{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:37:41Z","timestamp":1788187061947,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control, Prevention and Funds of Shandong \u201cDouble Tops\u201d Program"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.vetmic.2018.07.014","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T19:24:42Z","timestamp":1532114682000},"page":"34-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Fowl adenovirus serotype 4-induced apoptosis, autophagy, and a severe inflammatory response in liver"],"prefix":"10.1016","volume":"223","author":[{"given":"Yujuan","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingpo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2018.07.014_bib0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/03079457908418336","article-title":"Ultrastructural studies of the replication of fowl adenoviruses in primary cell cultures","volume":"8","author":"Adair","year":"1979","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0010","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/vr.124.10.247","article-title":"Hydropericarditis syndrome in broiler chickens in Pakistan","volume":"124","author":"Anjum","year":"1989","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0015","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrm1666","article-title":"Autophagy: dual roles in life and death?","volume":"6","author":"Baehrecke","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0020","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1038\/sj.onc.1210977","article-title":"Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer","volume":"27","author":"Baird","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1128\/JVI.01265-10","article-title":"Adenovirus membrane penetration activates the nlrp3 inflammasome","volume":"85","author":"Barlan","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061405","article-title":"Intratracheal il-6 protects against lung inflammation in direct, but not indirect, causes of acute lung injury in mice","volume":"8","author":"Bhargava","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0035","series-title":"The Veterinary Hematology and Clinical Chemistry","first-page":"582","article-title":"Clinical chemistry of birds","author":"Campbell","year":"2012"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0040","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.cdd.4401148","article-title":"The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction","volume":"10","author":"Chen","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0045","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.vaccine.2008.12.040","article-title":"Baff enhances b-cell-mediated immune response and vaccine-protection against a very virulent IBDV in chickens","volume":"27","author":"Chen","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/1348-0421.12123","article-title":"Axin expression delays herpes simplex virus-induced autophagy and enhances viral replication in L929 cells","volume":"58","author":"Choi","year":"2014","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0055","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/jinf.2001.0836","article-title":"Apoptotic cell death in the pathogenesis of infectious diseases","volume":"42","author":"Dockrell","year":"2001","journal-title":"J. Infect."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0060","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.cell.2006.01.034","article-title":"Anti-immunology: evasion of the host immune system by bacterial and viral pathogens","volume":"124","author":"Finlay","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0065","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/hep.21310","article-title":"Lack of UCP2 reduces Fas-mediated liver injury in ob\/ob mice and reveals importance of cell-specific UCP2 expression","volume":"44","author":"Fulop","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0070","first-page":"159","article-title":"Hydropericardium syndrome in poultry","volume":"18","author":"Gowda","year":"1994","journal-title":"Indian J. Vet. Pathol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0075","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/jnci\/djj161","article-title":"Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus","volume":"98","author":"Ito","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0080","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/jnci\/djm102","article-title":"Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death","volume":"99","author":"Jiang","year":"2007","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0085","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4161\/auto.5260","article-title":"Adenovirus\u2019s last trick: you say lysis, we say autophagy","volume":"4","author":"Jiang","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0090","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1128\/JVI.02032-10","article-title":"Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity","volume":"85","author":"Jiang","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1443.020","article-title":"Toll-like receptor and RIG-I-like receptor signaling","volume":"1143","author":"Kawai","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0100","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1637\/8178-112207-Case","article-title":"Outbreaks of hydropericardium syndrome and molecular characterization of Korean fowl adenoviral isolates","volume":"52","author":"Kim","year":"2008","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0105","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1128\/IAI.69.4.2527-2534.2001","article-title":"Analysis of chicken mucosal immune response to Eimeria tenella and Eimeria maxima infection by quantitative reverse transcription-PCR","volume":"69","author":"Laurent","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0110","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.3382\/ps.2009-00251","article-title":"Vaccination of chickens with recombinant salmonella expressing m2e and cd154 epitopes increases protection and decreases viral shedding after low pathogenic avian influenza, challenge","volume":"88","author":"Layton","year":"2009","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0115","first-page":"159","article-title":"Eating oneself and uninvited guests: autophagy-related pathways in cellular defense","volume":"120","author":"Levine","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0120","series-title":"The Clinical Biochemistry of Domestic Animals","first-page":"839","article-title":"Avian clinical biochemistry","author":"Lumeij","year":"2008"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0125","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.smim.2009.05.005","article-title":"Modulation of adaptive immunity with Toll-like receptors","volume":"21","author":"Manicassamy","year":"2009","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0130","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2307\/1592638","article-title":"Pathologic study of specific pathogen free chicks and hens inoculated with adenovirus isolated from hydropericardium syndrome","volume":"43","author":"Nakamura","year":"1999","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0135","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1099\/jgv.0.000567","article-title":"Hydropericardium syndrome outbreak caused by fowl adenovirus serotype 4 in China in 2015","volume":"97","author":"Niu","year":"2016","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0140","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.3382\/ps\/pex206","article-title":"Pathogenicity and immunosuppressive potential of fowl adenovirus in specific pathogen free chickens","volume":"96","author":"Niu","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0145","doi-asserted-by":"crossref","first-page":"12980","DOI":"10.1128\/JVI.01931-13","article-title":"Apoptosis induction influences reovirus replication and virulence in newborn mice","volume":"87","author":"Pruijssers","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0150","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1128\/JVI.02372-13","article-title":"Adenovirus E1B 19-kilodalton protein modulates innate immunity through apoptotic mimicry","volume":"88","author":"Radke","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virol.2011.04.017","article-title":"Adenoviruses induce autophagy to promote virus replication and oncolysis","volume":"416","author":"Rodriguez-Rocha","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0160","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/vr.155.9.273","article-title":"Hydropericardium syndrome in Japanese Quails (Coturnix coturnix japonica)","volume":"155","author":"Roy","year":"2004","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0165","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cimid.2010.12.001","article-title":"Avian CD154 enhances humoral and cellular immune responses induced by an adenovirus vector-based vaccine in chickens","volume":"34","author":"Sanchez","year":"2011","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0170","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2307\/1592616","article-title":"Characterization of fowl adenoviruses from outbreaks of inclusion body hepatitis hydropericardium syndrome in Chile","volume":"43","author":"Toro","year":"1999","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0175","series-title":"The Cytokine Handbook","first-page":"229","article-title":"Interleukin-8 and other CXC chemokines","author":"Wuyts","year":"1998"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0180","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ncb1007-1102","article-title":"Autophagosome formation: core machinery and adaptations","volume":"9","author":"Xie","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.vetmic.2018.07.014_bib0185","doi-asserted-by":"crossref","first-page":"8147","DOI":"10.1016\/j.vaccine.2010.09.081","article-title":"Immunogenicity and protective efficacy of a dna vaccine encoding a chimeric protein of avian influenza hemagglutinin subtype h5 fused to cd154 (cd40l) in pekin ducks","volume":"28","author":"Yao","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2018.07.014_bib0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030191","article-title":"Up-regulation of Mcl-1 and Bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replication","volume":"7","author":"Zhong","year":"2012","journal-title":"PLoS One"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113517314487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113517314487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:00:31Z","timestamp":1759878031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113517314487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":38,"alternative-id":["S0378113517314487"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2018.07.014","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fowl adenovirus serotype 4-induced apoptosis, autophagy, and a severe inflammatory response in liver","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2018.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}