{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:13:57Z","timestamp":1790439237009,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.vetmic.2018.05.001","type":"journal-article","created":{"date-parts":[[2018,5,5]],"date-time":"2018-05-05T15:56:28Z","timestamp":1525535788000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The moderate drift towards less tetracycline-susceptible isolates of contagious agalactia causative agents might result from different molecular mechanisms"],"prefix":"10.1016","volume":"220","author":[{"given":"M.","family":"Prats-van der Ham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tatay-Dualde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ambroset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"De la Fe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2018.05.001_bib0005","doi-asserted-by":"crossref","DOI":"10.1136\/vr.100481","article-title":"Severe outbreaks of polyarthritis in kids caused by Mycoplasma mycoides subspecies capri in Sicily","volume":"170","author":"Agnello","year":"2012","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0010","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.smallrumres.2012.12.022","article-title":"A comparison of the efficacy of commercial and experimental vaccines for contagious agalactia in sheep","volume":"112","author":"Agnone","year":"2013","journal-title":"Small Rumin. Res."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0015","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/AAC.03876-14","article-title":"16S rRNA gene mutations associated with decreased susceptibility to tetracycline in Mycoplasma bovis","volume":"59","author":"Amram","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0020","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tvjl.2015.04.018","article-title":"Mechanisms involved in quinolone resistance in Mycoplasma mycoides subsp capri","volume":"204","author":"Antunes","year":"2015","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0025","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1128\/AAC.00420-07","article-title":"In vitro susceptibilities of Mycoplasma putrefaciens field isolates","volume":"51","author":"Antunes","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0030","doi-asserted-by":"crossref","DOI":"10.1186\/1746-6148-8-171","article-title":"A survey of Mycoplasma agalactiae in dairy sheep farms in Spain","volume":"8","author":"Ariza-Miguel","year":"2012","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0035","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0092-8674(00)00216-6","article-title":"The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit","volume":"103","author":"Brodersen","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2018.05.001_bib0040","doi-asserted-by":"crossref","DOI":"10.1186\/1746-6148-6-32","article-title":"Mycoplasmoses of ruminants in France: recent data from the national surveillance network","volume":"6","author":"Chazel","year":"2010","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0045","article-title":"Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals","volume":"vol. 35","author":"CLSI","year":"2015"},{"key":"10.1016\/j.vetmic.2018.05.001_bib0050","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.smallrumres.2006.09.010","article-title":"Contagious agalactia in small ruminants","volume":"68","author":"Corrales","year":"2007","journal-title":"Small Rumin. Res."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0055","doi-asserted-by":"crossref","DOI":"10.1136\/vr.102462","article-title":"Antibiotics used most commonly to treat animals in Europe","volume":"175","author":"De Briyne","year":"2014","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0060","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1746-6148-8-146","article-title":"Unexpected genetic diversity of Mycoplasma agalactiae caprine isolates from an endemic geographically restricted area of Spain","volume":"8","author":"De la Fe","year":"2012","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0065","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tvjl.2004.05.002","article-title":"Microbiological survey for Mycoplasma spp. in a contagious agalactia endemic area","volume":"170","author":"De la Fe","year":"2005","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0070","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.tvjl.2005.09.011","article-title":"First isolation of Mycoplasma capricolum subsp capricolum, one of the causal agents of caprine contagious agalactia, on the island of Lanzarote (Spain)","volume":"173","author":"De la Fe","year":"2007","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0075","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/jac\/dkn118","article-title":"Reduced susceptibility to tetracyclines is associated in vitro with the presence of 16S rRNA mutations in Mycoplasma hominis and Mycoplasma pneumoniae","volume":"61","author":"Degrange","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0080","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/vr.163.9.278","article-title":"Mortality in adult goats attributed to Mycoplasma capricolum subspecies capricolum","volume":"163","author":"Giadinis","year":"2008","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0085","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/tvjl.1999.0383","article-title":"Isolation of mycoplasmas from the external ear canal of goats affected with contagious agalactia","volume":"158","author":"Gil","year":"1999","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0090","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tvjl.2013.04.015","article-title":"Contagious agalactia due to Mycoplasma spp. in small dairy ruminants: epidemiology and prospects for diagnosis and control","volume":"198","author":"Gomez-Martin","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0095","first-page":"6","article-title":"Tetracycline antibiotics and resistance","author":"Grossman","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0100","first-page":"145","article-title":"Characterization of mycoplasmas by PCR and sequence analysis with universal 16S rDNA primers","volume":"104","author":"Johansson","year":"1998","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0105","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1128\/AEM.03280-15","article-title":"Alterations