{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T03:46:52Z","timestamp":1772077612461,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Danish Poultry Levy Board","award":["36058"],"award-info":[{"award-number":["36058"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.vetmic.2016.04.011","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T19:10:39Z","timestamp":1460401839000},"page":"59-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Experimental induced avian E. coli salpingitis: Significant impact of strain and host factors on the clinical and pathological outcome"],"prefix":"10.1016","volume":"188","author":[{"given":"Rikke Heidemann","family":"Olsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida Cecilie Naundrup","family":"Th\u00f8fner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne Elisabeth","family":"Pors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Pires dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Peter","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2016.04.011_bib0005","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/1471-2164-12-402","article-title":"BLAST ring image generator (BRIG): simple prokaryote genome comparisons","volume":"12","author":"Alikhan","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.vetmic.2016.04.011_bib0010","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.micpath.2008.08.005","article-title":"The chicken as a natural model for extraintestinal infections caused by avian pathogenic Escherichia coli (APEC)","volume":"45","author":"Antao","year":"2008","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/03079450600597998","article-title":"Defining susceptibility of broiler chicks to colibacillosis","volume":"35","author":"Ask","year":"2006","journal-title":"Av. Path."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-2164-9-75","article-title":"The RAST server: rapid annotations using subsystems technology","volume":"9","author":"Aziz","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.vetmic.2016.04.011_bib0025","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1128\/AAC.02412-14","article-title":"In silico detection and typing of plasmids using plasmid finder and plasmid multilocus sequence typing","volume":"58","author":"Carattoli","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0030","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.3382\/ps.2009-00168","article-title":"Breeding to reduce susceptibility to Escherichia coli in layers","volume":"88","author":"Cavero","year":"2009","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0035","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gki008","article-title":"VFDB: a reference database for bacterial virulence factors","volume":"33","author":"Chen","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0040","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1073\/pnas.0600938103","article-title":"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach","volume":"103","author":"Chen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0045","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2014.00005","article-title":"Is the concept of avian pathogenic Escherichia coli as a single pathotype fundamentally flawed?","author":"Collingwood","year":"2014","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0050","doi-asserted-by":"crossref","first-page":"e77302","DOI":"10.1371\/journal.pone.0077302","article-title":"Pathogen finder\u2013distinguishing friend from foe using bacterial whole genome sequence data","volume":"8","author":"Cosentino","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2016.04.011_bib0055","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijmm.2007.01.003","article-title":"Avian pathogenic, uropathogenic, and newborn meningitis-causing Escherichia coli: how closely related are they?","volume":"297","author":"Ewers","year":"2007","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0060","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1128\/AEM.01324-08","article-title":"Intestine and environment of the chicken as reservoirs for extraintestinal pathogenic Escherichia coli strains with zoonotic potential","volume":"75","author":"Ewers","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0065","doi-asserted-by":"crossref","first-page":"W52","DOI":"10.1093\/nar\/gkm360","article-title":"CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats","volume":"35","author":"Grissa","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0070","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnv118","article-title":"Avian colibacillosis: still many black holes","author":"Guabiraba","year":"2015","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0075","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1128\/MMBR.00015-09","article-title":"Pathogenomics of the virulence plasmids of Escherichia coli","volume":"73","author":"Johnson","year":"2009","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1067\/mlc.2002.121550","article-title":"Extraintestinal pathogenic Escherichia coli: the other bad E. coli","volume":"139","author":"Johnson","year":"2002","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0085","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/JB.188.2.745-758.2006","article-title":"DNA sequence of a ColV plasmid and prevalence of selected plasmid-encoded virulence genes among avian Escherichia coli strains","volume":"188","author":"Johnson","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0090","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1128\/JB.01726-06","article-title":"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes","volume":"189","author":"Johnson","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0095","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1128\/AEM.02171-06","article-title":"Plasmid replicon typing of commensal and pathogenic Escherichia coli isolates","volume":"73","author":"Johnson","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0100","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1128\/JCM.00816-08","article-title":"Identification of minimal predictors of avian pathogenic Escherichia coli virulence for use as a rapid diagnostic tool","volume":"46","author":"Johnson","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0105","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/vr.157.19.573","article-title":"Observations on salpingitis, peritonitis and salpingoperitonitis in a layer breeder flock","volume":"157","author":"Jordan","year":"2005","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0110","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1099\/jmm.0.044263-0","article-title":"Prevalence of genes encoding virulence factors among Escherichia coli with K1 antigen and non-K1 E. coli strains","volume":"61","author":"Kaczmarek","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/03079457.2013.866213","article-title":"The contribution of systemic Escherichia coli infection to the early mortalities of commercial broiler chickens","volume":"43","author":"Kemmett","year":"2014","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0120","first-page":"814","article-title":"Escherichia coli salpingitis and peritonitis in layer chickens: an overview","volume":"131","author":"Landman","year":"2006","journal-title":"Tijdschr. Diergeneeskd."