{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:19:27Z","timestamp":1786997967016,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.vetmic.2012.07.016","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T04:19:30Z","timestamp":1342757970000},"page":"137-144","source":"Crossref","is-referenced-by-count":22,"title":["Vaccination with recombinant flagellar proteins FlgJ and FliN induce protection against Brucella abortus 544 infection in BALB\/c mice"],"prefix":"10.1016","volume":"161","author":[{"given":"Xianbo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xitong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingquan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongkun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoujia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangneng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2012.07.016_bib0005","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-micro-090110-102905","article-title":"Interactions of the human pathogenic Brucella species with their hosts","volume":"65","author":"Atluri","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0010","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ab.2005.05.015","article-title":"Construction of a set Gateway-based destination vectors for high-throughput cloning and expression screening in Escherichia coli","volume":"343","author":"Busso","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0015","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1016\/j.vaccine.2007.07.002","article-title":"Vaccination with Brucella recombinant DnaK and SurA proteins induces protection against Brucella abortus infection in BALB\/c mice","volume":"25","author":"Delpino","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2012.07.016_bib0020","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0378-1135(02)00238-9","article-title":"The genome of Brucella melitensis","volume":"90","author":"DelVecchio","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0025","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.221575398","article-title":"The genome sequence of the facultative intracellular pathogen Brucella melitensis","volume":"99","author":"DelVecchio","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0030","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1128\/IAI.68.1.257-263.2000","article-title":"Effects of opsonization and gamma interferon on growth of Brucella melitensis 16M in mouse peritoneal macrophages in vitro","volume":"68","author":"Eze","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0035","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1128\/IAI.63.3.1130-1133.1995","article-title":"Interleukin-10 downregulates protective immunity to Brucella abortus","volume":"63","author":"Fernandes","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0040","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1462-5822.2005.00502.x","article-title":"The sheathed flagellum of Brucella melitensis is involved in persistence in a murine model of infection","volume":"7","author":"Fretin","year":"2005","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0045","doi-asserted-by":"crossref","first-page":"e29552","DOI":"10.1371\/journal.pone.0029552","article-title":"Immunization of mice with recombinant protein CobB or AsnC confers protection against Brucella abortus infection","volume":"7","author":"Fu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2012.07.016_bib0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1089\/omi.1.1998.3.21","article-title":"On the presence and organization of open reading frames of the nonmotile pathogen Brucella abortus similar to class II, III, and IV flagellar genes and to LcrD virulence superfamily","volume":"3","author":"Halling","year":"1998","journal-title":"Microb. Comp. Genomics"},{"issue":"6 Suppl.","key":"10.1016\/j.vetmic.2012.07.016_bib0055","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1745-7580-6-S1-S5","article-title":"Bioinformatics analysis of Brucella vaccines and vaccine targets using VIOLIN","volume":"1","author":"He","year":"2010","journal-title":"Immunome Res."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0060","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1078\/1438-4221-00173","article-title":"The role of motility as a virulence factor in bacteria","volume":"291","author":"Josenhans","year":"2002","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0065","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.2010.01001.x","article-title":"Intracellular pathogens: living in an extreme environment","volume":"240","author":"Kaufmann","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/JB.00712-06","article-title":"FtcR is a new master regulator of the flagellar system of Brucella melitensis 16M with homologs in Rhizobiaceae","volume":"189","author":"Leonard","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0075","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1128\/IAI.00242-09","article-title":"High-throughput identification of new protective antigens from a Yersinia pestis live vaccine by enzyme-linked immunospot assay","volume":"77","author":"Li","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0080","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.57.030502.090832","article-title":"How bacteria assemble flagella","volume":"57","author":"Macnab","year":"2003","journal-title":"Ann. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0085","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-065X.2010.00982.x","article-title":"An evolutionary strategy for a stealthy intracellular Brucella pathogen","volume":"240","author":"Martirosyan","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0090","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0264-410X(96)00018-7","article-title":"Immunization of mice with recombinant L7\/L12 ribosomal protein confers protection against Brucella abortus infection","volume":"14","author":"Oliveira","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2012.07.016_bib0095","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1586\/erv.11.110","article-title":"Confronting the barriers to develop novel vaccines against brucellosis","volume":"10","author":"Oliveira","year":"2011","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.vetmic.2012.07.016_bib0100","doi-asserted-by":"crossref","first-page":"13148","DOI":"10.1073\/pnas.192319099","article-title":"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts","volume":"99","author":"Paulsen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0105","doi-asserted-by":"crossref","first-page":"9892","DOI":"10.1074\/jbc.M805458200","article-title":"Brucella TIR domain-containing protein mimics properties of the Toll-like receptor adaptor protein TIRAP","volume":"284","author":"Radhakrishnan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0110","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1471-2180-9-81","article-title":"Brucella melitensis global gene expression study provides novel information on growth phase-specific gene regulation with potential insights for understanding Brucella: host initial interactions","volume":"9","author":"Rossetti","year":"2009","journal-title":"BMC Microbiology"},{"key":"10.1016\/j.vetmic.2012.07.016_bib0115","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0378-1135(02)00255-9","article-title":"Brucellosis vaccines: past present and future","volume":"90","author":"Schurig","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0120","doi-asserted-by":"crossref","first-page":"16514","DOI":"10.1073\/pnas.0603362103","article-title":"A B lymphocyte mitogen is a Brucella abortus virulence factor required for persistent infection","volume":"103","author":"Spera","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0125","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/intimm\/5.8.877","article-title":"Brucella abortus induces a novel cytokine gene expression pattern characterized by elevated IL-10 and IFN-gamma in CD4+ T cells","volume":"5","author":"Sveti\u0107","year":"1993","journal-title":"Int. Immunol."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0130","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/clinids\/21.2.283","article-title":"An overview of human brucellosis","volume":"21","author":"Young","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.vetmic.2012.07.016_bib0135","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1128\/IAI.61.11.4899-4901.1993","article-title":"Endogenous gamma interferon mediates resistance to Brucella abortus infection","volume":"61","author":"Zhan","year":"1993","journal-title":"Infect. Immun."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113512004014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113512004014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T02:37:17Z","timestamp":1594435037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113512004014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":27,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0378113512004014"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2012.07.016","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}