{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:46:38Z","timestamp":1774982798374,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pfizer Animal Health"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.vetmic.2013.12.016","type":"journal-article","created":{"date-parts":[[2014,1,4]],"date-time":"2014-01-04T15:00:34Z","timestamp":1388847634000},"page":"163-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recombinant LipL32 stimulates interferon-gamma production in cattle vaccinated with a monovalent Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis vaccine"],"prefix":"10.1016","volume":"169","author":[{"given":"Deanna S.","family":"Deveson Lucas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter M.","family":"Bulach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelene S.","family":"Quinsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald L.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Adler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2013.12.016_bib0005","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.vetmic.2009.03.012","article-title":"Leptospira and leptospirosis","volume":"140","author":"Adler","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0165-2427(02)00091-0","article-title":"Activation of bovine peripheral blood \u03b3\u03b4T cells for cell division and IFN-\u03b3 production","volume":"87","author":"Baldwin","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0015","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/eji.200636216","article-title":"WC1+ \u03b3\u03b4T cell memory population is induced by killed bacterial vaccine","volume":"37","author":"Blumerman","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2460\/ajvr.1989.50.01.161","article-title":"Effect of vaccination with a pentavalent leptospiral vaccine on Leptospira interrogans serovar hardjo type hardjo-bovis infection of pregnant cattle","volume":"50","author":"Bolin","year":"1989","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0025","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.2460\/ajvr.1989.50.12.2004","article-title":"Effect of vaccination with a pentavalent leptospiral vaccine containing Leptospira interrogans serovar hardjo type hardjo-bovis on type hardjo-bovis infection of cattle","volume":"50","author":"Bolin","year":"1989","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0030","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2460\/ajvr.2001.62.995","article-title":"Use of a monovalent leptospiral vaccine to prevent renal colonization and urinary shedding in cattle exposed to Leptospira borgpetersenii serovar hardjo","volume":"62","author":"Bolin","year":"2001","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0035","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.2460\/ajvr.1991.52.10.1639","article-title":"Effect of vaccination with a monovalent Leptospira interrogans serovar hardjo type hardjo-bovis vaccine on type hardjo-bovis infection of cattle","volume":"52","author":"Bolin","year":"1991","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0040","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1016\/S0264-410X(03)00439-0","article-title":"Comparison of three different leptospiral vaccines for induction of a type 1 immune response to Leptospira borgpetersenii serovar Hardjo","volume":"21","author":"Brown","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2013.12.016_bib0045","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1128\/IAI.70.5.2311-2318.2002","article-title":"Global analysis of outer membrane proteins from Leptospira interrogans serovar Lai","volume":"70","author":"Cullen","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0050","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1099\/00222615-46-9-801","article-title":"Identification of the major T-cell antigens present in the Brucella melitensis B115 protein preparation, Brucellergene OCB","volume":"46","author":"Denoel","year":"1997","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0055","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1016\/j.vaccine.2011.02.084","article-title":"Recombinant LipL32 and LigA from Leptospira are unable to stimulate protective immunity against leptospirosis in the hamster model","volume":"29","author":"Deveson Lucas","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2013.12.016_bib0060","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1432-1033.1974.tb03671.x","article-title":"Proteinase K from Tritirachium album Limber","volume":"47","author":"Ebeling","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0065","series-title":"Leptospira and Leptospirosis","author":"Faine","year":"1999"},{"key":"10.1016\/j.vetmic.2013.12.016_bib0070","first-page":"505","article-title":"A rapid macroscopic-slide screening test for the serodiagnosis of leptospirosis","volume":"19","author":"Galton","year":"1958","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0075","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.1128\/IAI.69.8.4958-4968.2001","article-title":"Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans","volume":"69","author":"Guerreiro","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0080","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1128\/IAI.68.4.2276-2285.2000","article-title":"The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection","volume":"68","author":"Haake","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0085","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0378-4320(96)01508-4","article-title":"Immunological aspects of pregnancy: concepts and speculations using sheep as a model","volume":"42","author":"Hansen","year":"1996","journal-title":"Ann. Reprod. Sci."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0090","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3168\/jds.S0022-0302(76)84339-1","article-title":"Bovine leptospirosis","volume":"59","author":"Hanson","year":"1975","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0095","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1128\/IAI.01639-07","article-title":"In LipL32, the major leptospiral lipoprotein, the C terminus is the primary immunogenic domain and mediates interaction with collagen IV and plasma fibronectin","volume":"76","author":"Hauk","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0100","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1128\/IAI.01643-07","article-title":"LipL32 is an extracellular matrix-interacting protein of Leptospira spp. and Pseudoalteromonas tunicata","volume":"76","author":"Hoke","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0105","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1365-2567.1998.00449.x","article-title":"Recognition of a common mycobacterial T-cell epitope in MPB59 of Mycobacterium bovis","volume":"93","author":"Lightbody","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.vetmic.2013.12.016_bib0110","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/CVI.00405-09","article-title":"Identification of immunodominant B- and T-cell