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0125","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/03079457.2015.1060584","article-title":"The incidence and economic impact of the Escherichia coli peritonitis syndrome in Dutch poultry farming","volume":"44","author":"Landman","year":"2015","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/01652176.2012.675092","article-title":"Effect of anti-inflammatory drugs on colibacillosis lesions in broilers after infectious bronchitis virus and subsequent Escherichia coli infection","volume":"32","author":"Landman","year":"2012","journal-title":"Vet. Q."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0135","first-page":"3","article-title":"E. coli as an all-rounder: the thin line between commensalism and pathogenicity","volume":"358","author":"Leimbach","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0140","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1186\/1471-2164-10-552","article-title":"Genome reannotation of Escherichia coli CFT073 with new insights into virulence","volume":"10","author":"Luo","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.vetmic.2016.04.011_bib0145","doi-asserted-by":"crossref","first-page":"e0002613","DOI":"10.1128\/genomeA.00026-13","article-title":"Complete genome sequence of the avian pathogenic Escherichia coli strain APEC O78","volume":"1","author":"Mangiamele","year":"2013","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1874285801105010055","article-title":"Subpathotypes of avian pathogenic Escherichia coli (APEC) exist as defined by their syndromes and virulence traits","volume":"5","author":"Maturana","year":"2011","journal-title":"Open Microbiol. J."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0155","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.vetmic.2013.08.007","article-title":"Poultry as reservoir for extraintestinal pathogenic Escherichia coli O45:K1:H7-B2-ST95 in humans","volume":"167","author":"Mora","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0160","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1590\/S0100-736X2009000700001","article-title":"Virulence factors of avian pathogenic Escherichia coli (APEC)","volume":"29","author":"Nakazato","year":"2009","journal-title":"Pesquisa Veterinaria Brasileira"},{"key":"10.1016\/j.vetmic.2016.04.011_bib0165","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/03079457.2011.618942","article-title":"Clonality and virulence traits of Escherichia coli associated with haemorrhagic septicaemia in turkeys","volume":"40","author":"Olsen","year":"2011","journal-title":"Avian Path."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0170","unstructured":"Olsen, R.H., Christensen, H., Kabell, S., Bisgaard, M. (2013). Escherichia coli obtained from outbreaks of salpingitis and peritonitis in layers demonstrate clonality and a primary rather than secondary role. Conferrence proc. WVPA, Nantes, France."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0175","article-title":"Pathology and molecular characterization of Escherichia coli associated to the avian salpingitis-peritonitis disease syndrome","author":"Olsen","year":"2015","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0180","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00399-15","article-title":"Draft genome sequences of three Escherichia coli strains with different in vivo pathogenicities in an avian (ascending) infection model of the oviduct","volume":"3","author":"Olsen","year":"2015","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0185","doi-asserted-by":"crossref","first-page":"D206","DOI":"10.1093\/nar\/gkt1226","article-title":"The SEED and the rapid annotation of microbial genomes using subsystems technology (RAST)","volume":"42","author":"Overbeek","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0190","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.vetmic.2012.11.008","article-title":"Genetic diversity and virulence profiles of Escherichia coli causing salpingitis and peritonitis in broiler breeders","volume":"162","author":"Pires dos Santos","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0195","unstructured":"Pires dos Santos, T. 2014. Population genetics, evolution and molecular epidemiology og Escherichia coli isolated from chickens. PhD disseration, UCPH, Frederiksberg"},{"key":"10.1016\/j.vetmic.2016.04.011_bib0200","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.vetmic.2014.02.043","article-title":"Variations in virulence of avian pathogenic Escherichia coli demonstrated by the use of a new in vivo infection model","volume":"170","author":"Pors","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0205","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1099\/mic.0.27499-0","article-title":"Comparison of Escherichia coli isolates implicated in human urinary tract infection and avian colibacillosis","volume":"151","author":"Rodriguez-Siek","year":"2005","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2016.04.011_bib0210","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1128\/JB.00394-12","article-title":"Draft genome of a Brazilian avian-pathogenic Escherichia coli strain and in silico characterization of virulence-related genes","volume":"194","author":"Rojas","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0215","doi-asserted-by":"crossref","first-page":"e0011013","DOI":"10.1128\/genomeA.00110-13","article-title":"Genome sequences of avian pathogenic Escherichia coli strains isolated from brazilian commercial poultry","volume":"1","author":"Rojas","year":"2013","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0220","unstructured":"Thofner, I.C., Poulsen, L., Bisgaard, M., Chistensen, H., Olsen, R., Christensen, J., Longitudinal study of mortality observed in four broiler breeder flocks. 19th Congress of the World Veterinary Poultry Association, At Cape Town, Volume: 19. 2015."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0225","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.vetmic.2005.02.009","article-title":"Virulence-associated traits in avian Escherichia coli: comparison between isolates from colibacillosis-affected and clinically healthy layer flocks","volume":"108","author":"Vandekerchove","year":"2005","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0230","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1093\/jac\/dkq347","article-title":"Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants","volume":"65","author":"Villa","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0235","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1365-2958.2006.05172.x","article-title":"Sex and virulence in Escherichia coli: an evolutionary perspective","volume":"60","author":"Wirth","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.vetmic.2016.04.011_bib0240","doi-asserted-by":"crossref","first-page":"e112048","DOI":"10.1371\/journal.pone.0112048","article-title":"Comparative genomic analysis shows that avian pathogenic Escherichia coli isolate IMT5155 (O2:K1:H5; ST complex 95, ST140) shares close relationship with ST95 APEC O1:K1 and human ExPEC O18:K1 strains","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS One"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113516300931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113516300931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T12:27:49Z","timestamp":1536841669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113516300931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":48,"alternative-id":["S0378113516300931"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2016.04.011","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental induced avian E. coli salpingitis: Significant impact of strain and host factors on the clinical and pathological outcome","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2016.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}