in the quinolone resistance-determining regions and fluoroquinolone resistance in clinical isolates and laboratory-derived mutants of Mycoplasma bovis: not all genotypes may be equal","volume":"82","author":"Khalil","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0110","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1089\/mdr.2016.0268","article-title":"Monitoring the decrease in susceptibility to ribosomal RNAs targeting antimicrobials and its molecular basis in clinical Mycoplasma bovis isolates over time","volume":"23","author":"Khalil","year":"2017","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0115","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1128\/JCM.01617-07","article-title":"Suppression-subtractive hybridization as a strategy to identify taxon-specific sequences within the Mycoplasma mycoides cluster: design and validation of an M. capricolum subsp. capricolum-specific PCR assay","volume":"46","author":"Maigre","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0120","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1099\/ijs.0.64918-0","article-title":"Phylogeny of the Mycoplasma mycoides cluster based on analysis of five conserved protein-coding sequences and possible implications for the taxonomy of the group","volume":"57","author":"Manso-Silvan","year":"2007","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0125","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1099\/mic.0.27590-0","article-title":"Suppression subtractive hybridization as a basis to assess Mycoplasma agalactiae and Mycoplasma bovis genomic diversity and species-specific sequences","volume":"151","author":"Marenda","year":"2005","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2018.05.001_bib0130","first-page":"69","article-title":"Agalactia caused by Mycoplasma putrefaciens in a goat herd","volume":"31","author":"Mercier","year":"2000","journal-title":"Point Vet."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0135","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1515\/hsz-2013-0292","article-title":"Tetracycline antibiotics and resistance mechanisms","volume":"395","author":"Nguyen","year":"2014","journal-title":"Biol. Chem."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0140","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cimid.2012.04.005","article-title":"Molecular typing of Mycoplasma agalactiae: tracing European-wide genetic diversity and an endemic clonal population","volume":"35","author":"Nouvel","year":"2012","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0145","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-11-86","article-title":"Comparative genomic and proteomic analyses of two Mycoplasma agalactiae strains: clues to the macro- and micro-events that are shaping mycoplasma diversity","volume":"11","author":"Nouvel","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.vetmic.2018.05.001_bib0150","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.3168\/jds.2012-6492","article-title":"In vitro antimicrobial susceptibility of Mycoplasma agalactiae strains isolated from dairy goats","volume":"96","author":"Paterna","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0155","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.tvjl.2016.05.010","article-title":"In vitro assessment of the antimicrobial susceptibility of caprine isolates of Mycoplasma mycoides subsp capri","volume":"214","author":"Paterna","year":"2016","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0160","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/emboj\/20.8.1829","article-title":"Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3","volume":"20","author":"Pioletti","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0165","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/jam.13083","article-title":"Diversity and variation in antimicrobial susceptibility patterns over time in Mycoplasma agalactiae isolates collected from sheep and goats in France","volume":"120","author":"Poumarat","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0170","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0378-1135(91)90140-B","article-title":"Identification of ruminant mycoplasmas by dot immunobinding on membrane filtration (MF-dot)","volume":"29","author":"Poumarat","year":"1991","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0175","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1128\/AAC.49.1.421-424.2005","article-title":"Increased expression of two multidrug transporter-like genes is associated with ethidium bromide and ciprofloxacin resistance in Mycoplasma hominis","volume":"49","author":"Raherison","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0180","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01983-16","article-title":"Mutations associated with decreased susceptibility to seven antimicrobial families in field and laboratory-derived Mycoplasma bovis strains","volume":"61","author":"Sulyok","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2018.05.001_bib0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174700","article-title":"Antimicrobial susceptibility and multilocus sequence typing of Mycoplasma capricolum subsp capricolum","volume":"12","author":"Tatay-Dualde","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2018.05.001_bib0190","series-title":"Mollicutes. Molecular Biology and Pathogenesis","first-page":"289","article-title":"Emerging antimicrobial resistance in mycoplasmas of humans and animals","author":"Waites","year":"2014"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113518301949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113518301949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T16:39:27Z","timestamp":1604248767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113518301949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":38,"alternative-id":["S0378113518301949"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2018.05.001","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The moderate drift towards less tetracycline-susceptible isolates of contagious agalactia causative agents might result from different molecular mechanisms","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2018.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}