{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:25:19Z","timestamp":1767853519131,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.vetmic.2017.04.023","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T22:45:54Z","timestamp":1493937954000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Immunogenicity of T7 bacteriophage nanoparticles displaying G-H loop of foot-and-mouth disease virus (FMDV)"],"prefix":"10.1016","volume":"205","author":[{"given":"Hai","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bihua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jibo","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 12","key":"10.1016\/j.vetmic.2017.04.023_bib0005","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1099\/0022-1317-76-12-3089","article-title":"Assembly of foot-and-mouth disease virus empty capsids synthesized by a vaccinia virus expression system","volume":"76","author":"Abrams","year":"1995","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0010","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.vaccine.2013.02.060","article-title":"An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine","volume":"31","author":"Alejo","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0015","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00705-004-0460-2","article-title":"Protective immune response against foot-and-mouth disease virus challenge in guinea pigs vaccinated with recombinant P1 polyprotein expressed in Pichia pastoris","volume":"150","author":"Balamurugan","year":"2005","journal-title":"Arch. Virol."},{"issue":"Pt 12","key":"10.1016\/j.vetmic.2017.04.023_bib0020","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1099\/0022-1317-68-12-3137","article-title":"Fusion proteins with multiple copies of the major antigenic determinant of foot-and-mouth disease virus protect both the natural host and laboratory animals","volume":"68","author":"Broekhuijsen","year":"1987","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0025","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1016\/j.vaccine.2007.01.006","article-title":"Non-toxic Pseudomonas aeruginosa exotoxin A expressing the FMDV VP1 G-H loop for mucosal vaccination of swine against foot and mouth disease virus","volume":"25","author":"Challa","year":"2007","journal-title":"Vaccine"},{"issue":"Pt 8","key":"10.1016\/j.vetmic.2017.04.023_bib0030","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1099\/0022-1317-74-8-1547","article-title":"Identification of a fifth neutralizable site on type O foot-and-mouth disease virus following characterization of single and quintuple monoclonal antibody escape mutants","volume":"74","author":"Crowther","year":"1993","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0168-1702(02)00261-7","article-title":"FMD vaccines","volume":"91","author":"Doel","year":"2003","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0168-1702(02)00259-9","article-title":"Evolution of foot-and-mouth disease virus","volume":"91","author":"Domingo","year":"2003","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0022-2836(83)80282-4","article-title":"Complete nucleotide sequence of bacteriophage T7 DNA and the locations of T7 genetic elements","volume":"166","author":"Dunn","year":"1983","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0050","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.vaccine.2004.11.014","article-title":"Development of transgenic alfalfa plants containing the foot and mouth disease virus structural polyprotein gene P1 and its utilization as an experimental immunogen","volume":"23","author":"Dus Santos","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0055","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/330168a0","article-title":"Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinants","volume":"330","author":"Francis","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0060","first-page":"438","article-title":"Some thoughts on FMD vaccine, outbreaks","volume":"223","author":"Gerhart","year":"2003","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0065","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1128\/CMR.17.2.465-493.2004","article-title":"Foot-and-mouth disease","volume":"17","author":"Grubman","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1297-9716-44-48","article-title":"Foot-and-mouth disease virus-like particles produced by a SUMO fusion protein system in Escherichia coli induce potent protective immune responses in guinea pigs, swine and cattle","volume":"44","author":"Guo","year":"2013","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0075","first-page":"373","article-title":"Efficient endotoxin removal from T7 phage preparations by a mild detergent treatment followed by ultrafiltration","volume":"57","author":"Hashemi","year":"2013","journal-title":"Acta Virol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0080","doi-asserted-by":"crossref","first-page":"e45765","DOI":"10.1371\/journal.pone.0045765","article-title":"Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against influenza A virus challenge","volume":"7","author":"Hashemi","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jviromet.2006.11.041","article-title":"T7 phage display of Ep15 peptide for the detection of WNV IgG","volume":"141","author":"Herrmann","year":"2007","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/vim.1999.12.1","article-title":"Recombinant fusion protein and DNA vaccines against foot and mouth disease virus infection in guinea pig and swine","volume":"12","author":"Huang","year":"1999","journal-title":"Viral Immunol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0095","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1297-9716-44-116","article-title":"Foot-and-mouth disease: past, present and future","volume":"44","author":"Jamal","year":"2013","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0100","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1126\/science.6272395","article-title":"Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine","volume":"214","author":"Kleid","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0105","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.virol.2004.07.025","article-title":"Comparison