combined epitopes in outer membrane lipoproteins LipL32 and LipL21 of Leptospira interrogans","volume":"17","author":"Lin","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0115","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1472-765X.2009.02723.x","article-title":"Epitope mapping of pathogenic Leptospira LipL32","volume":"49","author":"Lottersberger","year":"2009","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0120","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nature08184","article-title":"Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans","volume":"460","author":"Malmstrom","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2013.12.016_bib0125","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2460\/ajvr.1991.52.11.1761","article-title":"Survey to estimate prevalence of Leptospira interrogans infection in mature cattle in the United States","volume":"52","author":"Miller","year":"1991","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0130","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.vetmic.2012.11.005","article-title":"The lipoprotein LipL32, an enigma of leptospiral biology","volume":"162","author":"Murray","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0135","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.vaccine.2012.11.028","article-title":"Evaluation of 238 antigens of Leptospira borgpetersenii serovar Hardjo for protection against kidney colonisation","volume":"31","author":"Murray","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2013.12.016_bib0140","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1128\/IAI.01370-08","article-title":"Major surface protein LipL32 is not required for either acute or chronic infection with Leptospira interrogans","volume":"77","author":"Murray","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0145","doi-asserted-by":"crossref","first-page":"7550","DOI":"10.1128\/IAI.69.12.7550-7558.2001","article-title":"Protective killed Leptospira borgpetersenii vaccine induces potent Th1 immunity comprising responses by CD4 and gammadelta T lymphocytes","volume":"69","author":"Naiman","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0150","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1128\/IAI.70.11.6147-6157.2002","article-title":"Evaluation of type 1 immune response in naive and vaccinated animals following challenge with Leptospira borgpetersenii serovar Hardjo: involvement of WC1(+) gammadelta and CD4 T cells","volume":"70","author":"Naiman","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0155","doi-asserted-by":"crossref","first-page":"e51025","DOI":"10.1371\/journal.pone.0051025","article-title":"LipL32 is a subsurface lipoprotein of Leptospira interrogans: presentation of new data and reevaluation of previous studies","volume":"8","author":"Pinne","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2013.12.016_bib0160","first-page":"9","article-title":"Identification of bovine T-cell epitopes for three Mycobacterium bovis antigens: MPB70, 19,000 MW and MPB57","volume":"82","author":"Pollock","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.vetmic.2013.12.016_bib0165","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1365-3083.1995.tb03537.x","article-title":"Peptide mapping of bovine T-cell epitopes for the 38kDa tuberculosis antigen","volume":"41","author":"Pollock","year":"1995","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0170","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.vetimm.2005.08.008","article-title":"Function of ruminant \u03b3\u03b4T cells is defined by WC1.1 or WC1.2 isoform expression","volume":"108","author":"Rogers","year":"2005","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1751-0813.1990.tb07730.x","article-title":"A sandwich enzyme immunoassay for bovine interferon-gamma and its use for the detection of tuberculosis in cattle","volume":"67","author":"Rothel","year":"1990","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0180","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/IAI.69.1.89-96.2001","article-title":"In vitro responsiveness of gammadelta T cells from Mycobacterium bovis-infected cattle to mycobacterial antigens: predominant involvement of WC1(+) cells","volume":"69","author":"Smyth","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0185","first-page":"17","article-title":"Review of leptospirosis notifications in Queensland 1985\u20131996","volume":"21","author":"Smythe","year":"1997","journal-title":"Commun. Dis. Intell."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0190","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2460\/ajvr.1976.37.01.51","article-title":"Evaluation of the immune response of cattle to leptospiral bacterins","volume":"37","author":"Tripathy","year":"1976","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0195","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1074\/jbc.M109.006320","article-title":"Calcium binds to LipL32, a lipoprotein from pathogenic Leptospira, and modulates fibronectin binding","volume":"285","author":"Tung","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0200","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1128\/IAI.70.6.3026-3032.2002","article-title":"Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis","volume":"70","author":"Vordermeier","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0205","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1128\/IAI.70.11.6114-6120.2002","article-title":"Responses of bovine WC1(+) gammadelta T cells to protein and nonprotein antigens of Mycobacterium bovis","volume":"70","author":"Welsh","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2013.12.016_bib0210","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1054\/tube.2000.0272","article-title":"BOVIGAM: an in vitro cellular diagnostic test for bovine tuberculosis","volume":"81","author":"Wood","year":"2001","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1016\/j.vetmic.2013.12.016_bib0215","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1128\/CVI.00288-10","article-title":"Leptospira borgpetersenii serovar Hardjo vaccine induces Th1 response, activates NK cells, and reduces renal colonization","volume":"18","author":"Zuerner","year":"2011","journal-title":"Clin. Vaccine Immunol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113513005944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113513005944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:10:37Z","timestamp":1746097837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113513005944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":43,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0378113513005944"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2013.12.016","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant LipL32 stimulates interferon-gamma production in cattle vaccinated with a monovalent Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis vaccine","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2013.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}