{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:39:24Z","timestamp":1788871164416,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["EGP #431735-12"],"award-info":[{"award-number":["EGP #431735-12"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.vetmic.2013.07.028","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T17:58:26Z","timestamp":1376071106000},"page":"459-467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genetic diversity of Haemophilus parasuis from sick and healthy pigs"],"prefix":"10.1016","volume":"167","author":[{"given":"Patrick","family":"Boerlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvonimir","family":"Poljak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Gallant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabhan","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn A.","family":"Soltes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet I.","family":"MacInnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2013.07.028_bib0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1471-8278.2000.00014.x","article-title":"Indices of multilocus linkage disequilibrium","volume":"1","author":"Agapow","year":"2001","journal-title":"Mol. Ecol. Notes"},{"key":"10.1016\/j.vetmic.2013.07.028_bib0010","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.vetmic.2009.10.025","article-title":"Correlation between clinico-pathological outcome and typing of Haemophilus parasuis field strains","volume":"142","author":"Aragon","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0015","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.vetmic.2004.07.013","article-title":"Serological characterization of Danish Haemophilus parasuis isolates","volume":"103","author":"Angen","year":"2004","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-1135(96)01342-9","article-title":"Analysis of Haemophilus parasuis by multilocus enzyme electrophoresis","volume":"56","author":"Blackall","year":"1997","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0025","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.rvsc.2011.04.006","article-title":"Characterization of Haemophilus parasuis isolated from Brazilian swine through serotyping, AFLP and PFGE","volume":"92","author":"Castilla","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0030","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.vetmic.2007.09.018","article-title":"Typing of Clostridium perfringens by multiple-locus variable number of tandem repeats analysis","volume":"128","author":"Chalmers","year":"2008","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0035","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1297-9716-43-57","article-title":"VtaA8 and VtaA9 from Haemophilus parasuis delay phagocytosis by alveolar macrophages","volume":"43","author":"Costa-Hurtado","year":"2012","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0040","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0378-1135(02)00362-0","article-title":"Typing of Haemophilus parasuis strains by PCR-RFLP analysis of the tbpA gene","volume":"92","author":"De la Puente Redondo","year":"2003","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0045","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.rvsc.2011.10.013","article-title":"Analyses of Dutch Haemophilus parasuis isolates by serotyping, genotyping by ERIC-PCR and Hsp60 sequences and the presence of the virulence associated trimeric autotransporters marker","volume":"93","author":"Dijkman","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0050","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1128\/JB.186.5.1518-1530.2004","article-title":"eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data","volume":"186","author":"Feil","year":"2004","journal-title":"J. Bacteriol."},{"issue":"Database issue","key":"10.1016\/j.vetmic.2013.07.028_bib0055","doi-asserted-by":"crossref","first-page":"D80","DOI":"10.1093\/nar\/gkl1013","article-title":"TRDB\u2014the tandem repeats database","volume":"35","author":"Gelfand","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0060","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/bioinformatics\/16.9.847","article-title":"LIAN 3.0: detecting linkage disequilibrium in multilocus data","volume":"16","author":"Haubold","year":"2000","journal-title":"Bioinformatics"},{"key":"10.1016\/j.vetmic.2013.07.028_bib0065","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1128\/JCM.26.11.2465-2466.1988","article-title":"Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity","volume":"26","author":"Hunter","year":"1988","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0070","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1128\/JCM.00816-08","article-title":"Identification of minimal predictors of avian pathogenic Escherichia coli virulence for use as a rapid diagnostic tool","volume":"46","author":"Johnson","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0075","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1128\/JCM.30.4.862-865.1992","article-title":"Designation of 15 serovars of Haemophilus parasuis on the basis of immunodiffusion using heat-stable antigen extracts","volume":"30","author":"Kielstein","year":"1992","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0080","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1002\/elps.200500096","article-title":"Multiple-locus variable number tandem repeats analysis for genetic fingerprinting of pathogenic bacteria","volume":"26","author":"Lindstedt","year":"2005","journal-title":"Electrophoresis"},{"key":"10.1016\/j.vetmic.2013.07.028_bib0085","first-page":"242","article-title":"Prevalence of Actinobacillus pleuropneumoniae, Actinobacillus suis, Haemophilus parasuis, Pasteurella multocida, and Streptococcus suis in representative Ontario swine herds","volume":"72","author":"MacInnes","year":"2008","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0090","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1099\/mic.0.056994-0","article-title":"Distribution of genes involved in sialic acid utilization in strains of Haemophilus parasuis","volume":"158","author":"Mart\u00ednez-Moliner","year":"2012","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2013.07.028_bib0095","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1073\/pnas.90.10.4384","article-title":"How clonal are bacteria?","volume":"90","author":"Maynard Smith","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vetmic.2013.07.028_bib0100","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.vetmic.2012.11.019","article-title":"A curated public database for multilocus sequence typing (MLST) and analysis of Haemophilus parasuis based on an optimized typing scheme","volume":"162","author":"Mullins","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0105","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1177\/104063870101300607","article-title":"Development