of immune responses against foot-and-mouth disease virus induced by fusion proteins using the swine IgG heavy chain constant region or beta-galactosidase as a carrier of immunogenic epitopes","volume":"328","author":"Li","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0110","doi-asserted-by":"crossref","first-page":"e2273","DOI":"10.1371\/journal.pone.0002273","article-title":"Expression of foot-and-mouth disease virus capsid proteins in silkworm-baculovirus expression system and its utilization as a subunit vaccine","volume":"3","author":"Li","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0115","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0009-9120(97)00049-0","article-title":"Removal of endotoxin from recombinant protein preparations","volume":"30","author":"Liu","year":"1997","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1389201013378671","article-title":"Phage displayed biomolecules as preventive and therapeutic agents","volume":"2","author":"Manoutcharian","year":"2001","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1006\/viro.1999.9940","article-title":"Development of replication-defective adenovirus serotype 5 containing the capsid and 3C protease coding regions of foot-and-mouth disease virus as a vaccine candidate","volume":"263","author":"Mayr","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0130","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0264-410X(95)00031-U","article-title":"Synthetic peptide vaccines \u2013 success at last","volume":"13","author":"Meloen","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0135","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1472-765X.2010.02916.x","article-title":"Bacteriophage applications: where are we now?","volume":"51","author":"Monk","year":"2010","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0140","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/S0264-410X(01)00483-2","article-title":"Early protection against homologous challenge after a single dose of replication-defective human adenovirus type 5 expressing capsid proteins of foot-and-mouth disease virus (FMDV) strain A24","volume":"20","author":"Moraes","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0145","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1099\/0022-1317-81-6-1495","article-title":"A multiply substituted G-H loop from foot-and-mouth disease virus in complex with a neutralizing antibody: a role for water molecules","volume":"81","author":"Ochoa","year":"2000","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.virol.2005.04.014","article-title":"Rapid protection of cattle from direct challenge with foot-and-mouth disease virus (FMDV) by a single inoculation with an adenovirus-vectored FMDV subunit vaccine","volume":"337","author":"Pacheco","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0155","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1586\/14760584.8.3.347","article-title":"Vaccination against foot-and-mouth disease virus: strategies and effectiveness","volume":"8","author":"Parida","year":"2009","journal-title":"Exp. Rev. Vac."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0160","first-page":"43","article-title":"The hand, foot and mouth disease virus capsid: sequence analysis and prediction of antigenic sites from homology modelling","volume":"1","author":"Ranganathan","year":"2002","journal-title":"Appl. Bioinform."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0165","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.vaccine.2007.12.053","article-title":"Orally delivered foot-and-mouth disease virus capsid protomer vaccine displayed on T4 bacteriophage surface: 100% protection from potency challenge in mice","volume":"26","author":"Ren","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0170","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/0264-410X(94)90305-0","article-title":"OmpA-FMDV VP1 fusion proteins: production, cell surface exposure and immune responses to the major antigenic domain of foot-and-mouth disease virus","volume":"12","author":"Ruppert","year":"1994","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0175","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jmv.20479","article-title":"Antigenicity and immunogenicity of the immunodominant region of hepatitis B surface antigen displayed on bacteriophage T7","volume":"77","author":"Tan","year":"2005","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0180","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1016\/S0264-410X(02)00148-2","article-title":"Effective synthetic peptide vaccine for foot-and-mouth disease in swine","volume":"20","author":"Wang","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2017.04.023_bib0185","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.vetmic.2010.09.013","article-title":"Identification of a conformational epitope on the VP1 G-H Loop of type Asia1 foot-and-mouth disease virus defined by a protective monoclonal antibody","volume":"148","author":"Wang","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2017.04.023_bib0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4149\/av_2012_02_111","article-title":"A DNA vaccine encoding the FMDV capsid precursor polypeptide P1 and the enhancing effect of bovine herpesvirus 1 VP22 protein as molecular adjuvant","volume":"56","author":"Yu","year":"2012","journal-title":"Acta Virol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113517302110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113517302110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T23:56:59Z","timestamp":1535846219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113517302110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":38,"alternative-id":["S0378113517302110"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2017.04.023","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunogenicity of T7 bacteriophage nanoparticles displaying G-H loop of foot-and-mouth disease virus (FMDV)","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2017.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}