{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:42:23Z","timestamp":1783507343431,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.vetmic.2011.06.008","type":"journal-article","created":{"date-parts":[[2011,6,26]],"date-time":"2011-06-26T18:15:02Z","timestamp":1309112102000},"page":"332-338","source":"Crossref","is-referenced-by-count":12,"title":["Defective bacterial clearance is responsible for the enhanced lung pathology characteristic of Mannheimia haemolytica pneumonia in bighorn sheep"],"prefix":"10.1016","volume":"153","author":[{"given":"Renuka","family":"Subramaniam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline N.","family":"Herndon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarvili","family":"Shanthalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohana P.","family":"Dassanayake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jegarubee","family":"Bavananthasivam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Foreyt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Srikumaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2011.06.008_bib0005","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2460\/ajvr.1981.42.08.1383","article-title":"Cytotoxic effects of Pasteurella haemolytica on bovine neutrophils","volume":"42","author":"Berggren","year":"1981","journal-title":"Am. J. Vet. Res."},{"issue":"Suppl.","key":"10.1016\/j.vetmic.2011.06.008_bib0010","first-page":"S48","article-title":"Molecular aspects of virulence of Pasteurella haemolytica","volume":"54","author":"Confer","year":"1990","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0015","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.vetmic.2008.07.015","article-title":"Mannheimia haemolytica serotype A1 exhibits differential pathogenicity in two related species Ovis canadensis and Ovis aries","volume":"133","author":"Dassanayake","year":"2009","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0020","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/AEM.02086-09","article-title":"Bibersteinia trehalosi inhibits the growth of Mannheimia haemolytica by a proximity-dependent mechanism","volume":"76","author":"Dassanayake","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0025","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.vetmic.2010.04.011","article-title":"Mycoplasma ovipneumoniae can predispose bighorn sheep to fatal Mannheimia haemolytica pneumonia","volume":"145","author":"Dassanayake","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.7589\/0090-3558-30.2.137","article-title":"Fatal pneumonia following inoculation of healthy bighorn sheep with Pasteurella haemolytica from healthy domestic sheep","volume":"30","author":"Foreyt","year":"1994","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0035","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0882-4010(91)90086-P","article-title":"Neutralizing monoclonal antibodies to Pasteurella haemolytica leukotoxin affinity\u2013purify the toxin from crude culture supernatants","volume":"10","author":"Gentry","year":"1991","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0040","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1128\/IAI.00327-10","article-title":"Differential expression of interleukin-8 by polymorphonuclear leukocytes of two closely related species Ovis canadensis and Ovis aries, in response to Mannheimia haemolytica infection","volume":"78","author":"Herndon","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0045","doi-asserted-by":"crossref","first-page":"D1128","DOI":"10.2741\/Highland","article-title":"Molecular genetic analysis of virulence in Mannheimia (pasteurella) haemolytica","volume":"6","author":"Highlander","year":"2001","journal-title":"Front. Biosci."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0050","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1128\/IAI.68.7.3916-3922.2000","article-title":"Inactivation of Pasteurella (Mannheimia) haemolytica leukotoxin causes partial attenuation of virulence in a calf challenge model","volume":"68","author":"Highlander","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1079\/AHRR200242","article-title":"Role of Mannheimia haemolytica leukotoxin in the pathogenesis of bovine pneumonic pasteurellosis","volume":"3","author":"Jeyaseelan","year":"2002","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0060","doi-asserted-by":"crossref","first-page":"325","DOI":"10.7589\/0090-3558-34.2.325","article-title":"Evaluation of a multivalent Pasteurella haemolytica vaccine in bighorn sheep: protection from experimental challenge","volume":"34","author":"Kraabel","year":"1998","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0065","doi-asserted-by":"crossref","first-page":"663","DOI":"10.7589\/0090-3558-24.4.663","article-title":"Experimental contact transmission of Pasteurella haemolytica from clinically normal domestic sheep causing pneumonia in Rocky mountain bighorn sheep","volume":"24","author":"Ondreka","year":"1988","journal-title":"J. Wildl. Dis"},{"key":"10.1016\/j.vetmic.2011.06.008_bib0070","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1128\/IAI.63.3.1033-1039.1995","article-title":"Antigenic and virulence properties of Pasteurella haemolytica leukotoxin mutants","volume":"63","author":"Petras","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0075","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1152\/jappl.1986.60.2.532","article-title":"Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution","volume":"60","author":"Rennard","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0080","doi-asserted-by":"crossref","first-page":"30","DOI":"10.7589\/0090-3558-29.1.30","article-title":"Pasteurella haemolytica cytotoxin-dependent killing of neutrophils from bighorn and domestic sheep","volume":"29","author":"Silflow","year":"1993","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0085","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2460\/ajvr.1985.46.11.2253","article-title":"Importance of neutrophils in the pathogenesis of acute pneumonic pasteurellosis in calves","volume":"46","author":"Slocombe","year":"1985","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0090","doi-asserted-by":"crossref","first-page":"523","DOI":"10.7589\/0090-3558-30.4.523","article-title":"Comparative leukotoxicities of Pasteurella haemolytica isolates from domestic sheep and free-ranging bighorn sheep (Ovis canadensis)","volume":"30","author":"Sweeney","year":"1994","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/mpat.1997.0181","article-title":"Construction of an isogenic leukotoxin deletion mutant of Pasteurella haemolytica serotype 1: characterization and virulence","volume":"24","author":"Tatum","year":"1998","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.micpath.2005.01.002","article-title":"Mechanisms underlying Mannhemia haemolytica leukotoxin-induced oncosis and apoptosis of bovine alveolar macrophages","volume":"38","author":"Thumbikat","year":"2005","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(95)00072-I","article-title":"A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V","volume":"184","author":"Vermes","year":"1995","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.vetmic.2011.06.008_bib0110","doi-asserted-by":"crossref","first-page":"285","DOI":"10.7589\/0090-3558-35.2.285","article-title":"Immunologic responses of domestic and bighorn sheep to a multivalent Pasteurella haemolytica vaccine","volume":"35","author":"Ward","year":"1999","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.vetmic.2011.06.008_bib0115","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1939-1676.1992.tb00980.x","article-title":"Pasteurella haemolytica A1 and bovine respiratory disease: pathogenesis","volume":"6","author":"Whiteley","year":"1992","journal-title":"J. Vet. Intern. Med."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113511003361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113511003361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T18:38:54Z","timestamp":1741286334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113511003361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":23,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0378113511003361"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2011.06.008","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}