{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:15:36Z","timestamp":1790356536971,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.vetmic.2015.06.015","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T17:53:20Z","timestamp":1436032400000},"page":"242-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Characterization of three porcine reproductive and respiratory syndrome virus isolates from a single swine farm bearing strong homology to a vaccine strain"],"prefix":"10.1016","volume":"179","author":[{"given":"Yi-feng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-qi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-xue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin-feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-hui","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-zhi","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2015.06.015_bib0005","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3201\/eid1602.090005","article-title":"Origin of highly pathogenic porcine reproductive and respiratory syndrome virus, China","volume":"16","author":"An","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0010","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/BF01718837","article-title":"Structural polypeptides of the American (VR-2332) strain of porcine reproductive and respiratory syndrome virus","volume":"141","author":"Bautista","year":"1996","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/104063879200400202","article-title":"Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332)","volume":"4","author":"Benfield","year":"1992","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0020","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/vr.141.19.497","article-title":"Appearance of acute PRRS-like symptoms in sow herds after vaccination with a modified live PRRS vaccine","volume":"141","author":"Botner","year":"1997","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0025","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.vetmic.2015.01.018","article-title":"Characterization of two novel porcine reproductive and respiratory syndrome virus isolates with deletions in the GP2 gene","volume":"176","author":"Chen","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0030","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s11262-013-0892-4","article-title":"Two natural recombinant highly pathogenic porcine reproductive and respiratory syndrome viruses with different pathogenicities","volume":"46","author":"Chen","year":"2013","journal-title":"Virus Genes"},{"key":"10.1016\/j.vetmic.2015.06.015_bib0035","first-page":"200","article-title":"Comparative infection efficiency of porcine reproductive and respiratory syndrome virus field isolates on MA104 cells and porcine alveolar macrophages","volume":"73","author":"de Abin","year":"2009","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0040","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1128\/JVI.69.7.4500-4505.1995","article-title":"Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases","volume":"69","author":"den Boon","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0045","doi-asserted-by":"crossref","first-page":"306130","DOI":"10.1155\/2014\/306130","article-title":"A novel isolate with deletion in GP3 gene of porcine reproductive and respiratory syndrome virus from mid-eastern China","volume":"2014","author":"Fan","year":"2014","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0050","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1099\/vir.0.029264-0","article-title":"Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production","volume":"92","author":"Firth","year":"2011","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2046-0481-65-14","article-title":"Outbreaks of highly pathogenic porcine reproductive and respiratory syndrome in Jiangxi province, China","volume":"65","author":"Guo","year":"2012","journal-title":"Ir. Vet. J."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0060","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s11262-008-0322-1","article-title":"Molecular mutations associated with the in vitro passage of virulent porcine reproductive and respiratory syndrome virus","volume":"38","author":"Han","year":"2009","journal-title":"Virus Genes"},{"key":"10.1016\/j.vetmic.2015.06.015_bib0065","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.vetmic.2015.01.017","article-title":"Genetic diversity of porcine reproductive and respiratory syndrome virus in Thailand and Southeast Asia from 2008 to 2013","volume":"176","author":"Jantafong","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0070","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.vetmic.2014.03.005","article-title":"Characterization of two newly emerged isolates of porcine reproductive and respiratory syndrome virus from Northeast China in 2013","volume":"171","author":"Leng","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0075","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1128\/CVI.05646-11","article-title":"Evaluation of the efficacy of an attenuated live vaccine against highly pathogenic porcine reproductive and respiratory syndrome virus in young pigs","volume":"19","author":"Leng","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0080","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s11262-010-0453-z","article-title":"Genomic analysis of two Chinese strains of porcine reproductive and respiratory syndrome viruses with different virulence","volume":"40","author":"Li","year":"2010","journal-title":"Virus Genes"},{"key":"10.1016\/j.vetmic.2015.06.015_bib0085","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s00705-013-1669-8","article-title":"Genetic diversity and evolutionary characterization of Chinese porcine reproductive and respiratory syndrome viruses based on NSP2 and ORF5","volume":"158","author":"Liu","year":"2013","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0090","first-page":"542","article-title":"[Molecular characterization of a porcine reproductive and respiratory syndrome virus isolate NT0801 from China]","volume":"27","author":"Lu","year":"2011","journal-title":"Bing Du Xue Bao"},{"key":"10.1016\/j.vetmic.2015.06.015_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2010.10.009","article-title":"Porcine reproductive and respiratory syndrome virus: an update on an emerging and re-emerging viral disease of swine","volume":"154","author":"Lunney","year":"2010","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0100","first-page":"441","article-title":"Lelystad virus belongs to a new virus family, comprising lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus","volume":"9","author":"Meulenberg","year":"1994","journal-title":"Arch. Virol. Suppl."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0105","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-1135(96)01335-1","article-title":"Molecular characterization of Lelystad virus","volume":"55","author":"Meulenberg","year":"1997","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0110","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1128\/JVI.73.1.270-280.1999","article-title":"Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents","volume":"73","author":"Nelsen","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0115","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2460\/javma.2005.227.385","article-title":"Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States","volume":"227","author":"Neumann","year":"2005","journal-title":"J. Am. Vet. Med. Assoc"},{"key":"10.1016\/j.vetmic.2015.06.015_bib0120","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1099\/0022-1317-82-6-1263","article-title":"Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations","volume":"82","author":"Nielsen","year":"2001","journal-title":"J. Gen. Virol."