{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:50:27Z","timestamp":1771026627159,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.vetmic.2017.08.022","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T02:00:22Z","timestamp":1504922422000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Testing cathelicidin susceptibility of bacterial mastitis isolates: Technical challenges and data output for clinical isolates"],"prefix":"10.1016","volume":"210","author":[{"given":"Melissa N.","family":"Langer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Blodkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bayerbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea T.","family":"Fe\u00dfler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"de Buhr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gutsmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lothar","family":"Kreienbrock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren","family":"von K\u00f6ckritz-Blickwede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2017.08.022_bib0005","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ijantimicag.2004.10.010","article-title":"Factors affecting the antimicrobial activity of ovine-derived cathelicidins against E. coli 0157:H7","volume":"25","author":"Anderson","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.vetmic.2017.08.022_bib0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1515\/BC.2009.039","article-title":"Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes","volume":"390","author":"Andr\u00e4","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0015","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.bbamem.2015.02.021","article-title":"Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria","volume":"1848","author":"Anunthawan","year":"2015","journal-title":"Biochim. Biophys. Acta \u2013 Biomembr."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/rr25","article-title":"Epithelial antimicrobial peptides in host defense against infection","volume":"1","author":"Bals","year":"2000","journal-title":"Respir. Res."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0025","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3168\/jds.S0022-0302(84)81400-9","article-title":"Circadian and ultradian temperature rhythms of lactating dairy cows","volume":"67","author":"Bitman","year":"1984","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0030","article-title":"In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus","author":"Blodkamp","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2012.00195","article-title":"Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides?","volume":"3","author":"Brender","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0040","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0924-8579(03)00180-8","article-title":"Antimicrobial peptides in animals and their role in host defences","volume":"22","author":"Brogden","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.vetmic.2017.08.022_bib0045","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.vetmic.2006.09.005","article-title":"Antimicrobial breakpoints-Definitions and conflicting requirements","volume":"118","author":"Bywater","year":"2006","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0050","first-page":"74","article-title":"Document VET01-S2: performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals","volume":"7","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2013","journal-title":"Clin. Lab. Stand. Inst."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0055","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.fm.2017.01.020","article-title":"Use of enhanced nisin derivatives in combination with food-grade oils or citric acid to control Cronobacter sakazakii and Escherichia coli O157:H7","volume":"65","author":"Campion","year":"2017","journal-title":"Food Microbiol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0060","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.3168\/jds.2008-1258","article-title":"Short communication: early detection of mastitis using infrared thermography in dairy cows","volume":"91","author":"Colak","year":"2008","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0065","doi-asserted-by":"crossref","first-page":"26622","DOI":"10.1038\/srep26622","article-title":"Protective effect of in ovo treatment with the chicken cathelicidin analog D-CATH-2 against avian pathogenic E. coli","volume":"6","author":"Cuperus","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0070","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1473-3099(15)00466-1","article-title":"Alternatives to antibiotics-a pipeline portfolio review","volume":"16","author":"Czaplewski","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0075","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1007\/s00253-015-6375-x","article-title":"Antimicrobial peptides: an alternative for innovative medicines?","volume":"99","author":"Da Costa","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0080","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s10529-005-0936-5","article-title":"Human antimicrobial peptides: defensins, cathelicidins and histatins","author":"De Smet","year":"2005","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0085","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-2836(84)90309-7","article-title":"Analysis of membrane and surface protein sequences with the hydrophobic moment plot","volume":"179","author":"Eisenberg","year":"1984","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0090","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/jac\/dkq021","article-title":"Characterization of methicillin-resistant Staphylococcus aureus ST398 from cases of bovine mastitis","volume":"65","author":"Fe\u00dfler","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0095","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.vetmic.2011.11.032","article-title":"A proposal of interpretive criteria for cefoperazone applicable to bovine mastitis pathogens","volume":"157","author":"Fe\u00dfler","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0100","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.vetmic.2016.08.010","article-title":"Detection of plasmid-borne extended-spectrum \u03b2-lactamase (ESBL) genes in Escherichia coli isolates from bovine mastitis","volume":"200","author":"Freitag","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0105","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1128\/AAC.44.6.1694-1696.2000","article-title":"In vitro susceptibility tests for cationic peptides: comparison of broth microdilution