of a PCR test to diagnose Haemophilus parasuis infections","volume":"13","author":"Oliveira","year":"2001","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0110","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1099\/mic.0.29254-0","article-title":"Study of the population structure of Haemophilus parasuis by multilocus sequence typing","volume":"152","author":"Olvera","year":"2006","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2013.07.028_bib0115","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1051\/vetres\/2009007","article-title":"Differences in phagocytosis susceptibility in Haemophilus parasuis strains","volume":"40","author":"Olvera","year":"2009","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0120","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1051\/vetres\/2009074","article-title":"Virulence-associated trimeric autotransporters of Haemophilus parasuis are antigenic proteins expressed in vivo","volume":"41","author":"Olvera","year":"2010","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tvjl.2010.12.014","article-title":"Identification of potentially virulent strains of Haemophilus parasuis using a multiplex PCR for virulence-associated autotransporters (vtaA)","volume":"191","author":"Olvera","year":"2012","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0130","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1128\/JB.00703-08","article-title":"Trimeric autotransporters of Haemophilus parasuis: generation of an extensive passenger domain repertoire specific for pathogenic strains","volume":"191","author":"Pina","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0135","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1751-0813.2000.tb10507.x","article-title":"Application of ERIC-PCR for the comparison of isolates of Haemophilus parasuis","volume":"78","author":"Rafiee","year":"2000","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0140","series-title":"Diseases of Swine,","first-page":"681","article-title":"Haemophilus parasuis","author":"Rapp-Gabrielson","year":"2006"},{"key":"10.1016\/j.vetmic.2013.07.028_bib0145","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.vetmic.2008.11.008","article-title":"Identification of novel potential virulence-associated factors in Haemophilus parasuis","volume":"136","author":"Sack","year":"2009","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0150","first-page":"319","article-title":"Analysis of Haemophilus parasuis isolates from southern Ontario swine by restriction endonuclease fingerprinting","volume":"52","author":"Smart","year":"1988","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0155","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1098\/rstb.1999.0423","article-title":"Bacterial population genetics, evolution and epidemiology","volume":"354","author":"Spratt","year":"1999","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0160","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.vetmic.2004.12.019","article-title":"Comparison of the indirect haemagglutination and gel diffusion test for serotyping Haemophilus parasuis","volume":"106","author":"Turni","year":"2005","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1574-695X.2006.00173.x","article-title":"Tracing isolates of bacterial species by multilocus variable number of tandem repeat analysis (MLVA)","volume":"49","author":"van Belkum","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0170","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.micpath.2011.06.007","article-title":"Identification and analysis of potential virulence-associated genes in Haemophilus parasuis based on genomic subtraction","volume":"51","author":"Wang","year":"2011","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0175","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tvjl.2012.06.017","article-title":"Involvement of lipooligosaccharide heptose residues of Haemophilus parasuis SC096 strain in serum resistance, adhesion and invasion","volume":"195","author":"Xu","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0180","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1128\/JB.01682-08","article-title":"Complete genome sequence of Haemophilus parasuis SH0165","volume":"191","author":"Yue","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0185","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2180-12-108","article-title":"Comparison of Haemophilus parasuis reference strains and field isolates by using random amplified polymorphic DNA and protein profiles","volume":"12","author":"Zehr","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0190","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1472-765X.2011.03048.x","article-title":"A rapid pulsed-field gel electrophoresis method of genotyping Haemophilus parasuis isolates","volume":"52","author":"Zhang","year":"2011","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0195","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1574-6968.2011.02433.x","article-title":"Serum resistance in Haemophilus parasuis SC096 strain requires outer membrane protein P2 expression","volume":"326","author":"Zhang","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0200","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.vetmic.2011.12.002","article-title":"Cytolethal distending toxin (CDT) of the Haemophilus parasuis SC096 strain contributes to serum resistance and adherence to and invasion of PK-15 and PUVEC cells","volume":"157","author":"Zhang","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0205","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1292\/jvms.11-0260","article-title":"Immunological identification and characterization of extracellular serine protease-like protein encoded in a putative espP2 gene of Haemophilus parasuis","volume":"74","author":"Zhang","year":"2012","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.vetmic.2013.07.028_bib0210","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.vetmic.2010.01.023","article-title":"Identification of putative virulence-associated genes of Haemophilus parasuis through suppression subtractive hybridization","volume":"144","author":"Zhou","year":"2010","journal-title":"Vet. Microbiol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811351300391X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811351300391X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T15:24:23Z","timestamp":1596295463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811351300391X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":42,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S037811351300391X"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2013.07.028","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic diversity of Haemophilus parasuis from sick and healthy pigs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2013.07.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}