","article-title":"Susceptibility of Atlantic cod Gadus morhua juveniles to different routes of experimental challenge with infectious pancreatic necrosis virus (IPNV)","volume":"85","author":"Jensen","year":"2009","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0095","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3354\/dao047109","article-title":"Infectious pancreatic necrosis virus infection in Atlantic salmon Salmo salar post-smolts affects the outcome of secondary infections with infectious salmon anaemia virus or Vibro salmonicida","volume":"47","author":"Johansen","year":"2001","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0100","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1099\/0022-1317-80-8-2061","article-title":"Characteristics of a new birnavirus associated with a warm water fish cell line","volume":"80","author":"John","year":"1999","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0105","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1099\/0022-1317-58-2-361","article-title":"Persistent infection with infectious pancreatic necrosis virus mediated by defective-interfering (DI) virus particles in a cell line showing strong interference but little DI replication","volume":"58","author":"Kennedy","year":"1982","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0110","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3354\/dao02000","article-title":"Protection of rainbow trout from infectious hematopoietic necrosis (IHN) by injection of infectious pancreatic necrosis virus (IPNV) or poly(I:C)","volume":"83","author":"Kim","year":"2009","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0115","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1128\/IAI.44.3.716-723.1984","article-title":"Persistent infection with mouse hepatitis virus 3 in mouse lymphoid cell lines","volume":"44","author":"Lamontagne","year":"1984","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0120","first-page":"455","article-title":"Aquareovirus interference mediated resistance to infectious hematopoietic necrosis virus","volume":"26","author":"LaPatra","year":"1995","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0125","doi-asserted-by":"crossref","first-page":"7938","DOI":"10.1128\/JVI.78.15.7938-7944.2004","article-title":"Inhibition of infectious pancreatic necrosis virus replication by Atlantic salmon Mx1 protein","volume":"78","author":"Larsen","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0130","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1128\/JVI.79.6.3231-3242.2005","article-title":"Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication","volume":"79","author":"Lee","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3354\/dao037081","article-title":"Inter-laboratory comparison of cell lines for susceptibility to three viruses: VHSV, IHNV and IPNV","volume":"37","author":"Lorenzen","year":"1999","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-0934(95)01972-3","article-title":"Fast neutralization immunoperoxidase assay for viral haemorrhagic septicaemia with anti-nucleoprotein monoclonal antibody","volume":"58","author":"Lorenzo","year":"1996","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.vetmic.2010.10.017_bib0145","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0042-6822(79)90428-8","article-title":"Infectious pancreatic necrosis virus persistently infects chinook salmon embryo cells independent of interferon","volume":"95","author":"MacDonald","year":"1979","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2010.10.017_bib0150","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.fsi.2010.02.001","article-title":"Differentially expresed genes following persistent infection with infectious pancreatic necrosis virus in vitro and in vivo","volume":"28","author":"Marjara","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0155","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.antiviral.2008.07.007","article-title":"Inhibitory effect of mycophenolic acid on the replication of infectious pancreatic necrosis virus and viral hemorrhagic septicemia virus","volume":"80","author":"Marroqu\u00ed","year":"2008","journal-title":"Antiviral Res."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2761.2005.00680.x","article-title":"In infectious pancreatic necrosis virus carrier Atlantic salmon, Salmo salar L., post-smolts, almost all kidney macrophages ex vivo contain a low level of non-replicating virus","volume":"29","author":"Munro","year":"2006","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2003.10.005","article-title":"In vivo and in vitro analysis of the resistance against viral haemorrhagic septicaemia virus in Japanese flounder (Paralichtys olivaceus) precedingly infected with aquabirnavirus","volume":"17","author":"Pakingking","year":"2004","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-0934(02)00129-5","article-title":"Enhanced detection of viral hemorrhagic septicemia virus (a salmonid rhabdovirus) by pretreatment of the virus with a combinatorial library-selected peptide","volume":"106","author":"Perez","year":"2002","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.vetmic.2010.10.017_bib0175","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.fsi.2006.11.012","article-title":"Effects of salmonid fish viruses on Mx gene expression and resistance to single or dual viral infections","volume":"23","author":"Rodriguez Saint-Jean","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0225","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.vetimm.2010.02.015","article-title":"The persistence of infectious pancreatic necrosis virus and its influence on the early immune response","volume":"136","author":"Rodriguez Saint-Jean","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0185","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3354\/dao067183","article-title":"Comparison of two birnavirus\u2013rhabdovirus coinfections in cell lines","volume":"67","author":"Rodriguez","year":"2005","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0190","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1128\/JVI.02443-05","article-title":"Self and nonself manipulation of interferon defense during persistent infection: bovine viral diarrhea virus resists alpha\/beta interferon without blocking antiviral activity against unrelated virus replicating in its host cells","volume":"80","author":"Schweizer","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0195","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.virusres.2009.03.004","article-title":"The interplay between infectious pancreatic necrosis virus (IPNV) and the IFN system: IFN signaling is inhibited by IPNV infection","volume":"143","author":"Skjesol","year":"2009","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0200","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3354\/dao059101","article-title":"Susceptibility of spotted wolffish Anarhicas minor to experimental infection with nodavirus and infectious pancreatic necrosis virus","volume":"59","author":"Sommer","year":"2004","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0205","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1089\/jir.1995.15.691","article-title":"Characterization of a rainbow trout Mx gene","volume":"15","author":"Trobridge","year":"1995","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0210","first-page":"1","article-title":"A case of coinfection of IPN and IHN virus in farmed rainbow trout in Spain","volume":"14","author":"Vilas","year":"1994","journal-title":"Bull. Eur. Ass. Fish Pathol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0215","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.fsi.2006.03.002","article-title":"Persistence of betanodavirus in Barramundi brain (BB) cell line involves the induction of interferon response","volume":"21","author":"Wu","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetmic.2010.10.017_bib0220","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00251-004-0658-1","article-title":"Differential expression of two Carassius auratus Mx genes in cultured CAB cells induced by grass carp hemorhage virus and interferon","volume":"56","author":"Zhang","year":"2004","journal-title":"Immunogenetics"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113510005043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113510005043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T14:49:38Z","timestamp":1592059778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113510005043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":44,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0378113510005043"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2010.10.017","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}