methods for bacteria that grow aerobically","volume":"44","author":"Giacometti","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0110","first-page":"409","article-title":"Application of pcr based technique for detection of common mastitis pathogens in milk samples of Hf crossbred cattle","volume":"2","author":"Jadhav","year":"2013","journal-title":"Glob. J. Bio-Science Biotechnol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0115","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/jac\/dkg312","article-title":"European harmonization of MIC breakpoints for antimicrobial susceptibility testing of bacteria","volume":"52","author":"Kahlmeter","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0120","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1128\/AAC.45.11.3256-3261.2001","article-title":"Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells","volume":"45","author":"Kalfa","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12275-017-6452-1","article-title":"The therapeutic applications of antimicrobial peptides (AMPs): a patent review","volume":"55","author":"Kang","year":"2017","journal-title":"J. Microbiol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0130","first-page":"1","article-title":"Cathelicidins: family of antimicrobial peptides. A review","author":"Ko\u015bciuczuk","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0135","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fcimb.2016.00194","article-title":"Antimicrobial peptides: an emerging category of therapeutic agents","volume":"6","author":"Mahlapuu","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0140","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.bbamem.2015.11.004","article-title":"Gram-positive bacterial cell envelopes: the impact on the activity of antimicrobial peptides","volume":"1858","author":"Malanovic","year":"2016","journal-title":"Biochim. Biophys. Acta \u2013 Biomembr."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0145","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2217\/fmb.14.93","article-title":"Emerging issues in antimicrobial resistance of bacteria from food-producing animals","volume":"10","author":"Michael","year":"2015","journal-title":"Future Microbiol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0150","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1189\/jlb.0106048","article-title":"Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide","volume":"80","author":"Mookherjee","year":"2006","journal-title":"J. Leukoc. Biol."},{"issue":"Pt. 3","key":"10.1016\/j.vetmic.2017.08.022_bib0155","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1042\/bj3410501","article-title":"Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity","volume":"341","author":"Oren","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0160","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/femsre\/fux012","article-title":"Perspectives for clinical use of engineered human host defense antimicrobial peptides","volume":"41","author":"Pach\u00f3n-Ib\u00e1\u00f1ez","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0165","doi-asserted-by":"crossref","first-page":"8405","DOI":"10.1074\/jbc.274.13.8405","article-title":"Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides","volume":"274","author":"Peschel","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0170","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/exd.12114","article-title":"Staphylococcus aureus subverts cutaneous defense by d-alanylation of teichoic acids","volume":"22","author":"Simanski","year":"2013","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0175","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/jac\/dkm423","article-title":"Potential confusion regarding the term resistance in epidemiological surveys","volume":"61","author":"Simjee","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0180","doi-asserted-by":"crossref","first-page":"28375","DOI":"10.1074\/jbc.271.45.28375","article-title":"Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities","volume":"271","author":"Skerlavaj","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0185","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.bbamem.2007.11.016","article-title":"Binding of LL-37 to model biomembranes: insight into target vs host cell recognition","volume":"1778","author":"Sood","year":"2008","journal-title":"Biochim. Biophys. Acta \u2013 Biomembr."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0190","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0195","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1074\/jbc.274.1.29","article-title":"Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membrane","volume":"274","author":"Wu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(95)01050-O","article-title":"Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain","volume":"374","author":"Zanetti","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0205","series-title":"The Biology and Pathology of Innate Immunity Mechanisms","first-page":"203","article-title":"Structure and biology of cathelicidins","author":"Zanetti","year":"2002"},{"key":"10.1016\/j.vetmic.2017.08.022_bib0210","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2174\/1381612023395457","article-title":"Cathelicidin peptides as candidates for a novel class of antimicrobials","volume":"8","author":"Zanetti","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0215","first-page":"179","article-title":"The role of cathelicidins in the innate host defenses of mammals","volume":"7","author":"Zanetti","year":"2005","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.vetmic.2017.08.022_bib0220","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40348-016-0041-y","article-title":"The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens","volume":"3","author":"Zeitouni","year":"2016","journal-title":"Mol. Cell. Pediatr."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113517308313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113517308313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T04:08:15Z","timestamp":1538021295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113517308313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":44,"alternative-id":["S0378113517308313"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2017.08.022","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testing cathelicidin susceptibility of bacterial mastitis isolates: Technical challenges and data output for clinical isolates","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2017.08.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}