{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:12:24Z","timestamp":1791220344158,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.vetmic.2015.05.026","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T04:24:43Z","timestamp":1432873483000},"page":"217-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Capsid, membrane and NS3 are the major viral proteins involved in autophagy induced by Japanese encephalitis virus"],"prefix":"10.1016","volume":"178","author":[{"given":"Xiujin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jige","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinna","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanchun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2015.05.026_bib0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4161\/auto.5222","article-title":"Xenophagy in herpes simplex virus replication and pathogenesis","volume":"4","author":"Alexander","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2015.05.026_bib0010","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/embor.2011.157","article-title":"Mitochondria in innate immunity","volume":"12","author":"Arnoult","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0015","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1128\/JVI.00704-13","article-title":"Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles","volume":"87","author":"Balinsky","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0020","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.mi.44.100190.003245","article-title":"Flavivirus genome organization, expression, and replication","volume":"44","author":"Chambers","year":"1990","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0025","doi-asserted-by":"crossref","first-page":"8898","DOI":"10.1073\/pnas.87.22.8898","article-title":"Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein","volume":"87","author":"Chambers","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0030","doi-asserted-by":"crossref","first-page":"e28551","DOI":"10.1371\/journal.pone.0028551","article-title":"Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells","volume":"6","author":"Chu","year":"2011","journal-title":"PLoS One"},{"issue":"Suppl. 2","key":"10.1016\/j.vetmic.2015.05.026_bib0035","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/sj.cdd.4401751","article-title":"Autophagy and signaling: their role in cell survival and cell death","volume":"12","author":"Codogno","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0040","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ceb.2009.12.009","article-title":"Autophagy in infection","volume":"22","author":"Deretic","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0045","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-065X.2010.00995.x","article-title":"Autophagy in immunity and cell-autonomous defense against intracellular microbes","volume":"240","author":"Deretic","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0050","first-page":"781","article-title":"LC3-I conversion to LC3-II does not necessarily result in complete autophagy","volume":"22","author":"Gimenez-Xavier","year":"1998","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0055","doi-asserted-by":"crossref","first-page":"e1002422","DOI":"10.1371\/journal.ppat.1002422","article-title":"IRGM is a common target of RNA viruses that subvert the autophagy network","volume":"7","author":"Gregoire","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0065","doi-asserted-by":"crossref","first-page":"33149","DOI":"10.1074\/jbc.M114.610428","article-title":"Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, precursor membrane (prM) protein cleavage, and entry","volume":"289","author":"Hsieh","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0070","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1371\/journal.pbio.0030156","article-title":"Subversion of cellular autophagosomal machinery by RNA viruses","volume":"3","author":"Jackson","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0075","doi-asserted-by":"crossref","first-page":"e52909","DOI":"10.1371\/journal.pone.0052909","article-title":"Japanese encephalitis virus activates autophagy as a viral immune evasion strategy","volume":"8","author":"Jin","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.vetmic.2015.05.026_bib0080","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1172\/JCI41474","article-title":"Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro","volume":"121","author":"Ke","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0085","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/BF01718326","article-title":"RNA binding properties of core protein of the flavivirus Kunjin","volume":"141","author":"Khromykh","year":"1996","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0090","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrm2245","article-title":"Autophagy: from phenomenology to molecular understanding in less than a decade","volume":"8","author":"Klionsky","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0095","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4161\/auto.5338","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes","volume":"4","author":"Klionsky","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2015.05.026_bib0100","first-page":"159","article-title":"Eating oneself and uninvited guests: autophagy-related pathways in cellular defense","volume":"120","author":"Levine","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2015.05.026_bib0105","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.micinf.2011.09.001","article-title":"Autophagy is involved in the early step of Japanese encephalitis virus infection","volume":"14","author":"Li","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11250-011-0005-0","article-title":"Reproductive performance in sows in relation to Japanese encephalitis virus seropositivity in an endemic area","volume":"44","author":"Lindahl","year":"2011","journal-title":"Trop. Anim. Health Prod."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0115","doi-asserted-by":"crossref","first-page":"22147","DOI":"10.1074\/jbc.M110.192500","article-title":"Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication","volume":"286","author":"McLean","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0120","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/ncb0910-823","article-title":"Autophagy in mammalian development and differentiation","volume":"12","author":"Mizushima","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0125","doi-asserted-by":"crossref","first-page":"8477","DOI":"10.1128\/JVI.00477-07","article-title":"Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells","volume":"81","author":"Mori","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0130","doi-asserted-by":"crossref","first-page":"F244","DOI":"10.1152\/ajprenal.00033.2009","article-title":"Autophagy: molecular machinery, regulation, and implications for renal pathophysiology","volume":"297","author":"Periyasamy-Thandavan","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0135","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3389\/fimmu.2012.00426","article-title":"IRGM in autophagy and viral infections","volume":"3","author":"Petkova","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0140","doi-asserted-by":"crossref","first-page":"10136","DOI":"10.1074\/jbc.M306124200","article-title":"Coronavirus replication complex formation utilizes components of cellular autophagy","volume":"279","author":"Prentice","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0145","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1128\/JVI.64.9.4364-4374.1990","article-title":"In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3","volume":"64","author":"Preugschat","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0150","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.4161\/auto.29455","article-title":"Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes","volume":"10","author":"Sharma","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2015.05.026_bib0155","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/hep.24073","article-title":"Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes","volume":"53","author":"Shrivastava","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.vetmic.2015.05.026_bib0160","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1126\/science.1129577","article-title":"Human IRGM induces autophagy to eliminate intracellular mycobacteria","volume":"313","author":"Singh","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.vetmic.2015.05.026_bib0165","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/ncb2119","article-title":"Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria","volume":"12","author":"Singh","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0170","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1128\/JVI.72.3.2141-2149.1998","article-title":"Signal peptidase cleavage at the flavivirus C-prM junction: dependence on the viral NS2B-3 protease for efficient processing requires determinants in C, the signal peptide, and prM","volume":"72","author":"Stocks","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0175","doi-asserted-by":"crossref","first-page":"10561","DOI":"10.1128\/JVI.00173-11","article-title":"Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy","volume":"85","author":"Su","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0180","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"Tanida","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0185","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1348-0421.2006.tb03789.x","article-title":"Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication","volume":"50","author":"Tsuda","year":"2006","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0190","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/oxfordjournals.epirev.a036087","article-title":"The epidemiology of Japanese encephalitis: prospects for prevention","volume":"14","author":"Vaughn","year":"1992","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.vetmic.2015.05.026_bib0195","doi-asserted-by":"crossref","first-page":"766","DOI":"10.4161\/auto.27954","article-title":"Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression","volume":"10","author":"Wang","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2015.05.026_bib0200","series-title":"Diseases of Swine","first-page":"528","article-title":"Flaviviruses","author":"Williams","year":"2012"},{"key":"10.1016\/j.vetmic.2015.05.026_bib0205","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4161\/auto.5.3.7723","article-title":"Autophagy in coxsackievirus-infected neurons","volume":"5","author":"Yoon","year":"2009","journal-title":"Autophagy"},{"issue":"Pt 1","key":"10.1016\/j.vetmic.2015.05.026_bib0210","first-page":"27","article-title":"A conserved region in the prM protein is a critical determinant in the assembly of flavivirus particles","volume":"93","author":"Yoshii","year":"2011","journal-title":"J. Gen. Virol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113515002229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113515002229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:40:09Z","timestamp":1599079209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113515002229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":42,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0378113515002229"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2015.05.026","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Capsid, membrane and NS3 are the major viral proteins involved in autophagy induced by Japanese encephalitis virus","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2015.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}