},{"issue":"4","key":"10.1016\/j.vetmic.2015.06.015_bib0125","doi-asserted-by":"crossref","first-page":"e00486","DOI":"10.1128\/genomeA.00486-13","article-title":"Complete genome sequence of a novel deletion porcine reproductive and respiratory syndrome virus strain","volume":"1","author":"Shen","year":"2013","journal-title":"Genome Announc."},{"issue":"1","key":"10.1016\/j.vetmic.2015.06.015_bib0130","first-page":"e00123","article-title":"Complete genome sequence of a highly pathogenic porcine reproductive and respiratory syndrome virus variant isolated from a backyard piglet","volume":"1","author":"Shi","year":"2013","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0135","doi-asserted-by":"crossref","first-page":"10904","DOI":"10.1128\/JVI.01270-13","article-title":"Recombination is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratory syndrome viruses in China","volume":"87","author":"Shi","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0140","doi-asserted-by":"crossref","first-page":"8700","DOI":"10.1128\/JVI.02551-09","article-title":"Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses","volume":"84","author":"Shi","year":"2010","journal-title":"J. Virol."},{"issue":"Pt 5","key":"10.1016\/j.vetmic.2015.06.015_bib0145","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1099\/0022-1317-79-5-961","article-title":"The molecular biology of arteriviruses","volume":"79","author":"Snijder","year":"1998","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0150","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1128\/JVI.68.9.5755-5764.1994","article-title":"Proteolytic processing of the replicase ORF1a protein of equine arteritis virus","volume":"68","author":"Snijder","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0155","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1354\/vp.37-2-143","article-title":"Pathogenesis of porcine reproductive and respiratory syndrome virus-induced increase in susceptibility to Streptococcus suis infection","volume":"37","author":"Thanawongnuwech","year":"2000","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0160","doi-asserted-by":"crossref","first-page":"e526","DOI":"10.1371\/journal.pone.0000526","article-title":"Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark","volume":"2","author":"Tian","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2015.06.015_bib0165","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.vetmic.2009.03.003","article-title":"An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS","volume":"138","author":"Tian","year":"2009","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0170","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.3201\/eid1309.070399","article-title":"Highly pathogenic porcine reproductive and respiratory syndrome, China","volume":"13","author":"Tong","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0175","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1128\/JVI.80.7.3428-3437.2006","article-title":"Mutagenesis analysis of the nsp4 main proteinase reveals determinants of arterivirus replicase polyprotein autoprocessing","volume":"80","author":"van Aken","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0180","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.1128\/JVI.70.10.6625-6633.1996","article-title":"Processing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domains","volume":"70","author":"van Dinten","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0185","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.meegid.2014.02.006","article-title":"Genetic diversity and phylogenetic analysis of porcine reproductive and respiratory syndrome virus isolates in East China","volume":"24","author":"Wang","year":"2014","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0190","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0378-1135(92)90046-V","article-title":"Lelystad virus, the cause of porcine epidemic abortion and respiratory syndrome: a review of mystery swine disease research at Lelystad","volume":"33","author":"Wensvoort","year":"1992","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0195","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.micpath.2013.05.013","article-title":"Molecular epidemiology of PRRSV in South China from 2007 to 2011 based on the genetic analysis of ORF5","volume":"63","author":"Xie","year":"2013","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0200","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.micpath.2014.08.001","article-title":"Epidemiological and evolutionary characteristics of the PRRSV in Southern China from 2010 to 2013","volume":"75","author":"Xie","year":"2014","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0205","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/1743-422X-8-410","article-title":"Generation of an infectious clone of HuN4-F112, an attenuated live vaccine strain of porcine reproductive and respiratory syndrome virus","volume":"8","author":"Zhang","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0210","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.virusres.2009.06.014","article-title":"Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China","volume":"145","author":"Zhou","year":"2009","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0215","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virusres.2010.07.016","article-title":"Porcine reproductive and respiratory syndrome in China","volume":"154","author":"Zhou","year":"2010","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0220","doi-asserted-by":"crossref","first-page":"748068","DOI":"10.1155\/2014\/748068","article-title":"Genetic diversity analysis of genotype 2 porcine reproductive and respiratory syndrome viruses emerging in recent years in China","volume":"2014","author":"Zhou","year":"2014","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0225","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1865-1682.2008.01020.x","article-title":"Highly virulent porcine reproductive and respiratory syndrome virus emerged in China","volume":"55","author":"Zhou","year":"2008","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2015.06.015_bib0230","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.vetmic.2010.07.001","article-title":"Complete genomic characterization of a Chinese isolate of porcine reproductive and respiratory syndrome virus","volume":"147","author":"Zhu","year":"2011","journal-title":"Vet. Microbiol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113515002515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113515002515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T15:58:44Z","timestamp":1599235124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113515002515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":46,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0378113515002515"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2015.06.015","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of three porcine reproductive and respiratory syndrome virus isolates from a single swine farm bearing strong homology to a vaccine strain","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2015.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}